The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity
Open accessAbstract
Summary The CD8+ memory T cell population is heterogeneous and it is unclear which subset(s) optimally mediate the central goal of the immune system-protection against infection. Here we investigate the protective capacities of CD8+ T cell subsets present at the memory stage of the immune response. We show that a population of CD8+ T cells bearing markers associated with effector cells (KLRG1hi, CD27lo, T-bethi, Eomeslo) persisted to the memory phase and provided optimal control of Listeria monocytogenes and vaccinia virus, despite weak recall proliferative responses. After antigen specific boosting, this population formed the predominant secondary memory subset, and maintained superior pathogen control. The effector-like memory subset displayed a distinct pattern of tissue distribution and localization within the spleen, and their enhanced capacity to eliminate Listeria involved specialized utilization of cytolysis. Together these data suggest “long-lived effector” CD8+ T cells are optimal for protective immunity against certain pathogens.
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Cites
Two subsets of memory T lymphocytes with distinct homing potentials and effector functions
Sallusto, F., Lenig, D., Förster, R., Lipp, M., & Lanzavecchia, A. (1999) · Nature · doi:10.1038/44385 · Cited by 5,846 · cited 2×
“…as the expression of KLRG1 on cells that are 1250 Immunity 38, 1250–1260, June 27, 2013 ª2013 Elsevier Inc. typically thought to be senescent) (Hikono et al., 2007; Joshi et al., 2007; Masopust et al., 2006a; Nolz et al., 2012; Sallusto et al., 1999; Sallusto et al., 2004; Sarkar et al., 2008).”
BackgroundCentral Memory and Effector Memory T Cell Subsets: Function, Generation, and Maintenance
Sallusto, F., Geginat, J., & Lanzavecchia, A. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104702 · Cited by 3,067
T cell receptor antagonist peptides induce positive selection
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Self-citationLineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
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“However, in contrast to the drastic downregulation of CD127 reported for short-lived effector cells (Joshi et al., 2007; Kaech et al., 2003; Obar and Lefrançois, 2010), the memory stage CD27lo CD43lo population expressed CD127 at levels similar to naive CD8+ T cells (albeit at lower levels than…”
BackgroundInfluentialT-cell quality in memory and protection: implications for vaccine design
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Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin
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Profound early control of highly pathogenic SIV by an effector memory T-cell vaccine
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Effector and Memory CTL Differentiation
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Cited by
Normalizing the environment recapitulates adult human immune traits in laboratory mice
Beura, L. K., Hamilton, S. E., Bi, K., Schenkel, J. M., Odumade, O. A., Casey, K. A., Thompson, E. A., Fraser, K. A., Rosato, P. C., Filali-Mouhim, A., et al. (2016) · Nature · doi:10.1038/nature17655 · Cited by 1,072
Self-citationGerlach, C., Moseman, E. A., Loughhead, S. M., Alvarez, D., Zwijnenburg, A. J., Waanders, L., Garg, R., de la Torre, J. C., & von Andrian, U. H. (2016) · Immunity · doi:10.1016/j.immuni.2016.10.018 · Cited by 567
Understanding subset diversity in T cell memory
Jameson, S. C., & Masopust, D. (2018) · Immunity · doi:10.1016/j.immuni.2018.02.010 · Cited by 523
Self-citationAuto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH
Dudek, M., Pfister, D., Donakonda, S., Filpe, P., Schneider, A., Laschinger, M., Hartmann, D., Hüser, N., Meiser, P., Bayerl, F., et al. (2021) · Nature · doi:10.1038/s41586-021-03233-8 · Cited by 518
Dominguez, C. X., Amezquita, R. A., Guan, T., Marshall, H. D., Joshi, N. S., Kleinstein, S. H., & Kaech, S. M. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20150186 · Cited by 277
Metadata
- Authors
- Olson, J. A., McDonald-Hyman, C., Jameson, S. C., & Hamilton, S. E.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2013-06
- Volume
- 38
- Issue
- 6
- Pages
- 1250-1260
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1967311346
- Cited by
- 258
- References
- 59
- FWCI
- 11.17
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Olson, J. A., McDonald-Hyman, C., Jameson, S. C., & Hamilton, S. E. (2013). Effector-like CD8+ T Cells in the Memory Population Mediate Potent Protective Immunity. Immunity. https://doi.org/10.1016/j.immuni.2013.05.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
