The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells
Open accessAbstract
Macrophages are one of the most diverse cell populations in terms of their anatomical location and functional specialization during both homeostasis and disease. Although it has been shown in different fate mapping models that some macrophages present in adult tissues are already established during fetal development, their exact origins are still under debate. In the current study, we developed a fate mapping strain, based on the Kit locus, which allowed us to readdress "the origins" question. Different types of macrophages from various adult tissues were traced to their fetal or adult sources by inducing labeling in precursors at several time points either during fetal development or in adult mice. We show that all adult macrophages, resident or infiltrating, are progenies of classical hematopoietic stem cells (HSC) with the exception of microglia and, partially epidermal Langerhans cells, which are yolk sac (YS)-derived.
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Cites
Fate Mapping Analysis Reveals That Adult Microglia Derive from Primitive Macrophages
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Macrophage biology in development, homeostasis and disease
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“They have important roles in organ development, tissue homeostasis and repair, in addition to their roles as effectors of innate immunity (Wynn et al., 2013).”
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
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A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
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Tissue-resident macrophages originate from yolk-sac-derived erythro-myeloid progenitors
Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · cited 11×
“…are several limitations to the inducible fate mapping models currently available to study ontogenesis of tissue macrophages, including the Runx1MercreMer, Csf1rMercreMer, and Cx3cr1creER mouse models (Ginhoux et al., 2010; Kierdorf et al., 2013; Gomez Perdiguero et al., 2015; Yona et al., 2013).”
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“Classically-defined tissue resident macrophages such as Kupffer cells, alveolarmacrophages, and spleen red pulpmacrophages belonged to Fr I (F4/80), thus ‘‘Fr I phenotype cells’’ in other organs most likely represent resident macrophages (Hashimoto et al., 2013).”
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“To further characterize the fractions, we analyzed them for macrophage markers defined by the recent Immunological Genome (ImmGen) Project (Gautier et al., 2012), including CD64, CD16/32, MerTK, and transgenic Cx3cr1GFP/+ expression (core macrophage signatures).”
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Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
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“showed very recently that FL monocytes can replace earlier YS-derived macrophages in most tissues (Hoeffel et al., 2015).”
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Two physically, functionally, and developmentally distinct peritoneal macrophage subsets
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Cited by
Macrophage plasticity, polarization, and function in health and disease
Shapouri‐Moghaddam, A., Mohammadian, S., Vazini, H., Taghadosi, M., Esmaeili, S., Mardani, F., Seifi, B., Mohammadi, A., Afshari, J. T., & Sahebkar, A. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26429 · Cited by 4,930
The Nature of Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
Kumar, V., Patel, S., Tcyganov, E., & Gabrilovich, D. I. (2016) · Trends in Immunology · doi:10.1016/j.it.2016.01.004 · Cited by 2,008
Microglia and macrophages in brain homeostasis and disease
Li, Q., & Barres, B. A. (2018) · Nature Reviews Immunology · doi:10.1038/nri.2017.125 · Cited by 1,999
Tissue-Resident Macrophage Ontogeny and Homeostasis
Ginhoux, F., & Guilliams, M. (2016) · Immunity · doi:10.1016/j.immuni.2016.02.024 · Cited by 1,884
New tools for studying microglia in the mouse and human CNS
Bennett, M. L., Bennett, F. C., Liddelow, S. A., Ajami, B., Zamanian, J. L., Fernhoff, N. B., Mulinyawe, S. B., Bohlen, C. J., Adil, A., Tucker, A., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1525528113 · Cited by 1,804
Metadata
- Authors
- Sheng, J., Ruedl, C., & Karjalainen, K.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2015-08
- Volume
- 43
- Issue
- 2
- Pages
- 382-393
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W1948478725
- Cited by
- 489
- References
- 14
- FWCI
- 37.54
- Type
- journal article
- Language
- en
- Open access
- bronze
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