The regulation of immune tolerance by FOXP3

Commensal microbe-derived butyrate induces the differentiation of colonic regulatory T cells

Furusawa, Y., Obata, Y., Fukuda, S., Endo, T. A., Nakato, G., Takahashi, D., Nakanishi, Y., Uetake, C., Kato, K., Kato, T., et al. (2013) · Nature · doi:10.1038/nature12721 · Cited by 5,549 · see citing works

Metabolites produced by commensal bacteria promote peripheral regulatory T-cell generation

Arpaia, N., Campbell, C., Fan, X., Dikiy, S., van der Veeken, J., deRoos, P., Liu, H., Cross, J. R., Pfeffer, K., Coffer, P. J., et al. (2013) · Nature · doi:10.1038/nature12726 · Cited by 4,838 · see citing works

The Role of Tumoral FOXP3 on Cell Proliferation, Migration, and Invasion in Gastric Cancer

Zhang, L., Xu, J., Zhang, X., Zhang, Y., Wang, L., Huang, X., & Xu, Z. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479442 · Cited by 4,090 · see citing works

Commensal <i>Bifidobacterium</i> promotes antitumor immunity and facilitates anti–PD-L1 efficacy

Sivan, A., Corrales, L., Hubert, N., Williams, J. B., Aquino-Michaels, K., Earley, Z. M., Benyamin, F. W., Man Lei, Y., Jabri, B., Alegre, M.-L., et al. (2015) · Science · doi:10.1126/science.aac4255 · Cited by 3,888 · see citing works

The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

Bennett, C. L., Christie, J., Ramsdell, F., Brunkow, M., Ferguson, P., Whitesell, L., Kelly, T., Saulsbury, F., Chance, P., & Ochs, H. (2001) · Nature Genetics · doi:10.1038/83713 · Cited by 3,576 · see citing works

How regulatory T cells work

Vignali, D. A. A., Collison, L. W., & Workman, C. J. (2008) · Nature Reviews Immunology · doi:10.1038/nri2343 · Cited by 3,463 · see citing works

Regulatory T cells: mechanisms of differentiation and function

Josefowicz, S. Z., Lu, L.-F., & Rudensky, A. Y. (2012) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141623 · Cited by 2,866 · see citing works

Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

Brunkow, M. E., Jeffery, E. W., Hjerrild, K. A., Paeper, B. W., Clark, L. B., Yasayko, S.-A., Wilkinson, J. E., Galas, D. J., Ziegler, S. F., & Ramsdell, F. (2001) · Nature Genetics · doi:10.1038/83784 · Cited by 2,628 · see citing works

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

Deaglio, S., Dwyer, K. M., Gao, W., Friedman, D. J., Usheva, A., Erat, A., Chen, J., Enjyoji, K., Linden, J. M., Oukka, M., et al. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20062512 · Cited by 2,478 · see citing works

Functional Delineation and Differentiation Dynamics of Human CD4+ T Cells Expressing the FoxP3 Transcription Factor

Miyara, M., Yoshioka, Y., Kitoh, A., Shima, T., Wing, K., Niwa, A., Parizot, C., Taflin, C., Heike, T., Valeyre, D., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.03.019 · Cited by 2,291 · see citing works

The Biology of NKT Cells

Bendelac, A. S., Savage, P. B., & Teyton, L. (2006) · Annual Review of Immunology · doi:10.1146/annurev.immunol.25.022106.141711 · Cited by 2,169 · see citing works

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

Feuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works

The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation

Wang, R., Dillon, C. P., Shi, L. Z., Milasta, S., Carter, R., Finkelstein, D., McCormick, L. L., Fitzgerald, P., Chi, H., Munger, J., et al. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.021 · Cited by 2,140 · see citing works

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

Michalek, R. D., Gerriets, V. A., Jacobs, S. R., Macintyre, A. N., MacIver, N. J., Mason, E. F., Sullivan, S. A., Nichols, A. G., & Rathmell, J. C. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003613 · Cited by 2,091 · see citing works

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

Salomon, B. L., Lenschow, D. J., Rhee, L., Ashourian, N., Singh, B., Sharpe, A. H., & Bluestone, J. A. (2000) · Immunity · doi:10.1016/s1074-7613(00)80195-8 · Cited by 2,080 · see citing works

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells

Shi, L. Z., Wang, R., Huang, G., Vogel, P., Neale, G., Green, D. R., & Chi, H. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20110278 · Cited by 1,803 · see citing works

Mechanisms of Foxp3+ T Regulatory Cell-Mediated Suppression

Shevach, E. M. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.010 · Cited by 1,754 · see citing works

Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1

Dang, E. V., Barbi, J., Yang, H.-Y., Jinasena, D., Yu, H., Zheng, Y., Bordman, Z., Fu, J., Kim, Y., Yen, H.-R., et al. (2011) · Cell · doi:10.1016/j.cell.2011.07.033 · Cited by 1,595 · see citing works

Regulatory B Cells: Origin, Phenotype, and Function

Rosser, E. C., & Mauri, C. (2015) · Immunity · doi:10.1016/j.immuni.2015.04.005 · Cited by 1,455 · see citing works

mTOR differentially regulates effector and regulatory T cell lineage commitment

Delgoffe, G. M., Kole, T., Zheng, Y., Zarek, P. E., Matthews, K., Xiao, B., Worley, P., Kozma, S., & Powell, J. (2009) · Immunity · doi:10.1016/j.immuni.2009.04.014 · Cited by 1,293 · see citing works

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

Floess, S., Freyer, J., Siewert, C., Baron, U., Olek, S., Polansky, J. K., Schlawe, K., Chang, H., Bopp, T., Schmitt, E., et al. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050038 · Cited by 1,272 · see citing works

A Special Population of Regulatory T Cells Potentiates Muscle Repair

Burzyn, D., Kuswanto, W., Kolodin, D., Shadrach, J. L., Cerletti, M., Jang, Y., Sefik, E., Tan, T. G., Wagers, A. J., Benoist, C., et al. (2013) · Cell · doi:10.1016/j.cell.2013.10.054 · Cited by 1,234 · see citing works

FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

Wu, Y., Borde, M., Heissmeyer, V., Feuerer, M., Lapan, A. D., Stroud, J. C., Bates, D. L., Guo, L., Han, A., Ziegler, S. F., et al. (2006) · Cell · doi:10.1016/j.cell.2006.05.042 · Cited by 1,188 · see citing works

Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

Zheng, Y., Josefowicz, S. Z., Chaudhry, A., Peng, X. P., Forbush, K. A., & Rudensky, A. Y. (2010) · Nature · doi:10.1038/nature08750 · Cited by 1,170 · see citing works

Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation

Ianni, M. D., Falzetti, F., Carotti, A., Terenzi, A., Castellino, F., Bonifacio, E., Papa, B. D., Zei, T., Ostini, R. I., Cecchini, D., et al. (2011) · Blood · doi:10.1182/blood-2010-10-311894 · Cited by 1,065 · see citing works

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

de Lafaille, M. A. C., & Lafaille, J. J. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.002 · Cited by 1,057 · see citing works

Granzyme B and Perforin Are Important for Regulatory T Cell-Mediated Suppression of Tumor Clearance

Cao, X., Cai, S. F., Fehniger, T. A., Song, J., Collins, L. I., Piwnica-Worms, D. R., & Ley, T. J. (2007) · Immunity · doi:10.1016/j.immuni.2007.08.014 · Cited by 1,038 · see citing works

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

Bluestone, J. A., Buckner, J. H., Fitch, M., Gitelman, S. E., Gupta, S., Hellerstein, M. K., Herold, K. C., Lares, A., Lee, M. R., Li, K., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aad4134 · Cited by 1,033 · see citing works

Transient expression of FOXP3 in human activated nonregulatory CD4 ⁺ T cells

Wang, J., Ioan‐Facsinay, A., van der Voort, E. I. H., Huizinga, T. W. J., & Toes, R. E. M. (2007) · European Journal of Immunology · doi:10.1002/eji.200636435 · Cited by 1,011 · see citing works

Regulatory T-cell suppressor program co-opts transcription factor IRF4 to control TH2 responses

Zheng, Y., Chaudhry, A., Kas, A., deRoos, P., Kim, J. M., Chu, T.-T., Corcoran, L., Treuting, P., Klein, U., & Rudensky, A. Y. (2009) · Nature · doi:10.1038/nature07674 · Cited by 958 · see citing works

Deacetylase inhibition promotes the generation and function of regulatory T cells

Tao, R. N., de Zoeten, E. F., Özkaynak, E., Chen, C., Wang, L., Porrett, P. M., Li, B., Turka, L. A., Olson, E. N., Greene, M. I., et al. (2007) · Nature Medicine · doi:10.1038/nm1652 · Cited by 927 · see citing works

Genome-wide analysis of Foxp3 target genes in developing and mature regulatory T cells

Zheng, Y., Josefowicz, S. Z., Kas, A., Chu, T.-T., Gavin, M. A., & Rudensky, A. Y. (2007) · Nature · doi:10.1038/nature05563 · Cited by 835 · see citing works

Extrathymically generated regulatory T cells control mucosal TH2 inflammation

Josefowicz, S. Z., Niec, R. E., Kim, H. Y., Treuting, P. M., Chinen, T., Zheng, Y., Umetsu, D. T., & Rudensky, A. Y. (2012) · Nature · doi:10.1038/nature10772 · Cited by 823 · see citing works

Mechanisms of impaired regulation by CD4+CD25+FOXP3+ regulatory T cells in human autoimmune diseases

Buckner, J. H. (2010) · Nature reviews. Immunology · doi:10.1038/nri2889 · Cited by 790 · see citing works

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

Zeng, H., Yang, K., Cloer, C., Neale, G. A. M., Vogel, P., & Chi, H. (2013) · Nature · doi:10.1038/nature12297 · Cited by 789 · see citing works

DNA methylation controls Foxp3 gene expression

Polansky, J. K., Kretschmer, K., Freyer, J., Floess, S., Garbe, A. I., Baron, U., Olek, S., Hamann, A., von Boehmer, H., & Huehn, J. (2008) · European Journal of Immunology · doi:10.1002/eji.200838105 · Cited by 784 · see citing works

Single-cell analysis of normal and FOXP3-mutant human T cells: FOXP3 expression without regulatory T cell development

Gavin, M. A., Torgerson, T. R., Houston, E., DeRoos, P. C., Ho, W., Stray‐Pedersen, A., Ocheltree, E., Greenberg, P. D., Ochs, H. D., & Rudensky, A. Y. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0509484103 · Cited by 779 · see citing works

A ubiquitin ligase complex assembles linear polyubiquitin chains

Kirisako, T., Kamei, K., Murata, S., Kato, M., Fukumoto, H., Kanie, M., Sano, S., Tokunaga, F., Tanaka, K., & Iwaï, K. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601360 · Cited by 772 · see citing works

T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

Ohkura, N., Hamaguchi, M., Morikawa, H., Sugimura, K., Tanaka, A., Ito, Y., Osaki, M., Tanaka, Y., Yamashita, R., Nakano, N., et al. (2012) · Immunity · doi:10.1016/j.immuni.2012.09.010 · Cited by 756 · see citing works

Foxp3 occupancy and regulation of key target genes during T-cell stimulation

Marson, A., Kretschmer, K., Frampton, G. M., Jacobsen, E. S., Polansky, J. K., MacIsaac, K. D., Levine, S. S., Fraenkel, E., von Boehmer, H., & Young, R. A. (2007) · Nature · doi:10.1038/nature05478 · Cited by 724 · see citing works

Regulatory T cells in cancer immunotherapy

Nishikawa, H., & Sakaguchi, S. (2014) · Current Opinion in Immunology · doi:10.1016/j.coi.2013.12.005 · Cited by 702 · see citing works

Foxp3 controls regulatory T-cell function by interacting with AML1/Runx1

Ono, M., Yaguchi, H., Ohkura, N., Kitabayashi, I., Nagamura, Y., Nomura, T., Miyachi, Y., Tsukada, T., & Sakaguchi, S. (2007) · Nature · doi:10.1038/nature05673 · Cited by 692 · see citing works

Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells

Olkhanud, P. B., Damdinsuren, B., Bodogai, M., Gress, R. E., Sen, R., Wejksza, K., Malchinkhuu, E., Wersto, R. P., & Biragyn, A. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-4316 · Cited by 689 · see citing works

Anti-CCR4 mAb selectively depletes effector-type FoxP3 + CD4 + regulatory T cells, evoking antitumor immune responses in humans

Sugiyama, D., Nishikawa, H., Maeda, Y., Nishioka, M., Tanemura, A., Katayama, I., Ezoe, S., Kanakura, Y., Sato, E., Fukumori, Y., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1316796110 · Cited by 629 · see citing works

Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict

Samstein, R. M., Josefowicz, S. Z., Arvey, A. J., Treuting, P. M., & Rudensky, A. Y. (2012) · Cell · doi:10.1016/j.cell.2012.05.031 · Cited by 624 · see citing works

HECT and RING finger families of E3 ubiquitin ligases at a glance

Metzger, M. B., Hristova, V. A., & Weissman, A. M. (2012) · Journal of Cell Science · doi:10.1242/jcs.091777 · Cited by 622 · see citing works

CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2

Tai, X., Cowan, M. L., Feigenbaum, L., & Singer, A. (2005) · Nature Immunology · doi:10.1038/ni1160 · Cited by 613 · see citing works

CREB/ATF-dependent T cell receptor–induced FoxP3 gene expression: a role for DNA methylation

Kim, H., & Leonard, W. J. (2007) · The Journal of Experimental Medicine · doi:10.1084/jem.20070109 · Cited by 597 · see citing works

Epigenetic Regulation of Foxp3 Expression in Regulatory T Cells by DNA Methylation

Lal, G., Zhang, N., van der Touw, W., Ding, Y., Ju, W., Böttinger, E. P., Reid, S. P., Levy, D. E., & Bromberg, J. S. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.182.1.259 · Cited by 559 · see citing works

Cutting Edge: IL-2 Is Critically Required for the In Vitro Activation of CD4+CD25+ T Cell Suppressor Function

Thornton, A. M., Donovan, E. E., Piccirillo, C. A., & Shevach, E. M. (2004) · The Journal of Immunology · doi:10.4049/jimmunol.172.11.6519 · Cited by 559 · see citing works

A critical function for TGF-β signaling in the development of natural CD4+CD25+Foxp3+ regulatory T cells

Liu, Y., Zhang, P., Li, J., Kulkarni, A. B., Perruche, S., & Chen, W. (2008) · Nature Immunology · doi:10.1038/ni.1607 · Cited by 545 · see citing works

Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression

Gerriets, V. A., Kishton, R. J., Johnson, M. O., Cohen, S., Siska, P. J., Nichols, A., Warmoes, M. O., de Cubas, A. A., MacIver, N. J., Locasale, J. W., et al. (2016) · Nature Immunology · doi:10.1038/ni.3577 · Cited by 542 · see citing works

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF-β-Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

Xiao, S., Jin, H., Korn, T., Liu, S. M., Oukka, M., Lim, B., & Kuchroo, V. K. (2008) · The Journal of Immunology · doi:10.4049/jimmunol.181.4.2277 · Cited by 538 · see citing works

Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

Huehn, J., Polansky, J. K., & Hamann, A. (2008) · Nature reviews. Immunology · doi:10.1038/nri2474 · Cited by 527 · see citing works

Phosphorylation of FOXP3 controls regulatory T cell function and is inhibited by TNF-α in rheumatoid arthritis

Nie, H., Zheng, Y., Li, R., Guo, T. B., He, D., Fang, L., Liu, X., Xiao, L., Chen, X. X., Wan, B., et al. (2013) · Nature Medicine · doi:10.1038/nm.3085 · Cited by 516 · see citing works

Regulatory T-cell immunotherapy for tolerance to self antigens and alloantigens in humans

Roncarolo, M., & Battaglia, M. (2007) · Nature reviews. Immunology · doi:10.1038/nri2138 · Cited by 514 · see citing works

Interactions among the transcription factors Runx1, RORγt and Foxp3 regulate the differentiation of interleukin 17–producing T cells

Zhang, F., Meng, G., & Strober, W. (2008) · Nature Immunology · doi:10.1038/ni.1663 · Cited by 501 · see citing works

Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity

Talaat, R. M., Mohamed, S. F., Bassyouni, I. H., & Raouf, A. A. (2015) · Cytokine · doi:10.1016/j.cyto.2014.12.027 · Cited by 494 · see citing works

Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

Samstein, R. M., Arvey, A., Josefowicz, S. Z., Peng, X., Reynolds, A., Sandstrom, R., Neph, S., Sabo, P., Kim, J. M., Liao, W., et al. (2012) · Cell · doi:10.1016/j.cell.2012.06.053 · Cited by 472 · see citing works

Foxo proteins cooperatively control the differentiation of Foxp3+ regulatory T cells

Ouyang, W., Beckett, O. R., Ma, Q., Paik, J.-H., DePinho, R. A., & Li, M. O. (2010) · Nature Immunology · doi:10.1038/ni.1884 · Cited by 467 · see citing works

Transcription factor Foxp3 and its protein partners form a complex regulatory network

Rudra, D., DeRoos, P. C., Chaudhry, A., Niec, R. E., Arvey, A. J., Samstein, R. M., Leslie, C. S., Shaffer, S. A., Goodlett, D. R., & Rudensky, A. Y. (2012) · Nature Immunology · doi:10.1038/ni.2402 · Cited by 431 · see citing works

FOXP3 interactions with histone acetyltransferase and class II histone deacetylases are required for repression

Li, B., Samanta, A., Song, X., Iacono, K. T., Bembas, K., Tao, R. N., Basu, S., Riley, J. L., Hancock, W. W., Shen, Y., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700298104 · Cited by 410 · see citing works

Regulatory functions of ubiquitination in the immune system

Ben‐Neriah, Y. (2002) · Nature Immunology · doi:10.1038/ni0102-20 · Cited by 403 · see citing works

HLA-haploidentical transplantation with regulatory and conventional T-cell adoptive immunotherapy prevents acute leukemia relapse

Martelli, M. F., Ianni, M. D., Ruggeri, L., Falzetti, F., Carotti, A., Terenzi, A., Pierini, A., Massei, M. S., Amico, L., Urbani, E., et al. (2014) · Blood · doi:10.1182/blood-2014-03-564401 · Cited by 402 · see citing works

Glycolysis controls the induction of human regulatory T cells by modulating the expression of FOXP3 exon 2 splicing variants

Rosa, V. D., Galgani, M., Porcellini, A., Colamatteo, A., Santopaolo, M., Zuchegna, C., Romano, A., Simone, S. D., Procaccini, C., Rocca, C. L., et al. (2015) · Nature Immunology · doi:10.1038/ni.3269 · Cited by 399 · see citing works

FOXP3 Is an X-Linked Breast Cancer Suppressor Gene and an Important Repressor of the HER-2/ErbB2 Oncogene

Zuo, T., Wang, L., Morris, Q., Chang, X., Zhang, H., Li, J. W., Liu, Y., Wang, Y., Liu, X., Chan, M. W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.04.034 · Cited by 396 · see citing works

Regulation of Treg functionality by acetylation-mediated Foxp3 protein stabilization

van Loosdregt, J., Vercoulen, Y., Guichelaar, T., Gent, Y. Y. J., Beekman, J. M., van Beekum, O., Brenkman, A. B., Hijnen, D., Mutis, T., Kalkhoven, E., et al. (2009) · Blood · doi:10.1182/blood-2009-02-207118 · Cited by 389 · see citing works

Safety and Efficacy of Antigen-Specific Regulatory T-Cell Therapy for Patients With Refractory Crohn's Disease

Desreumaux, P., Foussat, A., Allez, M., Beaugerie, L., Hébuterne, X., Bouhnik, Y., Nachury, M., Brun, V., Bastian, H., Belmonte, N., et al. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.07.116 · Cited by 386 · see citing works

Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up

Marek-Trzonkowska, N., Myśliwiec, M., Dobyszuk, A., Grabowska, M., Derkowska, I., Juścińska, J., Owczuk, R., Szadkowska, A., Witkowski, P., Młynarski, W., et al. (2014) · Clinical Immunology · doi:10.1016/j.clim.2014.03.016 · Cited by 384 · see citing works

Development of Foxp3+ Regulatory T Cells Is Driven by the c-Rel Enhanceosome

Ruan, Q., Kameswaran, V., Tone, Y., Li, L., Liou, H., Greene, M. I., Tone, M., & Chen, Y. H. (2009) · Immunity · doi:10.1016/j.immuni.2009.10.006 · Cited by 378 · see citing works

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

Shrestha, S., Yang, K., Guy, C. S., Vogel, P., Neale, G. A. M., & Chi, H. (2015) · Nature Immunology · doi:10.1038/ni.3076 · Cited by 366 · see citing works

Regulatory T cells – a brief history and perspective

Sakaguchi, S., Wing, K., & Miyara, M. (2007) · European Journal of Immunology · doi:10.1002/eji.200737593 · Cited by 362 · see citing works

Retinoic Acid Enhances Foxp3 Induction Indirectly by Relieving Inhibition from CD4+CD44hi Cells

Hill, J. A., Hall, J. A., Sun, C., Cai, Q., Ghyselinck, N. B., Chambon, P., Belkaid, Y., Mathis, D. J., & Benoist, C. O. (2008) · Immunity · doi:10.1016/j.immuni.2008.09.018 · Cited by 358 · see citing works

Control of Foxp3 stability through modulation of TET activity

Yue, X., Trifari, S., Äijö, T., Tsagaratou, A., Pastor, W. A., Zepeda-Martínez, J. A., Lio, C.-W. J., Li, X., Huang, Y., Vijayanand, P., et al. (2016) · Journal of Experimental Medicine · doi:10.1084/jem.20151438 · Cited by 355 · see citing works

CD8+ Foxp3+ Regulatory T Cells Mediate Immunosuppression in Prostate Cancer

Kiniwa, Y., Miyahara, Y., Wang, H. Y., Peng, W., Peng, G., Wheeler, T. M., Thompson, T. C., Old, L. J., & Wang, R. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0842 · Cited by 353 · see citing works

CD25 Blockade Depletes and Selectively Reprograms Regulatory T Cells in Concert with Immunotherapy in Cancer Patients

Rech, A. J., Mick, R., Martin, S., Recio, A., Aqui, N. A., Powell, D. J., Colligon, T. A., Trosko, J. A., Leinbach, L. I., Pletcher, C. H., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003330 · Cited by 335 · see citing works

Eos Mediates Foxp3-Dependent Gene Silencing in CD4 + Regulatory T Cells

Pan, F., Yu, H., Dang, E. V., Barbi, J. J., Pan, X., Grosso, J. F., Jinasena, D., Sharma, S. M., McCadden, E., Getnet, D., et al. (2009) · Science · doi:10.1126/science.1176077 · Cited by 335 · see citing works

The chromatin-modifying enzyme Ezh2 is critical for the maintenance of regulatory T cell identity after activation

DuPage, M., Chopra, G., Quiros, J., Rosenthal, W. L., Morar, M. M., Holohan, D., Zhang, R., Turka, L., Marson, A., & Bluestone, J. A. (2015) · Immunity · doi:10.1016/j.immuni.2015.01.007 · Cited by 332 · see citing works

Stabilization of the Transcription Factor Foxp3 by the Deubiquitinase USP7 Increases Treg-Cell-Suppressive Capacity

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Tumor metabolite lactate promotes tumorigenesis by modulating MOESIN lactylation and enhancing TGF-β signaling in regulatory T cells

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Mitochondrial complex III is essential for suppressive function of regulatory T cells

Weinberg, S. E., Singer, B. D., Steinert, E. M., Martinez, C. A., Mehta, M., Martínez‐Reyes, I., Gao, P., Helmin, K. A., Abdala‐Valencia, H., Sena, L. A., et al. (2019) · Nature · doi:10.1038/s41586-018-0846-z · Cited by 496 · see citing works

Intricacies of TGF-β signaling in Treg and Th17 cell biology

Wang, J., Zhao, X., & Wan, Y. Y. (2023) · Cellular and Molecular Immunology · doi:10.1038/s41423-023-01036-7 · Cited by 377 · see citing works

NLRP3 Inflammasome Regulates Development of Systemic Inflammatory Response and Compensatory Anti-Inflammatory Response Syndromes in Mice With Acute Pancreatitis

Sendler, M., van den Brandt, C., Glaubitz, J., Wilden, A., Golchert, J., Weiß, F. U., Homuth, G., Chama, L. L. D. F., Mishra, N., Mahajan, U. M., et al. (2019) · Gastroenterology · doi:10.1053/j.gastro.2019.09.040 · Cited by 352 · see citing works

Genetic Architectures of Childhood- and Adult-Onset Asthma Are Partly Distinct

Ferreira, M. A. R., Mathur, R., Vonk, J. M., Szwajda, A., Brumpton, B. M., Granell, R., Brew, B. K., Ullemar, V., Lu, Y., Jiang, Y., et al. (2019) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2019.02.022 · Cited by 305 · see citing works

Parkinson’s disease patients have a complex phenotypic and functional Th1 bias: cross-sectional studies of CD4+ Th1/Th2/T17 and Treg in drug-naïve and drug-treated patients

Kuštrimović, N. Z., Comi, C., Magistrelli, L., Rasini, E., Legnaro, M., Bombelli, R., Aleksić, I., Blandini, F., Minafra, B., Riboldazzi, G., et al. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1248-8 · Cited by 281 · see citing works

Emerging Functions of Regulatory T Cells in Tissue Homeostasis

Sharma, A., & Rudra, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00883 · Cited by 263 · see citing works

Trial watch: TLR3 agonists in cancer therapy

Le Naour, J., Galluzzi, L., Zitvogel, L., Kroemer, G., & Vacchelli, E. (2020) · OncoImmunology · doi:10.1080/2162402x.2020.1771143 · Cited by 239 · see citing works

Molecular and Cellular Pathways Contributing to Joint Damage in Rheumatoid Arthritis

Fang, Q., Zhou, C., & Nandakumar, K. S. (2020) · Mediators of Inflammation · doi:10.1155/2020/3830212 · Cited by 218 · see citing works

The regulation and differentiation of regulatory T cells and their dysfunction in autoimmune diseases

Sumida, T. S., Cheru, N. T., & Hafler, D. A. (2024) · Nature reviews. Immunology · doi:10.1038/s41577-024-00994-x · Cited by 215 · see citing works

Tregs: Where We Are and What Comes Next?

Hai, Z., Liao, X., & Kang, Y. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01578 · Cited by 196 · see citing works

Control of regulatory T‐cell differentiation and function by T‐cell receptor signalling and Foxp3 transcription factor complexes

Ono, M. (2020) · Immunology · doi:10.1111/imm.13178 · Cited by 187 · see citing works

Short Chain Fatty Acid Metabolism in Relation to Gut Microbiota and Genetic Variability

Meyers, G. R., Samouda, H., & Bohn, T. (2022) · Nutrients · doi:10.3390/nu14245361 · Cited by 193 · see citing works

What’s Sex Got to Do With COVID-19? Gender-Based Differences in the Host Immune Response to Coronaviruses

Gadi, N., Wu, S., Spihlman, A. P., & Moulton, V. R. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.02147 · Cited by 185 · see citing works

Multispectral imaging for quantitative and compartment‐specific immune infiltrates reveals distinct immune profiles that classify lung cancer patients

Mezheyeuski, A., Bergsland, C. H., Backman, M., Djureinovic, D., Sjöblom, T., Bruun, J., & Micke, P. (2017) · The Journal of Pathology · doi:10.1002/path.5026 · Cited by 179 · see citing works

What did we learn from CTLA ‐4 insufficiency on the human immune system?

Mitsuiki, N., Schwab, C., & Grimbacher, B. (2018) · Immunological Reviews · doi:10.1111/imr.12721 · Cited by 177 · see citing works

Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer

Wang, L., Simons, D. L., Lu, X., Tu, T. Y., Solomon, S. T., Wang, R., Rosario, A., Avalos, C., Schmolze, D. B., Yim, J. H., et al. (2019) · Nature Immunology · doi:10.1038/s41590-019-0429-7 · Cited by 174 · see citing works

Cellular consequences of arginine methylation

Lorton, B. M., & Shechter, D. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03140-2 · Cited by 164 · see citing works

Sex steroids and autoimmune rheumatic diseases: state of the art

Cutolo, M., & Straub, R. H. (2020) · Nature Reviews Rheumatology · doi:10.1038/s41584-020-0503-4 · Cited by 164 · see citing works

Disease tolerance: concept and mechanisms

McCarville, J. L., & Ayres, J. S. (2017) · Current Opinion in Immunology · doi:10.1016/j.coi.2017.12.003 · Cited by 149 · see citing works

Trial watch: Peptide-based vaccines in anticancer therapy

Bezu, L., Kepp, O., Cerrato, G., Pol, J. G., Fucikova, J. P., Špíšek, R., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1511506 · Cited by 154 · see citing works

Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases

Huang, N., Chi, H., & Qiao, J. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01023 · Cited by 160 · see citing works

Activation of immunosuppressive network in the aging process

Salminen, A. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100998 · Cited by 153 · see citing works

The forkhead-box family of transcription factors: key molecular players in colorectal cancer pathogenesis

Laissue, P. (2019) · Molecular Cancer · doi:10.1186/s12943-019-0938-x · Cited by 143 · see citing works

The Interplay between Glioblastoma and Its Microenvironment

Dapash, M., Hou, D., Castro, B. A., Lee-Chang, C., & Lesniak, M. S. (2021) · Cells · doi:10.3390/cells10092257 · Cited by 151 · see citing works

Histone deacetylase function in CD4+ T cells

Ellmeier, W., & Seiser, C. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0037-z · Cited by 144 · see citing works

Itaconate ameliorates autoimmunity by modulating T cell imbalance via metabolic and epigenetic reprogramming

Aso, K., Kono, M., Kanda, M., Kudo, Y., Sakiyama, K., Hisada, R., Karino, K., Ueda, Y., Nakazawa, D., Fujieda, Y., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-36594-x · Cited by 141 · see citing works

CCL17 Aggravates Myocardial Injury by Suppressing Recruitment of Regulatory T Cells

Feng, G., Bajpai, G., Ma, P., Koenig, A. L., Bredemeyer, A. L., Lokshina, I., Lai, L., Förster, I., Leuschner, F., Kreisel, D., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.055888 · Cited by 140 · see citing works

Type 1 Diabetes: A Chronic Anti-Self-Inflammatory Response

Clark, M., Kroger, C. J., & Tisch, R. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01898 · Cited by 141 · see citing works

IL-10-producing T cells and their dual functions

Bedke, T., Muscate, F., Soukou, S., Gagliani, N., & Huber, S. (2019) · Seminars in Immunology · doi:10.1016/j.smim.2019.101335 · Cited by 140 · see citing works

Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation

Colamatteo, A., Carbone, F., Bruzzaniti, S., Galgani, M., Fusco, C., Maniscalco, G. T., Rella, F. D., de Candia, P., & Rosa, V. D. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2019.03136 · Cited by 139 · see citing works

Role of Bifidobacteria on Infant Health

Saturio, S., Nogacka, A. M., Alvarado-Jasso, G. M., Salazar, N., Reyes‐Gavilán, C. G. D. L., Gueimonde, M., & Arboleya, S. (2021) · Microorganisms · doi:10.3390/microorganisms9122415 · Cited by 140 · see citing works

The role of transcription factors in shaping regulatory T cell identity

Trujillo-Ochoa, J. L., Kazemian, M., & Afzali, B. (2023) · Nature reviews. Immunology · doi:10.1038/s41577-023-00893-7 · Cited by 136 · see citing works

Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications

Buqué, A., Bloy, N., Aranda, F., Castoldi, F., Eggermont, A. M. M., Cremer, I., Fridman, W. H., Fucikova, J. P., Galon, J., Marabelle, A., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1008814 · Cited by 130 · see citing works

HIF-2α is indispensable for regulatory T cell function

Hsu, T.-S., Lin, Y.-L., Wang, Y.-A., Mo, S.-T., Chi, P.-Y., Lai, A. C.-Y., Pan, H.-Y., Chang, Y.-J., & Lai, M.-Z. (2020) · Nature Communications · doi:10.1038/s41467-020-18731-y · Cited by 126 · see citing works

Spatially mapping the immune landscape of melanoma using imaging mass cytometry

Moldoveanu, D., Ramsay, L., Lajoie, M., Anderson-Trocmé, L., Lingrand, M., Berry, D., Perus, L. J. M., Wei, Y., Moraes, C., Alkallas, R., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abi5072 · Cited by 127 · see citing works

Tcf1 and Lef1 are required for the immunosuppressive function of regulatory T cells

Xing, S.-J., Gai, K., Li, X., Shao, P., Zeng, Z., Zhao, X.-D., Zhao, X., Chen, X., Paradee, W., Meyerholz, D., et al. (2019) · Journal of Experimental Medicine · doi:10.1084/jem.20182010 · Cited by 101 · see citing works

How to Hit Mesenchymal Stromal Cells and Make the Tumor Microenvironment Immunostimulant Rather Than Immunosuppressive

Poggi, A. D., Varesano, S., & Zocchi, M. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00262 · Cited by 111 · see citing works

Controlling the Immune Suppressor: Transcription Factors and MicroRNAs Regulating CD73/NT5E

Kordaß, T., Osen, W., & Eichmüller, S. B. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00813 · Cited by 109 · see citing works

Intrinsic TNFR2 signaling in T regulatory cells provides protection in CNS autoimmunity

Atretkhany, K. N., Mufazalov, I. A., Dunst, J., Kuchmiy, A. A., Gogoleva, V. S., Andruszewski, D., Drutskaya, M. S., Faustman, D. L., Schwabenland, M., Prinz, M., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1807499115 · Cited by 109 · see citing works

Glycan utilisation system in Bacteroides and Bifidobacteria and their roles in gut stability and health

Singh, R. P. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10012-z · Cited by 105 · see citing works

Epigenetic modifiers as new immunomodulatory therapies in solid tumours

Aspeslagh, S., Morel, D., Soria, J., & Postel-Vinay, S. C. (2018) · Annals of Oncology · doi:10.1093/annonc/mdy050 · Cited by 103 · see citing works

Maternal and fetal T cells in term pregnancy and preterm labor

Miller, D., Gershater, M., Slutsky, R., Romero, R. J., & Gomez‐Lopez, N. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0471-2 · Cited by 104 · see citing works

A Mutation in the Transcription Factor Foxp3 Drives T Helper 2 Effector Function in Regulatory T Cells

Van Gool, F., Nguyen, M. L. T., Mumbach, M. R., Satpathy, A. T., Rosenthal, W. L., Giacometti, S., Le, D. T., Liu, W., Brusko, T. M., Anderson, M. S., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.016 · Cited by 102 · see citing works

Molecular networks of FOXP family: dual biologic functions, interplay with other molecules and clinical implications in cancer progression

Kim, J., Hwang, J., Jung, J. H., Lee, H., Lee, D., & Kim, S. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1110-3 · Cited by 102 · see citing works

Th17 and Treg lymphocytes in obesity and Type 2 diabetic patients

Wang, M., Chen, F., Wang, J., Zeng, Z., Yang, Q., & Shao, S. (2018) · Clinical Immunology · doi:10.1016/j.clim.2018.09.005 · Cited by 99 · see citing works

Activation of Resolution Pathways to Prevent and Fight Chronic Inflammation: Lessons From Asthma and Inflammatory Bowel Disease

Barnig, C., Bezema, T., Calder, P. C., Charloux, A., Frossard, N., Garssen, J., Haworth, O., Dilevskaya, K., Levi‐Schaffer, F., Lonsdorfer‐Wolf, E., et al. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01699 · Cited by 99 · see citing works

Balancing cancer immunotherapy and immune-related adverse events: The emerging role of regulatory T cells

Alissafi, T., Hatzioannou, A., Legaki, A. I., Varveri, A., & Verginis, P. (2019) · Journal of Autoimmunity · doi:10.1016/j.jaut.2019.102310 · Cited by 96 · see citing works

TRAF6 directs FOXP3 localization and facilitates regulatory T‐cell function through K63‐linked ubiquitination

Ni, X., Kou, W., Gu, J. H., Wei, P., Wu, X. F., Peng, H., Tao, J., Yan, W., Yang, X., Lebid, A., et al. (2019) · The EMBO Journal · doi:10.15252/embj.201899766 · Cited by 94 · see citing works

Single-cell transcriptomic analysis reveals disparate effector differentiation pathways in human Treg compartment

Luo, Y., Xu, Z., Wang, B., Niu, Q., Su, X., Bai, Y., Zhu, S., Zhao, C., Sun, Y., Wang, J., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-24213-6 · Cited by 93 · see citing works

Immunological Mechanisms in Allergic Diseases and Allergen Tolerance: The Role of Treg Cells

Calzada, D., Baos, S., Cremades‐Jimeno, L., & Cárdaba, B. (2018) · Journal of Immunology Research · doi:10.1155/2018/6012053 · Cited by 90 · see citing works

Sensory Neurons, Neuroimmunity, and Pain Modulation by Sex Hormones

Lenert, M. E., Avona, A., Garner, K. M., Barron, L. R., & Burton, M. D. (2021) · Endocrinology · doi:10.1210/endocr/bqab109 · Cited by 94 · see citing works

Immunotherapy via PD-L1–presenting biomaterials leads to long-term islet graft survival

Coronel, M. M., Martin, K. E., Hunckler, M. D., Barber, G., O’Neill, E. B., Medina, J. D., Opri, E., McClain, C. A., Batra, L., Weaver, J. D., et al. (2020) · Science Advances · doi:10.1126/sciadv.aba5573 · Cited by 89 · see citing works

Role of orally induced regulatory T cells in immunotherapy and tolerance

Bertolini, T. B., Biswas, M., Terhorst, C., Daniell, H., Herzog, R. W., & Piñeros, A. R. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104251 · Cited by 89 · see citing works

Regulatory T Cells in Autoimmunity and Cancer: A Duplicitous Lifestyle

Hatzioannou, A., Boumpas, A., Papadopoulou, M., Papafragkos, I., Varveri, A., Alissafi, T., & Verginis, P. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.731947 · Cited by 87 · see citing works

When the balance is broken: X-linked gene dosage from two X chromosomes and female-biased autoimmunity

Syrett, C. M., & Anguera, M. C. (2019) · Journal of Leukocyte Biology · doi:10.1002/jlb.6ri0319-094r · Cited by 81 · see citing works

Post-Translational Regulations of Foxp3 in Treg Cells and Their Therapeutic Applications

Dong, Y. W., Yang, C., & Pan, F. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.626172 · Cited by 82 · see citing works

Transient mTOR inhibition rescues 4-1BB CAR-Tregs from tonic signal-induced dysfunction

Lamarthée, B., Marchal, A., Charbonnier, S., Blein, T., Léon, J., Martin, E., Rabaux‐Eygasier, L., Vogt, K., Titeux, M., Delville, M., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26844-1 · Cited by 80 · see citing works

DNA Methyltransferase Inhibitors: Catalysts For Antitumour Immune Responses

Dan, H., Zhang, S., Zhou, Y., & Guan, Q. (2019) · OncoTargets and Therapy · doi:10.2147/ott.s217767 · Cited by 81 · see citing works

Targeting Sirt-1 controls GVHD by inhibiting T-cell allo-response and promoting Treg stability in mice

Daenthanasanmak, A., Iamsawat, S., Chakraborty, P., Nguyen, H. D., Bastian, D. A., Liu, C., Mehrotra, S., & Yu, X. (2018) · Blood · doi:10.1182/blood-2018-07-863233 · Cited by 78 · see citing works

Ahr-Foxp3-RORγt axis controls gut homing of CD4 + T cells by regulating GPR15

Xiong, L., Dean, J. W., Fu, Z., Oliff, K. N., Bostick, J. W., Ye, J., Chen, Z. E., Mühlbauer, M., & Zhou, L. (2020) · Science Immunology · doi:10.1126/sciimmunol.aaz7277 · Cited by 76 · see citing works

The Role of Gut Microbiota-Derived Lithocholic Acid, Deoxycholic Acid and Their Derivatives on the Function and Differentiation of Immune Cells

Kiriyama, Y., & Nochi, H. (2023) · Microorganisms · doi:10.3390/microorganisms11112730 · Cited by 75 · see citing works

Gallic acid induces T-helper-1-like T reg cells and strengthens immune checkpoint blockade efficacy

Deng, B., Yang, B., Chen, J., Wang, S., Zhang, W., Guo, Y., Han, Y., Li, H., Dang, Y., Yuan, Y., et al. (2022) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2021-004037 · Cited by 73 · see citing works

Alternative Splicing of FOXP3—Virtue and Vice

Mailer, R. K. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00530 · Cited by 71 · see citing works

Alternative Splicing of FOXP3 Controls Regulatory T Cell Effector Functions and Is Associated With Human Atherosclerotic Plaque Stability

Joly, A.-L., Seitz, C., Liu, S., Kuznetsov, N. V., Gertow, K., Westerberg, L. S., Paulsson‐Berne, G., Hansson, G. K., & Andersson, J. (2018) · Circulation Research · doi:10.1161/circresaha.117.312340 · Cited by 70 · see citing works

Clinical, Immunological, and Genetic Features in Patients with Immune Dysregulation, Polyendocrinopathy, Enteropathy, X-linked (IPEX) and IPEX-like Syndrome

Jamee, M., Zaki‐Dizaji, M., Lo, B., Abolhassani, H., Aghamahdi, F., Moosavian, M., Nademi, Z., Mohammadi, H., Jadidi‐Niaragh, F., Rojas, M., et al. (2020) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2020.04.070 · Cited by 69 · see citing works

Gliadins as versatile biomaterials for drug delivery applications

Voci, S., Fresta, M., & Cosco, D. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.11.048 · Cited by 67 · see citing works

Interactions of IDO and the Kynurenine Pathway with Cell Transduction Systems and Metabolism at the Inflammation–Cancer Interface

Stone, T. W., & Williams, R. O. (2023) · Cancers · doi:10.3390/cancers15112895 · Cited by 66 · see citing works

Lactate supports Treg function and immune balance via MGAT1 effects on N-glycosylation in the mitochondria

Zhou, J., Gu, J., Qian, Q., Zhang, Y., Huang, T., Li, X., Liu, Z., Shao, Q., Liang, Y., Qiao, L., et al. (2024) · Journal of Clinical Investigation · doi:10.1172/jci175897 · Cited by 66 · see citing works

Epigenetic regulation and T-cell responses in endometriosis – something other than autoimmunity

Szukiewicz, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.943839 · Cited by 64 · see citing works

MUC16 C terminal-induced secretion of tumor-derived IL-6 contributes to tumor-associated Treg enrichment in pancreatic cancer

Fan, K., Yang, C., Fan, Z., Huang, Q., Zhang, Y., Cheng, H., Jin, K., Yu, L., Wang, Z., Luo, G., et al. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.01.017 · Cited by 65 · see citing works

A comprehensive profile of TCF1+ progenitor and TCF1− terminally exhausted PD-1+CD8+ T cells in head and neck squamous cell carcinoma: implications for prognosis and immunotherapy

Wang, D.-K., Fang, J., Wen, S., Li, Q., Wang, J., Yang, L., Dai, W., Lu, H., Guo, J., Shan, Z., et al. (2022) · International Journal of Oral Science · doi:10.1038/s41368-022-00160-w · Cited by 67 · see citing works

Regulatory T cells in peripheral tissue tolerance and diseases

Cheru, N. T., Hafler, D. A., & Sumida, T. S. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1154575 · Cited by 64 · see citing works

Prognostic value of tumor-infiltrating Foxp3+ regulatory T cells in patients with breast cancer: a meta-analysis

Zhou, Y., Shao, N., AiErken, N., Xie, C., Ye, R., Qian, X., Hu, Z., Zhang, J., & Lin, Y. (2017) · Journal of Cancer · doi:10.7150/jca.21030 · Cited by 62 · see citing works

An Immune Atlas of T Cells in Transplant Rejection: Pathways and Therapeutic Opportunities

Short, S., Lewik, G., & Issa, F. (2023) · Transplantation · doi:10.1097/tp.0000000000004572 · Cited by 64 · see citing works

The rationale for selenium supplementation in inflammatory bowel disease: A mechanism-based point of view

Ala, M., & Kheyri, Z. (2021) · Nutrition · doi:10.1016/j.nut.2021.111153 · Cited by 60 · see citing works

Engineered Tolerance: Tailoring Development, Function, and Antigen-Specificity of Regulatory T Cells

Dawson, N. A. J., Vent‐Schmidt, J., & Levings, M. K. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01460 · Cited by 56 · see citing works

IL-27 targets Foxp3+ Tregs to mediate antiinflammatory functions during experimental allergic airway inflammation

Nguyen, Q. T., Jang, E., Le, H. T., Kim, S., Kim, D., Dvorina, N., Aronica, M. A., Baldwin, W. M., Asosingh, K., COMHAIR, S. A. A., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.123216 · Cited by 55 · see citing works

The Impact of Dietary Components on Regulatory T Cells and Disease

Hornero, R. A., Hamad, I., Côrte‐Real, B. F., & Kleinewietfeld, M. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00253 · Cited by 57 · see citing works

Postbiotics: An alternative and innovative intervention for the therapy of inflammatory bowel disease

Kavita, K., Om, H., Chand, U., & Kushawaha, P. K. (2023) · Microbiological Research · doi:10.1016/j.micres.2023.127550 · Cited by 61 · see citing works

Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy

García-Martínez, E., Smith, M. M., Buqué, A., Aranda, F., de la Peña, F. A., Rubio, A. I., Cánovas, M. S., Conesa, M. A. V., Fucikova, J. P., Špíšek, R., et al. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1433982 · Cited by 56 · see citing works

T Cells in Adipose Tissue in Aging

Antony, A. K., Lian, Z., & Wu, H. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02945 · Cited by 58 · see citing works

Splicing factor SRSF1 is indispensable for regulatory T cell homeostasis and function

Katsuyama, T., & Moulton, V. R. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.109339 · Cited by 56 · see citing works

A central role for STAT5 in the transcriptional programing of T helper cell metabolism

Villarino, A. V., Laurence, A. D. J., Davis, F. P., Nivelo, L. A., Brooks, S. R., Sun, H., Jiang, K., Afzali, B., Frasca, D., Hennighausen, L. G., et al. (2022) · Science Immunology · doi:10.1126/sciimmunol.abl9467 · Cited by 54 · see citing works

Effects of MicroRNA on Regulatory T Cells and Implications for Adoptive Cellular Therapy to Ameliorate Graft-versus-Host Disease

Hippen, K. L., Loschi, M. L., Nicholls, J., MacDonald, K. P. A., & Blazar, B. R. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00057 · Cited by 55 · see citing works

Safety, tolerability, and immune-biomarker profiling for year-long sargramostim treatment of Parkinson's disease

Olson, K. E., Namminga, K. L., Lu, Y., Schwab, A. D., Thurston, M. J., Abdelmoaty, M. M., Kumar, V. S., Wojtkiewicz, M. S., Obaro, H., Santamaria, P. M., et al. (2021) · EBioMedicine · doi:10.1016/j.ebiom.2021.103380 · Cited by 54 · see citing works

The persistent inflammation in COPD: is autoimmunity the core mechanism?

Dong, L., Liu, Z., Chen, K.-J., Li, Z., Zhou, J.-S., Shen, H., & Chen, Z. (2024) · European Respiratory Review · doi:10.1183/16000617.0137-2023 · Cited by 59 · see citing works

Single‐cell transcriptomics reveal the intratumoral landscape of infiltrated T‐cell subpopulations in oral squamous cell carcinoma

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