The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Tumour necrosis factor signalling in health and disease
Open accessAbstract
The master pro-inflammatory cytokine, tumour necrosis factor (TNF), has been shown to modulate multiple signalling pathways, with wide-ranging downstream effects. TNF plays a vital role in the typical immune response through the regulation of a number of pathways encompassing an immediate inflammatory reaction with significant innate immune involvement as well as cellular activation with subsequent proliferation and programmed cell death or necrosis. As might be expected with such a broad spectrum of cellular effects and complex signalling pathways, TNF has also been implicated in a number of disease states, such as rheumatoid arthritis, ankylosing spondylitis, and Crohn’s disease. Since the time of its discovery over 40 years ago, TNF ligand and its receptors, TNF receptor (TNFR) 1 and 2, have been categorised into two complementary superfamilies, namely TNF (TNFSF) and TNFR (TNFRSF), and 19 ligands and 29 receptors have been identified to date. There have been significant advances in our understanding of TNF signalling pathways in the last decade, and this short review aims to elucidate some of the most recent advances involving TNF signalling in health and disease.
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1 retracted
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The Molecular Basis of Resilience: A Narrative Review
Ryan, M., & Ryznar, R. (2022) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.856998 · Cited by 65
Okoro, E. U. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22126236 · Cited by 18
Specific S100 Proteins Bind Tumor Necrosis Factor and Inhibit Its Activity
Kazakov, A. S., Zemskova, M. Y., Rystsov, G. K., Vologzhannikova, A. A., Deryusheva, E. I., Rastrygina, V. A., Sokolov, A. S., Permyakova, M. E., Litus, E. A., Uversky, V. N., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232415956 · Cited by 12
Metadata
- Authors
- Holbrook, J., Lara-Reyna, S., Jarosz-Griffiths, H., & McDermott, M. F.
- Venue
- F1000Research
- Publisher
- F1000 Research Ltd
- Published
- 2019-01-28
- Volume
- 8
- Pages
- 111
- ISSN
- 2046-1402 (ISSN-L)
- OpenAlex
- W2911789924
- Cited by
- 382
- References
- 19
- FWCI
- 11.61
- Type
- journal article
- Language
- en
- Open access
- gold
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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