The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
Dimerization and Ubiquitin Mediated Recruitment of A20, a Complex Deubiquitinating Enzyme
Open accessAbstract
A20 is an anti-inflammatory protein linked to multiple human autoimmune diseases and lymphomas. A20 possesses a deubiquitinating motif and a zinc finger, ZF4, that binds ubiquitin and supports its E3 ubiquitin ligase activity. To understand how these activities mediate A20’s physiological functions, we generated two lines of gene-targeted mice, abrogating either A20’s deubiquitinating activity (Tnfaip3OTU mice) or A20’s ZF4 (Tnfaip3ZF4 mice). Both Tnfaip3OTU and Tnfaip3ZF4 mice exhibited increased responses to TNF and sensitivity to colitis. A20’s C103 deubiquitinating motif restricted both K48- and K63-linked ubiquitination of receptor interacting protein 1 (RIP1). A20’s ZF4 was required for recruiting A20 to ubiquitinated RIP1. A20OTU proteins and A20ZF4 proteins complemented each other to regulate RIP1 ubiquitination and NFκB signaling normally in compound mutant Tnfaip3OTU/ZF4 cells. This complementation involved homodimerization of A20 proteins, and we have defined an extensive dimerization interface in A20. These studies reveal how A20 proteins collaborate to restrict TNF signaling.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Failure to Regulate TNF-Induced NF-κB and Cell Death Responses in A20-Deficient Mice
Lee, E. G., Boone, D. L., Chai, S., Libby, S. L., Chien, M., Lodolce, J. P., & Ma, A. (2000) · Science · doi:10.1126/science.289.5488.2350 · Cited by 1,409
Self-citationKrikos, A., Laherty, C. D., & Dixit, V. M. (1992) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37138-8 · Cited by 444
Song, H. Y., Rothe, M., & Goeddel, D. V. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.13.6721 · Cited by 414
Heyninck, K., & Beyaert, R. (1999) · FEBS Letters · doi:10.1016/s0014-5793(98)01645-7 · Cited by 169
A pervasive role of ubiquitin conjugation in activation and termination of IκB kinase pathways
Krappmann, D., & Scheidereit, C. (2005) · The EMBO Reports · doi:10.1038/sj.embor.7400380 · Cited by 128
Cited by
Limiting inflammation—the negative regulation of NF-κB and the NLRP3 inflammasome
Afonina, I. S., Zhong, Z., Karin, M., & Beyaert, R. (2017) · Nature Immunology · doi:10.1038/ni.3772 · Cited by 759
Newton, K., Dugger, D. L., Maltzman, A., Greve, J. M., Hedehus, M., Martin-McNulty, B., Carano, R. A. D., Cao, T. C., van Bruggen, N., Bernstein, L., et al. (2016) · Cell Death & Differentiation · doi:10.1038/cdd.2016.46 · Cited by 438
Tumour necrosis factor signalling in health and disease
Holbrook, J., Lara-Reyna, S., Jarosz-Griffiths, H., & McDermott, M. F. (2019) · F1000Research · doi:10.12688/f1000research.17023.1 · Cited by 382
Onizawa, M., Oshima, S., Schulze-Topphoff, U., Oses-Prieto, J. A., Lu, T., Tavares, R., Prodhomme, T., Duong, B., Whang, M. I., Advincula, R., et al. (2015) · Nature Immunology · doi:10.1038/ni.3172 · Cited by 284
Self-citationCYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different
Lork, M., Verhelst, K., & Beyaert, R. (2017) · Cell Death & Differentiation · doi:10.1038/cdd.2017.46 · Cited by 282
Metadata
- Authors
- Lu, T. T., Onizawa, M., Hammer, G. E., Turer, E. E., Yin, Q., Damko, E., Agelidis, A., Shifrin, N., Advincula, R., Barrera, J., Malynn, B. A., Wu, H., & Ma, A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 38
- Issue
- 5
- Pages
- 896-905
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2132333958
- Cited by
- 184
- References
- 5
- FWCI
- 4.35
- Type
- journal article
- Language
- en
- Open access
- bronze
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Dimerization and Ubiquitin Mediated Recruitment of A20, a Complex Deubiquitinating Enzyme. https://app.cochat.ai/papers/10.1016/j.immuni.2013.03.008
- The paper
- Lu, T. T., Onizawa, M., Hammer, G. E., Turer, E. E., Yin, Q., Damko, E., Agelidis, A., Shifrin, N., Advincula, R., Barrera, J., Malynn, B. A., Wu, H., & Ma, A. (2013). Dimerization and Ubiquitin Mediated Recruitment of A20, a Complex Deubiquitinating Enzyme. Immunity. https://doi.org/10.1016/j.immuni.2013.03.008
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
