CYLD, A20 and OTULIN deubiquitinases in NF-κB signaling and cell death: so similar, yet so different

The ubiquitin code

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CYLD is a deubiquitinating enzyme that negatively regulates NF-κB activation by TNFR family members

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Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-κB

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Recruitment of the Linear Ubiquitin Chain Assembly Complex Stabilizes the TNF-R1 Signaling Complex and Is Required for TNF-Mediated Gene Induction

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Identification of the familial cylindromatosis tumour-suppressor gene

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Inhibition of NF-κB Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

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Loss-of-function mutations in TNFAIP3 leading to A20 haploinsufficiency cause an early-onset autoinflammatory disease

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Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling

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Molecular discrimination of structurally equivalent Lys 63‐linked and linear polyubiquitin chains

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Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis

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A20 in inflammation and autoimmunity

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Caspase 8 inhibits programmed necrosis by processing CYLD

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OTULIN Antagonizes LUBAC Signaling by Specifically Hydrolyzing Met1-Linked Polyubiquitin

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Cyld Inhibits Tumor Cell Proliferation by Blocking Bcl-3-Dependent NF-κB Signaling

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T cell antigen receptor stimulation induces MALT1 paracaspase–mediated cleavage of the NF-κB inhibitor A20

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The A20 zinc finger protein protects cells from tumor necrosis factor cytotoxicity.

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Activation of the canonical IKK complex by K63/M1-linked hybrid ubiquitin chains

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CYLD: a tumor suppressor deubiquitinase regulating NF-κB activation and diverse biological processes

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The Ubiquitin Ligase XIAP Recruits LUBAC for NOD2 Signaling in Inflammation and Innate Immunity

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Tumor necrosis factor-alpha induction of novel gene products in human endothelial cells including a macrophage-specific chemotaxin.

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MINDY-1 Is a Member of an Evolutionarily Conserved and Structurally Distinct New Family of Deubiquitinating Enzymes

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The K48-K63 Branched Ubiquitin Chain Regulates NF-κB Signaling

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The Ubiquitin-Editing Enzyme A20 Restricts Nucleotide-Binding Oligomerization Domain Containing 2-Triggered Signals

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The deubiquitinase OTULIN is an essential negative regulator of inflammation and autoimmunity

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MicroRNAs miR-125a and miR-125b constitutively activate the NF-κB pathway by targeting the tumor necrosis factor alpha-induced protein 3 (TNFAIP3, A20)

Kim, S.-W., Ramasamy, K., Bouamar, H., Lin, A.-P., Jiang, D.-F., & Aguiar, R. (2012) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1200081109 · Cited by 336 · see citing works

Screening of DUB activity and specificity by MALDI-TOF mass spectrometry

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The tumour suppressor CYLD is a negative regulator of RIG‐I‐mediated antiviral response

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CYLD Deubiquitinates RIP1 in the TNFα-Induced Necrosome to Facilitate Kinase Activation and Programmed Necrosis

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A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis

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LUBAC-Recruited CYLD and A20 Regulate Gene Activation and Cell Death by Exerting Opposing Effects on Linear Ubiquitin in Signaling Complexes

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The ubiquitin-modifying enzyme A20 restricts ubiquitination of the kinase RIPK3 and protects cells from necroptosis

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The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis

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The E3 ligase Itch negatively regulates inflammatory signaling pathways by controlling the function of the ubiquitin-editing enzyme A20

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Enterocyte-specific A20 deficiency sensitizes to tumor necrosis factor–induced toxicity and experimental colitis

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The Structure of the CYLD USP Domain Explains Its Specificity for Lys63-Linked Polyubiquitin and Reveals a B Box Module

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Biallelic hypomorphic mutations in a linear deubiquitinase define otulipenia, an early-onset autoinflammatory disease

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The Ubiquitin Modifying Enzyme A20 Restricts B Cell Survival and Prevents Autoimmunity

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A20 Restricts Ubiquitination of Pro-Interleukin-1β Protein Complexes and Suppresses NLRP3 Inflammasome Activity

Duong, B. H., Onizawa, M., Osés-Prieto, J. A., Advincula, R., Burlingame, A. L., Malynn, B. A., & Ma, A. I. (2015) · Immunity · doi:10.1016/j.immuni.2014.12.031 · Cited by 269 · see citing works

OTULIN Restricts Met1-Linked Ubiquitination to Control Innate Immune Signaling

Fiil, B. K., Damgaard, R. B., Wagner, S., Keusekotten, K., Fritsch, M., Bekker‐Jensen, S., Mailand, N., Choudhary, C., Komander, D., & Gyrd‐Hansen, M. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.06.004 · Cited by 265 · see citing works

Regulation of NF‐κB by deubiquitinases

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The Ubiquitin-Editing Protein A20 Prevents Dendritic Cell Activation, Recognition of Apoptotic Cells, and Systemic Autoimmunity

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Deubiquitinating enzyme CYLD negatively regulates the ubiquitin-dependent kinase Tak1 and prevents abnormal T cell responses

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Direct, Noncatalytic Mechanism of IKK Inhibition by A20

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ABIN-1 Binds to NEMO/IKKγ and Co-operates with A20 in Inhibiting NF-κB

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Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

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Impaired regulation of NF-κB and increased susceptibility to colitis-associated tumorigenesis in CYLD-deficient mice

Zhang, J., Stirling, B., Temmerman, S. T., Ma, C. A., Fuss, I. J., Derry, J. M. J., & Jain, A. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28746 · Cited by 245 · see citing works

Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis

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Specific recognition of linear polyubiquitin by A20 zinc finger 7 is involved in NF‐κB regulation

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A20 Negatively Regulates T Cell Receptor Signaling to NF-κB by Cleaving Malt1 Ubiquitin Chains

Düwel, M., Welteke, V., Oeckinghaus, A., Baens, M., Kloo, B., Ferch, U., Darnay, B. G., Ruland, J., Marynen, P., & Krappmann, D. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0803313 · Cited by 233 · see citing works

Zinc-finger protein A20, a regulator of inflammation and cell survival, has de-ubiquitinating activity

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Phosphorylation of the Tumor Suppressor CYLD by the Breast Cancer Oncogene IKKɛ Promotes Cell Transformation

Hutti, J. E., Shen, R. R., Abbott, D. W., Zhou, A. Y., Sprott, K. M., Asara, J. M., Hahn, W. C., & Cantley, L. C. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.04.031 · Cited by 229 · see citing works

Ubiquitin binding mediates the NF-κB inhibitory potential of ABIN proteins

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T‐cell receptor‐induced JNK activation requires proteolytic inactivation of CYLD by MALT1

Staal, J., Driege, Y., Bekaert, T., Demeyer, A., Muyllaert, D., Damme, P. V., Gevaert, K., & Beyaert, R. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.85 · Cited by 221 · see citing works

Expression, biological activities and mechanisms of action of A20 (TNFAIP3)

Verstrepen, L., Verhelst, K., Loo, G., Carpentier, I., Ley, S. C., & Beyaert, R. (2010) · Biochemical Pharmacology · doi:10.1016/j.bcp.2010.06.044 · Cited by 219 · see citing works

Regulation of T cell development by the deubiquitinating enzyme CYLD

Reiley, W. W., Zhang, M., Jin, W., Losiewicz, M. K., Donohue, K. B., Norbury, C. C., & Sun, S. (2006) · Nature Immunology · doi:10.1038/ni1315 · Cited by 216 · see citing works

Regulation of Early Wave of Germ Cell Apoptosis and Spermatogenesis by Deubiquitinating Enzyme CYLD

Wright, A., Reiley, W. W., Chang, M., Jin, W., Lee, A. J., Zhang, M., & Sun, S. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.09.007 · Cited by 212 · see citing works

The ubiquitin‐editing enzyme A20 requires RNF11 to downregulate NF‐κB signalling

Shembade, N., Parvatiyar, K., Harhaj, N. S., & Harhaj, E. W. (2009) · The EMBO Journal · doi:10.1038/emboj.2008.285 · Cited by 211 · see citing works

A20 inhibits LUBAC‐mediated NF‐κB activation by binding linear polyubiquitin chains via its zinc finger 7

Verhelst, K., Carpentier, I., Kreike, M., Meloni, L., Verstrepen, L., Kensche, T., Đikić, I., & Beyaert, R. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.240 · Cited by 203 · see citing works

The Tumor Suppressor Cylindromatosis (CYLD) Acts as a Negative Regulator for Toll-like Receptor 2 Signaling via Negative Cross-talk with TRAF6 and TRAF7

Yoshida, H., Jono, H., Kai, H., & Li, J. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m509526200 · Cited by 199 · see citing works

A20 Inhibits Tumor Necrosis Factor (TNF) Alpha-Induced Apoptosis by Disrupting Recruitment of TRADD and RIP to the TNF Receptor 1 Complex in Jurkat T Cells

He, K., & Ting, A. T. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.17.6034-6045.2002 · Cited by 196 · see citing works

Deubiquitinating enzyme CYLD negatively regulates RANK signaling and osteoclastogenesis in mice

Jin, W., Chang, M., Paul, E. M., Babu, G. R., Lee, A. J., Reiley, W. W., Wright, A., Zhang, M., You, J., & Sun, S. (2008) · Journal of Clinical Investigation · doi:10.1172/jci34257 · Cited by 195 · see citing works

Regulation of the Deubiquitinating Enzyme CYLD by IκB Kinase Gamma-Dependent Phosphorylation

Reiley, W. W., Zhang, M., Wu, X., Granger, E. L., & Sun, S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.10.3886-3895.2005 · Cited by 193 · see citing works

Essential role for TAX1BP1 in the termination of TNF‐α‐, IL‐1‐ and LPS‐mediated NF‐κB and JNK signaling

Shembade, N., Harhaj, N. S., Liebl, D. J., & Harhaj, E. W. (2007) · The EMBO Journal · doi:10.1038/sj.emboj.7601823 · Cited by 191 · see citing works

Ubiquitin Binding to A20 ZnF4 Is Required for Modulation of NF-κB Signaling

Bosanac, I., Wertz, I. E., Pan, B., Yu, C., Kusam, S., Lam, C., Phu, L., Phung, Q. T., Maurer, B., Arnott, D. P., et al. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.10.009 · Cited by 190 · see citing works

Molecular Basis and Regulation of OTULIN-LUBAC Interaction

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Dimerization and Ubiquitin Mediated Recruitment of A20, a Complex Deubiquitinating Enzyme

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NF-κB Is Essential for Induction of CYLD, the Negative Regulator of NF-κB

Jono, H., Lim, J. H., Chen, L. F., Xu, H., Trompouki, E., Pan, Z. K., Mosialos, G., & Li, J. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m406638200 · Cited by 180 · see citing works

Binding of OTULIN to the PUB Domain of HOIP Controls NF-κB Signaling

Schaeffer, V., Akutsu, M., Olma, M. H., Gomes, L. C., Kawasaki, M., & Đikić, I. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.03.016 · Cited by 179 · see citing works

Structure of the A20 OTU domain and mechanistic insights into deubiquitination

Komander, D., & Barford, D. (2007) · Biochemical Journal · doi:10.1042/bj20071399 · Cited by 170 · see citing works

IκB Kinase β Phosphorylates the K63 Deubiquitinase A20 To Cause Feedback Inhibition of the NF-κB Pathway

Hutti, J. E., Turk, B. E., Asara, J. M., Ma, A. I., Cantley, L. C., & Abbott, D. W. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01101-07 · Cited by 169 · see citing works

The E3 ligase Itch and deubiquitinase Cyld act together to regulate Tak1 and inflammation

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Fucose-specific DC-SIGN signalling directs T helper cell type-2 responses via IKKε- and CYLD-dependent Bcl3 activation

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SPATA2 Links CYLD to LUBAC, Activates CYLD, and Controls LUBAC Signaling

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Inflammatory cardiac valvulitis in TAX1BP1‐deficient mice through selective NF‐κB activation

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CYLD Limits Lys63- and Met1-Linked Ubiquitin at Receptor Complexes to Regulate Innate Immune Signaling

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A20 controls intestinal homeostasis through cell-specific activities

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Regulation of A20 and other OTU deubiquitinases by reversible oxidation

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SPATA2-Mediated Binding of CYLD to HOIP Enables CYLD Recruitment to Signaling Complexes

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Structures of CYLD USP with Met1- or Lys63-linked diubiquitin reveal mechanisms for dual specificity

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SPATA2 links CYLD to the TNF‐α receptor signaling complex and modulates the receptor signaling outcomes

Wagner, S., Satpathy, S., Beli, P., & Choudhary, C. (2016) · The EMBO Journal · doi:10.15252/embj.201694300 · Cited by 128 · see citing works

Inactivation of the Deubiquitinase CYLD in Hepatocytes Causes Apoptosis, Inflammation, Fibrosis, and Cancer

Nikolaou, K., Tsagaratou, A., Eftychi, C., Kollias, G. A., Mosialos, G., & Talianidis, I. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.04.026 · Cited by 128 · see citing works

MicroRNA and transcription factor co-regulatory network analysis reveals miR-19 inhibits CYLD in T-cell acute lymphoblastic leukemia

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The deubiquitinase activity of A20 is dispensable for NF‐κB signaling

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miR-29 Acts as a Decoy in Sarcomas to Protect the Tumor Suppressor A20 mRNA from Degradation by HuR

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A20 is targeted by promoter methylation, deletion and inactivating mutation in MALT lymphoma

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CYLD: A Deubiquitination Enzyme with Multiple Roles in Cancer

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Suppression of LUBAC ‐mediated linear ubiquitination by a specific interaction between LUBAC and the deubiquitinases CYLD and OTULIN

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Optineurin Is Required for CYLD-Dependent Inhibition of TNFα-Induced NF-κB Activation

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Genetic relationships betweenA20/TNFAIP3, chronic inflammation and autoimmune disease

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SPATA2 promotes CYLD activity and regulates TNF‐induced NF‐κB signaling and cell death

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Haploinsufficiency of TNFAIP3 (A20) by germline mutation is involved in autoimmune lymphoproliferative syndrome

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The CAP-Gly Domain of CYLD Associates with the Proline-Rich Sequence in NEMO/IKKγ

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Regulation of B cell homeostasis and activation by the tumor suppressor gene CYLD

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CYLD Proteolysis Protects Macrophages from TNF-Mediated Auto-necroptosis Induced by LPS and Licensed by Type I IFN

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DUBs, the regulation of cell identity and disease

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Genetic and microbial factors modulating the ubiquitin proteasome system in inflammatory bowel disease

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CYLD-Mediated Signaling and Diseases

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African-Derived Genetic Polymorphisms in TNFAIP3 Mediate Risk for Autoimmunity

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A20 (Tnfaip3) Deficiency in Myeloid Cells Protects against Influenza A Virus Infection

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Novel anti-apoptotic mechanism of A20 through targeting ASK1 to suppress TNF-induced JNK activation

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Astrocytic A20 ameliorates experimental autoimmune encephalomyelitis by inhibiting NF-κB- and STAT1-dependent chemokine production in astrocytes

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O-Glycosylation Regulates Ubiquitination and Degradation of the Anti-Inflammatory Protein A20 to Accelerate Atherosclerosis in Diabetic ApoE-Null Mice

Shrikhande, G., Scali, S. T., da Silva, C. G., Damrauer, S. M., Csizmadia, E., Putheti, P., Matthey, M., Arjoon, R., Patel, R., Siracuse, J. J., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0014240 · Cited by 85 · see citing works

Keratinocyte-specific ablation of the NF-κB regulatory protein A20 (TNFAIP3) reveals a role in the control of epidermal homeostasis

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Deubiquitinating Enzyme CYLD Regulates the Peripheral Development and Naive Phenotype Maintenance of B Cells

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The RING ubiquitin E3 RNF114 interacts with A20 and modulates NF-κB activity and T-cell activation

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A20 Deficiency in Lung Epithelial Cells Protects against Influenza A Virus Infection

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Truncation of the Catalytic Domain of the Cylindromatosis Tumor Suppressor Impairs Lung Maturation

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MALT1 Protease Activation Triggers Acute Disruption of Endothelial Barrier Integrity via CYLD Cleavage

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Deubiquitinating activity of CYLD is impaired by SUMOylation in neuroblastoma cells

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TALEN-mediated enhancer knockout influences TNFAIP3 gene expression and mimics a molecular phenotype associated with systemic lupus erythematosus

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Regulation of natural killer T‐cell development by deubiquitinase CYLD

Lee, A. J., Zhou, X., Chang, M., Hunzeker, J., Bonneau, R. H., Zhou, D., & Sun, S. (2010) · The EMBO Journal · doi:10.1038/emboj.2010.31 · Cited by 40 · see citing works

NKT sublineage specification and survival requires the ubiquitin-modifying enzyme TNFAIP3/A20

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The Tumor Suppressor CYLD Controls the Function of Murine Regulatory T Cells

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A20 is a negative regulator of BCL10- and CARMA3-mediated activation of NF-κB

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Toll-like Receptor-mediated Down-regulation of the Deubiquitinase Cylindromatosis (CYLD) Protects Macrophages from Necroptosis in Wild-derived Mice

Schworer, S. A., Smirnova, I., Валерьевна, К. И., Bagina, U., Churova, M. V., Fowler, T., Roy, A. L., Degterev, A., & Poltorak, A. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.547547 · Cited by 37 · see citing works

The seventh zinc finger motif of A20 is required for the suppression of TNF‐α‐induced apoptosis

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The Universal NF-kappaB Inhibitor A20 Protects From Transplant Vasculopathy by Differentially Affecting Apoptosis in Endothelial and Smooth Muscle Cells

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IKK regulates the deubiquitinase CYLD at the postsynaptic density

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Naturally occurring short splice variant of CYLD positively regulates dendritic cell function

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SCFβ-TRCP regulates osteoclastogenesis via promoting CYLD ubiquitination

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Receptor-Interacting Protein Kinase-2 Inhibition by CYLD Impairs Antibacterial Immune Responses in Macrophages

Wex, K., Schmid, U., Just, S., Wang, X., Wurm, R., Naumann, M., Schlüter, D., & Nishanth, G. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00650 · Cited by 25 · see citing works

A20 and CYLD Do Not Share Significant Overlapping Functions during B Cell Development and Activation

Chu, Y., Soberon, V., Glockner, L., Beyaert, R., Massoumi, R., Loo, G., Krappmann, D., & Schmidt‐Supprian, M. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1200396 · Cited by 24 · see citing works

The deubiquitinating enzyme CYLD regulates the differentiation and maturation of thymic medullary epithelial cells

Reißig, S., Hövelmeyer, N., Tang, Y., Weih, D., Nikolaev, A., Riemann, M., Weih, F., & Waisman, A. (2015) · Immunology and Cell Biology · doi:10.1038/icb.2014.122 · Cited by 21 · see citing works

The role of A20 in the pathogenesis of lymphocytic malignancy

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Epidermal CYLD inactivation sensitizes mice to the development of sebaceous and basaloid skin tumors

Jin, Y. J., Wang, S., Cho, J., Selim, M. A., Wright, T., Mosialos, G., & Zhang, J. Y. (2016) · JCI Insight · doi:10.1172/jci.insight.86548 · Cited by 18 · see citing works

A20: attractive without showing cleavage

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Inactivation of CYLD in intestinal epithelial cells exacerbates colitis-associated colorectal carcinogenesis - a short report

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Cellular proteolytic modification of tumor-suppressor CYLD is critical for the initiation of human T-cell acute lymphoblastic leukemia

Arora, M., Kaul, D., Varma, N., & Marwaha, R. K. (2014) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2014.07.008 · Cited by 10 · see citing works

The ubiquitin editing enzyme A20 (TNFAIP3) is upregulated during permanent middle cerebral artery occlusion but does not influence disease outcome

Guire, C. M., Rahman, M., Schwaninger, M., Beyaert, R., & Loo, G. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.55 · Cited by 6 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

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NF-κB in biology and targeted therapy: new insights and translational implications

Guo, Q., Jin, Y., Chen, X., Ye, X., Shen, X., Lin, M., Zeng, C., Zhou, T., & Zhang, J. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01757-9 · Cited by 2,267 · see citing works

Death by TNF: a road to inflammation

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Limiting inflammation—the negative regulation of NF-κB and the NLRP3 inflammasome

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NF-κB: At the Borders of Autoimmunity and Inflammation

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Cell Type-Specific Roles of NF-κB Linking Inflammation and Thrombosis

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Ubiquitination in the regulation of inflammatory cell death and cancer

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Tumor immune evasion arises through loss of TNF sensitivity

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Deubiquitinases in cancer

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Cell death pathways: intricate connections and disease implications

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NF-κB in monocytes and macrophages – an inflammatory master regulator in multitalented immune cells

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Human papillomavirus and the landscape of secondary genetic alterations in oral cancersPreprint

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The RING finger protein family in health and disease

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Tumor Necrosis Factor α Blockade: An Opportunity to Tackle Breast Cancer

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Circ0008399 Interaction with WTAP Promotes Assembly and Activity of the m6A Methyltransferase Complex and Promotes Cisplatin Resistance in Bladder Cancer

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miRNA-17-92 protects endothelial cells from erastin-induced ferroptosis through targeting the A20-ACSL4 axis

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A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain

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Wound healing in aged skin exhibits systems-level alterations in cellular composition and cell-cell communication

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