Functional Analysis via Standardized Whole-Blood Stimulation Systems Defines the Boundaries of a Healthy Immune Response to Complex Stimuli

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in Tlr4 Gene

Poltorak, A., He, X., Smirnova, I., Liu, M.-Y., Huffel, C. V., Du, X., Birdwell, D., Alejos, E., Silva, M., Galanos, C., et al. (1998) · Science · doi:10.1126/science.282.5396.2085 · Cited by 7,631

A Toll-like receptor recognizes bacterial DNA

Hemmi, H., Takeuchi, O., Kawai, T., Kaisho, T., Sato, S., Sanjo, H., Matsumoto, M., Hoshino, K., Wagner, H., Takeda, K., et al. (2000) · Nature · doi:10.1038/35047123 · Cited by 6,491 · cited 1×

Toll-Like Receptors

Takeda, K., Kaisho, T., & Akira, S. (2003) · Annual Review of Immunology · doi:10.1146/annurev.immunol.21.120601.141126 · Cited by 6,143

Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3

Alexopoulou, L., Holt, A. C., Medzhitov, R., & Flavell, R. A. (2001) · Nature · doi:10.1038/35099560 · Cited by 6,129

Gout-associated uric acid crystals activate the NALP3 inflammasome

Martinon, F., Pétrilli, V., Mayor, A., Tardivel, A., & Tschopp, J. (2006) · Nature · doi:10.1038/nature04516 · Cited by 5,326

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

Kato, H., Takeuchi, O., Sato, S., Yoneyama, M., Yamamoto, M., Matsui, K., Uematsu, S., Jung, A., Kawai, T., Ishii, K. J., et al. (2006) · Nature · doi:10.1038/nature04734 · Cited by 3,888

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Takeuchi, O., Hoshino, K., Kawai, T., Sanjo, H., Takada, H., Ogawa, T., Takeda, K., & Akira, S. (1999) · Immunity · doi:10.1016/s1074-7613(00)80119-3 · Cited by 3,680

Mechanisms of type-I- and type-II-interferon-mediated signalling

Platanias, L. C. (2005) · Nature reviews. Immunology · doi:10.1038/nri1604 · Cited by 3,631

The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5

Hayashi, F., Smith, K. D., Ozinsky, A., Hawn, T. R., Yi, E. C., Goodlett, D. R., Eng, J. K., Akira, S., Underhill, D. M., & Aderem, A. A. (2001) · Nature · doi:10.1038/35074106 · Cited by 3,605

Immunological and inflammatory functions of the interleukin-1 family

Dinarello, C. A. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132612 · Cited by 3,466

Functional immune reconstitution early after allogeneic haematopoietic cell transplantation: A comparison of pre‐ and post‐transplantation cytokine responses in stimulated whole blood

Gjærde, L. K., Brooks, P. T., Andersen, N. S., Friis, L. S., Kornblit, B. T., Petersen, S. L., Schjødt, I. M., Nielsen, S. D., Ostrowski, S. R., & Sengeløv, H. (2021) · Scandinavian Journal of Immunology · doi:10.1111/sji.13042 · Cited by 16

Bovine innate immune phenotyping via a standardized whole blood stimulation assay

Reid, C., Beynon, C., Kennedy, E., O’Farrelly, C., & Meade, K. G. (2021) · Scientific Reports · doi:10.1038/s41598-021-96493-3 · Cited by 16

Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols

Chansard, A., Dubrulle, N., de Molliens, M. P., Falanga, P. B., Stephen, T., Hasan, M., van Zandbergen, G., Aulner, N., Shorte, S. L., & David‐Watine, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.569331 · Cited by 16

CD4+ T-Cell Profiles and Peripheral Blood Ex-Vivo Responses to T-Cell Directed Stimulation Delineate COPD Phenotypes

Roberts, M. E. P., Higgs, B. W., Brohawn, P. Z., Pilataxi, F., Guo, X., Kuziora, M. A., Bowler, R. P., & White, W. I. (2015) · Chronic Obstructive Pulmonary Diseases Journal of the COPD Foundation · doi:10.15326/jcopdf.2.4.2015.0131 · Cited by 17

When genetics meets epigenetics: deciphering the mechanisms controlling inter-individual variation in immune responses to infection

Pacis, A., Nédélec, Y., & Barreiro, L. B. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2014.06.002 · Cited by 19

Impaired cytotoxic function and exhausted phenotype of natural killer cells in VEXAS syndrome

Breillat, P., Carbone, F., Lereclus, E., Riller, Q., d’Izarny-Gargas, T., Posseme, C., Templé, M., Zhao, L., Luka, M., Lazaro, E., et al. (2025) · Blood · doi:10.1182/blood.2024028216 · Cited by 15

Preoperative TruCulture® whole blood cytokine response predicts post‐operative inflammation in pancreaticoduodenectomy patients—A pilot cohort study

Aasvang, E. K., Pitter, S. E. L. T., Hansen, C. P., Storkholm, J. H., Krohn, P. S., Burgdorf, S. K., von Stemann, J. H., Lundgren, J. D., Nielsen, S. D., Kehlet, H., et al. (2020) · Scandinavian Journal of Immunology · doi:10.1111/sji.12930 · Cited by 15

Protective immunity induced by concurrent intradermal injection of porcine circovirus type 2 and Mycoplasma hyopneumoniae inactivated vaccines in pigs

Lee, S.-I., Jeong, C., Mattoo, S.-U.-S., Nazki, S., Aganja, R. P., Kim, S.-C., Khatun, A., Oh, Y., Noh, S.-H., Lee, S.-M., et al. (2021) · Vaccine · doi:10.1016/j.vaccine.2021.07.043 · Cited by 15

Quantitative Simulations Predict Treatment Strategies Against Fungal Infections in Virtual Neutropenic Patients

Timme, S., Lehnert, T., Prauße, M. T. E., Hünniger, K., Leonhardt, I., Kurzai, O., & Figge, M. T. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00667 · Cited by 15

Immune function as predictor of infectious complications and clinical outcome in patients undergoing solid organ transplantation (the ImmuneMo:SOT study): a prospective non-interventional observational trial

Drabe, C. H., Sørensen, S. S., Rasmussen, A., Perch, M., Gustafsson, F., Rezahosseini, O., Lundgren, J. D., Ostrowski, S. R., & Nielsen, S. D. (2019) · BMC Infectious Diseases · doi:10.1186/s12879-019-4207-9 · Cited by 15

Autoantibody-Mediated Depletion of IL-1RA in Still’s Disease and Potential Impact of IL-1 Targeting Therapies

Hoffmann, M.-C., Cavalli, G., Fadle, N., Cantoni, E., Regitz, E., Fleser, O., Klemm, P., Zaks, M., Stöger, E., Campochiaro, C., et al. (2024) · Journal of Clinical Immunology · doi:10.1007/s10875-023-01642-0 · Cited by 14

The specific ex vivo released cytokine profile is associated with ischemic stroke outcome and improves its prediction

Klimiec, E., Piechota, M., Pera, J., Węglarczyk, K., Słowik, A., Siedlar, M., & Dziedzic, T. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-019-1691-1 · Cited by 14

Integrated analysis of whole blood oxylipin and cytokine responses after bacterial, viral, and T cell stimulation reveals new immune networks

Villain, É., Chanson, A., Mainka, M., Kampschulte, N., Faouder, P. L., Bertrand‐Michel, J., Brandolini-Bunlon, M., Charbit, B., Musvosvi, M., Bilek, N., et al. (2023) · iScience · doi:10.1016/j.isci.2023.107422 · Cited by 13

The Impact ofStaphylococcus aureus-Associated Molecular Patterns on Staphylococcal Superantigen-Induced Toxic Shock Syndrome and Pneumonia

Tilahun, A. Y., Karau, M. J., Ballard, A. D., Gunaratna, M. P., Thapa, A., David, C. S., Patel, R., & Rajagopalan, G. (2014) · Mediators of Inflammation · doi:10.1155/2014/468285 · Cited by 13

Effects of an FcγRIIA polymorphism on leukocyte gene expression and cytokine responses to anti-CD3 and anti-CD28 antibodies

Stein, M. M., Hrusch, C. L., Sperling, A. I., & Ober, C. (2018) · Genes and Immunity · doi:10.1038/s41435-018-0038-8 · Cited by 13

T cell migration and effector function differences in familial adenomatous polyposis patients with APC gene mutations

Cuche, C., Mastrogiovanni, M., Juzans, M., Laude, H., Ungeheuer, M., Krentzel, D., Gariboldi, M. I., Scott‐Algara, D., Madec, M., Goyard, S., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1163466 · Cited by 12

Immunophenotyping Reveals No Significant Perturbation to PBMC Subsets When Co-cultured With Colorectal Adenocarcinoma Caco-2 Cells Exposed to X-Rays

Borsci, G., Barbieri, S., Guardamagna, I., Lonati, L., Ottolenghi, A., Ivaldi, G., Liotta, M., de Fatis, P. T., Baiocco, G., & Savio, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01077 · Cited by 12

Release of adenosine-induced immunosuppression: Comprehensive characterization of dual A2A/A2B receptor antagonist

Dziedzic, K., Węgrzyn, P., Gałȩzowski, M., Bońkowska, M., Grycuk, K., Satała, G., Wiatrowska, K., Wiklik, K., Brzózka, K. D., & Nowak, M. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.107645 · Cited by 12

Milieu intérieur: Defining the boundaries of a healthy immune response for improved vaccination strategies

Duffy, D. (2018) · Human Vaccines & Immunotherapeutics · doi:10.1080/21645515.2018.1466764 · Cited by 11

Demographic and genetic factors shape the epitope specificity of the human antibody repertoire against viruses

Olin, A., Pou, C., Jaquaniello, A., Crook, J. M., Tan, Z., Roux, M., Dubois, F., Charbit, B., Liu, D., Donnadieu, F., et al. (2026) · Nature Immunology · doi:10.1038/s41590-026-02432-7 · Cited by 12

Borrelia burgdorferi Is a Poor Inducer of Gamma Interferon: Amplification Induced by Interleukin-12

van de Schoor, F. R., Vrijmoeth, H. D., Brouwer, M. A. E., ter Hofstede, H. J. M., Lemmers, H., Dijkstra, H., Boahen, C. K., Oosting, M., Kullberg, B. J., Hovius, J. W., et al. (2022) · Infection and Immunity · doi:10.1128/iai.00558-21 · Cited by 10

Medizinisch klinische Diagnostik bei Schimmelpilzexposition in Innenräumen – Update 2023 (AWMF-Register-Nr. 161/001)

Hurraß, J., Heinzow, B., Walser‐Reichenbach, S., Aurbach, U., Becker, S., Bellmann, R., Bergmann, K., Cornely, O. A., Engelhart, S., Fischer, G., et al. (2024) · Pneumologie · doi:10.1055/a-2194-6914 · Cited by 10

Immune monitoring technology primer: immunoprofiling of antigen-stimulated blood

Brunet, L. R., LaBrie, S. T., & Hagemann, T. (2016) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-016-0122-4 · Cited by 10

Biomarker-guided stratification of autoimmune patients for biologic therapy

Ivison, S. M., Rosiers, C. D., Lesage, S., Rioux, J. D., & Levings, M. K. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.09.006 · Cited by 10

VaccHemInf project: protocol for a prospective cohort study of efficacy, safety and characterisation of immune functional response to vaccinations in haematopoietic stem cell transplant recipients

Conrad, A., Boccard, M., Valour, F., Alcazer, V., Sanchez, A.-T. T., Chidiac, C., Laurent, F. J., Vanhems, P., Salles, G., Brengel‐Pesce, K., et al. (2019) · BMJ Open · doi:10.1136/bmjopen-2018-026093 · Cited by 10

Stimulated Immune Response by TruCulture® Whole Blood Assay in Patients With European Lyme Neuroborreliosis: A Prospective Cohort Study

Ørbæk, M., Gynthersen, R. M. M., Mens, H., Stenør, C., Wiese, L., Brandt, C., Ostrowski, S. R., Nielsen, S. D., & Lebech, A. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.666037 · Cited by 10

Prevalence, Characteristics, and Determinants of Suboptimal Care in the Initial Management of Community-Onset Severe Bacterial Infections in Children

Lorton, F., Chalumeau, M., Martinot, A., Assathiany, R., Roué, J., Bourgoin, P., Chantreuil, J., Boussicault, G., Gaillot, T., Saulnier, J.-P., et al. (2022) · JAMA Network Open · doi:10.1001/jamanetworkopen.2022.16778 · Cited by 10

Of Mycelium and Men: Inherent Human Susceptibility to Fungal Diseases

Vinh, D. C. (2023) · Pathogens · doi:10.3390/pathogens12030456 · Cited by 11

Development and evaluation of a whole blood-based approach for flow cytometric quantification of CD154+ mould-reactive T cells

Weis, P., Helm, J., Page, L., Lauruschkat, C. D., Lazariotou, M., Einsele, H., Loeffler, J., Ullmann, A. J., & Wurster, S. (2019) · Medical Mycology · doi:10.1093/mmy/myz038 · Cited by 10

IL-2 and IFN-γ are biomarkers of SARS-CoV-2 specific cellular response in whole blood stimulation assaysPreprint

Pérez‐Cabezas, B., Ribeiro, R. J. T., Costa, I., Esteves, S., Teixeira, A. R., Reis, T., Monteiro, R., Afonso, A., Pinheiro, V. C. A., Antunes, M. I., et al. (2021) · medRxiv · doi:10.1101/2021.01.04.20248897 · Cited by 11

Ex vivo peripheral blood mononuclear cell response to R848 in children after supplementation with the probiotic Lactobacillus acidophilus NCFM/Bifidobacterium lactis Bi-07

DeMuri, G. P., Lehtoranta, L., Eickhoff, J. C., Lehtinen, M. J., & Wald, E. R. (2021) · Beneficial Microbes · doi:10.3920/bm2020.0068 · Cited by 9

Translational immunology: Applying fundamental discoveries to human health and autoimmune diseases

Buckner, J. H. (2023) · European Journal of Immunology · doi:10.1002/eji.202250197 · Cited by 11

Corrigendum: Unveiling Interindividual Variability of Human Fibroblast Innate Immune Response Using Robust Cell-Based Protocols

Chansard, A., Dubrulle, N., de Molliens, M. P., Falanga, P. B., Stephen, T., Hasan, M., van Zandbergen, G., Aulner, N., Shorte, S. L., & David‐Watine, B. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.685768 · Cited by 9

Methods integrating innate and adaptive immune responses in human in vitro immunization assays

Bowley, T. Y., Lenz, K. D., Shanker, A., & Kubicek-Sutherland, J. Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1584852 · Cited by 8

Toll-Like Receptor-Induced Immune Responses During Early Childhood and Their Associations With Clinical Outcomes Following Acute Illness Among Infants in Sub-Saharan Africa

Uebelhoer, L. S., Gwela, A., Thiel, B., Nalukwago, S., Mukisa, J., Lwanga, C., Getonto, J., Nyatichi, E., Dena, G., Makazi, A. B., et al. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2021.748996 · Cited by 8

Host-directed immunotherapy to fight infectious diseases

Langelier, M. J., & Vinh, D. C. (2022) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000001176 · Cited by 9

Germline Genetics in Immuno-oncology: From Genome-Wide to Targeted Biomarker Strategies

Kirchhoff, T., & Ferguson, R. (2019) · Methods in molecular biology · doi:10.1007/978-1-4939-9773-2_4 · Cited by 9

A whole blood intracellular cytokine assay optimised for field site studies demonstrates polyfunctionality of CD4+ T cells in acute scrub typhus

Inthawong, M., Pinthong, N., Thaiprakhong, A., Wangrangsimakul, T., Sunyakumthorn, P., Hill, J. W., Sonthayanon, P., Paris, D. H., Dunachie, S. J., & Kronsteiner, B. (2023) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0010905 · Cited by 7

Distinct Immune Reconstitution Profiles Captured by Immune Functional Assays at 6 Months Post Allogeneic Hematopoietic Stem Cell Transplantation

Mouton, W., Conrad, A., Alcazer, V., Boccard, M., Bodinier, M., Oriol, G., Subtil, F., Labussière‐Wallet, H., Ducastelle-Leprêtre, S., Barraco, F., et al. (2022) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2022.10.025 · Cited by 7

Improved induced innate immune response after cART initiation in people with HIV

Hove‐Skovsgaard, M., Møller, D. L., Hald, A., Gerstoft, J., Lundgren, J. D., Ostrowski, S. R., & Nielsen, S. D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.974767 · Cited by 7

Cytokine Autoantibodies Alter Gene Expression Profiles of Healthy Donors

von Stemann, J. H., Dubois, F., Saint‐André, V., Bondet, V., Posseme, C., Charbit, B., Quintana‐Murci, L., Hansen, M. B., Ostrowski, S. R., & Duffy, D. (2024) · European Journal of Immunology · doi:10.1002/eji.202451211 · Cited by 6

The Induced Immune Response in Patients With Infectious Spondylodiscitis: A Prospective Observational Cohort Study

Loft, J. A., Møller, D. L., Thudium, R. F., Knudsen, J. D., Ostrowski, S. R., Andersen, Å. B., & Nielsen, S. D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.858934 · Cited by 6

Rhesus negative males have an enhanced IFNγ-mediated immune response to influenza A virus

Sugrue, J. A., Smith, M., Posseme, C., Charbit, B., Abel, L., Alcover, A., Aschard, H., Bousso, P., Bourke, N. M., Brodin, P., et al. (2022) · Genes and Immunity · doi:10.1038/s41435-022-00169-5 · Cited by 8

Creating the Future of Evidence-Based Nutrition Recommendations: Case Studies from Lipid Research

Dwyer, J. T., Rubin, K. H., Fritsche, K. L., Psota, T., Liska, D. J., Harris, W. S., Montain, S. J., & Lyle, B. J. (2016) · Advances in Nutrition · doi:10.3945/an.115.010926 · Cited by 6

Immunological Changes During Space Travel: A Ground-Based Evaluation of the Impact of Neutron Dose Rate on Plasma Cytokine Levels in Human Whole Blood Cultures

Fisher, R., Baselet, B., Vermeesen, R., Moreels, M., Baatout, S., Rahiman, F., Miles, X., Nair, S., du Plessis, P., Engelbrecht, M., et al. (2020) · Frontiers in Physics · doi:10.3389/fphy.2020.568124 · Cited by 6

Application of the TruCulture® whole blood stimulation system for immune response profiling in cattle

O’Brien, M. B., McLoughlin, R. M., & Meade, K. G. (2020) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2020.110025 · Cited by 6

Epigenetic variation impacts ancestry-associated differences in the transcriptional response to influenza infectionPreprint

Aracena, K. A., Lin, Y., Luo, K., Pacis, A., Gona, S., Mu, Z., Yotova, V., Sindeaux, R., Pramatarova, A., Simon, M.-M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.05.10.491413 · Cited by 6

Ex vivo synthesized cytokines as a biomarker of stroke-associated pneumonia

Gradek-Kwinta, E., Czyżycki, M., Węglarczyk, K., Słowik, A., Siedlar, M., & Dziedzic, T. A. (2020) · Clinica Chimica Acta · doi:10.1016/j.cca.2020.07.035 · Cited by 5

Longitudinally stable T cell function and innate immune activation distinguish healthy adult immunotypes

Smithmyer, M. E., Hu, A. K., Dufort, M. J., Hocking, A. M., WIEDEMAN, A. E., Fasano, K. J., Torgerson, T. R., Skene, P. J., Reading, J., Li, X., et al. (2025) · Science Translational Medicine · doi:10.1126/scitranslmed.adt4605 · Cited by 6

Adverse Events and Immune Response in Psoriasis Patients Receiving Interleukin-17 Inhibitors

Schwarz, C., Näslund‐Koch, C., Zachariae, C. O. C., Seidelin, J. B., Nielsen, S. D., Ostrowski, S. R., Astvad, K. M. T., Brock, I., Iversen, L., Rasmussen, M. K., et al. (2025) · Acta Dermato Venereologica · doi:10.2340/actadv.v105.43685 · Cited by 5

Is in vitro cytokine release a suitable marker to improve the diagnosis of suspected mold-related respiratory symptoms? A proof-of-concept study

Liebers, V., Kespohl, S., Borowitzki, G., Stubel, H., & Raulf, M. (2022) · Allergologie select · doi:10.5414/alx02299e · Cited by 5

Exploration of the induced cytokine responses in European Lyme neuroborreliosis: A longitudinal cohort study

Gynthersen, R. M. M., Ørbæk, M., Mens, H., Stenør, C., Wiese, L., Ostrowski, S. R., Nielsen, S. D., & Lebech, A. (2022) · Ticks and Tick-borne Diseases · doi:10.1016/j.ttbdis.2022.102057 · Cited by 5

Innate immune function during antineoplastic treatment is associated with 12-months survival in non-small cell lung cancer

Ryssel, H., Egebjerg, K., Nielsen, S. D., Lundgren, J. D., Pøhl, M., Langer, S. W., Kjær, A., Ostrowski, S. R., & Fischer, B. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1024224 · Cited by 5

Immunogenomic approaches to understand the function of immune disease variants

Glinos, D. A., Soskic, B., & Trynka, G. (2017) · Immunology · doi:10.1111/imm.12796 · Cited by 6

Germline genetic host factors as predictive biomarkers in immuno-oncology

Chat, V., Ferguson, R., & Kirchhoff, T. (2019) · Immuno-Oncology Technology · doi:10.1016/j.iotech.2019.08.001 · Cited by 6

Potential use of a canine whole blood culture system to evaluate the immune response to Leptospira

Rajeev, S., Toka, F. N., & Shiokawa, K. (2020) · Comparative Immunology Microbiology and Infectious Diseases · doi:10.1016/j.cimid.2020.101546 · Cited by 5

Primary Human Dendritic Cells and Whole-Blood Based Assays to Evaluate Immuno-Modulatory Properties of Heat-Killed Commensal Bacteria

Norton, J. E., Kommineni, S., Akrivoulis, P., Gutierrez, D. A., Hazuda, D. J., & Swaminathan, G. (2021) · Vaccines · doi:10.3390/vaccines9030225 · Cited by 5

Low interleukin-10 release after ex vivo stimulation of whole blood is associated with persistent organ dysfunction in sepsis: A prospective observational study

Nesseler, N., Martin‐Chouly, C., Perrichet, H., Ross, J. T., Rousseau, C., Sinha, P., Isslame, S., Masseret, É., Mallédant, Y., Launey, Y., et al. (2019) · Anaesthesia Critical Care & Pain Medicine · doi:10.1016/j.accpm.2019.01.009 · Cited by 5

Impact of methotrexate and adalimumab on immune function of patients with psoriasis

Todberg, T., Loft, N., Møller, D. L., Ostrowski, S. R., Nielsen, S. D., & Skov, L. (2021) · Dermatologic Therapy · doi:10.1111/dth.15284 · Cited by 5

Using the Traditional Ex Vivo Whole Blood Model to Discriminate Bacteria by Their Inducible Host Responses

Chick, H. M., Rees, M. E., Lewis, M. L., Williams, L., Bodger, O. G., Harris, L. G., Rushton, S., & Wilkinson, T. S. (2024) · Biomedicines · doi:10.3390/biomedicines12040724 · Cited by 4

Trained immunity in neuroinflammation: emerging evidence, clinical perspectives, and future directions

Guso, E., Lupoli, A., Olivieri, E., Bottoni, A., Gironi, M., Missarelli, D. M., Toosy, A., Rossi, E., & Furlan, R. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.02.047 · Cited by 4

Polygenic Risk Scores Associated with Tumor Immune Infiltration in Common Cancers

Choi, J. Y., Kim, J. S., Sung, H. J., Chen, Y., Chen, Z., Wen, W., Shu, X., & Guo, X. (2022) · Cancers · doi:10.3390/cancers14225571 · Cited by 4

11-deoxycortisol positively correlates with T cell immune traits in physiological conditions

Peng, C., Jiang, X., Jaeger, M., van Houten, P., van Herwaarden, A. E., Koeken, V. A. C. M., Moorlag, S. J. C. F. M., Mourits, V. P., Lemmers, H., Dijkstra, H., et al. (2023) · EBioMedicine · doi:10.1016/j.ebiom.2023.104935 · Cited by 5

Cytokine Profile in Patients with Postacute Sequelae of COVID-19

Ghorra, N., Popotas, A., Besse‐Hammer, T., Rogiers, A., Corazza, F., & Nagant, C. (2024) · Viral Immunology · doi:10.1089/vim.2024.0025 · Cited by 4

In Vitro Characterization of the Innate Immune Pathways Engaged by Live and Inactivated Tick-Borne Encephalitis Virus

Signorazzi, A., Pennings, J. L. A., Etna, M. P., Noya, M., Coccia, E. M., & Huckriede, A. L. W. (2021) · Vaccines · doi:10.3390/vaccines9060664 · Cited by 4

Flow Cytometry in Cancer Immunotherapy: Applications, Quality Assurance, and Future

Gouttefangeas, C., Walter, S., Welters, M. J. P., Ottensmeier, C. H. H., van der Burg, S. H., & Chan, C. C. W. (2020) · Springer eBooks · doi:10.1007/978-3-030-30845-2_33 · Cited by 4

A standardized method to study immune responses using porcine whole blood

Mattoo, S.-U.-S., Aganja, R. P., Kim, S.-C., Jeong, C., Nazki, S., Khatun, A., Kim, W., & Lee, S. (2022) · Journal of Veterinary Science · doi:10.4142/jvs.22210 · Cited by 4

Whole blood stimulation provides preliminary evidence of altered immune function following SRC

Battista, A. P. D., Rhind, S. G., Shiu, M. Y., & Hutchison, M. G. (2024) · BMC Immunology · doi:10.1186/s12865-023-00595-8 · Cited by 4

Whole-blood culture-derived cytokine combinations for the diagnosis of tuberculosis

Østergaard, A. A., Feddersen, S., Barnkob, M. B., Lynggaard, R. B., Karstoft, A. C. A., Borup, M. B., Titlestad, I. L., Jensen, T. T., Hilberg, O., Wejse, C. M., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1397941 · Cited by 4

The identification of blood-derived response eQTLs reveals complex effects of regulatory variants on inflammatory and infectious disease risk

Liefferinckx, C., Stern, D., Perée, H., Bottieau, J., Mayer, A., Dubussy, C., Quertinmont, E., Tafciu, V., Minsart, C., Петров, В. А., et al. (2025) · PLoS Genetics · doi:10.1371/journal.pgen.1011599 · Cited by 6

Inflammatory cell death and monocyte dysfunction in VEXAS syndrome

Breillat, P., Magaziner, S. J., Camus, S. M., Dionet, L., Valence, B. D., Sohier, P., Majdi, A., Delcros, Q., Pallotti, F., Rivet, N., et al. (2026) · Blood · doi:10.1182/blood.2025031593 · Cited by 3

From Mendel to mycoses: Immuno‐genomic warfare at the human–fungus interface

Vinh, D. C. (2023) · Immunological Reviews · doi:10.1111/imr.13295 · Cited by 3

Immune cell populations and induced immune responses at admission in patients hospitalized with vaccine breakthrough SARS-CoV-2 infections

Sejdic, A., Hartling, H. J., Holler, J. G., Gjærde, L. K., Lindegaard, B., Dungu, A. M., Gnesin, F., Møller, M. E. E., Teglgaard, R. S., Niemann, C. U., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1360843 · Cited by 3

Effects of ionizing radiations of different qualities and delivery types on blood cells

Alet, A. I., Porini, S., Riquelme, B. D., Bisio, A., Scifoni, E., & Galassi, M. E. (2025) · Biophysical Reviews · doi:10.1007/s12551-025-01302-0 · Cited by 3

Milieu Intérieur : définir les limites d’une réponse immunitaire saine pour mieux comprendre la maladie

Duffy, D. (2019) · médecine/sciences · doi:10.1051/medsci/2019069 · Cited by 3

TNF-alpha releasing capacity of the whole blood drops after open total splenectomy, but increases after partial/subtotal or minimally invasive splenectomy

Dragomir, M. P., Tudor, Ș., Lăcătuş, M., Stănciulea, O., Trandafir, B., Diaconu, A., Coriu, D., Coliţă, A., Droc, G., Purnichescu‐Purtan, R., et al. (2021) · Acta chirurgica Belgica · doi:10.1080/00015458.2021.1916282 · Cited by 3

Improved Innate Immune Function in Patients with Chronic Lymphocytic Leukemia Treated with Targeted Therapy in Clinical Trials

Teglgaard, R. S., Marquart, H. V., Hartling, H. J., Bay, J. T., da Cunha‐Bang, C., Brieghel, C., Faitová, T., Enggaard, L., Kater, A. P., Levin, M., et al. (2024) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-23-2522 · Cited by 4

Flow Cytometry in Cancer Immunotherapy: Applications, Quality Assurance, and Future

Gouttefangeas, C., Walter, S., Welters, M. J. P., Ottensmeier, C. H. H., van der Burg, S. H., Britten, C. M., & Chan, C. C. W. (2014) · Springer eBooks · doi:10.1007/978-3-662-44006-3_25 · Cited by 3

Dimensionality and the statistical power of multivariate genome-wide association studiesPreprint

Márquez, E., & Houle, D. (2015) · bioRxiv · doi:10.1101/016592 · Cited by 5

Editorial

Schultze, J. L. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.04.001 · Cited by 3

Elevated circulating cell-free mitochondrial DNA in fabry disease: insights into inflammatory activation

Yuan, Y., Zhang, X., Zhao, Y., Wang, Y., Huang, J., Wang, Q., Song, X., Deng, J., Wang, Z., Yuan, Y., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1706045 · Cited by 2

Enhanced TLR3 responsiveness in hepatitis C virus resistant women from the Irish anti-D cohort

Sugrue, J. A., Posseme, C., Tan, Z., Pou, C., Charbit, B., Bondet, V., Bourke, N. M., Brodin, P., Duffy, D., & O’Farrelly, C. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100804 · Cited by 3

Novel approaches to develop biomarkers predicting treatment responses to TNF-blockers

Mezghiche, I., Yahia‐Cherbal, H., Rogge, L., & Bianchi, E. (2021) · Expert Review of Clinical Immunology · doi:10.1080/1744666x.2021.1894926 · Cited by 2

Deciphering the Molecular Mechanism of Flares in Patients with Systemic Lupus Erythematosus through Single-Cell Transcriptome Analysis of the Peripheral Blood

Papanikolaou, S., Κοσμαρά, Δ., Stathopoulou, C., Sidiropoulos, P. I., Konstantopoulos, D., & Bertsias, G. K. (2022) · Mediterranean Journal of Rheumatology · doi:10.31138/mjr.33.1.94 · Cited by 2

The common IL1A single nucleotide polymorphism rs17561 is a hypomorphic mutation that significantly reduces interleukin‐1α release from human blood cells

Wiggins, K. A., Pyrillou, K., Humphry, M., Butterworth, A. S., & Clarke, M. C. H. (2022) · Immunology · doi:10.1111/imm.13584 · Cited by 2

A Human Whole Blood Culture System Reveals Detailed Cytokine Release Profiles of Implant Materials

Klimosch, S. N., Weber, M., Caballé‐Serrano, J., Knorpp, T., Munar-Frau, A., Schaefer, B. M., & Schmolz, M. (2024) · Medical Devices Evidence and Research · doi:10.2147/mder.s441403 · Cited by 2

Approaching Mass Cytometry Translational Studies by Experimental and Data Curation Settings

Rybakowska, P., Alarcón-Riquelme, M. E., & Marañón, C. (2024) · Methods in molecular biology · doi:10.1007/978-1-0716-3738-8_17 · Cited by 2

Immune profiling in M. tuberculosis infection enables stratification of patients with active diseasePreprint

Duffy, D., Nemes, E., Llibre, A., Rouilly, V., Filander, E., Africa, H., Mabwe, S., Jaxa, L., Charbit, B., Musvosvi, M., et al. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/581298 · Cited by 2

CD206 upregulation in monocytes within whole blood cultures correlates with lung function in Cystic Fibrosis: a pilot studyPreprint

Singh, S., Longmate, J., Onion, D., Williams, P. M., Cámara, M., Smyth, A. R., Barr, H. L., & Martínez‐Pomares, L. (2023) · medRxiv · doi:10.1101/2023.11.15.23298577 · Cited by 2

Deep immune cell phenotyping and induced immune cell responses at admission stratified by BMI in patients hospitalized with COVID-19: An observational multicenter cohort pilot study

Sejdic, A., Hartling, H. J., Holler, J. G., Gjærde, L. K., Dungu, A. M., Møller, M. E. E., Teglgaard, R. S., Niemann, C. U., Brooks, P. T., Mogensen, T. H., et al. (2024) · Clinical Immunology · doi:10.1016/j.clim.2024.110336 · Cited by 1

BET Isoform Selectivity through Diverse Linkers for Bivalent Inhibitors: GSK785, a BRD2/4-Selective Bivalent BET Inhibitor

Rianjongdee, F., Atkinson, S. J., Bamborough, P., Barnett, H. A., Friston, K., Grandi, P., Neipp, C. E., Petretich, M., Phillipou, A., Preston, A. G. S., et al. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.5c00622 · Cited by 1

Variability in the TLR3 type I interferon pathway is predictive of RNA vaccine responses

Ng, W. W., Sugrue, J. A., Duque, J. S. R., Rouilly, V., Bondet, V., Albert, C., Dubois, F., Robert, M., Leung, D., Chung, P., et al. (2026) · Science Advances · doi:10.1126/sciadv.aed8930 · Cited by 1

Milieu Intérieur

Hasan, M. (2019) · médecine/sciences · doi:10.1051/medsci/2019077 · Cited by 1

Cytokine Storm and Failed Resolution in COVID-19: Taking a Cue from Multiple Sclerosis

Zahoor, I., Li, Y., Rattan, R., & Giri, S. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-85109-5_13 · Cited by 1

Differences in toll‐like receptor ligand‐induced cytokine concentrations before and after solid organ transplantation: A prospective, observational cohort study in a clinical setting

Møller, D. L., Sørensen, S. S., Perch, M., Gustafsson, F., Hald, A., Knudsen, A. D., Abdulovski, R., Arentoft, N. S., Lundgren, J. D., Rasmussen, A., et al. (2023) · Scandinavian Journal of Immunology · doi:10.1111/sji.13337 · Cited by 1

Clinical implications of innate immune exhaustion in cystic fibrosis

Møller, R., Nielsen, B. U., Rossi, E., Lausen, M., Skov, M., Pressler, T., Ostrowski, S. R., & Johansen, H. K. (2024) · ERJ Open Research · doi:10.1183/23120541.00256-2024 · Cited by 1

Type 1 diabetes mellitus (T1DM) does not affect whole blood responses to alginate-based microspheres despite plasma lipid and glucose differences

Vasuthas, K., Christiansen, S. C., Kjesbu, J. S., Ryan, L., Andreassen, T., Slupphaug, G., Strand, B. L., Stenvik, J., & Rokstad, A. M. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102113 · Cited by 1

Polygenic risk scores associated with tumor immune infiltration in common cancersPreprint

Choi, J., Kim, J. S., Sung, H. J., Chen, Y., Chen, Z., Wen, W., Shu, X., & Guo, X. (2022) · Research Square · doi:10.21203/rs.3.rs-1796640/v2 · Cited by 1

UBA1 Mutations Drive RIPK1-Mediated Cell Death and Monocyte Dysfunction in VEXAS SyndromePreprint

Breillat, P., Magaziner, S. J., Camus, S. M., Dionet, L., Valence, B. D., Sohier, P., Majdi, A., Delcros, Q., Pallotti, F., Rivet, N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.10.06.680650 · Cited by 1

Malalties immunomediades (immunopatologia) en el moment actual

Juan, M., & González‐Navarro, E. A. (2014) · RACO (Revistes Catalanes amb Accés Obert) (Consorci de Serveis Universitaris de Catalunya) · doi:10.2436/tscb.v65i0.136730

Standardized whole blood stimulation improves immunomonitoring of induced immune responses in multi-center study

Duffy, D., Rouilly, V., Braudeau, C., Corbière, V., Djebali, R., Ungeheuer, M., Josien, R., LaBrie, S. T., Lantz, O. J., Louis, D., et al. (2017) · Clinical Immunology · doi:10.1016/j.clim.2017.09.019 · Cited by 82

Standardized Whole-Blood Transcriptional Profiling Enables the Deconvolution of Complex Induced Immune Responses

Urrutia, A., Duffy, D., Rouilly, V., Posseme, C., Djebali, R., Illanes, G., Libri, V., Albaud, B., Gentien, D., Piasecka, B., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.011 · Cited by 102

Intraindividual long term stability and response corridors of cytokines in healthy volunteers detected by a standardized whole-blood culture system for bed-side application

Mueller, S., März, R., Schmolz, M., & Drewelow, B. (2012) · BMC Medical Research Methodology · doi:10.1186/1471-2288-12-112 · Cited by 24

Application of the TruCulture® whole blood stimulation system for immune response profiling in cattle

O’Brien, M. B., McLoughlin, R. M., & Meade, K. G. (2020) · Veterinary Immunology and Immunopathology · doi:10.1016/j.vetimm.2020.110025 · Cited by 6

Standardization of Functional Immune Cell-Based Assays: An Integral Aspect to Vaccine and Biologic Development and Validation.

Wilkinson, J. G., Smith, C., D'Costa, S. S., & Rabellino, E. M. (2005) · Blood · doi:10.1182/blood.v106.11.3933.3933