Cited by 1,059T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisImmunotherapy and Immune Responses

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Tissue-Resident Memory T Cells

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Schenkel, Jason M., Masopust, David·2014·Immunity

DOI 10.1016/j.immuni.2014.12.007PMC PMC4276131

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Abstract

Tissue-resident memory T (Trm) cells constitute a recently identified lymphocyte lineage that occupies tissues without recirculating. They provide a first response against infections reencountered at body surfaces, where they accelerate pathogen clearance. Because Trm cells are not present within peripheral blood, they have not yet been well characterized, but are transcriptionally, phenotypically, and functionally distinct from recirculating central and effector memory T cells. In this review, we will summarize current knowledge of Trm cell ontogeny, regulation, maintenance, and function and will highlight technical considerations for studying this population.

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BackgroundInfluential

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BackgroundMethod
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Self-reactivity controls functional diversity of naive CD8+ T cells by co-opting tonic type I interferon
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Bai, Z., Wan, D., Lan, T., Hong, W., Dong, H., Wei, Y., & Wei, X. (2024) · ACS Nano · doi:10.1021/acsnano.3c10797 · Cited by 58
“50,51 In the upper respiratory tract, T RM B cells are found in the adenoids and tonsils of humans, 52 NALT of mice, 53 and the submucosa of the nasal cavity and trachea of most mammals.”
Background
Chemokines: Critical Regulators of Memory T Cell Development, Maintenance, and Function
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“The presence of TRM in tissues has been associated with protection against several pathogens, and the high number of TRM found in mucosal sites support the concept that these cells represent a first line of defense against pathogens.(8) Most studies have focused on CD8 TRM cells in the context of viral infections and…”
BackgroundInfluential
Tolerogenic dendritic cells pulsed with islet antigen induce long-term reduction in T-cell autoreactivity in type 1 diabetes patients
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“(C) Frequency in time of total Treg and Treg subclusters, shows significant increase of eTregs (subcluster 6.4) 1 month after tolDC treatment (*p=0.035). frontiersin.org Frontiers in Immunology 10 therapy was also followed by a transient increase of Trm CD4+ T-cells expressing CD103 (30).”
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Characterization of CD45RO+ memory T lymphocytes in keloid disease
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“CD 103+ Participation in binding TRM cells to E-cadherin to promote retention within epithelial tissues [72]”
Background
Tissue-resident memory CD8+ T cells in cancer immunology and immunotherapy
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“boosting led to a massive accumulation of spike-specific CD8 T cells expressing CD103 and CD69, markers for tissue residency in the lungs (71).”
Background
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Immune cell composition in normal human kidneys
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“Strikingly, expression of CD103, a canonical CD8+ TRM marker (29), was enriched within the efflux(+) compared with efflux(–) fraction in both spleen and lung, with some interdonor variability for the lung (Figure 2C).”
Background
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“TRM are thought to be derived from precursors that entered the tissues during the effector phase of the immune response, which remain positioned in the periphery [28].”
Background
Current Vaccine Platforms in Enhancing T-Cell Response
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“Trm cells remain in peripheral tissues for a long time [7].”
Background
Canonical BAF complex activity shapes the enhancer landscape that licenses CD8+ T cell effector and memory fates
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“T RM represents a distinct subset of memory lymphocyte lineage that colo-nizestissuesindependentlyofnewrecruitmentofTcellsfromthebloodandprovidesarapidresponseagainstreencounteredinfections 69,70 .”
Background
The spatial landscape of glial pathology and T cell response in Parkinson’s disease substantia nigra
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“This restricted migratory pattern of tissue-resident lymphocytes is often associated with their lack of lymphoid tissue homing chemokine receptors and elevated expressions of several adhesion molecules (7, 12).”
Background
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“org 9 resident memory T-cells (TRM) based on CD69 and integrin subunit alpha E ITGAE (CD103) or integrin subunit alpha 4 ITGA4 (CD49d) expression (Figures 6D–F) (35, 36).”
Background
Modulation of tissue resident memory T cells by glucocorticoids after acute cellular rejection in lung transplantation
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“TRM cells are memory T cells that persist in either lymphoid or mucosal organs, do not recirculate, and are poised to have a rapid effector response in the setting of secondary challenge to pathogen (Schenkel and Masopust, 2014; Thome et al., 2014).”
Background
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“Respiratory T RM cells are essential components of ﬁ rst-line defense against viral infection at local sites without recirculating 49 – 51 .”
PD-1 Dynamically Regulates Inflammation and Development of Brain-Resident Memory CD8 T Cells During Persistent Viral Encephalitis
Shwetank, Frost, E. L., Mockus, T. E., Ren, H. M., Toprak, M., Lauver, M. D., Netherby, C. S., Jin, G., Cosby, J., Evavold, B. D., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00783 · Cited by 47
“Tissue-resident memory CD8 T cells are an essential component of the first line of defense against re-infection in non-lymphoid tissues (24) (25) (26) .”
Background
In Vivo Blockade of Murine ARTC2.2 During Cell Preparation Preserves the Vitality and Function of Liver Tissue-Resident Memory T Cells
Rissiek, B., Lukowiak, M., Raczkowski, F., Magnus, T., Mittrücker, H.-W., & Koch-Nolte, F. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01580 · Cited by 45
“Tissue-resident memory T cells (Trm) comprise a population of T cells, which stays in peripheral tissues after an immune response against invading pathogens, forming a rapid first-line defense against recurring infection (18).”
Background
Skin-Resident Memory T Cells: Pathogenesis and Implication for the Treatment of Psoriasis
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Influence of Age on Functional Memory T Cell Diversity
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Accumulation of γδ T cells in visceral fat with aging promotes chronic inflammation
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An Insight into Current Treatment Strategies, Their Limitations, and Ongoing Developments in Vaccine Technologies against Herpes Simplex Infections
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“In addition, CD8+ TRM, a subtype of memory lymphocyte that dwells in non-lymphoid tissues [77], has been shown to activate the adaptive immune response in HSV-1 infection [78] via IFN-Y and granzyme B effectors.”
Background
Development and Function of Protective and Pathologic Memory CD4 T Cells
Jaigirdar, S. A., & MacLeod, M. K. L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00456 · Cited by 49

Authors: Schenkel, J. M., & Masopust, D.
Affiliations: University of Minnesota (US)
Corresponding author: Masopust, David
ORCID: Schenkel, Jason M.
Masopust, David
Venue: Immunity
Publisher: Elsevier BV
Published: 2014-12
Volume: 41
Issue: 6
Pages: 886-897
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2014.12.007
PMC: PMC4276131
OpenAlex: W2046700010
Cited by: 1,059
References: 135
Citations by year: 2026: 74 · 2025: 84 · 2024: 88 · 2023: 92 · 2022: 108 · 2021: 113 · 2020: 103 · 2019: 102 · 2018: 96 · 2017: 81 · 2016: 71 · 2015: 45 · 2014: 1
FWCI: 6.44
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 382 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institute of Allergy and Infectious Diseases (R01AI084913, R01AI111671, R37AI084913, T32AI007313)
National Institute of Diabetes and Digestive and Kidney Diseases (F30DK100159)
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: tissue-resident memory T cells, mucosal immunity, memory T cell differentiation
MeSH terms: Animals, Cell Differentiation, Cell Movement, Humans, Immunity, Immunologic Memory, T-Lymphocytes, T-Lymphocyte Subsets

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