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Segmented Filamentous Bacteria Antigens Presented by Intestinal Dendritic Cells Drive Mucosal Th17 Cell Differentiation
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How commensal microbiota contributes to immune cell homeostasis at barrier surfaces is poorly understood. Lamina propria (LP) T helper 17 (Th17) cells participate in mucosal protection and are induced by commensal segmented filamentous bacteria (SFB). Here we show that MHCII-dependent antigen presentation of SFB antigens by intestinal dendritic cells (DCs) is crucial for Th17 cell induction. Expression of MHCII on CD11c(+) cells was necessary and sufficient for SFB-induced Th17 cell differentiation. Most SFB-induced Th17 cells recognized SFB in an MHCII-dependent manner. SFB primed and induced Th17 cells locally in the LP and Th17 cell induction occurred normally in mice lacking secondary lymphoid organs. The importance of other innate cells was unveiled by the finding that MHCII deficiency in group 3 innate lymphoid cells (ILCs) resulted in an increase in SFB-independent Th17 cell differentiation. Our results outline the complex role of DCs and ILCs in the regulation of intestinal Th17 cell homeostasis.
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“presentation of SFB-derived antigens by intestinal APCs was shown to be sufficient for TH17 cell development (Goto et al., 2014; Panea et al., 2015).”
From Understanding the Holobiont: How Microbial Metabolites Affect Human Health and Shape the Immune System (2017) · cites this paper as Goto et al., 2014
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Metadata
- Authors
- Goto, Y., Panea, C., Nakato, G., Cebula, A., Lee, C., Diez, M. G., Laufer, T. M., Ignatowicz, L., & Ivanov, I. I.
- Affiliations
- Columbia University Irving Medical Center (US)
- Augusta University (US)
- Philadelphia VA Medical Center (US)
- Corresponding author
- Ivanov, Ivaylo I.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 40
- Issue
- 4
- Pages
- 594-607
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC4084624
- OpenAlex
- W2004714320
- Cited by
- 465
- References
- 49
- Citations by year
- 2026: 24 · 2025: 29 · 2024: 24 · 2023: 30 · 2022: 38 · 2021: 34 · 2020: 42 · 2019: 36 · 2018: 35 · 2017: 32 · 2016: 46 · 2015: 61 · 2014: 32
- FWCI
- 26.02
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK098378)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › IL-33, ST2, and ILC Pathways
- Keywords
- segmented filamentous bacteria, Th17 cell differentiation, intestinal dendritic cells, MHC class II, antigen presentation, lamina propria, commensal microbiota, ILC3, mucosal immunity, innate lymphoid cells, secondary lymphoid organs
- MeSH terms
- Animals, Antigens, Bacterial, Histocompatibility Antigens Class II, Cell Differentiation, Cells, Cultured, Clostridium, Clostridium Infections, Dendritic Cells, Intestines, Lymphocyte Activation, Lymphocytes, Mice, Transgenic, Antigen Presentation, Mice, Knockout, Mice, Nuclear Receptor Subfamily 1, Group F, Member 3, Th17 Cells, Microbiota
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