The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Interleukin-17 Receptor A Signaling in Transformed Enterocytes Promotes Early Colorectal Tumorigenesis
Open accessAbstract
Summary Interleukin-17A (IL-17A) is a proinflammatory cytokine linked to rapid malignant progression of colorectal cancer (CRC) and therapy resistance. IL-17A exerts its pro-tumorigenic activity through its type A receptor (IL-17RA). However, how IL-17RA engagement promotes colonic tumorigenesis is unknown, as IL-17RA is expressed in many cell types in the tumor microenvironment, including hematopoietic, fibroblastoid and epithelial cells. Here we show that IL-17RA signals directly within transformed colonic epithelial cells (enterocytes) to promote early tumor development. IL-17RA engagement activates ERK, p38 MAPK and NF-κB signaling and promotes the proliferation of tumorigenic enterocytes who just lost expression of the APC tumor suppressor. Although IL-17RA signaling also controls production of IL-6, this mechanism makes only a partial contribution to colonic tumorigenesis. Combined treatment with chemotherapy, which induces IL-17A expression, and an IL-17A neutralizing antibody enhanced the therapeutic responsiveness of established colon tumors. These findings establish IL-17A and IL-17RA as therapeutic targets in colorectal cancer.
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Cites
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Self-citationImpaired immune and acute-phase responses in interleukin-6-deficient mice
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An interleukin-17-mediated paracrine network promotes tumor resistance to anti-angiogenic therapy
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Cited by
Inflammation and cancer: triggers, mechanisms, and consequences
Greten, F. R., & Grivennikov, S. I. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.025 · Cited by 3,806
Self-citationNF-κB, inflammation, immunity and cancer: coming of age
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Self-citationReparative inflammation takes charge of tissue regeneration
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Self-citationImmunity, inflammation, and cancer: an eternal fight between good and evil
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Self-citationNF‐κB signaling in inflammation and cancer
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Metadata
- Authors
- Wang, K., Kim, M. K., Di Caro, G., Wong, J., Shalapour, S., Wan, J., Zhang, W., Zhong, Z., Sanchez-Lopez, E., Wu, L.-W., Taniguchi, K., Feng, Y., Fearon, E., Grivennikov, S. I., & Karin, M.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 41
- Issue
- 6
- Pages
- 1052-1063
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2081236127
- Cited by
- 341
- References
- 11
- FWCI
- 11.06
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wang, K., Kim, M. K., Di Caro, G., Wong, J., Shalapour, S., Wan, J., Zhang, W., Zhong, Z., Sanchez-Lopez, E., Wu, L.-W., Taniguchi, K., Feng, Y., Fearon, E., Grivennikov, S. I., & Karin, M. (2014). Interleukin-17 Receptor A Signaling in Transformed Enterocytes Promotes Early Colorectal Tumorigenesis. Immunity. https://doi.org/10.1016/j.immuni.2014.11.009
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
