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Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation
Open accessAbstract
How commensal microbiota contributes to immune cell homeostasis at barrier surfaces is poorly understood. Lamina propria (LP) T helper 17 (Th17) cells participate in mucosal protection and are induced by commensal segmented filamentous bacteria (SFB). Here we show that MHCII-dependent antigen presentation of SFB antigens by intestinal dendritic cells (DCs) is crucial for Th17 cell induction. Expression of MHCII on CD11c(+) cells was necessary and sufficient for SFB-induced Th17 cell differentiation. Most SFB-induced Th17 cells recognized SFB in an MHCII-dependent manner. SFB primed and induced Th17 cells locally in the LP and Th17 cell induction occurred normally in mice lacking secondary lymphoid organs. The importance of other innate cells was unveiled by the finding that MHCII deficiency in group 3 innate lymphoid cells (ILCs) resulted in an increase in SFB-independent Th17 cell differentiation. Our results outline the complex role of DCs and ILCs in the regulation of intestinal Th17 cell homeostasis.
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“presentation of SFB-derived antigens by intestinal APCs was shown to be sufficient for TH17 cell development (Goto et al., 2014; Panea et al., 2015).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Goto et al., 2014
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Cites
Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells
Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549
Self-citationThe Microbial Metabolites, Short-Chain Fatty Acids, Regulate Colonic T reg Cell Homeostasis
Smith, P. M., Howitt, M. R., Panikov, N., Michaud, M., Gallini, C. A., Bohlooly-Y, M., Glickman, J. N., & Garrett, W. S. (2013) · Science · doi:10.1126/science.1241165 · Cited by 5,413
Korn, T., Bettelli, E., Oukka, M., & Kuchroo, V. K. (2009) · Annual Review of Immunology · doi:10.1146/annurev.immunol.021908.132710 · Cited by 4,873
Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation
Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838
Induction of Intestinal Th17 Cells by Segmented Filamentous Bacteria
Ivanov, I. I., Atarashi, K., Manel, N., Brodie, E. L., Shima, T., Karaoz, U., Wei, D., Goldfarb, K. C., Santee, C. A., Lynch, S. V., et al. (2009) · Cell · doi:10.1016/j.cell.2009.09.033 · Cited by 4,554
Interactions Between the Microbiota and the Immune System
Hooper, L. V., Littman, D. R., & Macpherson, A. J. (2012) · Science · doi:10.1126/science.1223490 · Cited by 4,173
Induction of Colonic Regulatory T Cells by Indigenous Clostridium Species
Atarashi, K., Tanoue, T., Shima, T., Imaoka, A., Kuwahara, T., Momose, Y., Cheng, G., Yamasaki, S., Saito, T., Ohba, Y., et al. (2011) · Science · doi:10.1126/science.1198469 · Cited by 3,752
Self-citationTreg induction by a rationally selected mixture of Clostridia strains from the human microbiota
Atarashi, K., Tanoue, T., Oshima, K., Suda, W., Nagano, Y., Nishikawa, H., Fukuda, S., Saito, T., Narushima, S., Hase, K., et al. (2013) · Nature · doi:10.1038/nature12331 · Cited by 2,872
Regulatory T cells: mechanisms of differentiation and function
Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866
Rescigno, M., Urbano, M., Valzasina, B., Francolini, M., Rotta, G., Bonasio, R., Granucci, F., Kraehenbuhl, J.-P., & Ricciardi‐Castagnoli, P. (2001) · Nature Immunology · doi:10.1038/86373 · Cited by 2,554
Kitamura, D., Roes, J., Kühn, R., & Rajewsky, K. (1991) · Nature · doi:10.1038/350423a0 · Cited by 1,783
Ivanov, I. I., Frutos, R. D. L., Manel, N., Yoshinaga, K., Rifkin, D. B., Sartor, R. B., Finlay, B. B., & Littman, D. R. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.09.009 · Cited by 1,770
Self-citationInteractions between commensal intestinal bacteria and the immune system
Macpherson, A. J., & Harris, N. L. (2004) · Nature reviews. Immunology · doi:10.1038/nri1373 · Cited by 1,683
Gut-Residing Segmented Filamentous Bacteria Drive Autoimmune Arthritis via T Helper 17 Cells
Wu, H.-J., Ivanov, I. I., Darce, J., Hattori, K., Shima, T., Umesaki, Y., Littman, D. R., Benoist, C., & Mathis, D. (2010) · Immunity · doi:10.1016/j.immuni.2010.06.001 · Cited by 1,577
Barnden, M., Allison, J., Heath, W. R., & Carbone, F. (1998) · Immunology and Cell Biology · doi:10.1046/j.1440-1711.1998.00709.x · Cited by 1,491
Gaboriau-Routhiau, V., Rakotobe, S., Lécuyer, E., Mulder, I., Lan, A., Bridonneau, C., Rochet, V., Pisi, A., De Paepe, M., Brandi, G., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.020 · Cited by 1,452
Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis
Lee, Y. K., Menezes, J. S., Umesaki, Y., & Mazmanian, S. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000082107 · Cited by 1,323
Commensal microbiota and myelin autoantigen cooperate to trigger autoimmune demyelination
Berer, K., Mues, M., Koutrolos, M., Rasbi, Z. A., Boziki, M., Johner, C., Wekerle, H., & Krishnamoorthy, G. (2011) · Nature · doi:10.1038/nature10554 · Cited by 1,251
ATP drives lamina propria TH17 cell differentiation
Atarashi, K., Nishimura, J., Shima, T., Umesaki, Y., Yamamoto, M., Onoue, M., Yagita, H., Ishii, N., Evans, R., Honda, K., et al. (2008) · Nature · doi:10.1038/nature07240 · Cited by 1,089
Notch–RBP-J signaling controls the homeostasis of CD8− dendritic cells in the spleen
Caton, M. L., Smith-Raska, M., & Reizis, B. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062648 · Cited by 870
Tumor-specific Th17-polarized cells eradicate large established melanoma
Muranski, P. J., Boni, A., Antony, P. A., Cassard, L., Irvine, K. R., Kaiser, A., Paulos, C. M., Palmer, D. C., Touloukian, C. E., Ptak, K., et al. (2008) · Blood · doi:10.1182/blood-2007-11-120998 · Cited by 864
Mice lacking MHC class II molecules
Cosgrove, D. E., Gray, D., Dierich, A., Kaufman, J., LeMeur, M., Benoist, C. O., & Mathis, D. J. (1991) · Cell · doi:10.1016/0092-8674(91)90448-8 · Cited by 853
Innate lymphoid cells regulate CD4+ T-cell responses to intestinal commensal bacteria
Hepworth, M. R., Monticelli, L. A., Fung, T. C., Ziegler, C. G. K., Grunberg, S., Sinha, R., Mantegazza, A. R., Ma, H., Crawford, A., Angelosanto, J., et al. (2013) · Nature · doi:10.1038/nature12240 · Cited by 816
The microbiome in infectious disease and inflammation
Honda, K., & Littman, D. R. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-074937 · Cited by 791
Madison, B., Dunbar, L., Qiao, X. T., Braunstein, K., Braunstein, E. M., & Gumucio, D. L. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204935200 · Cited by 748
Depletion of CD4 + T Cells in Major Histocompatibility Complex Class II-Deficient Mice
Grusby, M. J., Johnson, R. S., Papaioannou, V. E., & Glimcher, L. H. (1991) · Science · doi:10.1126/science.1910207 · Cited by 660
Intestinal Bacteria and the Regulation of Immune Cell Homeostasis
Hill, D. A., & Artis, D. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101330 · Cited by 600
Thymic Origin of Intestinal αß T Cells Revealed by Fate Mapping of RORγt + Cells
Eberl, G., & Littman, D. R. (2004) · Science · doi:10.1126/science.1096472 · Cited by 514
Intestinal Commensal Microbes as Immune Modulators
Ivanov, I. I., & Honda, K. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.09.009 · Cited by 437
Qiu, J., Guo, X., Chen, Z. E., He, L., Sonnenberg, G. F., Artis, D., Fu, Y., & Zhou, L. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.002 · Cited by 431
In situ class switching and differentiation to IgA-producing cells in the gut lamina propria
Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K., & Honjo, T. (2001) · Nature · doi:10.1038/35098100 · Cited by 430
Feedback control of regulatory T cell homeostasis by dendritic cells in vivo
Darrasse-Jèze, G., Deroubaix, S., Mouquet, H., Victora, G. D., Eisenreich, T., Yao, K.-H., Masilamani, R. F., Dustin, M. L., Rudensky, A. Y., Liu, K., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20090746 · Cited by 420
CD1-restricted CD4+ T cells in major histocompatibility complex class II-deficient mice.
Cardell, S., Tangri, S., Chan, S. H., Kronenberg, M., Benoist, C. O., & Mathis, D. J. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.4.993 · Cited by 384
Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation
Torchinsky, M. B., Garaude, J., Martin, A. P., & Blander, J. M. (2009) · Nature · doi:10.1038/nature07781 · Cited by 364
Umesaki, Y., Okada, Y., Matsumoto, S., Imaoka, A., & Setoyama, H. (1995) · Microbiology and Immunology · doi:10.1111/j.1348-0421.1995.tb02242.x · Cited by 346
Two better cell lines for making hybridomas expressing specific T cell receptors.
White, J., Blackman, M. A., Bill, J. R., Kappler, J. W., Marrack, P., Gold, D. P., & Born, W. K. (1989) · The Journal of Immunology · doi:10.4049/jimmunol.143.6.1822 · Cited by 294
Antigen processing and presentation by intestinal epithelial cells – polarity and complexity
Hershberg, R. M., & Mayer, L. (2000) · Immunology Today · doi:10.1016/s0167-5699(99)01575-3 · Cited by 289
Nonself-Antigens Are the Cognate Specificities of Foxp3+ Regulatory T Cells
Pacholczyk, R., Kern, J., Singh, N., Iwashima, M., Kraj, P. J., & Ignatowicz, L. (2007) · Immunity · doi:10.1016/j.immuni.2007.07.019 · Cited by 216
Acquisition of a multifunctional IgA+ plasma cell phenotype in the gut
Fritz, J. H., Rojas, O. L., Simard, N. N., McCarthy, D. D., Hapfelmeier, S., Rubino, S. J., Robertson, S. J., Larijani, M., Gosselin, J., Ivanov, I. I., et al. (2011) · Nature · doi:10.1038/nature10698 · Cited by 203
Sczesnak, A., Segata, N., Qin, X., Gevers, D., Petrosino, J. F., Huttenhower, C., Littman, D. R., & Ivanov, I. I. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.08.005 · Cited by 184
T Helper 1 and T Helper 2 Cells Are Pathogenic in an Antigen-specific Model of Colitis
Iqbal, N., Oliver, J. R., Wagner, F. H., Lazenby, A. J., Elson, C. O., & Weaver, C. T. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.2001889 · Cited by 141
Contributions of dendritic cells and macrophages to intestinal homeostasis and immune defense
Farache, J., Zigmond, E., Shakhar, G., & Jung, S. (2013) · Immunology and Cell Biology · doi:10.1038/icb.2012.79 · Cited by 134
T cell tolerance and immunity to commensal bacteria
Nutsch, K., & Hsieh, C. (2012) · Current Opinion in Immunology · doi:10.1016/j.coi.2012.04.009 · Cited by 105
A conditional null allele of the major histocompatibility IA‐beta chain gene
Hashimoto, K., Joshi, S. K., & Koni, P. A. (2002) · genesis · doi:10.1002/gene.10056 · Cited by 87
Lochner, M., Berard, M., Sawa, S., Hauer, S., Gaboriau‐Routhiau, V., Fernández, T. D., Snel, J., Bousso, P., Cerf–Bensussan, N., & Eberl, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1001723 · Cited by 86
Newberry, R. D., McDonough, J. S., McDonald, K. G., & Lorenz, R. G. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.10.4988 · Cited by 55
Shima, T., Fukushima, K., Setoyama, H., Imaoka, A., Matsumoto, S., Hara, T., Suda, K., & Umesaki, Y. (2007) · FEMS Immunology & Medical Microbiology · doi:10.1111/j.1574-695x.2007.00344.x · Cited by 51
CD8α+ and CD11b+ Dendritic Cell-Restricted MHC Class II Controls Th1 CD4+ T Cell Immunity
Lemos, M. P., Fan, L., Lo, D. D., & Laufer, T. M. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.10.5077 · Cited by 48
Mononuclear phagocyte diversity in the intestine
Bogunovic, M., Mortha, A., Muller, P. A., & Mérad, M. (2012) · Immunologic Research · doi:10.1007/s12026-012-8323-5 · Cited by 31
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Atarashi, K., Tanoue, T., Ando, M., Kamada, N., Nagano, Y., Narushima, S., Suda, W., Imaoka, A., Setoyama, H., Nagamori, T., et al. (2015) · Cell · doi:10.1016/j.cell.2015.08.058 · Cited by 1,071
Pitt, J. M., Vétizou, M., Daillère, R., Roberti, M. P., Yamazaki, T., Routy, B., Lepage, P., Boneca, I. G., Chamaillard, M., Kroemer, G., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.06.001 · Cited by 1,060
Postler, T. S., & Ghosh, S. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.05.008 · Cited by 876
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Metadata
- Authors
- Goto, Y., Panea, C., Nakato, G., Cebula, A., Lee, C., Diez, M. G., Laufer, T. M., Ignatowicz, L., & Ivanov, I. I.
- Affiliations
- Columbia University Irving Medical Center (US)
- Augusta University (US)
- Philadelphia VA Medical Center (US)
- Corresponding author
- Ivanov, Ivaylo I.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 40
- Issue
- 4
- Pages
- 594-607
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC4084624
- OpenAlex
- W2004714320
- Cited by
- 465
- References
- 49
- Citations by year
- 2026: 24 · 2025: 29 · 2024: 24 · 2023: 30 · 2022: 38 · 2021: 34 · 2020: 42 · 2019: 36 · 2018: 35 · 2017: 32 · 2016: 46 · 2015: 61 · 2014: 32
- FWCI
- 26.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK098378)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- segmented filamentous bacteria, Th17 cell differentiation, intestinal dendritic cells, MHC class II, antigen presentation, lamina propria, commensal microbiota, ILC3, mucosal immunity, innate lymphoid cells, secondary lymphoid organs
- MeSH terms
- Animals, Antigens, Bacterial, Histocompatibility Antigens Class II, Cell Differentiation, Cells, Cultured, Clostridium, Clostridium Infections, Dendritic Cells, Intestines, Lymphocyte Activation, Lymphocytes, Mice, Transgenic, Antigen Presentation, Mice, Knockout, Mice, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells, Microbiota
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