Cited by 1,122Gut microbiota and healthInflammatory Bowel DiseaseOral microbiology and periodontitis research

Current Understanding of Dysbiosis in Disease in Human and Animal Models

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DeGruttola, Arianna K., Low, Daren, Mizoguchi, Atsushi, Mizoguchi, Emiko·2016·Inflammatory Bowel Diseases

Abstract

Inflammatory bowel disease (IBD) is an intestinal inflammatory condition that affects more than 2 million people in the United States. Although the etiology and pathogenesis of IBD are still largely unknown, dysregulated host/enteric microbial interactions are requisite for the development of IBD. So far, many researchers have tried to identify a precise relationship between IBD and an imbalance of the intestinal microbiota, termed "dysbiosis." Despite extensive efforts, it is still largely unknown about the interplay among microbes, their hosts, and their environments, and whether dysbiosis is a causal factor or an effect of IBD. Recently, deep-sequencing analyses of the microbiota in patients with IBD patients have been instrumental in characterizing the strong association between dysbiosis and IBD development, although it is still unable to identify specific-associated species level changes in most cases. Based on many recent reports, dysbiosis of the commensal microbiota is implicated in the pathogenesis of several diseases, including IBD, obesity, and allergic disorders, in both human and animal models. In this review article, the authors have focused on explaining the multiple types of dysbiosis, as well as dysbiosis-related diseases and potential treatments to apply this knowledge to understand a possible cause and potentially find therapeutic strategies for IBD as well as the other dysbiosis-related diseases.

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Crossref · 10.1097/mib.0000000000000750

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  • Changes in microbial equilibrium (dysbiosis) can promote and influence the course of many intestinal and extra-intestinal diseases.

    “Changes in this microbial equilibrium that is, dysbiosis can promote and influence the course of many intestinal and extra-intestinal diseases[14-16].”

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1 of the 108 references couldn’t be matched to a known paper.

Research works printed but not linked: 4

  1. Shanahan, 2013, Gastroenterology, 29, 49
  2. Shanahan, 2009, Gastroenterology, 25, 301
  3. Moran, 2015, Gastroenterology, 31, 130
  4. Low, 2013, Drug Des Devel Ther., 7, 1341

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Authors
DeGruttola, A. K., Low, D., Mizoguchi, A., & Mizoguchi, E.
Affiliations
  • Kurume University (JP)
  • Harvard University (US)
Venue
Inflammatory Bowel Diseases
Published
2016-05
Volume
22
Issue
5
Pages
1137-1150
ISSN
1078-0998 (ISSN-L)
OpenAlex
W2337372962
Cited by
1,122
References
108
Citations by year
2026: 110 · 2025: 234 · 2024: 217 · 2023: 150 · 2022: 105 · 2021: 106 · 2020: 79 · 2019: 59 · 2018: 29 · 2017: 24 · 2016: 8
FWCI
3.57
Type
journal article
Language
en
Open access
Locations
  • Inflammatory Bowel Diseases (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • Japan Society for the Promotion of Science (15H04813)
  • National Institute of Allergy and Infectious Diseases (R01AI081807, AI81807)
  • National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080070, R01DK091247, DK91247)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
  • Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
Keywords
dysbiosis, inflammatory bowel disease
MeSH terms
Animals, Humans, Models, Biological, Inflammatory Bowel Diseases, Dysbiosis

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