Independent roles for IL-2 and GATA-3 in stimulating naive CD4+ T cells to generate a Th2-inducing cytokine environment

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by <i>Listeria</i> -Induced Macrophages

Hsieh, C.-S., Macatonia, S. E., Tripp, C. S., Wolf, S. F., O'Garra, A., & Murphy, K. M. (1993) · Science · doi:10.1126/science.8097338 · Cited by 3,134 · see citing works

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

Zheng, W.-P., & Flavell, R. A. (1997) · Cell · doi:10.1016/s0092-8674(00)80240-8 · Cited by 2,384 · see citing works

Induction of Th1 and Th2 CD4+ T cell responses: the alternative approaches.

Constant, S., & Bottomly, K. (1997) · Annual Review of Immunology · doi:10.1146/annurev.immunol.15.1.297 · Cited by 1,698 · see citing works

A Critical Role for Dnmt1 and DNA Methylation in T Cell Development, Function, and Survival

Lee, P. P., Fitzpatrick, D. R., Beard, C., Jessup, H. K., Lehar, S. M., Makar, K. W., Pérez‐Melgosa, M., Sweetser, M. T., Schlissel, M. S., Nguyen, S. P., et al. (2001) · Immunity · doi:10.1016/s1074-7613(01)00227-8 · Cited by 1,280 · see citing works

IL‐4 directs the development of Th2‐like helper effectors

Swain, S. L., Weinberg, A. D., English, M., & Huston, G. (1990) · The Journal of Immunology · doi:10.4049/jimmunol.145.11.3796 · Cited by 1,254 · see citing works

Lipopolysaccharide-enhanced, Toll-like Receptor 4–dependent T Helper Cell Type 2 Responses to Inhaled Antigen

Eisenbarth, S. C., Piggott, D. A., Huleatt, J. W., Visintin, I., Herrick, C. A., & Bottomly, K. (2002) · The Journal of Experimental Medicine · doi:10.1084/jem.20021340 · Cited by 1,171 · see citing works

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

Plaut, M., Pierce, J. H., Watson, C. J., Hanley-Hyde, J., Nordan, R. P., & Paul, W. E. (1989) · Nature · doi:10.1038/339064a0 · Cited by 1,170 · see citing works

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

Seder, R. A., Gazzinelli, R. T., Sher, A., & Paul, W. E. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.10188 · Cited by 976 · see citing works

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

Le Gros, G., Ben-Sasson, S. Z., Seder, R., Finkelman, F. D., & Paul, W. E. (1990) · The Journal of experimental medicine · doi:10.1084/jem.172.3.921 · Cited by 954 · see citing works

PKC-θ is required for TCR-induced NF-κB activation in mature but not immature T lymphocytes

Sun, Z., Arendt, C., Ellmeier, W., Schaeffer, E. M., Sunshine, M. J., Gandhi, L., Annes, J. P., Petrzilka, D., Kupfer, A., Schwartzberg, P. L., et al. (2000) · Nature · doi:10.1038/35006090 · Cited by 894 · see citing works

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

Yoshimoto, T., & Paul, W. E. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.179.4.1285 · Cited by 841 · see citing works

IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression.

Ding, L., Linsley, P. S., Huang, L. Y., Germain, R. N., & Shevach, E. M. (1993) · The Journal of Immunology · doi:10.4049/jimmunol.151.3.1224 · Cited by 829 · see citing works

Inhibition of Th1 Development Mediated by GATA-3 through an IL-4-Independent Mechanism

Ouyang, W., Ranganath, S. H., Weindel, K., Bhattacharya, D., Murphy, T. L., Sha, W. C., & MURPHY, K. M. M. (1998) · Immunity · doi:10.1016/s1074-7613(00)80671-8 · Cited by 778 · see citing works

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

Constant, S. L., Pfeiffer, C., Woodard, A., Pasqualini, T., & Bottomly, K. (1995) · The Journal of Experimental Medicine · doi:10.1084/jem.182.5.1591 · Cited by 677 · see citing works

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

Ho, I., Hodge, M. R., Rooney, J. W., & Glimcher, L. H. (1996) · Cell · doi:10.1016/s0092-8674(00)81299-4 · Cited by 667 · see citing works

Conditional deletion of Gata3 shows its essential function in TH1-TH2 responses

Zhu, J., Min, B., Hu‐Li, J., Watson, C. J., Grinberg, A., Wang, Q., Killeen, N. P., Urban, J. F., Guo, L., & Paul, W. E. (2004) · Nature Immunology · doi:10.1038/ni1128 · Cited by 648 · see citing works

A critical role for NF-κB in Gata3 expression and TH2 differentiation in allergic airway inflammation

Das, J., Chen, C.-H., Yang, L., Cohn, L., Ray, P., & Ray, A. (2001) · Nature Immunology · doi:10.1038/83158 · Cited by 518 · see citing works

TCR ligand discrimination is enforced by competing ERK positive and SHP-1 negative feedback pathways

Štefanová, I., Hemmer, B., Vergelli, M., Martin, R., Biddison, W. E., & Germain, R. N. (2003) · Nature Immunology · doi:10.1038/ni895 · Cited by 465 · see citing works

Transforming growth factor-β controls T helper type 1 cell development through regulation of natural killer cell interferon-γ

Laouar, Y., Sutterwala, F. S., Gorelik, L., & Flavell, R. A. (2005) · Nature Immunology · doi:10.1038/ni1197 · Cited by 452 · see citing works

Basophils Produce IL-4 and Accumulate in Tissues after Infection with a Th2-inducing Parasite

Min, B., Prout, M. S., Hu‐Li, J., Zhu, J., Jankovic, D. L., Morgan, E. S., Urban, J. F., Dvořàk, A. M., Finkelman, F. D., Gros, G. S. L., et al. (2004) · The Journal of Experimental Medicine · doi:10.1084/jem.20040590 · Cited by 443 · see citing works

Type 2 Immunity Reflects Orchestrated Recruitment of Cells Committed to IL-4 Production

Voehringer, D., Shinkai, K., & Locksley, R. M. (2004) · Immunity · doi:10.1016/s1074-7613(04)00026-3 · Cited by 425 · see citing works

Interleukin 2 plays a central role in Th2 differentiation

Cote-Sierra, J., Foucras, G., Guo, L., Chiodetti, L., Young, H. A., Hu‐Li, J., Zhu, J., & Paul, W. E. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0400339101 · Cited by 422 · see citing works

Stat5 Activation Plays a Critical Role in Th2 Differentiation

Zhu, J., Cote-Sierra, J., Guo, L., & Paul, W. E. (2003) · Immunity · doi:10.1016/s1074-7613(03)00292-9 · Cited by 384 · see citing works

The Transcription Factor c-Maf Controls the Production of Interleukin-4 but Not Other Th2 Cytokines

Kim, J. I., Ho, I., Grusby, M. J., & Glimcher, L. H. (1999) · Immunity · doi:10.1016/s1074-7613(00)80073-4 · Cited by 383 · see citing works

Protein Kinase Cθ in T Cell Activation

Isakov, N., & Altman, A. (2002) · Annual Review of Immunology · doi:10.1146/annurev.immunol.20.100301.064807 · Cited by 369 · see citing works

Inhibition of allergic inflammation in a murine model of asthma by expression of a dominant-negative mutant of GATA-3.

Zhang, D.-H., Yang, L.-Y., Cohn, L., Parkyn, L., Homer, R. J., Ray, P., & Ray, A. (1999) · Immunity · doi:10.1016/s1074-7613(00)80122-3 · Cited by 364 · see citing works

B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells

Brown, M. A., Pierce, J. H., Watson, C. J., Falco, J., Ihle, J. N., & Paul, W. E. (1987) · Cell · doi:10.1016/0092-8674(87)90339-4 · Cited by 351 · see citing works

Intestinal dendritic cells increase T cell expression of α4β7 integrin

Stagg, A. J., Kamm, M. A., & Knight, S. C. (2002) · European Journal of Immunology · doi:10.1002/1521-4141(200205)32:5 · Cited by 306 · see citing works

Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils.

Seder, R. A., Paul, W. E., Dvořàk, A. M., Sharkis, S. J., Kagey‐Sobotka, A., Niv, Y., Finkelman, F. D., Barbieri, S. A., Galli, S. J., & Plaut, M. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.7.2835 · Cited by 257 · see citing works

MyD88-dependent induction of allergic Th2 responses to intranasal antigen

Piggott, D. A., Eisenbarth, S. C., Xu, L., Constant, S. L., Huleatt, J. W., Herrick, C. A., & Bottomly, K. (2005) · Journal of Clinical Investigation · doi:10.1172/jci22462 · Cited by 234 · see citing works

Identification of messenger RNA for IL-4 in human eosinophils with granule localization and release of the translated product

Moqbel, R., Ying, S., Barkans, J. R., Newman, T. M., Kimmitt, P. T., Wakelin, M., Taborda‐Barata, L., Meng, Q., Corrigan, C. J., Durham, S. R., et al. (1995) · The Journal of Immunology · doi:10.4049/jimmunol.155.10.4939 · Cited by 218 · see citing works

Induction of IL-4-producing CD4+ T cells by antigenic peptides altered for TCR binding

Tao, X., Grant, C., Constant, S. L., & Bottomly, K. (1997) · The Journal of Immunology · doi:10.4049/jimmunol.158.9.4237 · Cited by 159 · see citing works

Role of TCR-Induced Extracellular Signal-Regulated Kinase Activation in the Regulation of Early IL-4 Expression in Naive CD4+ T Cells

Jorritsma, P. J., Brogdon, J. L., & Bottomly, K. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.5.2427 · Cited by 144 · see citing works

The Potency of TCR Signaling Differentially Regulates NFATc/p Activity and Early IL-4 Transcription in Naive CD4+ T Cells

Brogdon, J. L., Leitenberg, D., & Bottomly, K. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.8.3825 · Cited by 137 · see citing works

The Runx1 Transcription Factor Inhibits the Differentiation of Naive CD4 + T Cells into the Th2 Lineage by Repressing GATA3 Expression

Komine, O., Hayashi, K., Natsume, W., Watanabe, T., Seki, Y., Seki, N., Yagi, R., Sukzuki, W., Tamauchi, H., Hozumi, K., et al. (2003) · The Journal of Experimental Medicine · doi:10.1084/jem.20021200 · Cited by 133 · see citing works

Stat5a regulates T helper cell differentiation by several distinct mechanisms

Kagami, S., Nakajima, H., Suto, A., Hirose, K., Suzuki, K., Morita, S., Kato, I., Saitō, Y., Kitamura, T., & Iwamoto, I. (2001) · Blood · doi:10.1182/blood.v97.8.2358 · Cited by 97 · see citing works

Probabilistic Regulation of IL-4 Production in Th2 Cells

Guo, L., Hu‐Li, J., & Paul, W. E. (2004) · Immunity · doi:10.1016/s1074-7613(04)00025-1 · Cited by 73 · see citing works

Naive CD4+ T Cells Exhibit Distinct Expression Patterns of Cytokines and Cell Surface Molecules on Their Primary Responses to Varying Doses of Antigen

Ise, W., Totsuka, M., Sogawa, Y., Ametani, A., Hachimura, S., Sato, T., Kumagai, Y., Habu, S., & Kaminogawa, S. (2002) · The Journal of Immunology · doi:10.4049/jimmunol.168.7.3242 · Cited by 55 · see citing works

Differentiation of Effector CD4 T Cell Populations

Zhu, J., Yamane, H., & Paul, W. E. (2010) · Annual Review of Immunology · doi:10.1146/annurev-immunol-030409-101212 · Cited by 3,452 · see citing works

CD4 T cells: fates, functions, and faults

Zhu, J., & Paul, W. E. (2008) · Blood · doi:10.1182/blood-2008-05-078154 · Cited by 1,796 · see citing works

The kinase mTOR regulates the differentiation of helper T cells through the selective activation of signaling by mTORC1 and mTORC2

Delgoffe, G. M., Pollizzi, K. N., Waickman, A. T., Heikamp, E., Meyers, D. J., Horton, M. R., Xiao, B., Worley, P. F., & Powell, J. D. (2011) · Nature Immunology · doi:10.1038/ni.2005 · Cited by 1,111 · see citing works

How are TH2-type immune responses initiated and amplified?

Paul, W. E., & Zhu, J. (2010) · Nature reviews. Immunology · doi:10.1038/nri2735 · Cited by 957 · see citing works

MHCII-Mediated Dialog between Group 2 Innate Lymphoid Cells and CD4+ T Cells Potentiates Type 2 Immunity and Promotes Parasitic Helminth Expulsion

Oliphant, C. J., Hwang, Y. Y., Walker, J. A., Salimi, M., Wong, S. H., Brewer, J. M., Englezakis, A., Barlow, J. L., Hams, E., Scanlon, S. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.016 · Cited by 697 · see citing works

Peripheral CD4+ T‐cell differentiation regulated by networks of cytokines and transcription factors

Zhu, J., & Paul, W. E. (2010) · Immunological Reviews · doi:10.1111/j.1600-065x.2010.00951.x · Cited by 596 · see citing works

GATA3 controls Foxp3+ regulatory T cell fate during inflammation in mice

Wohlfert, E. A., Grainger, J. R., Bouladoux, N., Konkel, J. E., Oldenhove, G., Ribeiro, C. H., Hall, J. A., Yagi, R., Naik, S., Bhairavabhotla, R., et al. (2011) · Journal of Clinical Investigation · doi:10.1172/jci57456 · Cited by 556 · see citing works

T helper 2 (Th2) cell differentiation, type 2 innate lymphoid cell (ILC2) development and regulation of interleukin-4 (IL-4) and IL-13 production

Zhu, J. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.010 · Cited by 505 · see citing works

GATA-3 promotes Th2 responses through three different mechanisms: induction of Th2 cytokine production, selective growth of Th2 cells and inhibition of Th1 cell-specific factors

Zhu, J., Yamane, H., Cote-Sierra, J., Guo, L.-Y., & Paul, W. (2006) · Cell Research · doi:10.1038/sj.cr.7310002 · Cited by 497 · see citing works

IL-33 Induces Antigen-Specific IL-5+ T Cells and Promotes Allergic-Induced Airway Inflammation Independent of IL-4

Kurowska‐Stolarska, M., Kewin, P., Murphy, G., Russo, R. C., Stolarski, B., Garcia, C. C., Komai‐Koma, M., Pitman, N. I., Li, Y., McKenzie, A. N. J., et al. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.7.4780 · Cited by 461 · see citing works

Single Naive CD4+ T Cells from a Diverse Repertoire Produce Different Effector Cell Types during Infection

Tubo, N. J., Pagán, A. J., Taylor, J. J., Nelson, R. W., Linehan, J. L., Ertelt, J. M., Huseby, E. S., Way, S. S., & Jenkins, M. K. (2013) · Cell · doi:10.1016/j.cell.2013.04.007 · Cited by 444 · see citing works

GATA3 and the T-cell lineage: essential functions before and after T-helper-2-cell differentiation

Ho, I., Tai, T.-S., & Pai, S. (2009) · Nature reviews. Immunology · doi:10.1038/nri2476 · Cited by 425 · see citing works

Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation

Hu, G., Tang, Q., Sharma, S., Yu, F., Escobar, T. M., Muljo, S. A., Zhu, J., & Zhao, K. (2013) · Nature Immunology · doi:10.1038/ni.2712 · Cited by 406 · see citing works

Th2 Cells in Health and Disease

Nakayama, T., Hirahara, K., Onodera, A., Endo, Y., Hosokawa, H., Shinoda, K., Tumes, D. J., & Okamoto, Y. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-051116-052350 · Cited by 398 · see citing works

T Helper Cell Differentiation, Heterogeneity, and PlasticityPreprint

Zhu, J. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a030338 · Cited by 352 · see citing works

The Transcription Factor T-bet Is Induced by Multiple Pathways and Prevents an Endogenous Th2 Cell Program during Th1 Cell Responses

Zhu, J., Jankovic, D., Oler, A. J., Wei, G., Sharma, S., Hu, G., Guo, L., Yagi, R., Yamane, H., Punkosdy, G., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.007 · Cited by 335 · see citing works

The differential expression of IL-4 and IL-13 and its impact on type-2 immunity

Bao, K., & Reinhardt, R. L. (2015) · Cytokine · doi:10.1016/j.cyto.2015.05.008 · Cited by 316 · see citing works

Interleukin-10 Production by Th1 Cells Requires Interleukin-12-Induced STAT4 Transcription Factor and ERK MAP Kinase Activation by High Antigen Dose

Saraiva, M., Christensen, J. R., Veldhoen, M., Murphy, T. L., MURPHY, K. M. M., & O’Garra, A. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.012 · Cited by 315 · see citing works

Early signaling events that underlie fate decisions of naive CD 4+ T cells toward distinct T‐helper cell subsets

Yamane, H., & Paul, W. E. (2013) · Immunological Reviews · doi:10.1111/imr.12032 · Cited by 304 · see citing works

IL-2– and CD25-dependent immunoregulatory mechanisms in the homeostasis of T-cell subsets

Létourneau, S., Krieg, C., Pantaleo, G., & Boyman, O. (2009) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2009.02.011 · Cited by 268 · see citing works

GATA-3 Function in Innate and Adaptive Immunity

Tindemans, I., Serafini, N., Santo, J. P. D., & Hendriks, R. W. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.006 · Cited by 258 · see citing works

Cellular and molecular mechanisms of allergic asthma

Komlósi, Z. I., van de Veen, W., Kovács, N., Szűcs, G., Sokołowska, M., O’Mahony, L., Akdiş, M., & Akdiş, C. A. (2021) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2021.100995 · Cited by 260 · see citing works

An updated view on transcription factor GATA3-mediated regulation of Th1 and Th2 cell differentiation

Yagi, R., Zhu, J., & Paul, W. E. (2011) · International Immunology · doi:10.1093/intimm/dxr029 · Cited by 251 · see citing works

GATA3: a master of many trades in immune regulation

Wan, Y. Y. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.04.002 · Cited by 248 · see citing works

T-Cell-Receptor-Dependent Signal Intensity Dominantly Controls CD4+ T Cell Polarization In Vivo

van Panhuys, N., Klauschen, F., & Germain, R. N. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.003 · Cited by 246 · see citing works

Induction of IL-4 Expression in CD4+ T Cells by Thymic Stromal Lymphopoietin

Omori, M., & Ziegler, S. F. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1396 · Cited by 239 · see citing works

Th1/Th2 Cell Differentiation and Molecular Signals

Zhang, Y., Zhang, Y., Gu, W., & Sun, B. (2014) · Advances in experimental medicine and biology · doi:10.1007/978-94-017-9487-9_2 · Cited by 223 · see citing works

NFAT pulls the strings during CD4+ T helper cell effector functions

Hermann-Kleiter, N., & Baier, G. (2010) · Blood · doi:10.1182/blood-2009-10-233585 · Cited by 218 · see citing works

Strength of TCR–Peptide/MHC Interactions and In Vivo T Cell Responses

Corse, E., Gottschalk, R. A., & Allison, J. P. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003650 · Cited by 206 · see citing works

IL-4-producing ILC2s are required for the differentiation of TH2 cells following Heligmosomoides polygyrus infection

Pelly, V. S., Kannan, Y., Coomes, S. M., Entwistle, L. J., Rückerl, D., Seddon, B. P., MacDonald, A. S., McKenzie, A., & Wilson, M. S. (2016) · Mucosal Immunology · doi:10.1038/mi.2016.4 · Cited by 202 · see citing works

Phenotypic models of T cell activation

Lever, M., Maini, P. K., van der Merwe, P. A., & Dushek, O. (2014) · Nature reviews. Immunology · doi:10.1038/nri3728 · Cited by 177 · see citing works

History of interleukin-4

Paul, W. E. (2015) · Cytokine · doi:10.1016/j.cyto.2015.01.038 · Cited by 178 · see citing works

Recent advances in understanding the Th1/Th2 effector choice

Butcher, M. J., & Zhu, J. (2021) · Faculty Reviews · doi:10.12703/r/10-30 · Cited by 176 · see citing works

Targeted Deletion of HIF-1α Gene in T Cells Prevents their Inhibition in Hypoxic Inflamed Tissues and Improves Septic Mice Survival

Thiel, M., Caldwell, C. C., Kreth, S., Kuboki, S., Chen, P., Smith, P., Ohta, A., Lentsch, A. B., Lukashev, D., & Sitkovsky, M. V. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000853 · Cited by 175 · see citing works

The Transcription Factor GATA3 Actively Represses RUNX3 Protein-Regulated Production of Interferon-γ

Yagi, R., Junttila, I., Wei, G., Urban, J. F., Zhao, K., Paul, W. E., & Zhu, J. (2010) · Immunity · doi:10.1016/j.immuni.2010.04.004 · Cited by 174 · see citing works

Regulation of Th2 Cytokine Genes by p38 MAPK-Mediated Phosphorylation of GATA-3

Maneechotesuwan, K., Xin, Y., Ito, K., Jazrawi, E., Lee, K.-Y., Usmani, O. S., Barnes, P. J., & Adcock, I. M. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.4.2491 · Cited by 167 · see citing works

Pulmonary CD103+ dendritic cells prime Th2 responses to inhaled allergens

Nakano, H., Free, M. E., Whitehead, G. S., Maruoka, S., Wilson, R. H., Nakano, K., & Cook, D. N. (2011) · Mucosal Immunology · doi:10.1038/mi.2011.47 · Cited by 165 · see citing works

Recent advances in understanding the role of IL-4 signaling

Keegan, A. D., Leonard, W. J., & Zhu, J. (2021) · Faculty Reviews · doi:10.12703/r/10-71 · Cited by 154 · see citing works

TCR signal quantity and quality in CD4+ T cell differentiation

Tubo, N. J., & Jenkins, M. K. (2014) · Trends in Immunology · doi:10.1016/j.it.2014.09.008 · Cited by 146 · see citing works

SHP1 Phosphatase-Dependent T Cell Inhibition by CEACAM1 Adhesion Molecule Isoforms

Nagaishi, T., Pao, L. I., Lin, S.-H., Iijima, H., Kaser, A., Qiao, S., Chen, Z., Glickman, J. N., Najjar, S. M., Nakajima, A., et al. (2006) · Immunity · doi:10.1016/j.immuni.2006.08.026 · Cited by 146 · see citing works

Longitudinal investigation of natural killer cells and cytokines in chronic fatigue syndrome/myalgic encephalomyelitis

Brenu, E. W., van Driel, M. L., Staines, D. R., Ashton, K. J., Hardcastle, S. L., Keane, J., Tajouri, L., Peterson, D., Ramos, S. B., & Marshall-Gradisnik, S. M. (2012) · Journal of Translational Medicine · doi:10.1186/1479-5876-10-88 · Cited by 135 · see citing works

The signaling suppressor CIS controls proallergic T cell development and allergic airway inflammation

Yang, X. O., Zhang, H., Kim, B. S., Niu, X., Peng, J., Chen, Y., Kerketta, R., Lee, Y., Chang, S. H., Corry, D. B., et al. (2013) · Nature Immunology · doi:10.1038/ni.2633 · Cited by 134 · see citing works

Competition for IL-2 between Regulatory and Effector T Cells to Chisel Immune Responses

Höfer, T., Krichevsky, O., & Altan-Bonnet, G. Y. (2012) · Frontiers in Immunology · doi:10.3389/fimmu.2012.00268 · Cited by 129 · see citing works

The IRF4 Gene Regulatory Module Functions as a Read-Write Integrator to Dynamically Coordinate T Helper Cell Fate

Krishnamoorthy, V., Kannanganat, S., Maienschein‐Cline, M., Cook, S. L., Chen, J., Bahroos, N., Sievert, E. P., Corse, E., Chong, A. S., & Sciammas, R. (2017) · Immunity · doi:10.1016/j.immuni.2017.09.001 · Cited by 129 · see citing works

Cytokines of the γc family control CD4+ T cell differentiation and function

Yamane, H., & Paul, W. E. (2012) · Nature Immunology · doi:10.1038/ni.2431 · Cited by 128 · see citing works

The Interleukin-4 Enhancer CNS-2 Is Regulated by Notch Signals and Controls Initial Expression in NKT Cells and Memory-Type CD4 T Cells

Tanaka, S., Tsukada, J., Suzuki, W., Hayashi, K., Tanigaki, K., Tsuji, M., Inoue, H., Honjo, T., & Kubo, M. (2006) · Immunity · doi:10.1016/j.immuni.2006.04.009 · Cited by 125 · see citing works

Cellular and Molecular Dynamics of Th17 Differentiation and its Developmental Plasticity in the Intestinal Immune Response

Bhaumik, S., & Basu, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00254 · Cited by 119 · see citing works

Regulation of T Helper Cell Fate by TCR Signal Strength

Bhattacharyya, N. D., & Feng, C. G. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00624 · Cited by 114 · see citing works

T Helper Cell Differentiation

Zygmunt, B. M., & Veldhoen, M. (2011) · Advances in immunology · doi:10.1016/b978-0-12-387664-5.00005-4 · Cited by 110 · see citing works

Antigen affinity and antigen dose exert distinct influences on CD4 T-cell differentiation

Keck, S., Schmaler, M., Ganter, S., Wyss, L., Oberle, S. G., Huseby, E. S., Zehn, D., & King, C. G. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1403271111 · Cited by 111 · see citing works

Lymphopenic mice reconstituted with limited repertoire T cells develop severe, multiorgan, Th2-associated inflammatory disease

Milner, J. D., Ward, J. M., Keane‐Myers, A., & Paul, W. E. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0610289104 · Cited by 110 · see citing works

Helper T‐cell identity and evolution of differential transcriptomes and epigenomes

Vahedi, G., Poholek, A. C., Hand, T. W., Laurence, A. D. J., Kanno, Y., O’Shea, J. J., & Hirahara, K. (2013) · Immunological Reviews · doi:10.1111/imr.12037 · Cited by 109 · see citing works

TCR Signal Strength Alters T–DC Activation and Interaction Times and Directs the Outcome of Differentiation

van Panhuys, N. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00006 · Cited by 106 · see citing works

CD4 ⁺ T Cells: Guardians of the Phagosome

Tubo, N. J., & Jenkins, M. K. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00097-13 · Cited by 105 · see citing works

What determines Th2 differentiation, in vitro and in vivo?

Paul, W. E. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2010.2 · Cited by 99 · see citing works

T cell-specific deletion of the inositol phosphatase SHIP reveals its role in regulating Th1/Th2 and cytotoxic responses

Tarasenko, T., Kole, H. K., Chi, A. W., Mentink‐Kane, M. M., Wynn, T. A., & Bolland, S. M. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704853104 · Cited by 97 · see citing works

The TCR-mediated signaling pathways that control the direction of helper T cell differentiation

Nakayama, T., & Yamashita, M. (2010) · Seminars in Immunology · doi:10.1016/j.smim.2010.04.010 · Cited by 96 · see citing works

Mode of dendritic cell activation: The decisive hand in Th2/Th17 cell differentiation. Implications in asthma severity?

Vroman, H. H., van den Blink, B., & Kool, M. (2014) · Immunobiology · doi:10.1016/j.imbio.2014.09.016 · Cited by 96 · see citing works

Human dendritic cells conditioned with Staphylococcus aureus enterotoxin B promote TH2 cell polarization

Mandron, M., Ariès, M.-F., Brehm, R. D., Tranter, H. S., Acharya, K. R., Charvéron, M., & Davrinche, C. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.12.1360 · Cited by 95 · see citing works

Viperin is required for optimal Th2 responses and T-cell receptor–mediated activation of NF-κB and AP-1

Qiu, L., Cresswell, P., & Chin, K.-C. (2008) · Blood · doi:10.1182/blood-2008-07-171942 · Cited by 94 · see citing works

Requirement for the basic helix-loop-helix transcription factor Dec2 in initial TH2 lineage commitment

Yang, X. O., Angkasekwinai, P., Zhu, J., Peng, J., Liu, Z., Nurieva, R., Liu, X., Chung, Y., Chang, S. H., Sun, B., et al. (2009) · Nature Immunology · doi:10.1038/ni.1821 · Cited by 93 · see citing works

STAT6 Deficiency Ameliorates Severity of Oxazolone Colitis by Decreasing Expression of Claudin-2 and Th2-Inducing Cytokines

Rosen, M. J., Chaturvedi, R., Washington, M. K., Kuhnhein, L. A., Moore, P. D., Coggeshall, S. S., McDonough, E. M., Weitkamp, J.-H., Singh, A. B., Coburn, L. A., et al. (2013) · The Journal of Immunology · doi:10.4049/jimmunol.1201373 · Cited by 87 · see citing works

Regulation of mature T cell responses by the Wnt signaling pathway

Xue, H., & Zhao, D. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2011.06302.x · Cited by 88 · see citing works

A critical role for alpha-synuclein in development and function of T lymphocytes

Shameli, A., Xiao, W., Zheng, Y., Shyu, S., Sumodi, J., Meyerson, H. J., Harding, C. V., & Maitta, R. W. (2015) · Immunobiology · doi:10.1016/j.imbio.2015.10.002 · Cited by 86 · see citing works

Polar Opposites: Erk Direction of CD4 T Cell Subsets

Chang, C., D’Souza, W. N., Ch’en, I. L., Pagès, G., Pouysségur, J., & Hedrick, S. Μ. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1103015 · Cited by 84 · see citing works

Lipopolysaccharide-driven Th2 Cytokine Production in Macrophages Is Regulated by Both MyD88 and TRAM

Mukherjee, S., Chen, L.-Y., Papadimos, T. J., Huang, S., Zuraw, B. L., & Pan, Z. K. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.005272 · Cited by 81 · see citing works

TCR-Dependent Translational Control of GATA-3 Enhances Th2 Differentiation

Cook, K. D., & Miller, J. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0902544 · Cited by 79 · see citing works

GATA3 Regulates the Development and Functions of Innate Lymphoid Cell Subsets at Multiple Stages

Zhu, J. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01571 · Cited by 79 · see citing works

Transcriptional regulation of Th2 cell differentiation

Zhu, J. (2010) · Immunology and Cell Biology · doi:10.1038/icb.2009.114 · Cited by 78 · see citing works

Lead effects on development and function of bone marrow-derived dendritic cells promote Th2 immune responses

Gao, D., Mondal, T. K., & Lawrence, D. A. (2007) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2007.04.001 · Cited by 76 · see citing works

Digital NFATc2 Activation per Cell Transforms Graded T Cell Receptor Activation into an All-or-None IL-2 Expression

Podtschaske, M., Benary, U., Zwinger, S., Höfer, T., Radbruch, A., & Baumgrass, R. (2007) · PLoS ONE · doi:10.1371/journal.pone.0000935 · Cited by 74 · see citing works

Control of CD4+ T‐cell memory by cytokines and costimulators

Dooms, H., & Abbas, A. K. (2006) · Immunological Reviews · doi:10.1111/j.0105-2896.2006.00387.x · Cited by 74 · see citing works

T helper cell effector fates — who, how and where?

Reinhardt, R. L., Kang, S., Liang, H.-E., & Locksley, R. M. (2006) · Current Opinion in Immunology · doi:10.1016/j.coi.2006.03.003 · Cited by 74 · see citing works

The Initiation of Th2 Immunity Towards Food Allergens

Ellenbogen, Y., Jiménez‐Saiz, R., Spill, P., Chu, D. K., Waserman, S., & Jordana, M. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19051447 · Cited by 71 · see citing works

Th2 Differentiation Is Unaffected by Jagged2 Expression on Dendritic Cells

Krawczyk, C. M., Sun, J., & Pearce, E. J. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.180.12.7931 · Cited by 71 · see citing works

Understanding the development of Th2 cell-driven allergic airway disease in early life

León, B. (2023) · Frontiers in Allergy · doi:10.3389/falgy.2022.1080153 · Cited by 71 · see citing works

Transcriptional Regulatory Networks for CD4 T Cell Differentiation

Christie, D. A., & Zhu, J. (2014) · Current topics in microbiology and immunology · doi:10.1007/82_2014_372 · Cited by 67 · see citing works

STAT5b: A master regulator of key biological pathways

Smith, M. R., Satter, L. F., & Vargas‐Hernández, A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1025373 · Cited by 66 · see citing works

CD4+ T helper 2 cells - microbial triggers, differentiation requirements and effector functions

Okoye, I., & Wilson, M. S. (2011) · Immunology · doi:10.1111/j.1365-2567.2011.03497.x · Cited by 65 · see citing works

Quantitative events determine the differentiation and function of helper T cells

O’Garra, A., Gabryšová, L., & Spits, H. (2011) · Nature Immunology · doi:10.1038/ni.2003 · Cited by 65 · see citing works

PD-1 Imposes Qualitative Control of Cellular Transcriptomes in Response to T Cell Activation

Shimizu, K., Sugiura, D., Okazaki, I.-M., Maruhashi, T., Takegami, Y., Cheng, C., Ozaki, S., & Okazaki, T. (2020) · Molecular Cell · doi:10.1016/j.molcel.2019.12.012 · Cited by 63 · see citing works

T cells translate individual, quantal activation into collective, analog cytokine responses via time-integrated feedbacks

Tkach, K. E., Barik, D., Voisinne, G., Malandro, N., Hathorn, M. M., Cotari, J. W., VOGEL, R. M., Merghoub, T., Wolchok, J. D., Krichevsky, O., et al. (2014) · eLife · doi:10.7554/elife.01944 · Cited by 60 · see citing works

Reduced airway hyperresponsiveness and tracheal responses during allergic asthma in mice lacking tyrosine kinase inducible T-cell kinase

Ferrara, T. J., Mueller, C., Sahu, N., Jebria, A. B., & August, A. (2006) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2005.12.1330 · Cited by 59 · see citing works

Mathematical modeling of atopic dermatitis reveals “double-switch” mechanisms underlying 4 common disease phenotypes

Domínguez‐Hüttinger, E., Christodoulides, P., Miyauchi, K., Irvine, A. D., Okada, M., Kubo, M., & Tanaka, R. J. (2016) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2016.10.026 · Cited by 57 · see citing works

Cutting Edge: Lack of High Affinity Competition for Peptide in Polyclonal CD4+ Responses Unmasks IL-4 Production

Milner, J. D., Fazilleau, N., McHeyzer‐Williams, M. G., & Paul, W. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.1000674 · Cited by 56 · see citing works

Characterization of ζ-associated protein, 70 kd (ZAP70)–deficient human lymphocytes

Roifman, C. M., Dadi, H., Somech, R., Nahum, A., & Sharfe, N. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.07.029 · Cited by 56 · see citing works

Enforced expression of GATA3 allows differentiation of IL‐17‐producing cells, but constrains Th17‐mediated pathology

van Hamburg, J. P., de Bruijn, M. J. W., de Almeida, C. R., van Zwam, M., van Meurs, M., de Haas, E. F. E., Boon, L., Samsom, J. N., & Hendriks, R. W. (2008) · European Journal of Immunology · doi:10.1002/eji.200737840 · Cited by 54 · see citing works

Helper T Cells in Idiopathic Membranous Nephropathy

Zhao, Q., Dai, H., Liu, X., Jiang, H., Liu, W., Feng, Z., Zhang, N., Gao, Y., Dong, Z., Zhou, X., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.665629 · Cited by 55 · see citing works

T Cell Receptor (TCR) and Transforming Growth Factor β (TGF-β) Signaling Converge on DNA (Cytosine-5)-methyltransferase to Control forkhead box protein 3 (foxp3) Locus Methylation and Inducible Regulatory T Cell Differentiation

Li, C., Ebert, P. J. R., & Li, Q.-J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.453357 · Cited by 52 · see citing works

The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity

Furmanski, A. L., Barbarulo, A., Solanki, A., Lau, C., Sahni, H., Saldaña, J. I., D’Acquisto, F., & Crompton, T. (2015) · Journal of Cell Science · doi:10.1242/jcs.165803 · Cited by 51 · see citing works

T Cells in Allergic Asthma: Key Players Beyond the Th2 Pathway

León, B. (2017) · Current Allergy and Asthma Reports · doi:10.1007/s11882-017-0714-1 · Cited by 52 · see citing works

T cell receptor signaling in the differentiation and plasticity of CD4+ T cells

Meitei, H. T., & Lal, G. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.08.001 · Cited by 49 · see citing works

A Mechanistic Computational Model Reveals That Plasticity of CD4+ T Cell Differentiation Is a Function of Cytokine Composition and Dosage

Puniya, B. L., Todd, R. G., Mohammed, A., Brown, D. M., Barberis, M., & Helikar, T. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00878 · Cited by 50 · see citing works

Transcriptional regulation of adaptive and innate lymphoid lineage specification

Spinner, C. A., & Lazarevic, V. (2020) · Immunological Reviews · doi:10.1111/imr.12935 · Cited by 50 · see citing works

Dopamine receptors D3 and D5 regulate CD4+T-cell activation and differentiation by modulating ERK activation and cAMP production

Demane, D. F., Contreras, F., González, H., Prado, C. E., Elgueta, D., Figueroa, C. A., & Pacheco, R. (2015) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2015.05.003 · Cited by 49 · see citing works

IL-2 and IL-27 synergistically promote growth and invasion of endometriotic stromal cells by maintaining the balance of IFN-γ and IL-10 in endometriosis

Qiu, X., Lai, Z., Ha, S., Yang, H., Liu, L.-B., Wang, Y., Shi, J., Ruan, L., Ye, J., Wu, J., et al. (2019) · Reproduction · doi:10.1530/rep-19-0411 · Cited by 48 · see citing works

‘All things considered’: transcriptional regulation of T helper type 2 cell differentiation from precursor to effector activation

Zeng, W. (2013) · Immunology · doi:10.1111/imm.12121 · Cited by 48 · see citing works

A simple theoretical framework for understanding heterogeneous differentiation of CD4+ T cells

Hong, T., Xing, J., Li, L., & Tyson, J. J. (2012) · BMC Systems Biology · doi:10.1186/1752-0509-6-66 · Cited by 49 · see citing works

Aberrantly methylated DNA regions lead to low activation of CD4+ T-cells in IgA nephropathy

Sallustio, F., Serino, G., Cox, S. N., Gassa, A. D., Curci, C., Palma, G. D., Banelli, B., Zaza, G., Romani, M., & Schena, F. P. (2016) · Clinical Science · doi:10.1042/cs20150711 · Cited by 48 · see citing works

IL-2- and IL-4-dependent signaling play separate and sequential roles in the differentiation of GATA3-hi TH2 cells in vivoPreprint

Webb, G. R., Carco, C., Tang, S.-C., Fabre, M. S., Ochiai, S., Larson, A. R., Chandler, J. S., Hilligan, K. L., Hyde, E. J., Old, S. I., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.03.04.709484

The Journal of Experimental Medicine CORRESPONDENCE

Yamane, H., Zhu, J., Paul, W. E., & Paul, W. E. (2013)

Role of TCR-Induced Extracellular Signal-Regulated Kinase Activation in the Regulation of Early IL-4 Expression in Naive CD4+ T Cells

Jorritsma, P. J., Brogdon, J. L., & Bottomly, K. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.170.5.2427 · Cited by 144 · see citing works

GATA3 and STAT5 – Critical Inducers of the Th2 Fate

Zhu, J., Yamane, H., & Paul, W. E. (2005) · Retrovirology · doi:10.1186/1742-4690-2-s1-s16 · Cited by 1 · see citing works

Suppression of Early IL-4 Production Underlies the Failure of CD4 T Cells Activated by TLR-Stimulated Dendritic Cells to Differentiate into Th2 Cells

Sun, J., & Pearce, E. J. (2007) · The Journal of Immunology · doi:10.4049/jimmunol.178.3.1635 · Cited by 35 · see citing works