Constant replenishment from circulating monocytes maintains the macrophage pool in the intestine of adult mice
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The paradigm that macrophages that reside in steady-state tissues are derived from embryonic precursors has never been investigated in the intestine, which contains the largest pool of macrophages. Using fate-mapping models and monocytopenic mice, together with bone marrow chimera and parabiotic models, we found that embryonic precursor cells seeded the intestinal mucosa and demonstrated extensive in situ proliferation during the neonatal period. However, these cells did not persist in the intestine of adult mice. Instead, they were replaced around the time of weaning by the chemokine receptor CCR2-dependent influx of Ly6C(hi) monocytes that differentiated locally into mature, anti-inflammatory macrophages. This process was driven largely by the microbiota and had to be continued throughout adult life to maintain a normal intestinal macrophage pool.
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Monocyte-to-macrophage differentiation does occur in tissues such as the gut and dermis.
“This does indeed happen, for example in the gut or the dermis (53,54).”
From The impact of ageing on monocytes and macrophages (2021) · cites this paper as [53]
Microglia in the developing brain proliferate locally at a low rate and are not normally replaced by other monocytes and macrophages from outside the brain, unlike most other tissue-resident macrophages.
“Microglia in the developing brain proliferate locally at a low rate and are not normally replaced by other monocytes and macrophages from outside the brain, in contrast to most other tissue-resident macrophages (which also initially originate from yolk sac-derived macrophages, but are partially or fully replaced by fetal liver- or blood monocyte-derived macrophages [Bain et al., 2014, Calderon et”
From A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response (2017) · cites this paper as Bain et al., 2014
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Cites
Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis
Yona, S., Kim, K.-W., Wolf, Y., Mildner, A., Varol, D., Breker, M., Strauss-Ayali, D., Viukov, S., Guilliams, M., Misharin, A., et al. (2013) · Immunity · doi:10.1016/j.immuni.2012.12.001 · Cited by 3,245 · see citing works
Self-citationCCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis
Qian, B.-Z., Li, J., Zhang, H., Kitamura, T., Zhang, J., Campion, L. R., Kaiser, E. A., Snyder, L. A., & Pollard, J. W. (2011) · Nature · doi:10.1038/nature10138 · Cited by 2,874 · see citing works
Jung, S., Aliberti, J., Graemmel, P., Sunshine, M. J., Kreutzberg, G. W., Sher, A., & Littman, D. R. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.11.4106-4114.2000 · Cited by 2,632 · see citing works
A Lineage of Myeloid Cells Independent of Myb and Hematopoietic Stem Cells
Schulz, C., Perdiguero, E. G., Chorro, L., Szabo-Rogers, H., Cagnard, N., Kierdorf, K., Prinz, M., Wu, B., Jacobsen, S. E. W., Pollard, J. W., et al. (2012) · Science · doi:10.1126/science.1219179 · Cited by 2,578 · see citing works
Self-citationHashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311 · see citing works
Davies, L. C., Jenkins, S. J., Allen, J. E., & Taylor, P. R. (2013) · Nature Immunology · doi:10.1038/ni.2705 · Cited by 2,096 · see citing works
Serbina, N. V., & Pamer, E. G. (2006) · Nature Immunology · doi:10.1038/ni1309 · Cited by 1,658 · see citing works
Local self-renewal can sustain CNS microglia maintenance and function throughout adult life
Ajami, B., Bennett, J. L., Krieger, C., Tetzlaff, W., & Rossi, F. M. V. (2007) · Nature Neuroscience · doi:10.1038/nn2014 · Cited by 1,643 · see citing works
Origin and functions of tissue macrophages
Epelman, S., Lavine, K. J., & Randolph, G. J. (2014) · Immunity · doi:10.1016/j.immuni.2014.06.013 · Cited by 1,585 · see citing works
Epelman, S., Lavine, K. J., Beaudin, A. E., Sojka, D. K., Carrero, J. A., Calderon, B., Brija, T., Gautier, E. L., Ivanov, S., Satpathy, A. T., et al. (2014) · Immunity · doi:10.1016/j.immuni.2013.11.019 · Cited by 1,494 · see citing works
Guilliams, M., de Kleer, I., Henri, S., Post, S., Vanhoutte, L., Prijck, S. D., Deswarte, K., MALISSEN, B., Hammad, H., & Lambrecht, B. N. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20131199 · Cited by 1,259 · see citing works
Self-citationvan Furth, R., Cohn, Z. A., Jg, H., Humphrey, J., Spector, W. G., & Langevoort, H. L. (1972) · PubMed Central · Cited by 1,133 · see citing works
Boring, L., Gosling, J., Chensue, S. W., Kunkel, S. L., Farese, R. V., Broxmeyer, H. E., & Charo, I. F. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119798 · Cited by 1,096 · see citing works
Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
Mildner, A., Schmidt, H., Nitsche, M., Merkler, D., Hanisch, U.-K., Mack, M., Heikenwalder, M., Brück, W., Priller, J., & Prinz, M. (2007) · Nature Neuroscience · doi:10.1038/nn2015 · Cited by 1,089 · see citing works
Infiltrating monocytes trigger EAE progression, but do not contribute to the resident microglia pool
Ajami, B., Bennett, J. L., Krieger, C., McNagny, K. M., & Rossi, F. M. V. (2011) · Nature Neuroscience · doi:10.1038/nn.2887 · Cited by 1,061 · see citing works
Haematopoietic stem cells derive directly from aortic endothelium during development
Bertrand, J. Y., Chi, N. C., Santoso, B., Teng, S., Stainier, D. Y. R., & Traver, D. J. (2010) · Nature · doi:10.1038/nature08738 · Cited by 1,053 · see citing works
Bain, C. C., Scott, C. L., Uronen‐Hansson, H., Guðjónsson, S., Jansson, O., Grip, O., Guilliams, M., MALISSEN, B., Agace, W. W., & Mowat, A. M. (2012) · Mucosal Immunology · doi:10.1038/mi.2012.89 · Cited by 947 · see citing works
Self-citationOrigin of the Lamina Propria Dendritic Cell Network
Bogunovic, M., Ginhoux, F., Helft, J., Shang, L., Hashimoto, D., Greter, M., Liu, K., Jakubzick, C., Ingersoll, M. A., Leboeuf, M., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.08.010 · Cited by 859 · see citing works
Hoeffel, G., Wang, Y., Greter, M., See, P., Teo, P., Malleret, B., Leboeuf, M., Low, D., Oller, G., Almeida, F., et al. (2012) · Journal of Experimental Medicine · doi:10.1084/jem.20120340 · Cited by 786 · see citing works
Tamoutounour, S., Guilliams, M., Montanana Sanchis, F., Liu, H., Terhorst, D., Malosse, C., Pollet, E., Ardouin, L., Luche, H., Sanchez, C., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.10.004 · Cited by 783 · see citing works
Self-citationJakubzick, C. V., Gautier, E., Gibbings, S. L., Sojka, D. K., Schlitzer, A., Johnson, T. E., Ivanov, S., Duan, Q., Bala, S., Condon, T., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.08.007 · Cited by 762 · see citing works
The origin and development of nonlymphoid tissue CD103+ DCs
Ginhoux, F., Liu, K., Helft, J., Bogunovic, M., Greter, M., Hashimoto, D., Price, J. G., Yin, N., Bromberg, J. S., Lira, S. A., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091756 · Cited by 744 · see citing works
Intestinal Lamina Propria Dendritic Cell Subsets Have Different Origin and Functions
Varol, C., Vallon-Eberhard, A., Elinav, E., Aychek, T., Shapira, Y., Luche, H., Fehling, H. J., Hardt, W., Shakhar, G., & Jung, S. (2009) · Immunity · doi:10.1016/j.immuni.2009.06.025 · Cited by 710 · see citing works
Macrophages in intestinal homeostasis and inflammation
Bain, C. C., & Mowat, A. M. (2014) · Immunological Reviews · doi:10.1111/imr.12192 · Cited by 615 · see citing works
Self-citationSaederup, N., Cardona, A. E., Croft, K., Mizutani, M., Cotleur, A. C., Tsou, C.-L., Ransohoff, R. M., & Charo, I. F. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013693 · Cited by 599 · see citing works
Rivollier, A., He, J., Kole, A., Valatas, V., & Kelsall, B. L. (2012) · The Journal of Experimental Medicine · doi:10.1084/jem.20101387 · Cited by 548 · see citing works
Tamoutounour, S., Henri, S., Lelouard, H., de Bovis, B., de Haar, C. G., van der Woude, C. J., Woltman, A. M., Reyal, Y., Bonnet, D. A., Sichien, D., et al. (2012) · European Journal of Immunology · doi:10.1002/eji.201242847 · Cited by 526 · see citing works
Self-citationOrigin of dendritic cells in peripheral lymphoid organs of mice
Liu, K., Waskow, C., Liu, X., Yao, K.-H., Hoh, J. J., & Nussenzweig, M. C. (2007) · Nature Immunology · doi:10.1038/ni1462 · Cited by 473 · see citing works
Hill, D. A., Hoffmann, C., Abt, M. C., Du, Y., Kobuley, D. E., Kirn, T. J., Bushman, F. D., & Artis, D. (2009) · Mucosal Immunology · doi:10.1038/mi.2009.132 · Cited by 425 · see citing works
Self-citationLee, S. H., Starkey, P. M., & Gordon, S. (1985) · The Journal of Experimental Medicine · doi:10.1084/jem.161.3.475 · Cited by 423 · see citing works
Chorro, L., Sarde, A., Li, M., Woollard, K. J., Chambon, P., MALISSEN, B., Kissenpfennig, A., Barbaroux, J.-B., Groves, R. W., & Geissmann, F. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20091586 · Cited by 395 · see citing works
Self-citationKennedy, D. W., & Abkowitz, J. L. (1997) · Blood · doi:10.1182/blood.v90.3.986 · Cited by 342 · see citing works
Davies, L. C., Rosas, M., Smith, P. J., Fraser, D. J., Jones, S. A., & Taylor, P. R. (2011) · European Journal of Immunology · doi:10.1002/eji.201141817 · Cited by 232 · see citing works
An Independent Subset of TLR Expressing CCR2-Dependent Macrophages Promotes Colonic Inflammation
Platt, A. M., Bain, C. C., Bordon, Y., Sester, D. P., & Mowat, A. M. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0903987 · Cited by 207 · see citing works
Self-citationNiess, J. H., & Adler, G. (2010) · The Journal of Immunology · doi:10.4049/jimmunol.0901936 · Cited by 196 · see citing works
Direct evidence of monocyte recruitment to inflammatory bowel disease mucosa
GRIMM, M., Pullman, W. E., BENNETT, G., Sullivan, P., Pavli, P., & Doe, W. F. (1995) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.1995.tb01589.x · Cited by 185 · see citing works
The monocyte-macrophage axis in the intestine
Bain, C. C., & Mowat, A. M. (2014) · Cellular Immunology · doi:10.1016/j.cellimm.2014.03.012 · Cited by 166 · see citing works
Self-citationBenz, C., Martins, V. C., Radtke, F., & Bleul, C. C. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20072168 · Cited by 159 · see citing works
Multicolor fate mapping of Langerhans cell homeostasis
Ghigo, C., Mondor, I., Jorquera, A., Nowak, J., Wienert, S., Zahner, S. P., Clausen, B. E., Luche, H., MALISSEN, B., Klauschen, F., et al. (2013) · The Journal of Experimental Medicine · doi:10.1084/jem.20130403 · Cited by 156 · see citing works
Self-citationMüller, A. J., Kaiser, P., Dittmar, K. E. J., Weber, T. C., Haueter, S., Endt, K., Songhet, P., Zellweger, C., Kremer, M., Fehling, H. J., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2011.11.013 · Cited by 151 · see citing works
Smythies, L. E., Maheshwari, A., Clements, R. H., Eckhoff, D. E., Novak, L., Vu, H., Mosteller, L. M., Sellers, M. T., & Smith, P. D. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.1005566 · Cited by 139 · see citing works
Ueda, Y., Kayama, H., Jeon, S. G., Kusu, T., Isaka, Y., Rakugi, H., Yamamoto, M., & Takeda, K. (2010) · International Immunology · doi:10.1093/intimm/dxq449 · Cited by 138 · see citing works
Nagashima, R., Maeda, K., Imai, Y., & Takahashi, T. (1996) · Journal of Histochemistry & Cytochemistry · doi:10.1177/44.7.8675993 · Cited by 98 · see citing works
CD200 receptor and macrophage function in the intestine
Bain, C. C., & Mowat, A. M. (2011) · Immunobiology · doi:10.1016/j.imbio.2011.11.004 · Cited by 36 · see citing works
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- [37]Tamoutounour S CD64 distinguishes macrophages from dendritic cells in the gut and reveals the Th1-inducing role of mesenteric lymph node macrophages during colitis Eur. J. Immunol 2012 42 3150 3166 22936024
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Murray, P. J. (2017) · Annual Review of Physiology · doi:10.1146/annurev-physiol-022516-034339 · Cited by 2,981 · see citing works
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Gomez Perdiguero, E., Klapproth, K., Schulz, C., Busch, K., Azzoni, E., Crozet, L., Garner, H., Trouillet, C., de Bruijn, M. F., Geissmann, F., et al. (2015) · Nature · doi:10.1038/nature13989 · Cited by 2,339 · see citing works
Self-citationTissue-Resident Macrophage Enhancer Landscapes Are Shaped by the Local Microenvironment
Lavin, Y., Winter, D., Blecher-Gonen, R., David, E., Keren-Shaul, H., Merad, M., Jung, S., & Amit, I. (2014) · Cell · doi:10.1016/j.cell.2014.11.018 · Cited by 2,167 · see citing works
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Rohm, T. V., Meier, D. T., Olefsky, J. M., & Donath, M. Y. (2022) · Immunity · doi:10.1016/j.immuni.2021.12.013 · Cited by 2,066 · see citing works
The microbiome and innate immunity
Thaiss, C. A., Zmora, N., Levy, M., & Elinav, E. (2016) · Nature · doi:10.1038/nature18847 · Cited by 2,012 · see citing works
Tissue-Resident Macrophage Ontogeny and Homeostasis
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Regional specialization within the intestinal immune system
Mowat, A. M., & Agace, W. W. (2014) · Nature reviews. Immunology · doi:10.1038/nri3738 · Cited by 1,769 · see citing works
Self-citationUnderstanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms
Rőszer, T. (2015) · Mediators of Inflammation · doi:10.1155/2015/816460 · Cited by 1,762 · see citing works
Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease
Pickard, J. M., Zeng, M. Y., Caruso, R., & Núñez, G. (2017) · Immunological Reviews · doi:10.1111/imr.12567 · Cited by 1,699 · see citing works
Microglia Biology: One Century of Evolving Concepts
Prinz, M., Jung, S., & Priller, J. (2019) · Cell · doi:10.1016/j.cell.2019.08.053 · Cited by 1,525 · see citing works
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Ruffell, B., & Coussens, L. M. (2015) · Cancer Cell · doi:10.1016/j.ccell.2015.02.015 · Cited by 1,474 · see citing works
Homeostatic Immunity and the Microbiota
Belkaid, Y., & Harrison, O. J. (2017) · Immunity · doi:10.1016/j.immuni.2017.04.008 · Cited by 1,261 · see citing works
The maternal microbiota drives early postnatal innate immune development
Gomez de Agüero, M., Ganal-Vonarburg, S. C., Fuhrer, T., Rupp, S., Uchimura, Y., Li, H., Steinert, A., Heikenwalder, M., Hapfelmeier, S., Sauer, U., et al. (2016) · Science · doi:10.1126/science.aad2571 · Cited by 1,231 · see citing works
Hoeffel, G., Chen, J., Lavin, Y., Low, D., Almeida, F. F., See, P., Beaudin, A. E., Lum, J., Low, I., Forsberg, E. C., et al. (2015) · Immunity · doi:10.1016/j.immuni.2015.03.011 · Cited by 1,135 · see citing works
The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages
Schulthess, J., Pandey, S., Capitani, M., Rue-Albrecht, K. C., Arnold, I., Franchini, F., Chomka, A., Ilott, N. E., Johnston, D. G. W., Pires, E., et al. (2019) · Immunity · doi:10.1016/j.immuni.2018.12.018 · Cited by 1,037 · see citing works
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Cannarile, M. A., Weisser, M., Jacob, W., Jegg, A.-M., Ries, C. H., & Rüttinger, D. (2017) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-017-0257-y · Cited by 1,029 · see citing works
Developmental and Functional Heterogeneity of Monocytes
Guilliams, M., Mildner, A., & Yona, S. (2018) · Immunity · doi:10.1016/j.immuni.2018.10.005 · Cited by 973 · see citing works
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Varol, C., Mildner, A., & Jung, S. (2015) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032414-112220 · Cited by 962 · see citing works
The fate and lifespan of human monocyte subsets in steady state and systemic inflammation
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The role of macrophages in the resolution of inflammation
Watanabe, S., Alexander, M., Misharin, A. V., & Budinger, G. R. S. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124615 · Cited by 925 · see citing works
Monocyte differentiation and antigen-presenting functions
Jakubzick, C. V., Randolph, G. J., & Henson, P. M. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.28 · Cited by 910 · see citing works
Macrophages in intestinal inflammation and resolution: a potential therapeutic target in IBD
Na, Y. R., Stakenborg, M., Seok, S. H., & Matteoli, G. (2019) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-019-0172-4 · Cited by 900 · see citing works
Martin, J. P. D., Chang, C., Boschetti, G., Ungaro, R. C., Giri, M., Grout, J. A., Gettler, K., Chuang, L.-S. F., Nayar, S., Greenstein, A. J., et al. (2019) · Cell · doi:10.1016/j.cell.2019.08.008 · Cited by 866 · see citing works
Bone marrow-derived monocytes give rise to self-renewing and fully differentiated Kupffer cells
Scott, C. L., Zheng, F., De Baetselier, P., Martens, L., Saeys, Y., De Prijck, S., Lippens, S., Abels, C., Schoonooghe, S., Raes, G., et al. (2016) · Nature Communications · doi:10.1038/ncomms10321 · Cited by 860 · see citing works
Self-citationNew insights into the multidimensional concept of macrophage ontogeny, activation and function
Ginhoux, F., Schultze, J. L., Murray, P. J., Ochando, J., & Biswas, S. K. (2015) · Nature Immunology · doi:10.1038/ni.3324 · Cited by 832 · see citing works
Helft, J., Böttcher, J. P., Chakravarty, P., Zelenay, S., Huotari, J., Schraml, B. U., Goubau, D., & Sousa, C. R. E. (2015) · Immunity · doi:10.1016/j.immuni.2015.05.018 · Cited by 818 · see citing works
Tissue residency of innate lymphoid cells in lymphoid and nonlymphoid organs
Gasteiger, G., Fan, X., Dikiy, S., Lee, S. Y., & Rudensky, A. Y. (2015) · Science · doi:10.1126/science.aac9593 · Cited by 813 · see citing works
Zhu, Y., Herndon, J. M., Sojka, D. K., Kim, K.-W., Knolhoff, B. L., Zuo, C., Cullinan, D. R., Luo, J. R., Bearden, A. R., Lavine, K. J., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.014 · Cited by 799 · see citing works
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Perdiguero, E. G., & Geissmann, F. (2015) · Nature Immunology · doi:10.1038/ni.3341 · Cited by 634 · see citing works
Self-citationSchneider, C., Nobs, S. P., Kurrer, M. O., Rehrauer, H., Thiele, C., & Köpf, M. (2014) · Nature Immunology · doi:10.1038/ni.3005 · Cited by 603 · see citing works
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Tissue macrophages: heterogeneity and functions
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Wang, J., Zhu, N., Su, L., Gao, Y., & Yang, R. (2023) · Cells · doi:10.3390/cells12050793 · Cited by 621 · see citing works
Haenseler, W., Sansom, S. N., Buchrieser, J., Newey, S. E., Moore, C. S., Nicholls, F. J., Chintawar, S., Schnell, C., Antel, J. P., Allen, N. D., et al. (2017) · Stem Cell Reports · doi:10.1016/j.stemcr.2017.05.017 · Cited by 593 · see citing works
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Self-Maintaining Gut Macrophages Are Essential for Intestinal Homeostasis
Schepper, S. D., Verheijden, S., Aguilera‐Lizarraga, J., Viola, M. F., Boesmans, W., Stakenborg, N., Voytyuk, I., Schmidt, I., Boeckx, B., de Casterlé, I. D., et al. (2018) · Cell · doi:10.1016/j.cell.2018.07.048 · Cited by 578 · see citing works
Ugel, S., Sanctis, F. D., Mandruzzato, S., & Bronte, V. (2015) · Journal of Clinical Investigation · doi:10.1172/jci80006 · Cited by 563 · see citing works
Guidelines for the use of flow cytometry and cell sorting in immunological studies *
Cossarizza, A., Chang, H., Radbruch, A., Akdiş, M., Andrä, I., Annunziato, F., Bächer, P., Barnaba, V., Battistini, L., Bauer, W. M., et al. (2017) · European Journal of Immunology · doi:10.1002/eji.201646632 · Cited by 572 · see citing works
Physiology and diseases of tissue-resident macrophages
Lazarov, T., Juarez-Carreño, S., Cox, N., & Geissmann, F. (2023) · Nature · doi:10.1038/s41586-023-06002-x · Cited by 540 · see citing works
Self-citationBain, C. C., Hawley, C. A., Garner, H., Scott, C. L., Schridde, A., Steers, N. J., Mack, M., Joshi, A., Guilliams, M., Mowat, A. M. I., et al. (2016) · Nature Communications · doi:10.1038/ncomms11852 · Cited by 527 · see citing works
Self-citationA combination of ontogeny and CNS environment establishes microglial identity
Bennett, F. C., Bennett, M. L., Yaqoob, F., Mulinyawe, S. B., Grant, G. A., Hayden Gephart, M., Plowey, E. D., & Barres, B. A. (2018) · Neuron · doi:10.1016/j.neuron.2018.05.014 · Cited by 524 · see citing works
Mack, M. (2017) · Matrix Biology · doi:10.1016/j.matbio.2017.11.010 · Cited by 516 · see citing works
Establishment and Maintenance of the Macrophage Niche
Guilliams, M., Thierry, G. R., Bonnardel, J., & Bajenoff, M. (2020) · Immunity · doi:10.1016/j.immuni.2020.02.015 · Cited by 512 · see citing works
Determinants of resident tissue macrophage identity and function
Blériot, C., Chakarov, S., & Ginhoux, F. (2020) · Immunity · doi:10.1016/j.immuni.2020.05.014 · Cited by 507 · see citing works
Most Tissue-Resident Macrophages Except Microglia Are Derived from Fetal Hematopoietic Stem Cells
Sheng, J., Ruedl, C., & Karjalainen, K. (2015) · Immunity · doi:10.1016/j.immuni.2015.07.016 · Cited by 482 · see citing works
Three Unique Interstitial Macrophages in the Murine Lung at Steady State
Gibbings, S. L., Thomas, S. M., Atif, S. M., McCubbrey, A. L., Desch, A. N., Danhorn, T., Leach, S. M., Bratton, D. L., Henson, P. M., Janssen, W. J., et al. (2017) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2016-0361oc · Cited by 476 · see citing works
Monocyte trafficking across the vessel wall
Gerhardt, T., & Ley, K. F. (2015) · Cardiovascular Research · doi:10.1093/cvr/cvv147 · Cited by 473 · see citing works
Tumor‐associated macrophages in liver cancer: From mechanisms to therapy
Cheng, K., Cai, N., Zhu, J.-H., Yang, X., Liang, H.-F., & Zhang, W.-G. (2022) · Cancer Communications · doi:10.1002/cac2.12345 · Cited by 447 · see citing works
Seidman, J. S., Troutman, T. D., Sakai, M., Gola, A., Spann, N. J., Bennett, H., Bruni, C. M., Ouyang, Z., Li, R. Z., Sun, X., et al. (2020) · Immunity · doi:10.1016/j.immuni.2020.04.001 · Cited by 443 · see citing works
Macrophages and lipid metabolism
Remmerie, A., & Scott, C. L. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.020 · Cited by 385 · see citing works
Self-citationSpatiotemporal immune zonation of the human kidney
Stewart, B. J., Ferdinand, J. R., Young, M. D., Mitchell, T. J., Loudon, K. W., Riding, A., Richoz, N., Frazer, G. L., Staniforth, J., Braga, F. A. V., et al. (2019) · Science · doi:10.1126/science.aat5031 · Cited by 416 · see citing works
Macrophages: The Good, the Bad, and the Gluttony
Ross, E. A., Devitt, A., & Johnson, J. R. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.708186 · Cited by 436 · see citing works
Gut Microbiota-Derived Tryptophan Metabolites Maintain Gut and Systemic Homeostasis
Su, X., Gao, Y., & Yang, R. (2022) · Cells · doi:10.3390/cells11152296 · Cited by 424 · see citing works
The roles of tumor-associated macrophages in tumor angiogenesis and metastasis.
Fu, L., Du, W.-L., Cai, M.-H., Yao, J.-Y., Zhao, Y.-Y., & Mou, X.-Z. (2020) · Cellular Immunology · doi:10.1016/j.cellimm.2020.104119 · Cited by 380 · see citing works
Amit, I., Winter, D. R., & Jung, S. (2015) · Nature Immunology · doi:10.1038/ni.3325 · Cited by 406 · see citing works
Does niche competition determine the origin of tissue-resident macrophages?
Guilliams, M., & Scott, C. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2017.42 · Cited by 409 · see citing works
Self-citationFetal monocytes and the origins of tissue-resident macrophages
Hoeffel, G., & Ginhoux, F. (2018) · Cellular Immunology · doi:10.1016/j.cellimm.2018.01.001 · Cited by 393 · see citing works
Tissue-resident macrophages in the intestine are long lived and defined by Tim-4 and CD4 expression
Shaw, T. N., Houston, S. A., Wemyss, K., Bridgeman, H. M., Barbera, T. A., Zangerle-Murray, T., Strangward, P., Ridley, A. J. L., Wang, P., Tamoutounour, S., et al. (2018) · The Journal of Experimental Medicine · doi:10.1084/jem.20180019 · Cited by 382 · see citing works
Rojo, R., Raper, A., Ozdemir, D. D., Lefèvre, L., Grabert, K., Wollscheid-Lengeling, E., Bradford, B. M., Caruso, M., Gažová, I., Sánchez, A., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11053-8 · Cited by 372 · see citing works
Aryl hydrocarbon receptor Controls Monocyte Differentiation into dendritic Cells versus Macrophages
Goudot, C., Coillard, A., Villani, A.-C., Gueguen, P., Cros, A., Sarkizova, S., Tang-Huau, T.-L., Bohec, M., Baulande, S., Hacohen, N., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.08.016 · Cited by 382 · see citing works
Tumor macrophages are pivotal constructors of tumor collagenous matrix
Afik, R., Zigmond, E., Vugman, M., Klepfish, M., Shimshoni, E., Pasmanik‐Chor, M., Shenoy, A., Bassat, E., Halpern, Z., Geiger, T., et al. (2016) · The Journal of Experimental Medicine · doi:10.1084/jem.20151193 · Cited by 376 · see citing works
Martin, K. E., & Garcı́a, A. J. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.03.038 · Cited by 375 · see citing works
Ensan, S., Li, A., Besla, R., Degousee, N., Cosme, J., Roufaiel, M., Shikatani, E. A., El-Maklizi, M., Williams, J. W., Robins, L., et al. (2016) · Nature Immunology · doi:10.1038/ni.3343 · Cited by 372 · see citing works
Kumar, V., Cheng, P., Condamine, T., Mony, S., Languino, L. R., McCaffrey, J. C., Hockstein, N., Guarino, M., Masters, G., Penman, E., et al. (2016) · Immunity · doi:10.1016/j.immuni.2016.01.014 · Cited by 371 · see citing works
Macrophage biology in the peripheral nervous system after injury
Zigmond, R. E., & Echevarría, F. D. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.001 · Cited by 369 · see citing works
Macrophages in intestinal homeostasis and inflammatory bowel disease
Hegarty, L. M., Jones, G., & Bain, C. C. (2023) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-023-00769-0 · Cited by 371 · see citing works
Self-citationOntogeny of Tissue-Resident Macrophages
Hoeffel, G., & Ginhoux, F. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00486 · Cited by 364 · see citing works
Islet inflammation in type 2 diabetes and physiology
Eguchi, K., & Nagai, R. (2017) · Journal of Clinical Investigation · doi:10.1172/jci88877 · Cited by 359 · see citing works
Origin, Differentiation, and Function of Intestinal Macrophages
Bain, C. C., & Schridde, A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02733 · Cited by 348 · see citing works
Self-citationTissue‐resident macrophages: then and now
Davies, L. C., & Taylor, P. R. (2015) · Immunology · doi:10.1111/imm.12451 · Cited by 333 · see citing works
Scott, N. A., Andrusaite, A., Andersen, P., Lawson, M., Alcon-Giner, C., Leclaire, C., Caim, S., Le Gall, G., Shaw, T., Connolly, J. P. R., et al. (2018) · Science Translational Medicine · doi:10.1126/scitranslmed.aao4755 · Cited by 336 · see citing works
Self-citationÇatalkaya, G., Venema, K., Lucini, L., Rocchetti, G., Delmas, D., Daglia, M., Filippis, A. D., Xiao, H., Quiles, J. L., Xiao, J., et al. (2020) · Food Frontiers · doi:10.1002/fft2.25 · Cited by 339 · see citing works
NF-κB in monocytes and macrophages – an inflammatory master regulator in multitalented immune cells
Mußbacher, M., Derler, M., Basílio, J., & Schmid, J. A. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1134661 · Cited by 326 · see citing works
CCL2/CCR2 signaling in cancer pathogenesis
Hao, Q., Vadgama, J. V., & Wang, P. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00589-8 · Cited by 318 · see citing works
Epigenetic regulation of macrophages: from homeostasis maintenance to host defense
Chen, S., Yang, J., Wei, Y., & Wei, X. (2019) · Cellular and Molecular Immunology · doi:10.1038/s41423-019-0315-0 · Cited by 317 · see citing works
The pancreas anatomy conditions the origin and properties of resident macrophages
Calderon, B., Carrero, J. A., Ferris, S. T., Sojka, D. K., Moore, L., Epelman, S., Murphy, K. M., Yokoyama, W. M., Randolph, G. J., & Unanue, E. R. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20150496 · Cited by 308 · see citing works
Doloff, J. C., Omid Veiseh, A., de Mezerville, R., Sforza, M., Perry, T. A., Haupt, J. L., Jamiel, M., Chambers, C., Nash, A., Aghlara-Fotovat, S., et al. (2021) · Nature Biomedical Engineering · doi:10.1038/s41551-021-00739-4 · Cited by 305 · see citing works
Imprinting of the immune system by the microbiota early in life
Al Nabhani, Z., & Eberl, G. (2020) · Mucosal Immunology · doi:10.1038/s41385-020-0257-y · Cited by 301 · see citing works
Macrophages as Key Drivers of Cancer Progression and Metastasis
Nielsen, S. R., & Schmid, M. C. (2017) · Mediators of Inflammation · doi:10.1155/2017/9624760 · Cited by 281 · see citing works
Yolk sac macrophage progenitors traffic to the embryo during defined stages of development
Stremmel, C., Schuchert, R., Wagner, F., Thaler, R., Weinberger, T., Pick, R., Mass, E., Ishikawa-Ankerhold, H. C., Margraf, A., Hutter, S., et al. (2018) · Nature Communications · doi:10.1038/s41467-017-02492-2 · Cited by 290 · see citing works
Self-citationMacrophages: The Road Less Traveled, Changing Anticancer Therapy
Guerriero, J. L. (2018) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2018.03.006 · Cited by 293 · see citing works
The Transcription Factor ZEB2 Is Required to Maintain the Tissue-Specific Identities of Macrophages
Scott, C. L., T’Jonck, W., Martens, L., Todorov, H., Sichien, D., Soen, B., Bonnardel, J., Prijck, S. D., Vandamme, N., Cannoodt, R., et al. (2018) · Immunity · doi:10.1016/j.immuni.2018.07.004 · Cited by 287 · see citing works
Self-citationUral, B. B., Yeung, S. T., Damani‐Yokota, P., Devlin, J. C., de Vries, M., Vera‐Licona, P., Samji, T., Sawai, C. M., Jang, G., Perez, O. A., et al. (2020) · Science Immunology · doi:10.1126/sciimmunol.aax8756 · Cited by 281 · see citing works
Tissue macrophage identity and self‐renewal
Gentek, R., Molawi, K., & Sieweke, M. H. (2014) · Immunological Reviews · doi:10.1111/imr.12224 · Cited by 277 · see citing works
The impact of ageing on monocytes and macrophages
De Maeyer, R. P. H., & Chambers, E. S. (2021) · Immunology Letters · doi:10.1016/j.imlet.2020.12.003 · Cited by 275 · see citing works
Microglia Versus Myeloid Cell Nomenclature during Brain Inflammation
Greter, M., Lelios, I., & Croxford, A. L. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00249 · Cited by 273 · see citing works
Innate immune cell-epithelial crosstalk during wound repair.
Brazil, J., Quirós, M., Nusrat, A., & Parkos, C. (2019) · Journal of Clinical Investigation · doi:10.1172/jci124618 · Cited by 225 · see citing works
The Mononuclear Phagocyte System: The Relationship between Monocytes and Macrophages
Hume, D. A., Irvine, K. M., & Pridans, C. (2018) · Trends in Immunology · doi:10.1016/j.it.2018.11.007 · Cited by 262 · see citing works
Targeting GM-CSF in inflammatory diseases
Wicks, I. P., & Roberts, A. W. (2015) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2015.161 · Cited by 261 · see citing works
Lee, M., Lee, Y., Song, J., Lee, J., & Chang, S.-Y. (2018) · Immune Network · doi:10.4110/in.2018.18.e5 · Cited by 260 · see citing works
Sierro, F., Evrard, M., Rizzetto, S., Melino, M., Mitchell, A. J., Flórido, M., Beattie, L., Walters, S. B., Tay, S. S., Lü, B., et al. (2017) · Immunity · doi:10.1016/j.immuni.2017.07.018 · Cited by 256 · see citing works
Lund, H., Pieber, M., Parsa, R., Han, J., Grommisch, D., Ewing, E., Kular, L., Needhamsen, M., Espinosa, A., Nilsson, E., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-07295-7 · Cited by 249 · see citing works
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis
Castro-Dopico, T., Dennison, T. W., Ferdinand, J. R., Mathews, R. J., Fleming, A., Clift, D., Stewart, B. J., Jing, C., Strongili, K., Labzin, L. I., et al. (2019) · Immunity · doi:10.1016/j.immuni.2019.02.006 · Cited by 248 · see citing works
- Authors
- Bain, C. C., Bravo-Blas, A., Scott, C. L., Gomez Perdiguero, E., Geissmann, F., Henri, S., Malissen, B., Osborne, L. C., Artis, D., & Mowat, A. M.
- Affiliations
- University of Glasgow (GB)
- Centre National de la Recherche Scientifique (FR)
- University of Pennsylvania (US)
- Corresponding author
- Mowat, Allan McI
- ORCID
- Venue
- Nature Immunology
- Published
- 2014-08-24
- Volume
- 15
- Issue
- 10
- Pages
- 929-937
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC4169290
- OpenAlex
- W1977536320
- Cited by
- 1,178
- References
- 44
- Citations by year
- 2026: 79 · 2025: 80 · 2024: 98 · 2023: 97 · 2022: 106 · 2021: 104 · 2020: 116 · 2019: 94 · 2018: 118 · 2017: 111 · 2016: 81 · 2015: 71 · 2014: 8 · 2012: 1
- FWCI
- 41.29
- Type
- journal article
- Language
- en
- Update notices
- erratum (2014-10-20)
- Open access
- bronze
- doi.org
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- ENLIGHTEN (Jurnal Bimbingan dan Konseling Islam) (submittedVersion)
- Research Portal (King's College London) (submittedVersion, other-oa)
- Funders
- Wellcome Trust (094763, 101853, 089892)
- Tenovus
- University of Glasgow
- Medical Research Council
- National Institute of Allergy and Infectious Diseases (R01AI097333)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
- Life Sciences › Immunology and Microbiology › Immunology › Phagocytosis and Immune Regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Keywords
- intestinal macrophages, circulating monocytes, CCR2, Ly6Chi monocytes, microbiota, weaning, macrophage homeostasis, anti-inflammatory macrophages, bone marrow-derived macrophages, fate mapping, parabiosis, bone marrow chimeras
- MeSH terms
- CX3C Chemokine Receptor 1, Animals, Animals, Newborn, Antigens, Differentiation, Antigens, Ly, Cell Differentiation, Flow Cytometry, Intestinal Mucosa, Intestines, Macrophages, Mice, Inbred C57BL, Mice, Transgenic, Monocytes, Parabiosis, Time Factors, Gene Expression, Bone Marrow Transplantation, Mice, Knockout, Models, Immunological, Receptors, Chemokine, Reverse Transcriptase Polymerase Chain Reaction, CD11b Antigen, Cell Proliferation, Receptors, CCR2
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