The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.
RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4
Open accessAbstract
Summary Macrophages are a crucial component of the innate immune system in sensing pathogens and promoting local and systemic inflammation. RIPK1 and RIPK3 are homologous kinases, previously linked to activation of necroptotic death. In this study we have described roles for these kinases as master regulators of pro-inflammatory gene expression induced by lipopolysaccharide, independent of their well-documented cell death functions. In primary macrophages, this regulation was elicited in the absence of caspase-8 activity, required the adaptor molecule TRIF, and proceeded in a cell autonomous manner. RIPK1 and RIPK3 kinases promoted sustained activation of Erk, cFos and NFκB, which were required for inflammatory changes. Utilizing genetic and pharmacologic tools, we showed that RIPK1 and RIPK3 account for acute inflammatory responses induced by lipopolysaccharide in vivo; notably, this regulation did not require exogenous manipulation of caspases. These findings identified a new pharmacologically accessible pathway that may be relevant to inflammatory pathologies.
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Cites
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Necroptosis and its role in inflammation
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Self-citationRIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis
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Catalytic activity of the caspase-8–FLIPL complex inhibits RIPK3-dependent necrosis
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Cited by
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling
Ciesielska, A., Matyjek, M., & Kwiatkowska, K. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03656-y · Cited by 1,420
Necroptosis in development, inflammation and disease
Weinlich, R., Oberst, A., Beere, H. M., & Green, D. R. (2017) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.149 · Cited by 1,016
Regulated necrosis in kidney ischemia-reperfusion injury
Pefanis, A., Ierino, F. L., Murphy, J. M., & Cowan, P. J. (2019) · Kidney International · doi:10.1016/j.kint.2019.02.009 · Cited by 361
Molecular mechanisms of necroptosis and relevance for neurodegenerative diseases.
(2020) · International Review of Cell and Molecular Biology · doi:10.1016/bs.ircmb.2019.12.006 · Cited by 51
Metadata
- Authors
- Najjar, M., Saleh, D., Zelic, M., Nogusa, S., Shah, S., Tai, A., Finger, J. N., Polykratis, A., Gough, P. J., Bertin, J., Whalen, M. J., Pasparakis, M., Balachandran, S., Kelliher, M., Poltorak, A., & Degterev, A.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-07
- Volume
- 45
- Issue
- 1
- Pages
- 46-59
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2467178923
- Cited by
- 284
- References
- 59
- FWCI
- 15.65
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Najjar, M., Saleh, D., Zelic, M., Nogusa, S., Shah, S., Tai, A., Finger, J. N., Polykratis, A., Gough, P. J., Bertin, J., Whalen, M. J., Pasparakis, M., Balachandran, S., Kelliher, M., Poltorak, A., & Degterev, A. (2016). RIPK1 and RIPK3 Kinases Promote Cell-Death-Independent Inflammation by Toll-like Receptor 4. Immunity. https://doi.org/10.1016/j.immuni.2016.06.007
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