Cited by 465T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisIL-33, ST2, and ILC Pathways

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Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation

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Goto, Yoshiyuki, Panea, Casandra, Nakato, Gaku, Cebula, Anna, Lee, Carolyn, Diez, Marta Galan, Laufer, Terri M., Ignatowicz, Leszek, Ivanov, Ivaylo I.·2014·Immunity

DOI 10.1016/j.immuni.2014.03.005PMC PMC4084624

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Abstract

How commensal microbiota contributes to immune cell homeostasis at barrier surfaces is poorly understood. Lamina propria (LP) T helper 17 (Th17) cells participate in mucosal protection and are induced by commensal segmented filamentous bacteria (SFB). Here we show that MHCII-dependent antigen presentation of SFB antigens by intestinal dendritic cells (DCs) is crucial for Th17 cell induction. Expression of MHCII on CD11c(+) cells was necessary and sufficient for SFB-induced Th17 cell differentiation. Most SFB-induced Th17 cells recognized SFB in an MHCII-dependent manner. SFB primed and induced Th17 cells locally in the LP and Th17 cell induction occurred normally in mice lacking secondary lymphoid organs. The importance of other innate cells was unveiled by the finding that MHCII deficiency in group 3 innate lymphoid cells (ILCs) resulted in an increase in SFB-independent Th17 cell differentiation. Our results outline the complex role of DCs and ILCs in the regulation of intestinal Th17 cell homeostasis.

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Authors: Goto, Y., Panea, C., Nakato, G., Cebula, A., Lee, C., Diez, M. G., Laufer, T. M., Ignatowicz, L., & Ivanov, I. I.
Affiliations: Columbia University Irving Medical Center (US)
Augusta University (US)
Philadelphia VA Medical Center (US)
Corresponding author: Ivanov, Ivaylo I.
ORCID: Goto, Yoshiyuki
Panea, Casandra
Cebula, Anna
Laufer, Terri M.
Ignatowicz, Leszek
Ivanov, Ivaylo I.
Venue: Immunity
Publisher: Elsevier BV
Published: 2014-04
Volume: 40
Issue: 4
Pages: 594-607
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2014.03.005
PMC: PMC4084624
OpenAlex: W2004714320
Cited by: 465
References: 49
Citations by year: 2026: 24 · 2025: 29 · 2024: 24 · 2023: 30 · 2022: 38 · 2021: 34 · 2020: 42 · 2019: 36 · 2018: 35 · 2017: 32 · 2016: 46 · 2015: 61 · 2014: 32
FWCI: 26.02
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 450 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (R01DK098378)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
Keywords: segmented filamentous bacteria, Th17 cell differentiation, intestinal dendritic cells, MHC class II, antigen presentation, lamina propria, commensal microbiota, ILC3, mucosal immunity, innate lymphoid cells, secondary lymphoid organs
MeSH terms: Animals, Antigens, Bacterial, Histocompatibility Antigens Class II, Cell Differentiation, Cells, Cultured, Clostridium, Clostridium Infections, Dendritic Cells, Intestines, Lymphocyte Activation, Lymphocytes, Mice, Transgenic, Antigen Presentation, Mice, Knockout, Mice, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells, Microbiota

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Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation

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