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Tissue-Resident Memory T Cells
Open accessAbstract
Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that occupies tissues without recirculating. They provide a first response against infections reencountered at body surfaces, where they accelerate pathogen clearance. Because Trm cells are not present within peripheral blood, they have not yet been well characterized, but are transcriptionally, phenotypically, and functionally distinct from recirculating central and effector memory T cells. In this review, we will summarize current knowledge of Trm cell ontogeny, regulation, maintenance, and function and will highlight technical considerations for studying this population.
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“These Trm are specially programmed to persist in their host tissues [249, 250].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [249]
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BackgroundInfluentialTissue-resident memory T cells in tumor immunity and immunotherapy
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Self-citationMemory CD8+ T cell responses to cancer
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“These long-lived T cells infiltrate tissues and are retained peripherally to mediate rapid responses to invading pathogens [134].”
BackgroundBrain-resident memory T cells represent an autonomous cytotoxic barrier to viral infection
Steinbach, K., Vincenti, I., Kreutzfeldt, M., Pagé, N., Muschaweckh, A., Wagner, I., Drexler, I., Pinschewer, D. D., Korn, T., & Merkler, D. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151916 · Cited by 212
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“TRM T cells have been implicated in tissue homeostasis and defense against pathogens, mostly in the context of CD8+ T cell antiviral responses (Wakim et al., 2008; Schenkel and Masopust, 2014; Fan and Rudensky, 2016; Mackay et al., 2016; Milner et al., 2017).”
BackgroundInfluentialCD4+ resident memory T cells dominate immunosurveillance and orchestrate local recall responses
Beura, L. K., Fares-Frederickson, N. J., Steinert, E. M., Scott, M. C., Thompson, E. A., Fraser, K. A., Schenkel, J. M., Vezys, V., & Masopust, D. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20181365 · Cited by 190
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Skin Wound Healing: Of Players, Patterns, and Processes
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“%) being able to be recovered (54), which draws into question their representability.”
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Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses
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“CD69+ CD8+ T cells show enriched traits of residency in LTs Although CD69 is classically associated with activation, it also marks noncirculating TRMs in NLTs (32).”
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“tinels mediating rapid protection from reinfection (35).”
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Human T Cell Response to Dengue Virus Infection
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Integrin αvβ6: Structure, function and role in health and disease
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Transcriptional and Epigenetic Regulation of Effector and Memory CD8 T Cell Differentiation
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“Other studies have further identified that exposure to IL-15 helps skew CD8T cells along a memory pathway (60–62), whereas IL-2 signaling is implicated in promoting the differentiation of short-lived effector T cells (63, 64).”
BackgroundInfluential
Metadata
- Authors
- Schenkel, J. M., & Masopust, D.
- Affiliations
- University of Minnesota (US)
- Corresponding author
- Masopust, David
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2014-12
- Volume
- 41
- Issue
- 6
- Pages
- 886-897
- ISSN
- 1074-7613 (ISSN-L)
- PMC
- PMC4276131
- OpenAlex
- W2046700010
- Cited by
- 1,059
- References
- 135
- Citations by year
- 2026: 74 · 2025: 84 · 2024: 88 · 2023: 92 · 2022: 108 · 2021: 113 · 2020: 103 · 2019: 102 · 2018: 96 · 2017: 81 · 2016: 71 · 2015: 45 · 2014: 1
- FWCI
- 6.44
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Allergy and Infectious Diseases (R01AI084913, R01AI111671, R37AI084913, T32AI007313)
- National Institute of Diabetes and Digestive and Kidney Diseases (F30DK100159)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- tissue-resident memory T cells, mucosal immunity, memory T cell differentiation
- MeSH terms
- Animals, Cell Differentiation, Cell Movement, Humans, Immunity, Immunologic Memory, T-Lymphocytes, T-Lymphocyte Subsets
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