CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response

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Items 201–300 of 311

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6. Transcriptional regulation of protein synthesis by mediator kinase represents a therapeutic vulnerability in MYC-driven medulloblastoma
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11. Modulation of STAT1-Driven Transcriptional Activity by Histone Deacetylases
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12. Erk1/2, CDK8, Src and Ck1e Mediate Evodia rutaecarpa Induced Hepatotoxicity in Mice
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13. Gene Activation by the Cytokine-Driven Transcription Factor STAT1
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14. CDK8 phosphorylates SOX2 to maintain stemness of pituitary adenoma
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16. Transgenic mice for study of the CDK8/19 cyclin-dependent kinase kinase-independent mechanisms of action
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17. Design and synthesis of 7-azaindole derivatives as potent CDK8 inhibitors for the treatment of acute myeloid leukemia
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18. Reviewer #2 (Public Review): Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome
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19. CDK8 fine-tunes IL-6 transcriptional activities by limiting STAT3 resident time at the gene loci
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21. Distinct Phosphorylation of STAT1 Confers Distinct DNA Binding and Gene-regulatory Properties
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22. Forsythoside B activates Siglec-14 to inhibit HIV-1 replication via the JAK1/STAT1 pathway
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23. Quitting Your Day Job in Response to Stress: Cell Survival and Cell Death Require Secondary Cytoplasmic Roles of Cyclin C and Med13
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24. Anoikis resistance and metastasis of ovarian cancer can be overcome by CDK8/19 mediator kinase inhibition
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25. Distinct effects of CDK8 module subunits on cellular growth and proliferation in Drosophila
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27. Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome
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29. Targeting Mediator Kinase Cyclin-Dependent Kinases 8/19 Potentiates Chemotherapeutic Responses, Reverses Tumor Growth, and Prolongs Survival from Ovarian Clear Cell Carcinoma
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30. STAT1-mediated epigenetic regulation of LIN28A controls iPSC-derived platelet production through the let-7–RALB axis
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31. Transcriptional cyclin-dependent kinases Cdk8 and Cdk19 are required for normal macrophage differentiation
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32. Design and synthesis of a 1,3,6-trimethyl-1H-benzo[d]imidazole-5-sulfonamide derivative as a type I CDK8 inhibitor against colorectal cancer
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33. Therapeutic potential of CDK8 inhibitor combined with sorafenib for hepatocellular carcinoma: mechanistic insights and in vitro validation
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34. Discovery and research progress of CDK8 inhibitors
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35. OGT-mediated O-GlcNAcylation of STAT1 impairs its Ser727 phosphorylation and weakens antitumor immunity of tumor-associated macrophages in cervical cancer
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36. Mediator kinase module proteins, genetic alterations and expression of super-enhancer regulated genes in colorectal cancer
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37. Tumor immunology: a short IL18 cleavage product promotes cancer immunosurveillance
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38. CDK8/19 in Stress Response in Mouse Embryonic Fibroblast Model
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39. Investigations on Cancer Cell Biological Effects of CDK8 Inhibitor Q-12
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40. CDK8-mediated STAT1-S727 phosphorylation restrains NK cell cytotoxicity and tumor surveillance
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41. CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells
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42. MTBP allosterically activates Cdk8-CycC kinase activity
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43. CDK8 is a critical effector of cell fate dysregulation in SF3B1 -mutant MDS
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45. Transcriptional and epigenetic regulation of gene expression by arsenic in cancer and normal cells
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47. Chromatin Looping and Cell Type-specific Regulation of Sox2 Expression
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48. Metabólitos secundários como potenciais inibidores de CDK8 (proteína quinase humana)
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49. The CDK8 inhibitor DCA promotes a tolerogenic chemical immunophenotype in CD4 + T cells via a novel CDK8-GATA3-FOXP3 pathway
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50. Transcriptomic and Proteomic Effects of CDK8 and CDK19 Mediator Kinases
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51. Transgennye myshi dlya izucheniya kinaza-nezavisimyh mekhanizmov dejstviya ciklin-zavisimyh kinaz CDK8/19
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52. Data from CDK4/6 Inhibition Enhances Oncolytic Virus Efficacy by Potentiating Tumor-Selective Cell Killing and T-cell Activation in Refractory Glioblastoma
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54. Transcriptional Regulation of Protein Synthesis by Mediator Kinase in MYC-driven Medulloblastoma
    Dong Wang, Caitlin Ritz, Angela M. Pierce, Breauna Brunt, Yuhuan Luo, Nathan A. Dahl, Sujatha Venkataraman, Etienne P. Danis, Kamil Kuś, Milena M. Mazan et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
55. Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome
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56. eLife Assessment: Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome
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57. Reviewer #1 (Public Review): Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome
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58. mTORC3 Activity is Regulated by GSK3β Through the Activation of PKCδ that Phosphorylates and Activates STAT1
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59. Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome
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97. BindingDB Entry 50016187: Discovery of the Novel 1
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99. BindingDB Entry 50000815: Discovery of potent and selective CDK8 inhibitors through FBDD approach.
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