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Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli
Open accessAbstract
Standardization of immunophenotyping procedures has become a high priority. We have developed a suite of whole-blood, syringe-based assay systems that can be used to reproducibly assess induced innate or adaptive immune responses. By eliminating preanalytical errors associated with immune monitoring, we have defined the protein signatures induced by (1) medically relevant bacteria, fungi, and viruses; (2) agonists specific for defined host sensors; (3) clinically employed cytokines; and (4) activators of T cell immunity. Our results provide an initial assessment of healthy donor reference values for induced cytokines and chemokines and we report the failure to release interleukin-1α as a common immunological phenotype. The observed naturally occurring variation of the immune response may help to explain differential susceptibility to disease or response to therapeutic intervention. The implementation of a general solution for assessment of functional immune responses will help support harmonization of clinical studies and data sharing.
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“TruCulture® reproducibly reveals the induced innate and adaptive immune response in whole blood after stimulation, by quantifying the release of soluble immune activation products (cytokines, chemokines, soluble receptors etc.) in the supernatant and by measuring the transcription level (mRNA) in the circulating blood (immune) cells [77].”
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Distinct Cellular Immune Responses to SARS-CoV-2 in Pregnant Women
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Self-citationComparison of Rapid Cytokine Immunoassays for Functional Immune Phenotyping
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Neuraminidase is a host‐directed approach to regulate neutrophil responses in sepsis and COVID‐19
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COPD disease severity and innate immune response to pathogen-associated molecular patterns
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Tuberculosis alters immune-metabolic pathways resulting in perturbed IL-1 responses
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Self-citationImmune response biomarkers in human and veterinary research
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Self-citationLiquid biopsies to guide therapeutic decisions in rheumatoid arthritis
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Differential levels of IFNα subtypes in autoimmunity and viral infection
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Self-citation
Metadata
- Authors
- Duffy, D., Rouilly, V., Libri, V., Hasan, M., Beitz, B., David, M., Urrutia, A., Bisiaux, A., LaBrie, S. T., Dubois, A., Boneca, I. G., Delval, C., Thomas, S., Rogge, L., Schmolz, M., Quintana-Murci, L., Albert, M. L., Abel, L., Alcover, A., Bousso, P., Cumano, A., Daëron, M., Delval, C., Demangel, C., Deriano, L., Di Santo, J., Dromer, F., Eberl, G., Enninga, J., Freitas, A., Gomperts-Boneca, I., Hercberg, S., Lantz, O., Leclerc, C., Mouquet, H., Pellegrini, S., Pol, S., Rogge, L., Sakuntabhai, A., Schwartz, O., Schwikowski, B., Shorte, S., Soumelis, V., Tangy, F., Tartour, E., Toubert, A., Ungeheuer, M.-N., Quintana-Murci, L., & Albert, M. L.
- Affiliations
- Inserm (FR)
- Institut Pasteur (FR)
- Myriad Genetics (US)
- Centre d’Immunologie de Marseille-Luminy (FR)
- Department of Genomes & Genetics (FR)
- Hôpital Cochin (FR)
- Centre de Recherche sur les Liens Sociaux (FR)
- Hôpital Saint-Louis (FR)
- ORCID
- Duffy, Darragh
- Rouilly, Vincent
- Libri, Valentina
- Hasan, Milena
- Urrutia, Alejandra
- Bisiaux, Aurélie
- Schmolz, Manfred
- Abel, Laurent
- Bousso, Philippe
- Cumano, Ana
- Daëron, Marc
- Demangel, Caroline
- Deriano, Ludovic
- Dromer, Françoise
- Eberl, Gérard
- Enninga, Jost
- Lantz, Olivier
- Leclerc, Claude
- Mouquet, Hugo
- Pellegrini, Sandra
- Pol, Stanislas
- Sakuntabhai, Anavaj
- Schwartz, Olivier
- Schwikowski, Benno
- Shorte, Spencer
- Soumelis, Vassili
- Tangy, Frédéric
- Toubert, Antoine
- Ungeheuer, Marie-Noëlle
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-03
- Volume
- 40
- Issue
- 3
- Pages
- 436-450
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1984830992
- Cited by
- 242
- References
- 85
- Citations by year
- 2026: 16 · 2025: 14 · 2024: 23 · 2023: 17 · 2022: 34 · 2021: 23 · 2020: 21 · 2019: 18 · 2018: 18 · 2017: 19 · 2016: 13 · 2015: 20 · 2014: 6
- FWCI
- 8.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Advanced Biosensing Techniques and Applications
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Keywords
- innate immune response, adaptive immune response, cytokine signature, chemokines, interleukin-1 alpha, pre-analytical errors, T cell activation, immune response variability
- MeSH terms
- Antigens, Humans, Immunity, Innate, Reference Values, Monitoring, Immunologic, Reproducibility of Results, Cytokines, Inflammation Mediators, Adaptive Immunity, Healthy Volunteers
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