The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.
Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection
Open accessAbstract
Summary Extensive metabolic changes accompany T cell activation including a switch to glycolytic energy production and increased biosynthesis. Recent studies suggest that subsequent return to reliance on oxidative phosphorylation and increasing spare respiratory capacity are essential for the differentiation of memory CD8+ T cells. In contrast, we found that constitutive glycolytic metabolism and suppression of oxidative phosphorylation in CD8+ T cells, achieved by conditional deletion of hypoxia inducible factor regulator Vhl, accelerated CD8+ memory cell differentiation during viral infection. Despite sustained glycolysis, CD8+ memory cells emerged that upregulated key memory-associated cytokine receptors and transcription factors, and showed a heightened response to secondary challenge. In addition, increased glycolysis not only permitted memory formation, but it also favored the formation of long-lived effector-memory CD8+ T cells. These data redefine the role of cellular metabolism in memory cell differentiation, showing that reliance on glycolytic metabolism does not hinder formation of a protective memory population.
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The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation
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“These data correlated well with recent reports that demonstrate the importance of glycolytic metabolism in CD8 T cell effector function (Chang et al., 2013; Kidani et al., 2013; Sukumar et al., 2013; Wang et al., 2011) and may support the sustained effector capacity of VhldLck-cre CD8 T cells following chronic viral i…”
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Control of TH17/Treg Balance by Hypoxia-Inducible Factor 1
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mTOR regulates memory CD8 T-cell differentiation
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Enhancing CD8 T-cell memory by modulating fatty acid metabolism
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Fueling Immunity: Insights into Metabolism and Lymphocyte Function
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Metabolic Regulation of T Lymphocytes
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Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
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Mills, E. L., Kelly, B., & O'Neill, L. A. J. (2017) · Nature Immunology · doi:10.1038/ni.3704 · Cited by 1,161
Satpathy, A. T., Granja, J. M., Yost, K. E., Qi, Y., Meschi, F., McDermott, G. P., Olsen, B. N., Mumbach, M. R., Pierce, S. E., Corces, M. R., et al. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0206-z · Cited by 980
Scharping, N. E., Rivadeneira, D. B., Menk, A. V., Vignali, P. D. A., Ford, B. R., Rittenhouse, N. L., Peralta, R., Wang, Y., Wang, Y., DePeaux, K., et al. (2021) · Nature Immunology · doi:10.1038/s41590-020-00834-9 · Cited by 897
Metabolism of immune cells in cancer
Leone, R. D., & Powell, J. D. (2020) · Nature Reviews Cancer · doi:10.1038/s41568-020-0273-y · Cited by 877
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Metadata
- Authors
- Phan, A. T., Doedens, A. L., Palazon, A., Tyrakis, P. A., Cheung, K. P., Johnson, R. S., & Goldrath, A. W.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2016-11
- Volume
- 45
- Issue
- 5
- Pages
- 1024-1037
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2554003937
- Cited by
- 208
- References
- 17
- FWCI
- 10.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Phan, A. T., Doedens, A. L., Palazon, A., Tyrakis, P. A., Cheung, K. P., Johnson, R. S., & Goldrath, A. W. (2016). Constitutive Glycolytic Metabolism Supports CD8+ T Cell Effector Memory Differentiation during Viral Infection. Immunity. https://doi.org/10.1016/j.immuni.2016.10.017
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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