The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory
Open accessAbstract
SUMMARY Exhausted CD8+ T cells function poorly and are negatively regulated by inhibitory receptors. Transcriptional profiling has identified gene expression changes associated with exhaustion. However, the transcriptional pathways critical to the differences between exhausted and functional memory CD8+ T cells are unclear. We thus defined transcriptional coexpression networks to define pathways centrally involved in exhaustion versus memory. These studies revealed differences between exhausted and memory CD8+ T cells including the following: lack of coordinated transcriptional modules of quiescence during exhaustion, centrally connected hub genes, pathways such as transcription factors, genes involved in regulation of immune responses, and DNA repair genes, as well as differential connectivity for genes including T-bet, Eomes, and other transcription factors. These data identify pathways involved in CD8+ T cell exhaustion, and highlight the context-dependent nature of transcription factors in exhaustion versus memory.
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“Though first observed in lymphocytic choriomeningitis virus (LCMV) infection in mice, CD8+ T cell exhaustion is a prominent feature of many experimental models of chronic infections, as well as in humans with chronic infections and cancer, and this dysfunction prevents optimal control of infections and tumors in these…”
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Molecular and cellular insights into T cell exhaustion
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Metadata
- Authors
- Doering, T. A., Crawford, A., Angelosanto, J. M., Paley, M. A., Ziegler, C. G., & Wherry, E. J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 37
- Issue
- 6
- Pages
- 1130-1144
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1966644185
- Cited by
- 548
- References
- 54
- FWCI
- 10.72
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Doering, T. A., Crawford, A., Angelosanto, J. M., Paley, M. A., Ziegler, C. G., & Wherry, E. J. (2012). Network Analysis Reveals Centrally Connected Genes and Pathways Involved in CD8+ T Cell Exhaustion versus Memory. Immunity. https://doi.org/10.1016/j.immuni.2012.08.021
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
