The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function
Open accessAbstract
SUMMARY The mechanisms underlying human natural killer (NK) cell phenotypic and functional heterogeneity are unknown. Here, we describe the emergence of diverse subsets of human NK cells selectively lacking expression of signaling proteins after human cytomegalovirus (HCMV) infection. The absence of B and myeloid cell-related signaling protein expression in these NK cell subsets correlated with promoter DNA hyperme-thylation. Genome-wide DNA methylation patterns were strikingly similar between HCMV-associated adaptive NK cells and cytotoxic effector T cells but differed from those of canonical NK cells. Functional interrogation demonstrated altered cytokine responsiveness in adaptive NK cells that was linked to reduced expression of the transcription factor PLZF. Furthermore, subsets of adaptive NK cells demonstrated significantly reduced functional responses to activated autologous T cells. The present results uncover a spectrum of epigenetically unique adaptive NK cell subsets that diversify in response to viral infection and have distinct functional capabilities compared to canonical NK cell subsets.
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Cites
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Trained immunity: A program of innate immune memory in health and– disease
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“CD56CD16 c8-KLRC2 NK cells with high expression of KLRC2 (NKG2C) were regarded adaptive NK cells.(32,33) Our atlas additionally uncovered several underappreciated NK cell subsets with unique transcriptional phenotypes.”
BackgroundImmunometabolism and natural killer cell responses
O’Brien, K. L., & Finlay, D. K. (2019) · Nature Reviews Immunology · doi:10.1038/s41577-019-0139-2 · Cited by 435
Peptide-specific recognition of human cytomegalovirus strains controls adaptive natural killer cells
Hammer, Q., Rückert, T., Borst, E. M., Dunst, J., Haubner, A., Durek, P., Heinrich, F., Gasparoni, G., Babic, M., Tomic, A., et al. (2018) · Nature Immunology · doi:10.1038/s41590-018-0082-6 · Cited by 423
Metadata
- Authors
- Schlums, H., Cichocki, F., Tesi, B., Theorell, J., Beziat, V., Holmes, T. D., Han, H., Chiang, S. C. C., Foley, B., Mattsson, K., Larsson, S., Schaffer, M., Malmberg, K.-J., Ljunggren, H.-G., Miller, J. S., & Bryceson, Y. T.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 42
- Issue
- 3
- Pages
- 443-456
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1970591872
- Cited by
- 787
- References
- 57
- FWCI
- 31.60
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Schlums, H., Cichocki, F., Tesi, B., Theorell, J., Beziat, V., Holmes, T. D., Han, H., Chiang, S. C. C., Foley, B., Mattsson, K., Larsson, S., Schaffer, M., Malmberg, K.-J., Ljunggren, H.-G., Miller, J. S., & Bryceson, Y. T. (2015). Cytomegalovirus Infection Drives Adaptive Epigenetic Diversification of NK Cells with Altered Signaling and Effector Function. Immunity. https://doi.org/10.1016/j.immuni.2015.02.008
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