Cited by 1,059T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

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Tissue-Resident Memory T Cells

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Schenkel, Jason M., Masopust, David·2014·Immunity

DOI 10.1016/j.immuni.2014.12.007PMC PMC4276131

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Abstract

Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that occupies tissues without recirculating. They provide a first response against infections reencountered at body surfaces, where they accelerate pathogen clearance. Because Trm cells are not present within peripheral blood, they have not yet been well characterized, but are transcriptionally, phenotypically, and functionally distinct from recirculating central and effector memory T cells. In this review, we will summarize current knowledge of Trm cell ontogeny, regulation, maintenance, and function and will highlight technical considerations for studying this population.

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Background
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BackgroundResultInfluentialSelf-citation
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BackgroundInfluential
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Background
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BackgroundInfluential

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“Memory T RM cells, essential for providing frontline defense at potential sites of pathogen entry or replication [75, 76], were extensively characterized in both secondary lymphoid organ spleen and the liver, a critical site for malaria parasite development.”
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“T cells that are tissue-resident memory cells are like “ sentinels ” permanently stationed within the tissues, constantly monitoring the changes in antigens in the mucosal tissues (121).”
Touxie Quyin Compound regulates histone lactylation-mediated Fabp4/5 and tissue-resident memory T cells to improve psoriasis recurrence in mice
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Xie, E., He, Y., Cao, T., Li, C., & Wang, Z. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1822561 · Cited by 1
“They have been found in almost every non-lymphoid tissue, such as skin, lungs, intestine, reproductive tract, liver, kidneys, salivary glands, and brain (5 – 7, 23”
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Huang, J., Sun, Q., Zhong, Y., & Huang, J. (2026) · Archives of Microbiology · doi:10.1007/s00203-026-04928-0 · Cited by 1
“…where data remain limited, on H2N3-specific T cell immunity, including findings from preclinical models, epitope discovery efforts, cross-reactive recognition across influenza A subtypes, and long-term immune memory in H2-exposed human cohorts (Mettelman et al. 2023, Schenkel and Masopust 2014).”
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“Subsequently, LeFrancois, Masopust and others implemented novel approaches to study lymphocyte recirculation in rodents [ 22, 23 ].”
Adjuvants orchestrate cross-organ induction of mucosal CD8+ T cell immune responses in respiratory tracts
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“Rather, CD69 tended to be coexpressed with select integrins including CD103, another marker commonly used to identify TRMs (1), and some chemokine receptors including CXCR5, which directs cells to LN follicles.”
Background
Rôle des lymphocytes T résidents mémoires dans la physiopathologie des eczémas allergiques de contact
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Effects of Astragalus Polysaccharides on CD8+ Tissue-Resident Memory T Cells in Mice with Herpes Simplex
Shi, L., Zhang, C., Liu, L., Xi, Z., & Chen, M. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/7729136 · Cited by 1
“Based on memory T cell migration patterns, memory T cells are classified into recirculating memory T-cell population such as effector memory (TEM) and central memory (TCM) cells, and the nonrecirculating T-cell population such as tissue-resident memory (TRM) cells that are retained in peripheral tissues without recirc…”
Background
Beneficial and Detrimental Manifestations of Age on CD8 + T Cell Memory to Respiratory Pathogens
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Alt-RNAtive vaccines elicit anti-malarial TRM cells
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Myeloid derived suppressor cells potentiate virus-specific memory CD8+ T cell response
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Lung-resident CD3−NK1.1+CD69+CD103+ Cells Play an Important Role in Bacillus Calmette–Guérin Vaccine–Induced Protective Immunity against Mycobacterium tuberculosis Infection
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Multilayered T-cell memory in human skin.
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“, 2012), in vivo cell transfer experiments (Schenkel and Masopust, 2014), and downstream tissue and cell-specific genomic analysis (Cheng et al.”
BackgroundInfluential
Memory CD8+ T cell compartment associated with delayed onset of Plasmodium falciparum infection and better parasite control in sickle‐cell trait children
Loiseau, C., Traoré, B., Ongoïba, A., Kayentao, K., Doumbo, S., Doumtabé, D., de Sousa, K. P., Brady, J. L., Proietti, C., Crompton, P. D., et al. (2021) · Clinical & Translational Immunology · doi:10.1002/cti2.1265 · Cited by 2
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“into TRM cells to provide accelerated pathogen clearance upon reencounter (38).”
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Age-Specific T Cell Homeostasis
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“Age, mean (range) 61 (60–71) 57 (27–86) 59 (27–86) 52 (25-75)”
Background
Tuberculosis Vaccines
Hanekom, W. A., Hawn, T. R., & Ginsberg, A. M. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-79058-1.00061-x · Cited by 1
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Khan, S. H., Legge, K. L., Badovinac, V. P., Harty, J. T., Norian, L. A., & Xue, H. (2015) · doi:10.17077/etd.sx8ld2ik · Cited by 1
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Background
Influence of Age on Functional Memory T Cell DiversityPreprint
Fang, F., Cao, W., Zhu, W., Lam, N., Li, L., Gaddam, S., Wang, Y., Kim, C., Lambert, S., Zhang, H., et al. (2021) · SSRN Electronic Journal · doi:10.2139/ssrn.3877551 · Cited by 1
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Authors: Schenkel, J. M., & Masopust, D.
Affiliations: University of Minnesota (US)
Corresponding author: Masopust, David
ORCID: Schenkel, Jason M.
Masopust, David
Venue: Immunity
Publisher: Elsevier BV
Published: 2014-12
Volume: 41
Issue: 6
Pages: 886-897
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2014.12.007
PMC: PMC4276131
OpenAlex: W2046700010
Cited by: 1,059
References: 135
Citations by year: 2026: 74 · 2025: 84 · 2024: 88 · 2023: 92 · 2022: 108 · 2021: 113 · 2020: 103 · 2019: 102 · 2018: 96 · 2017: 81 · 2016: 71 · 2015: 45 · 2014: 1
FWCI: 6.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 382 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI084913, R01AI111671, R37AI084913, T32AI007313)
National Institute of Diabetes and Digestive and Kidney Diseases (F30DK100159)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: tissue-resident memory T cells, mucosal immunity, memory T cell differentiation
MeSH terms: Animals, Cell Differentiation, Cell Movement, Humans, Immunity, Immunologic Memory, T-Lymphocytes, T-Lymphocyte Subsets

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