The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
JAK and STAT Signaling Molecules in Immunoregulation and Immune-Mediated Disease
Open accessAbstract
Summary A landmark in cell biology, the discovery of the JAK-STAT pathway provided a simple mechanism for gene regulation that dramatically advanced our understanding of the action of hormones, interferons, colony stimulating factors, and interleukins. As we learn more about the complexities of immune responses, new insights into the functions of this pathway continue to be revealed, aided by technology that permits genomewide views. As we celebrate the 20th anniversary of the discovery of this paradigm in cell signaling, it is particularly edifying to see how this knowledge has rapidly been translated to human immune disease. Not only have genomewide association studies demonstrated that this pathway is highly relevant to human autoimmunity but targeting JAKs is now a reality in immune-mediated disease.
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Cites
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“TYK2, JAK2, and STAT4 were found to be critical for interleukin-12 (IL-12) signals and Th1 cell differentiation whereas JAK1, JAK3, and STAT6 were key for IL-4 signaling (Darnell et al., 1994; Leonard and O’Shea, 1998; O’Shea and Murray, 2008).”
BackgroundAlternative activation of macrophages: mechanism and functions
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Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci
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Self-citationImpaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome
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Function of Mitochondrial Stat3 in Cellular Respiration
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CD4 + Regulatory T Cells Control T H 17 Responses in a Stat3-Dependent Manner
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Cited by
The JAK/STAT signaling pathway: from bench to clinic
Hu, X., li, J., Fu, M., Zhao, X., & Wang, W. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-021-00791-1 · Cited by 2,633
Transcriptional control of effector and memory CD8+ T cell differentiation
Kaech, S. M., & Cui, W. (2012) · Nature Reviews Immunology · doi:10.1038/nri3307 · Cited by 1,628
The role of JAK/STAT signaling pathway and its inhibitors in diseases.
Xin, P., Xu, X., Deng, C., Liu, S., Wang, Y., Zhou, X., Ma, H., Wei, D., & Sun, S. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106210 · Cited by 1,010
Signaling pathways and targeted therapy for myocardial infarction
Zhang, Q., Wang, L., Wang, S., Cheng, H., Xu, L., Pei, G., Wang, Y., Fu, C., Jiang, Y., He, C., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-00925-z · Cited by 831
The role of JAK-STAT signaling pathway and its regulators in the fate of T helper cells
Seif, F., Khoshmirsafa, M., Aazami, H., Mohsenzadegan, M., Sedighi, G., & Bahar, M. (2017) · Cell Communication and Signaling · doi:10.1186/s12964-017-0177-y · Cited by 768
Metadata
- Authors
- O'Shea, J. J., & Plenge, R.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2012-04
- Volume
- 36
- Issue
- 4
- Pages
- 542-550
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1999218213
- Cited by
- 1,138
- References
- 26
- FWCI
- 31.25
- Type
- journal article
- Language
- en
- Open access
- bronze
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