Current Understanding of Dysbiosis in Disease in Human and Animal Models
Open accessAbstract
Inflammatory bowel disease (IBD) is an intestinal inflammatory condition that affects more than 2 million people in the United States. Although the etiology and pathogenesis of IBD are still largely unknown, dysregulated host/enteric microbial interactions are requisite for the development of IBD. So far, many researchers have tried to identify a precise relationship between IBD and an imbalance of the intestinal microbiota, termed "dysbiosis." Despite extensive efforts, it is still largely unknown about the interplay among microbes, their hosts, and their environments, and whether dysbiosis is a causal factor or an effect of IBD. Recently, deep-sequencing analyses of the microbiota in patients with IBD patients have been instrumental in characterizing the strong association between dysbiosis and IBD development, although it is still unable to identify specific-associated species level changes in most cases. Based on many recent reports, dysbiosis of the commensal microbiota is implicated in the pathogenesis of several diseases, including IBD, obesity, and allergic disorders, in both human and animal models. In this review article, the authors have focused on explaining the multiple types of dysbiosis, as well as dysbiosis-related diseases and potential treatments to apply this knowledge to understand a possible cause and potentially find therapeutic strategies for IBD as well as the other dysbiosis-related diseases.
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Changes in microbial equilibrium (dysbiosis) can promote and influence the course of many intestinal and extra-intestinal diseases.
“Changes in this microbial equilibrium that is, dysbiosis can promote and influence the course of many intestinal and extra-intestinal diseases[14-16].”
From Proton pump inhibitors and dysbiosis: current knowledge and aspects to be clarified (2019) · cites this paper as [15]
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Oral Bacteria and Intestinal Dysbiosis in Colorectal Cancer
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The microbiome in prostate inflammation and prostate cancer
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Innate Lymphoid Cells in Intestinal Homeostasis and Inflammatory Bowel Disease
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Intestinal Microbiota Influences Non-intestinal Related Autoimmune Diseases
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Lactobacillus rhamnosus GG: An Overview to Explore the Rationale of Its Use in Cancer
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Psoriasis and Microbiota: A Systematic Review
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Microbial Metabolism Modulates Antibiotic Susceptibility within the Murine Gut Microbiome
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Microbiome and diabetes: Where are we now?
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Functional Amino Acids in Pigs and Chickens: Implication for Gut Health
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Visceral Adiposity and Cancer: Role in Pathogenesis and Prognosis
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- Authors
- DeGruttola, A. K., Low, D., Mizoguchi, A., & Mizoguchi, E.
- Affiliations
- Kurume University (JP)
- Harvard University (US)
- Venue
- Inflammatory Bowel Diseases
- Publisher
- Oxford University Press (OUP)
- Published
- 2016-05
- Volume
- 22
- Issue
- 5
- Pages
- 1137-1150
- ISSN
- 1078-0998 (ISSN-L)
- PMC
- PMC4838534
- OpenAlex
- W2337372962
- Semantic Scholar
- d55e6c5c2d1274521dba339d981e3402b20dff10
- Cited by
- 1,122
- References
- 108
- Citations by year
- 2026: 110 · 2025: 234 · 2024: 217 · 2023: 150 · 2022: 105 · 2021: 106 · 2020: 79 · 2019: 59 · 2018: 29 · 2017: 24 · 2016: 8
- FWCI
- 3.57
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Inflammatory Bowel Diseases (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Japan Society for the Promotion of Science (15H04813)
- National Institute of Allergy and Infectious Diseases (R01AI081807, AI81807)
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK080070, R01DK091247, DK91247)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Keywords
- dysbiosis, inflammatory bowel disease
- MeSH terms
- Animals, Humans, Models, Biological, Inflammatory Bowel Diseases, Dysbiosis
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