CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response

STATs: transcriptional control and biological impact

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Mediator and cohesin connect gene expression and chromatin architecture

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Serine phosphorylation of STATs

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Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

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CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

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Immune Control of Tuberculosis by IFN-γ-Inducible LRG-47

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Mastermind Recruits CycC:CDK8 to Phosphorylate the Notch ICD and Coordinate Activation with Turnover

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The role of CDK8 in mesenchymal stem cells in controlling osteoclastogenesis and bone homeostasis

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Weighted enrichment method for prediction of transcription regulators from transcriptome and global chromatin immunoprecipitation data

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Short IL-18 generated by caspase-3 cleavage mobilizes NK cells to suppress tumor growth

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Ectopic expression of Cdk8 induces eccentric hypertrophy and heart failure

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Antitumor Activity of Vanicoside B Isolated from Persicaria dissitiflora by Targeting CDK8 in Triple-Negative Breast Cancer Cells

Kim, D., Wang, C. Y., Hu, R., Lee, J. Y., Luu, T.-T.-T., Park, H.-J., & Lee, S. K. (2019) · Journal of Natural Products · doi:10.1021/acs.jnatprod.9b00720 · Cited by 33

The emerging roles of the CDK/cyclin complexes in antiviral innate immunity

Zheng, C., & Tang, Y. (2021) · Journal of Medical Virology · doi:10.1002/jmv.27554 · Cited by 31

Discovery of potent and selective CDK8 inhibitors through FBDD approach

Han, X., Jiang, M., Zhou, C., Zhou, Z., Xu, Z., Wang, L., Mayweg, A. V. W., Niu, R., Jin, T. J., & Yang, S. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.07.080 · Cited by 30

FBXL19 recruits CDK-Mediator to CpG islands of developmental genes priming them for activation during lineage commitment

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SNX8 mediates IFNγ-triggered noncanonical signaling pathway and host defense against Listeria monocytogenes

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LATS1/2 loss promote tumor immune evasion in endometrial cancer through downregulating MHC-I expression

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Transcriptional control of interferon-stimulated genes

Babadei, O., Strobl, B., Müller, M. M., & Decker, T. (2024) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2024.107771 · Cited by 28

Targeting CDKs in cancer therapy: advances in PROTACs and molecular glues

Marei, H. E. S., Bedair, K., Hasan, A., Al-Mansoori, L., Gaiba, A., Morrione, A., Cenciarelli, C., & Giordano, A. (2025) · npj Precision Oncology · doi:10.1038/s41698-025-00931-8 · Cited by 31

MiR‐382‐5p suppresses M1 macrophage polarization and inflammatory response in response to bronchopulmonary dysplasia through targeting CDK8: Involving inhibition of STAT1 pathway

Lv, Y., Li, Y., Wang, J., Li, M., Zhang, W., Zhang, H., Shen, Y., Li, C. R., Du, Y., & Jiang, L. (2021) · Genes to Cells · doi:10.1111/gtc.12883 · Cited by 27

Ubiquitination network in the type I IFN‐induced antiviral signaling pathway

Zhao, Q., Zhang, R., Qiao, C., Miao, Y., Yuan, Y., & Zheng, H. (2023) · European Journal of Immunology · doi:10.1002/eji.202350384 · Cited by 28

Cdk8/CDK19 promotes mitochondrial fission through Drp1 phosphorylation and can phenotypically suppress pink1 deficiency in Drosophila

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Orf virus inhibits interferon stimulated gene expression and modulates the JAK/STAT signalling pathway

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Interferon Independent Non-Canonical STAT Activation and Virus Induced Inflammation

Nan, Y., Wu, C., & Zhang, Y. (2018) · Viruses · doi:10.3390/v10040196 · Cited by 26

STAT1 Isoforms Differentially Regulate NK Cell Maturation and Anti-tumor Activity

Meissl, K., Simonović, N., Amenitsch, L., Witalisz‐Siepracka, A., Klein, K., Lassnig, C., Puga, A., Vogl, C., Poelzl, A., Bosmann, M., et al. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02189 · Cited by 25

LATS1 is a central signal transmitter for achieving full type-I interferon activity

Zuo, Y., He, J., Liu, S., Xu, Y., Liu, J., Qiao, C., Zang, L., Sun, W., Yuan, Y., Zhang, H., et al. (2022) · Science Advances · doi:10.1126/sciadv.abj3887 · Cited by 27

The C-Terminal Transactivation Domain of STAT1 Has a Gene-Specific Role in Transactivation and Cofactor Recruitment

Parrini, M., Meissl, K., Ola, M. J., Lederer, T., Puga, A., Wienerroither, S., Kovarik, P., Decker, T., Müller, M. M., & Strobl, B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02879 · Cited by 24

Identification of novel regulators of STAT3 activity

Parri, E., Kuusanmäki, H. A., van Adrichem, A. J., Kaustio, M., & Wennerberg, K. (2020) · PLoS ONE · doi:10.1371/journal.pone.0230819 · Cited by 23

CDK8 and CDK19 regulate intestinal differentiation and homeostasis via the chromatin remodeling complex SWI/SNF

Dannappel, M., Zhu, D., Sun, X., Chua, H. K., Poppelaars, M., Suehiro, M., Khadka, S., Sian, T. C. C. L. K., Sooraj, D., Loi, M., et al. (2022) · Journal of Clinical Investigation · doi:10.1172/jci158593 · Cited by 26

Transcriptional Control of NK Cells

Sun, J. C.-Y. (2015) · Current topics in microbiology and immunology · doi:10.1007/82_2015_452 · Cited by 24

Serine Phosphorylation of the STAT1 Transactivation Domain Promotes Autoreactive B Cell and Systemic Autoimmunity Development

Chodisetti, S. B., Fike, A. J., Domeier, P. P., Schell, S. L., Mockus, T. E., Choi, N. M., Corradetti, C., Hou, B., Atkins, H., Caricchio, R., et al. (2020) · The Journal of Immunology · doi:10.4049/jimmunol.2000170 · Cited by 24

Studies of CDK 8/19 inhibitors: Discovery of novel and selective CDK8/19 dual inhibitors and elimination of their CYP3A4 time-dependent inhibition potential

Fujimoto, J., Hirayama, T., Hirata, Y., Hikichi, Y., Murai, S., Hasegawa, M., Hasegawa, Y., Yonemori, K., Hata, A., Aoyama, K., et al. (2017) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2017.03.049 · Cited by 23

CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium

Prieto, S., Dubra, G., Camasses, A., Simboeck, E., Aznar, A. B., Begon‐Pescia, C., Pirot, N., Gerbe, F., Angevin, L., Jay, P., et al. (2022) · EMBO Reports · doi:10.15252/embr.202154261 · Cited by 23

The study of a novel CDK8 inhibitor E966-0530–45418 that inhibits prostate cancer metastasis in vitro and in vivo

Ho, T.-Y., Sung, T., Pan, S., Huang, W., Hsu, K., Hsu, J., Lin, T. E., Hsu, C., & Yang, C. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114667 · Cited by 22

Mediator kinase inhibition reverses castration resistance of advanced prostate cancer

Li, J., Hilimire, T. A., Liu, Y., Wang, L., Liang, J., Győrffy, B., Sikirzhytski, V., Ji, H., Zhang, L., Chen, C., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci176709 · Cited by 22

Glu-mGluR2/3-ERK Signaling Regulates Apoptosis of Hippocampal Neurons in Diabetic-Depression Model Rats

Liu, Z., Han, Y., Zhao, H., Luo, W., Jia, L., & Wang, Y. (2019) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2019/3710363 · Cited by 22

Characterizing CDK8/19 Inhibitors through a NFκB-Dependent Cell-Based Assay

Li, J., Ji, H., Porter, D. C., Broude, E. V., Roninson, I. B., & Chen, M. (2019) · Cells · doi:10.3390/cells8101208 · Cited by 21

Design and Synthesis of a 2-Amino-pyridine Derivative as a Potent CDK8 Inhibitor for Anti-colorectal Cancer Therapy

Yan, Y. Y., Zhang, X. X., Xiao, Y., Shen, X. B., Jian, Y. J., Wang, Y., She, Z. H., Liu, M. M., & Liu, X. H. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01042 · Cited by 21

Remembering foods and foes: emerging principles of transcriptional memory

Tehrani, S., Kogan, A., Mikulski, P., & Jansen, L. E. T. (2023) · Cell Death and Differentiation · doi:10.1038/s41418-023-01200-6 · Cited by 21

Important scaffold function of the Janus kinase 2 uncovered by a novel mouse model harboring a Jak2 activation-loop mutation

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Critical Roles for Rictor/Sin1 Complexes in Interferon-dependent Gene Transcription and Generation of Antiproliferative Responses

Kaur, S., Kroczyńska, B., Sharma, B., Sassano, A., Arslan, A. D., Majchrzak-Kita, B., Stein, B. L., McMahon, B., Altman, J. K., Su, B., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.537852 · Cited by 22

Potent and orally bioavailable CDK8 inhibitors: Design, synthesis, structure-activity relationship analysis and biological evaluation

Yu, M., Teo, T., Yang, Y., Li, M., Long, Y., Philip, S., Noll, B. D., Heinemann, G. K., Diab, S., Eldi, P., et al. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113248 · Cited by 21

Triple-negative breast cancer cells rely on kinase-independent functions of CDK8 to evade NK-cell-mediated tumor surveillance

Knab, V. M., Gotthardt, D., Klein, K., Grausenburger, R., Heller, G., Menzl, I., Prinz, D., Trifinopoulos, J., List, J., Fux, D. A., et al. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04279-2 · Cited by 21

Crosstalk between type I and II interferons in regulation of myeloid cell responses during bacterial infection

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Regulation of metabolism by the Mediator complex

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The Mediator CDK8-Cyclin C complex modulates Dpp signaling in Drosophila by stimulating Mad-dependent transcription

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Cyclin-dependent Kinase 8 Module Expression Profiling Reveals Requirement of Mediator Subunits 12 and 13 for Transcription of Serpent-dependent Innate Immunity Genes in Drosophila

Kuuluvainen, E., Hakala, H., Havula, E., Estimé, M. S., Rämet, M., Hietakangas, V., & Mäkelä, T. P. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.541904 · Cited by 20

Fascin1 suppresses RIG-I–like receptor signaling and interferon-β production by associating with IκB kinase Ε (IKKΕ) in colon cancer

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Cdk8 Kinase Module: A Mediator of Life and Death Decisions in Times of Stress

Friedson, B., & Cooper, K. F. (2021) · Microorganisms · doi:10.3390/microorganisms9102152 · Cited by 19

Advances in kinase inhibition

Gadina, M. (2014) · Current Opinion in Rheumatology · doi:10.1097/bor.0000000000000023 · Cited by 19

Transcriptional Antagonism by CDK8 Inhibition Improves Therapeutic Efficacy of MEK Inhibitors

Malone, C. F., Kim, M., Alexe, G., Engel, K. L., Forman, A. B., Robichaud, A. L., Conway, A. S., Goodale, A. B., Meyer, A., Khalid, D., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-4309 · Cited by 19

CDK8 inhibitors antagonize HIV-1 reactivation and promote provirus latency in T cells

Horvath, R. M., Brumme, Z. L., & Sadowski, I. (2023) · Journal of Virology · doi:10.1128/jvi.00923-23 · Cited by 17

In Search of Novel CDK8 Inhibitors by Virtual Screening

Kumarasiri, M., Teo, T., Yu, M., Philip, S., Basnet, S. K. C., Albrecht, H., Sykes, M. J., Wang, P., & Wang, S. (2017) · Journal of Chemical Information and Modeling · doi:10.1021/acs.jcim.6b00711 · Cited by 17

Regulation of the human papillomavirus type 16 late promoter by transcriptional elongation

Songock, W. K., Scott, M. L., & Bodily, J. M. (2017) · Virology · doi:10.1016/j.virol.2017.04.021 · Cited by 17

Genetically Engineered Mice Unveil In Vivo Roles of the Mediator Complex

Ilchuk, L. A., Kubekina, M. V., Okulova, Y. D., Silaeva, Y. Y., Tatarskiy, V. V., Filatov, M. A., & Bruter, A. V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119330 · Cited by 16

Promoter Occupancy of STAT1 in Interferon Responses Is Regulated by Processive Transcription

Wiesauer, I., Gaumannmüller, C., Steinparzer, I., Strobl, B., & Kovarik, P. (2014) · Molecular and Cellular Biology · doi:10.1128/mcb.01097-14 · Cited by 16

Discovery of the Novel 1H-Pyrrolo[2,3-b]pyridine Derivative as a Potent Type II CDK8 Inhibitor against Colorectal Cancer

Zhang, X. X., Xiao, Y., Yan, Y. Y., Wang, Y., Jiang, H., Wu, L., Shi, J., & Liu, X. H. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c00820 · Cited by 15

The Mediator subunit MED12 promotes formation of HSF1 condensates on heat shock response element arrays in heat‐shocked cells

Okada, M., Fujimoto, M., Srivastava, P., Pandey, A., Takii, R., & Nakai, A. (2023) · FEBS Letters · doi:10.1002/1873-3468.14617 · Cited by 13

Discovery of a Novel and Potent Cyclin-Dependent Kinase 8/19 (CDK8/19) Inhibitor for the Treatment of Cancer

Xu, J., Qi, H., Wang, Z., Wang, L., Steurer, B., Cai, X., Liu, J., Aliper, A., Zhang, M., Ren, F., et al. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00248 · Cited by 15

Aberrant expression of CDK8 regulates the malignant phenotype and associated with poor prognosis in human laryngeal squamous cell carcinoma

Li, M., Zhao, X., Liu, Y., An, J., Xiao, H., & Wang, C. (2017) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-017-4484-0 · Cited by 16

The Candida albicans Cdk8-dependent phosphoproteome reveals repression of hyphal growth through a Flo8-dependent pathway

Hollomon, J. M., Liu, Z., Rusin, S. F., Jenkins, N. P., Smith, A. K., Koeppen, K., Kettenbach, A. N., Myers, L. C., & Hogan, D. A. (2022) · PLoS Genetics · doi:10.1371/journal.pgen.1009622 · Cited by 15

Distinct mouse models of Stargardt disease display differences in pharmacological targeting of ceramides and inflammatory responses

Engfer, Z. J., Lewandowski, D., Dong, Z., Palczewska, G., Zhang, J., Kordecka, K., Płaczkiewicz, J., Panas, D., Foik, A. T., Tabaka, M., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2314698120 · Cited by 13

Discovery of novel and potent CDK8 inhibitors for the treatment of acute myeloid leukaemia

Chen, Z., Wang, Q., Yan, Y. Y., Jin, D., Wang, Y., Zhang, X. X., & Liu, X. H. (2024) · Journal of Enzyme Inhibition and Medicinal Chemistry · doi:10.1080/14756366.2024.2305852 · Cited by 14

Unveiling the impact of CDK8 on tumor progression: mechanisms and therapeutic strategies

Yin, X., He, Z., Chen, K., Ouyang, K., Yang, C., Li, J., Tang, H., & Cai, M. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1386929 · Cited by 15

Pyrido[2,3-b][1,5]benzoxazepin-5(6H)-one derivatives as CDK8 inhibitors

Martı́nez, S., Garcı́a, A. B., Albarran, M. I., Cebriá, A., Amezquita-Alves, A., García-Campos, F. J., Martínez-Gago, J., Martinez-Torrecuadrada, J. L., Muñoz, I. G., Blanco‐Aparicio, C., et al. (2020) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2020.112443 · Cited by 14

The Cyclin-Dependent Kinase 8 (CDK8) Inhibitor DCA Promotes a Tolerogenic Chemical Immunophenotype in CD4 + T Cells via a Novel CDK8-GATA3-FOXP3 Pathway

Arnett, A., Moo, K. G., Flynn, K. J., Sundberg, T. B., Johannessen, L. H., Shamji, A. F., Gray, N. S., Decker, T., Zheng, Y., Gersuk, V. H., et al. (2021) · Molecular and Cellular Biology · doi:10.1128/mcb.00085-21 · Cited by 13

Co-targeting RANK pathway treats and prevents acquired resistance to CDK4/6 inhibitors in luminal breast cancer

Gomes, I., Gallego-Paez, L. M., Jiménez, M., Santamarı́a, P. G., Mansinho, A., Sousa, R., Abreu, C., González‐Suárez, E., Costa, L., & Casimiro, S. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101120 · Cited by 14

Suppression of a Subset of Interferon-Induced Genes by Human Papillomavirus Type 16 E7 via a Cyclin Dependent Kinase 8-Dependent Mechanism

Rice, S., Kim, S., Rodríguez, C., Songock, W. K., Raikhy, G., Lopez, R., Henderson, L., Yusufji, A., & Bodily, J. M. (2020) · Viruses · doi:10.3390/v12030311 · Cited by 13

Synergistic repression of thyroid hyperplasia by cyclin C and Pten

Ježek, J., Wang, K., Yan, R., Cristofano, A. D., Cooper, K. F., & Strich, R. (2019) · Journal of Cell Science · doi:10.1242/jcs.230029 · Cited by 13

Cyclin-Dependent Kinases 8 and 19 Regulate Host Cell Metabolism during Dengue Virus Serotype 2 Infection

Butler, M., Chotiwan, N., Brewster, C. D., DiLisio, J. E., Ackart, D. F., Podell, B. K., Basaraba, R. J., Perera, R. M., Quackenbush, S. L., & Rovnak, J. (2020) · Viruses · doi:10.3390/v12060654 · Cited by 13

All-Atomic Molecular Dynamic Studies of Human and Drosophila CDK8: Insights into Their Kinase Domains, the LXXLL Motifs, and Drug Binding Site

Xu, W., Xie, X., Faust, A. K., Liu, M., Li, X., Chen, F., Naquin, A. A., Walton, A. C., Kishbaugh, P. W., & Ji, J. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21207511 · Cited by 13

Pharmacological Inhibition of CDK8 in Triple-Negative Breast Cancer Cell Line MDA-MB-468 Increases E2F1 Protein, Induces Phosphorylation of STAT3 and Apoptosis

Spear, J. M., Lu, Z., & Russu, W. A. (2020) · Molecules · doi:10.3390/molecules25235728 · Cited by 13

IFNα signaling through PKC-θ is essential for antitumor NK cell function

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Type I interferon inhibits varicella-zoster virus replication by interfering with the dynamic interaction between mediator and IE62 within replication compartments

Ku, C., Chang, Y.-H., Chien, Y., & Lee, T.-L. (2016) · Cell & Bioscience · doi:10.1186/s13578-016-0086-6 · Cited by 13

MK256 is a novel CDK8 inhibitor with potent antitumor activity in AML through downregulation of the STAT pathway

Lee, J., Liu, S., Wang, Y., You, L., & Jablons, D. M. (2022) · Oncotarget · doi:10.18632/oncotarget.28305 · Cited by 12

Exploitation of the Mediator complex by viruses

Rovnak, J., & Quackenbush, S. L. (2022) · PLoS Pathogens · doi:10.1371/journal.ppat.1010422 · Cited by 12

Inducible, Dose-Adjustable and Time-Restricted Reconstitution of Stat1 Deficiency In Vivo

Leitner, N. R., Lassnig, C., Rom, R., Heider, S., Bagó-Horváth, Z., Eferl, R., Müller, S., Kolbe, T., Kenner, L., Rülicke, T., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0086608 · Cited by 12

CDK19 as a Potential HPV-Independent Biomarker for Recurrent Disease in HNSCC

Paulsen, F., Idel, C., Ribbat‐Idel, J., Kuppler, P., Klapper, L., Rades, D., Bruchhage, K., Wollenberg, B., Brägelmann, J., Perner, S., et al. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155508 · Cited by 12

Discovery of a potent, highly selective, and orally bioavailable inhibitor of CDK8 through a structure-based optimisation

Yu, M., Long, Y., Yang, Y., Li, M., Teo, T., Noll, B. D., Philip, S., & Wang, S. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113391 · Cited by 12

Mediator kinase inhibitors suppress triple-negative breast cancer growth and extend tumor suppression by mTOR and AKT inhibitors

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Inhibition of CD226 co-stimulation suppresses diabetes development in the NOD mouse by augmenting regulatory T cells and diminishing effector T cell function

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Mediator kinase inhibition suppresses hyperactive interferon signaling in Down syndrome

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Cyclin-dependent kinase (CDK) 8 and its paralog CDK19 develop group 2 innate lymphoid cell–related lung fibrosis by activating STAT5

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Cytokines use different intracellular mechanisms to upregulate the membrane expression of CX3CR1 in human monocytes

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cipitation; IFNγ, interferon-γ; RNAPII,

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The Role of CDK8 in Dynamics of IFN-γ-Induced Transcription

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Transcriptional Responses to IFN-γ Require Mediator Kinase-Dependent Pause Release and Mechanistically Distinct CDK8 and CDK19 Functions

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Abstract 89: Role of CDK8 and CDK19 in STAT1 phosphorylation at serine 727

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