Cited by 650Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismImmune cells in cancer

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Monocyte-Macrophages and T Cells in Atherosclerosis

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Tabas, Ira, Lichtman, Andrew H.·2017·Immunity

DOI 10.1016/j.immuni.2017.09.008PMC PMC5747297

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Abstract

Atherosclerosis is an arterial disease process characterized by the focal subendothelial accumulation of apolipoprotein-B-containing lipoproteins, immune and vascular wall cells, and extracellular matrix. The lipoproteins acquire features of damage-associated molecular patterns and trigger first an innate immune response, dominated by monocyte-macrophages, and then an adaptive immune response. These inflammatory responses often become chronic and non-resolving and can lead to arterial damage and thrombosis-induced organ infarction. The innate immune response is regulated at various stages, from hematopoiesis to monocyte changes and macrophage activation. The adaptive immune response is regulated primarily by mechanisms that affect the balance between regulatory and effector T cells. Mechanisms related to cellular cholesterol, phenotypic plasticity, metabolism, and aging play key roles in affecting these responses. Herein, we review select topics that shed light on these processes and suggest new treatment strategies.

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Authors: Tabas, I., & Lichtman, A. H.
Affiliations: Columbia University Irving Medical Center (US)
Brigham and Women's Hospital (US)
Corresponding author: Tabas, Ira
Lichtman, Andrew H.
ORCID: Tabas, Ira
Lichtman, Andrew H.
Venue: Immunity
Publisher: Elsevier BV
Published: 2017-10
Volume: 47
Issue: 4
Pages: 621-634
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2017.09.008
PMC: PMC5747297
OpenAlex: W2766451938
Cited by: 646
References: 155
Citations by year: 2026: 53 · 2025: 57 · 2024: 72 · 2023: 65 · 2022: 86 · 2021: 102 · 2020: 80 · 2019: 78 · 2018: 49 · 2017: 4
FWCI: 6.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 381 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (R01 HL132412, HL127464, HL075662, P01 HL087123, R01 HL087282, HL131862)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: atherosclerosis, monocytes/macrophages, T cells, innate immune response, adaptive immune response, damage-associated molecular patterns, apolipoprotein B-containing lipoproteins, macrophage activation, regulatory T cells, effector T cells, chronic inflammation, thrombosis, hematopoiesis, cholesterol, phenotypic plasticity, aging, atherosclerosis treatment
MeSH terms: Animals, Humans, Immunity, Innate, Lipoproteins, Macrophages, Monocytes, T-Lymphocytes, Models, Immunological, Atherosclerosis, Adaptive Immunity

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