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Cited by 1,455T-cell and B-cell ImmunologyImmunotherapy and Immune ResponsesPsoriasis: Treatment and Pathogenesis

Regulatory B Cells: Origin, Phenotype, and Function

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Rosser, Elizabeth C., Mauri, Claudia·2015·Immunity
DOI 10.1016/j.immuni.2015.04.005
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Abstract

Regulatory B (Breg) cells are immunosuppressive cells that support immunological tolerance. Through the production of interleukin-10 (IL-10), IL-35, and transforming growth factor β (TGF-β), Breg cells suppress immunopathology by prohibiting the expansion of pathogenic T cells and other pro-inflammatory lymphocytes. Recent work has shown that different inflammatory environments induce distinct Breg cell populations. Although these findings highlight the relevance of inflammatory signals in the differentiation of Breg cells, they also raise other questions about Breg cell biology and phenotype. For example, what are the functional properties and phenotype of Breg cells? Can a Breg cell arise at every stage in B cell development? Is inflammation the primary requisite for Breg cell differentiation? Here, we use these questions to discuss the advances in understanding Breg cell biology, with a particular emphasis on their ontogeny; we propose that multiple Breg cell subsets can be induced in response to inflammation at different stages in development.

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  • In mice, Bregs can arise from various developmental stages including B1 B cells, transitional B cells, marginal zone B cells, follicular B cells and plasmocytes.

    “In mice, Bregs can arise from various developmental stages, including B1 B cells, transitional B cells, marginal zone B cells, follicular B cells and plasmocytes [62].”

    From Is there a role for B cells in Alzheimer's disease? (2026) · cites this paper as [62]

    The Introduction (page unavailable) says that immature and mature B cells and plasmablasts can differentiate into IL-10-producing Breg cells in mice, and it describes transitional marginal-zone precursor cells and regulatory plasma cells. It does not specifically establish B1, follicular, and marginal-zone B cells as separate origins in the claimed list; it also says the developmental links among Breg subsets remain unknown. (LLM, conf=0.83)

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Cited by

Sorted by citations

Authors
Rosser, E. C., & Mauri, C.
Affiliations
University College London (GB)
Corresponding author
Mauri, Claudia
ORCID
Venue
Immunity
Publisher
Elsevier BV
Published
2015-04
Volume
42
Issue
4
Pages
607-612
ISSN
1074-7613 (ISSN-L)
DOI
10.1016/j.immuni.2015.04.005
OpenAlex
W2006236831
Cited by
1,455
References
1
Citations by year
2026: 105 · 2025: 132 · 2024: 151 · 2023: 151 · 2022: 157 · 2021: 177 · 2020: 131 · 2019: 130 · 2018: 139 · 2017: 101 · 2016: 62 · 2015: 17 · 2014: 1
FWCI
10.03
Type
journal article
Language
en
Open access
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Immunity (publishedVersion)
  • PubMed (publishedVersion)
  • UCL Discovery (University College London) (submittedVersion)
Funders
Versus Arthritis (MP/17707., 19314, 17707, MP/19314, 20959)
Topics
  • Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
  • Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
  • Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Keywords
regulatory B cells, immune tolerance, IL-10, IL-35, TGF-beta, immunosuppression, B cell development
MeSH terms
Cell Differentiation, Dendritic Cells, Humans, Immune Tolerance, Immunity, Innate, Inflammation, Interleukins, Killer Cells, Natural, Phenotype, T-Lymphocytes, Transforming Growth Factor beta, Interleukin-10, Cell Lineage, Cell Proliferation, B-Lymphocytes, Regulatory

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