The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
Human Antibodies Fix Complement to Inhibit Plasmodium falciparum Invasion of Erythrocytes and Are Associated with Protection against Malaria
Open accessAbstract
Antibodies play major roles in immunity to malaria; however, a limited understanding of mechanisms mediating protection is a major barrier to vaccine development. We have demonstrated that acquired human anti-malarial antibodies promote complement deposition on the merozoite to mediate inhibition of erythrocyte invasion through C1q fixation and activation of the classical complement pathway. Antibody-mediated complement-dependent (Ab-C') inhibition was the predominant invasion-inhibitory activity of human antibodies; most antibodies were non-inhibitory without complement. Inhibitory activity was mediated predominately via C1q fixation, and merozoite surface proteins 1 and 2 were identified as major targets. Complement fixation by antibodies was very strongly associated with protection from both clinical malaria and high-density parasitemia in a prospective longitudinal study of children. Ab-C' inhibitory activity could be induced by human immunization with a candidate merozoite surface-protein vaccine. Our findings demonstrate that human anti-malarial antibodies have evolved to function by fixing complement for potent invasion-inhibitory activity and protective immunity.
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Brinkmann, V., Reichard, U., Goosmann, C., Fauler, B., Uhlemann, Y., Weiss, D. S., Weinrauch, Y., & Zychlinsky, A. (2004) · Science · doi:10.1126/science.1092385 · Cited by 10,268
Siglecs and their roles in the immune system
Crocker, P. R., Paulson, J. C., & Varki, A. (2007) · Nature Reviews Immunology · doi:10.1038/nri2056 · Cited by 2,031
Gamma-Globulin and Acquired Immunity to Human Malaria
COHEN, S., McGREGOR, I. A., & CARRINGTON, S. (1961) · Nature · doi:10.1038/192733a0 · Cited by 1,393
Ravetch, J. V., & Lanier, L. L. (2000) · Science · doi:10.1126/science.290.5489.84 · Cited by 1,283
Fc receptor but not complement binding is important in antibody protection against HIV
Hessell, A. J., Hangartner, L., Hunter, M., Havenith, C. E. G., Beurskens, F. J., Bakker, J. M., Lanigan, C. M. S., Landucci, G., Forthal, D. N., Parren, P. W. H. I., et al. (2007) · Nature · doi:10.1038/nature06106 · Cited by 901
Glycan-based interactions involving vertebrate sialic-acid-recognizing proteins
Varki, A. (2007) · Nature · doi:10.1038/nature05816 · Cited by 853
Complement evasion by human pathogens
Lambris, J. D., Ricklin, D., & Geisbrecht, B. V. (2008) · Nature Reviews Microbiology · doi:10.1038/nrmicro1824 · Cited by 722
Genton, B., Betuela, I., Felger, I., Al‐Yaman, F., Anders, R. F., Saul, A., Rare, L., Baisor, M., Lorry, K., Brown, G. V., et al. (2002) · The Journal of Infectious Diseases · doi:10.1086/339342 · Cited by 523
Self-citationSiglecs—the major subfamily of I-type lectins
Varki, A., & Angata, T. (2006) · Glycobiology · doi:10.1093/glycob/cwj008 · Cited by 518
Cd47-Signal Regulatory Protein α (Sirpα) Regulates Fcγ and Complement Receptor–Mediated Phagocytosis
Oldenborg, P.-A., Gresham, H. D., & Lindberg, F. P. (2001) · The Journal of Experimental Medicine · doi:10.1084/jem.193.7.855 · Cited by 452
Cited by
Ashley, E. A., Pyae Phyo, A., & Woodrow, C. J. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30324-6 · Cited by 553
Sex differences in vaccine-induced humoral immunity
Fischinger, S., Boudreau, C. M., Butler, A. L., Streeck, H., & Alter, G. (2019) · Seminars in Immunopathology · doi:10.1007/s00281-018-0726-5 · Cited by 410
Garza, R., Marchioni, J. M., Honeycutt, J. D., Hurlburt, N. K., Torres, C., Garcia, A., Neog, S., Loranc, E., Yemington, E., Towers, D., et al. (2026) · Disease Models & Mechanisms · doi:10.1242/dmm.052979 · Cited by 1
Metadata
- Authors
- Boyle, M. J., Reiling, L., Feng, G., Langer, C., Osier, F. H., Aspeling-Jones, H., Cheng, Y. S., Stubbs, J., Tetteh, K. K. A., Conway, D. J., McCarthy, J. S., Muller, I., Marsh, K., Anders, R. F., & Beeson, J. G.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2015-03
- Volume
- 42
- Issue
- 3
- Pages
- 580-590
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2012593576
- Cited by
- 306
- References
- 60
- FWCI
- 35.91
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- The paper
- Boyle, M. J., Reiling, L., Feng, G., Langer, C., Osier, F. H., Aspeling-Jones, H., Cheng, Y. S., Stubbs, J., Tetteh, K. K. A., Conway, D. J., McCarthy, J. S., Muller, I., Marsh, K., Anders, R. F., & Beeson, J. G. (2015). Human Antibodies Fix Complement to Inhibit Plasmodium falciparum Invasion of Erythrocytes and Are Associated with Protection against Malaria. Immunity. https://doi.org/10.1016/j.immuni.2015.02.012
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
