The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion
Open accessAbstract
Group 2 innate lymphoid cells (ILC2s) release interleukin-13 (IL-13) during protective immunity to helminth infection and detrimentally during allergy and asthma. Using two mouse models to deplete ILC2s in vivo, we demonstrate that T helper 2 (Th2) cell responses are impaired in the absence of ILC2s. We show that MHCII-expressing ILC2s interact with antigen-specific T cells to instigate a dialog in which IL-2 production from T cells promotes ILC2 proliferation and IL-13 production. Deletion of MHCII renders IL-13-expressing ILC2s incapable of efficiently inducing Nippostrongylus brasiliensis expulsion. Thus, during transition to adaptive T cell-mediated immunity, the ILC2 and T cell crosstalk contributes to their mutual maintenance, expansion and cytokine production. This interaction appears to augment dendritic-cell-induced T cell activation and identifies a previously unappreciated pathway in the regulation of type-2 immunity.
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Cites
Innate lymphoid cells promote lung-tissue homeostasis after infection with influenza virus
Monticelli (2011) · PubMed · doi:10.1031/ni.2131 · Cited by 1,286
Mjösberg, J. M., Trifari, S., Crellin, N. K., Peters, C. P., van Drunen, C. M., Piet, B., Fokkens, W. J., Cupedo, T., & Spits, H. (2011) · Nature Immunology · doi:10.1038/ni.2104 · Cited by 1,166
Bartemes, K. R., Iijima, K., Kobayashi, T., Kephart, G. M., McKenzie, A. N., & Kita, H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102832 · Cited by 549
Self-citationYamane, H., Zhu, J., & Paul, W. E. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20051304 · Cited by 285
Gough, L., Schulz, O., Sewell, H. F., & Shakib, F. (1999) · The Journal of Experimental Medicine · doi:10.1084/jem.190.12.1897 · Cited by 216
Cited by
Lambrecht, B. N., & Hammad, H. (2015) · Nature Immunology · doi:10.1038/ni.3049 · Cited by 1,673
Tuft-cell-derived IL-25 regulates an intestinal ILC2-epithelial response circuit
von Moltke, J., Ji, M., Liang, H.-E., & Locksley, R. M. (2016) · Nature · doi:10.1038/nature16161 · Cited by 1,230
Innate lymphoid cells: A new paradigm in immunology
Eberl, G., Colonna, M., Di Santo, J. P., & McKenzie, A. N. J. (2015) · Science · doi:10.1126/science.aaa6566 · Cited by 878
Self-citationBarrier Epithelial Cells and the Control of Type 2 Immunity
Hammad, H., & Lambrecht, B. N. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.007 · Cited by 847
Interleukin-33 in tissue homeostasis, injury, and inflammation
Molofsky, A. B., Savage, A. K., & Locksley, R. M. (2015) · Immunity · doi:10.1016/j.immuni.2015.06.006 · Cited by 638
Metadata
- Authors
- Oliphant, C. J., Hwang, Y. Y., Walker, J. A., Salimi, M., Wong, S. H., Brewer, J. M., Englezakis, A., Barlow, J. L., Hams, E., Scanlon, S. T., Ogg, G. S., Fallon, P. G., & McKenzie, A. N. J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-08
- Volume
- 41
- Issue
- 2
- Pages
- 283-295
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2102829493
- Cited by
- 696
- References
- 5
- FWCI
- 28.01
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Oliphant, C. J., Hwang, Y. Y., Walker, J. A., Salimi, M., Wong, S. H., Brewer, J. M., Englezakis, A., Barlow, J. L., Hams, E., Scanlon, S. T., Ogg, G. S., Fallon, P. G., & McKenzie, A. N. J. (2014). MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion. Immunity. https://doi.org/10.1016/j.immuni.2014.06.016
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
