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Cited by 523T-cell and B-cell ImmunologyImmune responses and vaccinationsImmunotherapy and Immune Responses

Understanding subset diversity in T cell memory

Open access
Jameson, Stephen C., Masopust, David·2018·Immunity
DOI 10.1016/j.immuni.2018.02.010PMC PMC5863745
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Abstract

Considerable advances have been made in recent years in understanding the generation and function of memory T cells. Memory T cells are typically parsed into discreet subsets based on phenotypic definitions that connote distinct roles in immunity. Here we consider new developments in the field and focus on how emerging differences between memory cells with respect to their trafficking, metabolism, epigenetic regulation, and longevity may fail to fit into small groups of "memory subsets." Rather, the properties of individual memory T cells fall on a continuum within each of these and other parameters. We discuss how this continuum influences the way that the efficacy of vaccination is assessed, as well as the suitability of a memory population for protective immunity.

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Crossref · 10.1016/j.immuni.2018.02.010

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  • TCMs further differentiated into transitional memory T cells (TTMs) in vitro during viral outgrowth.

    “Moreover, by tSNE, we confirmed that TCMs further differentiated into transitional memory T cells (TTMs) in vitro during viral outgrowth (Figures 4C and 4D) as a logical consequence after stimulation.”

    From Revealing viral and cellular dynamics of HIV-1 at the single-cell level during early treatment periods (2023) · cites this paper as [52]

    The review discusses TCM and other memory T-cell subsets in its sections on memory maintenance and recirculating memory T cells, but the passages found do not address TCM differentiating into transitional memory T cells. Searches for TTM, in vitro stimulation, and viral outgrowth found no passage supporting the claimed transition. (LLM, conf=0.75)

    Experimental — accuracy not yet measured

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Authors
Jameson, S. C., & Masopust, D.
Affiliations
University of Minnesota (US)
Corresponding author
  • Jameson, Stephen C.
  • Masopust, David
ORCID
Venue
Immunity
Publisher
Elsevier BV
Published
2018-02
Volume
48
Issue
2
Pages
214-226
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2018.02.010
PMC
PMC5863745
OpenAlex
W2788070661
Cited by
523
References
23
Citations by year
2026: 53 · 2025: 62 · 2024: 63 · 2023: 66 · 2022: 62 · 2021: 92 · 2020: 55 · 2019: 50 · 2018: 19
FWCI
5.60
Type
journal article
Language
en
Open access
Licence
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Allergy and Infectious Diseases (R01AI084913, R01AI111671, R37AI084913, R01AI038903)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immune responses and vaccinations
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords
memory T cells, T cell memory subsets, T cell migration, T cell metabolism, epigenetic regulation, T cell longevity, vaccination efficacy, protective immunity
MeSH terms
Animals, Cell Differentiation, Cell Movement, Humans, Immunologic Memory, T-Lymphocyte Subsets, Epigenomics

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

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