The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
Integrated, Multi-cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses
Open accessAbstract
Respiratory viral infections are a significant burden to healthcare worldwide. Many whole genome expression profiles have identified different respiratory viral infection signatures, but these have not translated to clinical practice. Here, we performed two integrated, multi-cohort analyses of publicly available transcriptional data of viral infections. First, we identified a common host signature across different respiratory viral infections that could distinguish (a) individuals with viral infections from healthy controls and from those with bacterial infections, and (b) symptomatic from asymptomatic subjects prior to symptom onset in challenge studies. Second, we identified an influenza-specific host response signature that (a) could distinguish influenza-infected samples from those with bacterial and other respiratory viral infections, (b) was a diagnostic and prognostic marker in influenza-pneumonia patients and influenza challenge studies, and (c) was predictive of response to influenza vaccine. Our results have applications in the diagnosis, prognosis, and identification of drug targets in viral infections.
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Individual Comparisons by Ranking Methods
Wilcoxon, F. (1945) · Biometrics Bulletin · doi:10.2307/3001968 · Cited by 15,354
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Tarca, A. L., Draghici, S., Khatri, P., Hassan, S. S., Mittal, P., Kim, J.-S., Kim, C. J., Kusanovic, J. P., & Romero, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btn577 · Cited by 1,031
Self-citationMejias, A., Dimo, B., Suarez, N. M., Garcia, C., Suarez-Arrabal, M. C., Jartti, T., Blankenship, D., Jordan-Villegas, A., Ardura, M. I., Xu, Z., et al. (2013) · PLoS Medicine · doi:10.1371/journal.pmed.1001549 · Cited by 313
Moreno-García, M. E., López-Bojórques, L. N., Zentella, A., Humphries, L. A., Rawlings, D. J., & Santos-Argumedo, L. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.2687 · Cited by 54
Cited by
Bhattacharya, S., Dunn, P., Thomas, C. G., Smith, B., Schaefer, H., Chen, J., Hu, Z., Zalocusky, K. A., Shankar, R. D., Shen-Orr, S. S., et al. (2018) · Scientific Data · doi:10.1038/sdata.2018.15 · Cited by 786
Brodin, P., & Davis, M. M. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2016.125 · Cited by 730
Genome-wide expression for diagnosis of pulmonary tuberculosis: a multicohort analysis
Sweeney, T. E., Braviak, L., Tato, C. M., & Khatri, P. (2016) · The Lancet Respiratory Medicine · doi:10.1016/s2213-2600(16)00048-5 · Cited by 445
Self-citationSingle-cell chromatin modification profiling reveals increased epigenetic variations with aging
Cheung, P., Vallania, F., Warsinske, H. C., Donato, M., Schaffert, S., Chang, S. E., Dvorak, M., Dekker, C. L., Davis, M. M., Utz, P. J., et al. (2018) · Cell · doi:10.1016/j.cell.2018.03.079 · Cited by 323
Self-citationSweeney, T. E., Wong, H. R., & Khatri, P. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf7165 · Cited by 334
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Metadata
- Authors
- Andres-Terre, M., McGuire, H. M., Pouliot, Y., Bongen, E., Sweeney, T. E., Tato, C. M., & Khatri, P.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2015-12
- Volume
- 43
- Issue
- 6
- Pages
- 1199-1211
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2218326748
- Cited by
- 175
- References
- 4
- FWCI
- 13.53
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Andres-Terre, M., McGuire, H. M., Pouliot, Y., Bongen, E., Sweeney, T. E., Tato, C. M., & Khatri, P. (2015). Integrated, Multi-cohort Analysis Identifies Conserved Transcriptional Signatures across Multiple Respiratory Viruses. Immunity. https://doi.org/10.1016/j.immuni.2015.11.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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