Cited by 650Atherosclerosis and Cardiovascular DiseasesCholesterol and Lipid MetabolismImmune cells in cancer

The DOI matches its Crossref record; 152 of the 155 references it cites were found in a registry or an index.

Monocyte-Macrophages and T Cells in Atherosclerosis

Open access

Tabas, Ira, Lichtman, Andrew H.·2017·Immunity

DOI 10.1016/j.immuni.2017.09.008PMC PMC5747297

Open this paper in CoChat — free account Open PDF

Abstract

Atherosclerosis is an arterial disease process characterized by the focal subendothelial accumulation of apolipoprotein-B-containing lipoproteins, immune and vascular wall cells, and extracellular matrix. The lipoproteins acquire features of damage-associated molecular patterns and trigger first an innate immune response, dominated by monocyte-macrophages, and then an adaptive immune response. These inflammatory responses often become chronic and non-resolving and can lead to arterial damage and thrombosis-induced organ infarction. The innate immune response is regulated at various stages, from hematopoiesis to monocyte changes and macrophage activation. The adaptive immune response is regulated primarily by mechanisms that affect the balance between regulatory and effector T cells. Mechanisms related to cellular cholesterol, phenotypic plasticity, metabolism, and aging play key roles in affecting these responses. Herein, we review select topics that shed light on these processes and suggest new treatment strategies.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.immuni.2017.09.008

Cites

152 of 152 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
Ridker, P. M., Everett, B. M., Thuren, T., MacFadyen, J. G., Chang, W. H., Ballantyne, C., Fonseca, F., Nicolau, J., Koenig, W., Anker, S. D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1707914 · Cited by 9,482
Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease
Wang, Z., Klipfell, E., Bennett, B. J., Koeth, R., Levison, B. S., DuGar, B., Feldstein, A. E., Britt, E. B., Fu, X., Chung, Y.-M., et al. (2011) · Nature · doi:10.1038/nature09922 · Cited by 5,597
Atherosclerosis
Lusis, A. J. (2000) · Nature · doi:10.1038/35025203 · Cited by 4,880
Age-related clonal hematopoiesis associated with adverse outcomes
Jaiswal, S., Fontanillas, P., Flannick, J., Manning, A., Grauman, P. V., Mar, B. G., Lindsley, R. C., Mermel, C. H., Burtt, N., Chavez, A., et al. (2014) · New England Journal of Medicine · doi:10.1056/nejmoa1408617 · Cited by 4,841
Cytokine-mediated regulation of CXCR4 expression in human neutrophils
Nagase, H., Miyamasu, M., Yamaguchi, M., Imanishi, M., Tsuno, N. H., Matsushima, K., Yamamoto, K., Morita, Y., & Hirai, K. (2002) · Journal of Leukocyte Biology · doi:10.1189/jlb.71.4.711 · Cited by 4,713
NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals
Duewell, P., Kono, H., Rayner, K. J., Sirois, C. M., Vladimer, G., Bauernfeind, F. G., Abela, G. S., Franchi, L., Nuñez, G., Schnurr, M., et al. (2010) · Nature · doi:10.1038/nature08938 · Cited by 4,026 · cited 1×
“Although cholesterol crystals have been implicated in this process (Duewell et al., 2010; Sheedy et al., 2013), other mechanisms are likely to contribute as well (Hoseini et al., 2017).”
Atherosclerosis
Glass, C. K., & Witztum, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00238-0 · Cited by 3,094
Trained immunity: A program of innate immune memory in health and– disease
Netea, M. G., Joosten, L. A. B., Latz, E., Mills, K. H. G., Natoli, G., Stunnenberg, H. G., O’Neill, L. A. J., & Xavier, R. J. (2016) · Science · doi:10.1126/science.aaf1098 · Cited by 2,768
Clonal hematopoiesis and risk of atherosclerotic cardiovascular disease
Jaiswal, S., Natarajan, P., Silver, A. J., Gibson, C. J., Bick, A. G., Shvartz, E., McConkey, M., Gupta, N., Gabriel, S., Ardissino, D., et al. (2017) · New England Journal of Medicine · doi:10.1056/nejmoa1701719 · Cited by 2,683
Arterial and Cardiac Aging: Major Shareholders in Cardiovascular Disease Enterprises: Part I: Aging Arteries: A “Set Up” for Vascular Disease
Lakatta, E. G., & Levy, D. (2003) · Circulation · doi:10.1161/01.cir.0000048892.83521.58 · Cited by 2,244

Show all 155 references

Sorted by citations

2019 ESC/EAS Guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz455 · Cited by 8,961
2019 ESC/EAS guidelines for the management of dyslipidaemias: lipid modification to reduce cardiovascular risk
Mach, F., Baigent, C., Catapano, A. L., Koskinas, K. C., Casula, M., Badimon, L., Chapman, M. J., De Backer, G. G., Delgado, V., Ference, B. A., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.08.014 · Cited by 4,854
Diversity, Mechanisms, and Significance of Macrophage Plasticity
Locati, M., Curtale, G., & Mantovani, A. (2020) · Annual Review of Pathology: Mechanisms of Disease · doi:10.1146/annurev-pathmechdis-012418-012718 · Cited by 2,199
Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel
Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz962 · Cited by 1,601
IFNγ: signalling, epigenetics and roles in immunity, metabolism, disease and cancer immunotherapy
Ivashkiv, L. B. (2018) · Nature reviews. Immunology · doi:10.1038/s41577-018-0029-z · Cited by 1,418
Single-cell immune landscape of human atherosclerotic plaques
Fernandez, D. M., Rahman, A. H., Fernandez, N. F., Chudnovskiy, A., Amir, E.-A. D., Amadori, L., Khan, N. S., Wong, C. K., Shamailova, R., Hill, C. A., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0590-4 · Cited by 970
Treatment of atherosclerosis by macrophage-biomimetic nanoparticles via targeted pharmacotherapy and sequestration of proinflammatory cytokines
Cheng, G., Huang, Q., Liu, C., Kwong, C. H. T., Yue, L., Wan, J., Lee, S. M., & Wang, R. (2020) · Nature Communications · doi:10.1038/s41467-020-16439-7 · Cited by 635
Targeting Early Atherosclerosis: A Focus on Oxidative Stress and Inflammation
Marchio, P., Guerra‐Ojeda, S., Vila, J. M., Aldasoro, M., Víctor, V. M., & Mauricio, M. D. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/8563845 · Cited by 651
How the immune system shapes atherosclerosis: roles of innate and adaptive immunity
Roy, P., Orecchioni, M., & Ley, K. F. (2021) · Nature reviews. Immunology · doi:10.1038/s41577-021-00584-1 · Cited by 610
Regulation of macrophage immunometabolism in atherosclerosis
Koelwyn, G. J., Corr, E. M., Erbay, E., & Moore, K. J. (2018) · Nature Immunology · doi:10.1038/s41590-018-0113-3 · Cited by 569
Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury
Yurdagul, A., Subramanian, M., Wang, X., Crown, S. B., Ilkayeva, O. R., Darville, L., Kolluru, G. K., Rymond, C. C., Gerlach, B. D., Zheng, Z., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.01.001 · Cited by 525
Self-citation
Inflammation and cardiovascular disease: From mechanisms to therapeutics
Alfaddagh, A., Martin, S. S., Leucker, T. M., Michos, E. D., Blaha, M. J., Lowenstein, C. J., Jones, S. R., & Toth, P. P. (2020) · American Journal of Preventive Cardiology · doi:10.1016/j.ajpc.2020.100130 · Cited by 473
Therapeutic strategies targeting inflammation and immunity in atherosclerosis: how to proceed?
Engelen, S. E., Robinson, A., Zurke, Y.-X., & Monaco, C. G. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00668-4 · Cited by 455
The integration of inflammaging in age-related diseases
Fülöp, T., Witkowski, J. M., Olivieri, F., & Larbi, A. (2018) · Seminars in Immunology · doi:10.1016/j.smim.2018.09.003 · Cited by 368
Systemic Inflammation and Cardiovascular Comorbidity in Psoriasis Patients: Causes and Consequences
Boehncke, W. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00579 · Cited by 314
Mechanisms of ATP Release by Inflammatory Cells
Dosch, M., Gerber, J. L., Jebbawi, F., & Beldi, G. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19041222 · Cited by 284
Anti‐inflammatory therapies in myocardial infarction: failures, hopes and challenges
Huang, S., & Frangogiannis, N. G. (2018) · British Journal of Pharmacology · doi:10.1111/bph.14155 · Cited by 283
The relationship between nutrition and the immune system
Munteanu, C., & Schwartz, B. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.1082500 · Cited by 346
Apolipoproteins in vascular biology and atherosclerotic disease
Mehta, A., & Shapiro, M. D. (2022) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00613-5 · Cited by 273
Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases
Dela Cruz, C. S., & Kang, M.-J. (2018) · Mitochondrion · doi:10.1016/j.mito.2017.12.001 · Cited by 255
Age-Associated Mitochondrial Dysfunction Accelerates Atherogenesis
Tyrrell, D. J., Blin, M. G., Song, J., Wood, S. C., Zhang, M., Beard, D. A., & Goldstein, D. R. (2019) · Circulation Research · doi:10.1161/circresaha.119.315644 · Cited by 230
RIPK1 Expression Associates With Inflammation in Early Atherosclerosis in Humans and Can Be Therapeutically Silenced to Reduce NF-κB Activation and Atherogenesis in Mice
Karunakaran, D., Nguyen, M.-A., Geoffrion, M., Vreeken, D., Lister, Z., Cheng, H. S., Otte, N., Essebier, P., Wyatt, H., Kandiah, J. W., et al. (2020) · Circulation · doi:10.1161/circulationaha.118.038379 · Cited by 220
The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactionsPreprint
Fehr, A. R., Singh, S. A., Kerr, C. M., Mukai, S., Higashi, H., & Aikawa, M. (2020) · Genes & Development · doi:10.1101/gad.334425.119 · Cited by 220
Cysteine protease cathepsins in cardiovascular disease: from basic research to clinical trials
Liu, C.-L., Guo, J., Zhang, X., Sukhova, G. K., Libby, P., & Shi, G. (2018) · Nature Reviews Cardiology · doi:10.1038/s41569-018-0002-3 · Cited by 216
Impact of Cholesterol Metabolism in Immune Cell Function and Atherosclerosis
Aguilar-Ballester, M., Herrero-Cervera, A., Vinué, Á., Martínez‐Hervás, S., & Navarro, H. G. (2020) · Nutrients · doi:10.3390/nu12072021 · Cited by 216
LncRNA MIAT sponges miR-149-5p to inhibit efferocytosis in advanced atherosclerosis through CD47 upregulation
Ye, Z.-M., Yang, S., Xia, Y., Hu, R., Chen, S., Li, B., Chen, S.-L., Luo, X., Mao, L., Li, Y., et al. (2019) · Cell Death and Disease · doi:10.1038/s41419-019-1409-4 · Cited by 209
Bile acid coordinates microbiota homeostasis and systemic immunometabolism in cardiometabolic diseases
Guan, B., Tong, J., Hao, H., Yang, Z., Chen, K., Xu, H., & Wang, A. (2021) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2021.12.011 · Cited by 215
Adipokines, adiposity, and atherosclerosis
Liu, L., Shi, Z., Ji, X., Zhang, W., Luan, J., Zahr, T., & Qiang, L. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04286-2 · Cited by 191
Inflammation Resolution: Implications for Atherosclerosis
Doran, A. C. (2022) · Circulation Research · doi:10.1161/circresaha.121.319822 · Cited by 181
Neutrophil counts and cardiovascular disease
Luo, J. M., Thomassen, J. Q., Nordestgaard, B. G., Tybjærg‐Hansen, A., & Frikke‐Schmidt, R. (2023) · European Heart Journal · doi:10.1093/eurheartj/ehad649 · Cited by 183
Potential of anti-inflammatory agents for treatment of atherosclerosis
Chistiakov, D. A., Melnichenko, A. А., Grechko, A. V., Myasoedova, V. A., & Orekhov, A. N. (2018) · Experimental and Molecular Pathology · doi:10.1016/j.yexmp.2018.01.008 · Cited by 169
Foam Cells: One Size Doesn’t Fit All
Guerrini, V., & Gennaro, M. L. (2019) · Trends in Immunology · doi:10.1016/j.it.2019.10.002 · Cited by 164
Single-nucleus chromatin accessibility profiling highlights regulatory mechanisms of coronary artery disease risk
Turner, A. W., Hu, S. S., Mosquera, J. V., Feng, W., Hodonsky, C. J., Wong, D., Auguste, G. E., Song, Y., Sol‐Church, K., Farber, E., et al. (2022) · Nature Genetics · doi:10.1038/s41588-022-01069-0 · Cited by 152
The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair
Kusnadi, A., Park, S. H., Yuan, R., Pannellini, T., Giannopoulou, E., Oliver, D., Lu, T., Park-Min, K.-H., & Ivashkiv, L. B. (2019) · Immunity · doi:10.1016/j.immuni.2019.06.005 · Cited by 157
Monocyte-endothelial cell interactions in vascular and tissue remodeling
Medrano-Bosch, M., Simón-Codina, B., Jiménez, W., Edelman, E. R., & Melgar‐Lesmes, P. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1196033 · Cited by 168
Infection and atherosclerosis: TLR-dependent pathways
Li, B., Xia, Y., & Hu, B. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03453-7 · Cited by 149
Identification of circular RNA Hsa_circ_0001879 and Hsa_circ_0004104 as novel biomarkers for coronary artery disease
Wang, L., Shen, C., Wang, Y., Zou, T., Zhu, H., Lu, X., Li, L., Yang, B., Chen, J., Chen, S., et al. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.05.006 · Cited by 143
Heterogeneity of immune cells in human atherosclerosis revealed by scRNA-Seq
Vallejo, J., Cochain, C., Zernecke, A., & Ley, K. F. (2021) · Cardiovascular Research · doi:10.1093/cvr/cvab260 · Cited by 143
Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway✰
Lian, G., Li, X., Zhang, L., Zhang, Y., Sun, L., Zhang, X., Liu, H., Pang, Y., Kong, W., Zhang, T., et al. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.09.041 · Cited by 139
Immune and inflammatory mechanisms of abdominal aortic aneurysm
Márquez-Sánchez, A. C., & Koltsova, E. K. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.989933 · Cited by 143
Inflammation in HIV and Its Impact on Atherosclerotic Cardiovascular Disease
Obare, L. M., Temu, T. M., Mallal, S. A., & Wanjalla, C. N. (2024) · Circulation Research · doi:10.1161/circresaha.124.323891 · Cited by 150
Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis
Pham, L. M., Kim, E.-C., Ou, W., Phung, C. D., Nguyen, T. T., Pham, T. T., Poudel, K., Gautam, M., Nguyen, H. T., Jeong, J., et al. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.120677 · Cited by 136
A bibliometric analysis of T cell and atherosclerosis
Wei, N., Xu, Y., Li, Y., Shi, J., Zhang, X., You, Y., Sun, Q., Zhai, H., & Hu, Y. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.948314 · Cited by 141
PCSK9 inhibition and inflammation: A narrative review
Ruscica, M., Tokgözoğlu, L. S., Corsini, A., & Sirtori, C. R. (2019) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2019.07.015 · Cited by 133
Major vault protein suppresses obesity and atherosclerosis through inhibiting IKK–NF-κB signaling mediated inflammation
Ben, J., Jiang, B., Wang, D., Liu, Q., Zhang, Y., Qi, Y., Tong, X., Chen, L., Liu, X., Zhang, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-09588-x · Cited by 127
The Crossroads of the Coagulation System and the Immune System: Interactions and Connections
Wilhelm, G., Mertowska, P., Mertowski, S., Przysucha, A., Strużyna, J., Grywalska, E., & Torres, K. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241612563 · Cited by 138
Immune cell profiling in atherosclerosis: role in research and precision medicine
Fernandez, D. M., & Giannarelli, C. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00589-2 · Cited by 126
Therapeutic potentials and mechanisms of the Chinese traditional medicine Danshensu
Zhang, J., Zhang, Q., Liu, G., & Zhang, N. (2019) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2019.172710 · Cited by 123
Type-I interferons in atherosclerosis
Chen, H., Tas, S. W., & de Winther, M. P. J. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190459 · Cited by 124
High-Dimensional Single-Cell Multimodal Landscape of Human Carotid Atherosclerosis
Bashore, A. C., Yan, H., Xue, C., Zhu, L. Y., Kim, E., Mawson, T. L., Coronel, J., Chung, A. Y., Sachs, N., Ho, S., et al. (2024) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.123.320524 · Cited by 123
DNA methyltransferase 3 alpha and TET methylcytosine dioxygenase 2 restrain mitochondrial DNA-mediated interferon signaling in macrophages
Cobo, I., Tanaka, T. N., Mangalhara, K. C., Lana, A. J., Yeang, C., Han, C. Z., Schlachetzki, J. C. M., Challcombe, J., Fixsen, B. R., Sakai, M., et al. (2022) · Immunity · doi:10.1016/j.immuni.2022.06.022 · Cited by 117
GDF15 as a biomarker of ageing
Liu, H., Huang, Y., Lyu, Y., Dai, W., Tong, Y., & Li, Y. (2021) · Experimental Gerontology · doi:10.1016/j.exger.2021.111228 · Cited by 118
Melatonin stabilizes rupture‐prone vulnerable plaques via regulating macrophage polarization in a nuclear circadian receptor RORα‐dependent manner
Ding, S. Z., Lin, N., Sheng, X., Zhao, Y., Su, Y., Xu, L., Tong, R., Yang, Y., Fu, Y., He, J., et al. (2019) · Journal of Pineal Research · doi:10.1111/jpi.12581 · Cited by 113
Arteriosclerosis e inflamación. Nuevos enfoques terapéuticos
Pedro‐Botet, J., Climent, E., & Benaiges, D. (2020) · Medicina Clínica · doi:10.1016/j.medcli.2020.04.024 · Cited by 114
Modulating Plaque Inflammation via Targeted mRNA Nanoparticles for the Treatment of Atherosclerosis
Gao, M., Tang, M., Ho, W., Teng, Y., Chen, Q., Bu, L., Xu, X., & Zhang, X. (2023) · ACS Nano · doi:10.1021/acsnano.3c00958 · Cited by 108
Lactate and lactylation in cardiovascular diseases: current progress and future perspectives
Zhu, W., Guo, S., Sun, J., Zhao, Y., & Liu, C. (2024) · Metabolism · doi:10.1016/j.metabol.2024.155957 · Cited by 111
Prosaposin mediates inflammation in atherosclerosis
van Leent, M. M. T., Beldman, T. J., Toner, Y. C., Lameijer, M., Rother, N., Bekkering, S., Teunissen, A. J. P., Zhou, X., van der Meel, R., Malkus, J., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abe1433 · Cited by 108
Notch Signaling Regulates Immune Responses in Atherosclerosis
Sega, F. V. D., Fortini, F., Aquila, G., Campo, G. C., Vaccarezza, M., & Rizzo, P. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01130 · Cited by 102
The Effects of Porphyromonas gingivalis on Atherosclerosis-Related Cells
Zhang, J., Xie, M., Huang, X., Chen, G., Yin, Y., Lu, X., Feng, G., Yu, R., & Chen, L. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.766560 · Cited by 108
Human species-specific loss of CMP- N -acetylneuraminic acid hydroxylase enhances atherosclerosis via intrinsic and extrinsic mechanisms
Kawanishi, K., Dhar, C., Do, R., Varki, N., Gordts, P. L. S. M., & Varki, A. (2019) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1902902116 · Cited by 94
Single-cell T cell receptor sequencing of paired human atherosclerotic plaques and blood reveals autoimmune-like features of expanded effector T cells
Depuydt, M. A. C., Schaftenaar, F. H., Prange, K. H. M., Boltjes, A., Hemme, E., Delfos, L., de Mol, J., de Jong, M. J. M., Kleijn, M. N. A. B., Peeters, J. A. H. M., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-022-00208-4 · Cited by 105
Lipid Metabolism and Cancer Immunotherapy: Immunosuppressive Myeloid Cells at the Crossroad
Bleve, A., Durante, B., Sica, A., & Consonni, F. M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165845 · Cited by 101
B Cells in Atherosclerosis
Pattarabanjird, T., Li, C., & McNamara, C. A. (2021) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2021.01.006 · Cited by 99
The Interplay of Lipids, Lipoproteins, and Immunity in Atherosclerosis
Pirillo, A., Bonacina, F., Norata, G. D., & Catapano, A. L. (2018) · Current Atherosclerosis Reports · doi:10.1007/s11883-018-0715-0 · Cited by 97
Phytosterols and Inflammation
Vilahur, G., Ben‐Aicha, S., Diaz-Riera, E., Badimón, L., & Padró, T. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867325666180622151438 · Cited by 96
Ratiometric Semiconducting Polymer Nanoparticle for Reliable Photoacoustic Imaging of Pneumonia-Induced Vulnerable Atherosclerotic Plaque in Vivo
Ma, Y., Xu, L. J., Yin, B., Shang, J., Chen, F., Xu, J., Song, Z., Nan, B., Song, G., & Zhang, X. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c01359 · Cited by 97
A Non‐Invasive Nanoprobe for In Vivo Photoacoustic Imaging of Vulnerable Atherosclerotic Plaque
Ge, X., Cui, H., Kong, J., Lu, S., Zhan, R., Gao, J., Xu, Y., Lin, S., Meng, K., Zu, L., et al. (2020) · Advanced Materials · doi:10.1002/adma.202000037 · Cited by 93
Glucose metabolism controls disease-specific signatures of macrophage effector functions
Watanabe, R., Hilhorst, M. L., Zhang, H., Zeisbrich, M., Berry, G. J., Wallis, B. B., Harrison, D. G., Giacomini, J. C., Goronzy, J. J., & Weyand, C. M. (2018) · JCI Insight · doi:10.1172/jci.insight.123047 · Cited by 91
The role of interferon-γ in cardiovascular disease: an update
Elyasi, A., Voloshyna, I., Ahmed, S., Kasselman, L. J., Behbodikhah, J., Leon, J. D., & Reiss, A. B. (2020) · Inflammation Research · doi:10.1007/s00011-020-01382-6 · Cited by 84
Intercepting the Lipid-Induced Integrated Stress Response Reduces Atherosclerosis
Onat, U. İ., Yıldırım, A., Tufanlı, Ö., Çimen, İ., Kocatürk, B., Veli, Z., Hamid, S. M., Shimada, K., Chen, S., Sin, J., et al. (2019) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2018.12.055 · Cited by 84
Disorder of Coagulation-Fibrinolysis System: An Emerging Toxicity of Anti-PD-1/PD-L1 Monoclonal Antibodies
Sato, R., Imamura, K., Sakata, S., Ikeda, T., Horio, Y., Iyama, S., Akaike, K., Hamada, S., Jodai, T., Nakashima, K., et al. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8060762 · Cited by 88
Apolipoprotein E in Cardiometabolic and Neurological Health and Diseases
Alagarsamy, J., Jaeschke, A., & Hui, D. Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23179892 · Cited by 86
Pairing of single-cell RNA analysis and T cell antigen receptor profiling indicates breakdown of T cell tolerance checkpoints in atherosclerosis
Wang, Z., Zhang, X., Lu, S., Zhang, C., Ma, Z., Su, R. J., Li, Y., Sun, T., Li, Y., Hong, M., et al. (2023) · Nature Cardiovascular Research · doi:10.1038/s44161-023-00218-w · Cited by 87
Clonal hematopoiesis driven by DNMT3A and TET2 mutations: role in monocyte and macrophage biology and atherosclerotic cardiovascular disease
Cobo, I., Tanaka, T. N., Glass, C. K., & Yeang, C. (2021) · Current Opinion in Hematology · doi:10.1097/moh.0000000000000688 · Cited by 90
Monocytes present age-related changes in phospholipid concentration and decreased energy metabolism
Saare, M., Tserel, L., Haljasmägi, L., Taalberg, E., Peet, N., Eimre, M., Vetik, R., Kingo, K., Saks, K., Tamm, R., et al. (2020) · Aging Cell · doi:10.1111/acel.13127 · Cited by 79
Anionic 1,2-distearoyl-sn-glycero-3-phosphoglycerol (DSPG) liposomes induce antigen-specific regulatory T cells and prevent atherosclerosis in mice
Benne, N., van Duijn, J., Vigario, F. L., Leboux, R., van Veelen, P. A., Kuiper, J., Jiskoot, W., & Slütter, B. (2018) · Journal of Controlled Release · doi:10.1016/j.jconrel.2018.10.028 · Cited by 82
Self-oxygenation mesoporous MnO2 nanoparticles with ultra-high drug loading capacity for targeted arteriosclerosis therapy
Sun, W., Xu, Y., Yao, Y., Yue, J., Wu, Z., Li, H., Shen, G., Liao, Y., Wang, H., & Zhou, W. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01296-x · Cited by 81
An apoptotic body-biomimic liposome in situ upregulates anti-inflammatory macrophages for stabilization of atherosclerotic plaques
Wu, Y., Zhang, Y., Dai, L., Wang, Q., Xue, L., Su, Z., & Zhang, C. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.10.043 · Cited by 78
Platelets in Thrombosis and Atherosclerosis
Bravo, G. M., Annarapu, G. K., Carmona, E., Nawarskas, J. J., Clark, R. M., Novelli, E. M., & Mota, R. I. (2024) · American Journal Of Pathology · doi:10.1016/j.ajpath.2024.05.010 · Cited by 92
Modified Lipoproteins Induce Arterial Wall Inflammation During Atherogenesis
Lorey, M. B., Öörni, K., & Kovanen, P. T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.841545 · Cited by 82
Clonal hematopoiesis related TET2 loss-of-function impedes IL1β-mediated epigenetic reprogramming in hematopoietic stem and progenitor cells
McClatchy, J., Strogantsev, R., Wolfe, E., Lin, H., Mohammadhosseini, M., Davis, B. A., Eden, C. O., Goldman, D., Fleming, W., Conley, P., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-43697-y · Cited by 86
Senescent cells suppress innate smooth muscle cell repair functions in atherosclerosis
Childs, B. G., Zhang, C., Shuja, F., Sturmlechner, I., Trewartha, S., Velasco, R. F., Baker, D. J., Li, H., & van Deursen, J. M. (2021) · Nature Aging · doi:10.1038/s43587-021-00089-5 · Cited by 76
Innate and adaptive immunity in cardiovascular calcification
Passos, L. S. A., Lupieri, A., BECKER-GREENE, D. R., & Aïkawa, E. (2020) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2020.02.016 · Cited by 77
Pharmacological targets of metabolism in disease: Opportunities from macrophages
Castegna, A., Gissi, R., Menga, A., Montopoli, M., Favia, M., Viola, A., & Canton, M. (2020) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2020.107521 · Cited by 75
Heat shock proteins and cardiovascular disease
Rodríguez‐Iturbe, B., & Johnson, R. (2018) · Physiology International · doi:10.1556/2060.105.2018.1.4 · Cited by 76
Single systemic transfer of a human gene associated with exceptional longevity halts the progression of atherosclerosis and inflammation in ApoE knockout mice through a CXCR4-mediated mechanism
Puca, A. A., Carrizzo, A., Spinelli, C., Damato, A., Ambrosio, M., Villa, F., Ferrario, A., Maciag, A. E., Fornai, F., Lenzi, P., et al. (2019) · European Heart Journal · doi:10.1093/eurheartj/ehz459 · Cited by 75
Apoptotic endothelial cells release small extracellular vesicles loaded with immunostimulatory viral-like RNAs
Hardy, M., Audemard, E. O., Migneault, F., Feghaly, A., Brochu, S., Gendron, P., Boilard, É., Major, F., Dieudé, M., Hébert, M., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-43591-y · Cited by 75
The role of β-carotene and vitamin A in atherogenesis: Evidences from preclinical and clinical studies
Miller, A. P., Coronel, J., & Amengual, J. (2020) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2020.158635 · Cited by 72
Mast Cells as Potential Accelerators of Human Atherosclerosis—From Early to Late Lesions
Kovanen, P. T. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184479 · Cited by 73
Rapamycin: A Bacteria-Derived Immunosuppressant That Has Anti-atherosclerotic Effects and Its Clinical Application
Liu, Y., Yang, F., Zou, S., & Qu, L. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2018.01520 · Cited by 69
Differential Effects of Depleting versus Programming Tumor-Associated Macrophages on Engineered T Cells in Pancreatic Ductal Adenocarcinoma
Stromnes, I. M., Burrack, A. L., Hulbert, A., Bonson, P., Black, C., Brockenbrough, J. S., Raynor, J. F., Spartz, E. J., Pierce, R. H., Greenberg, P. D., et al. (2019) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0448 · Cited by 67
Inflammation, Oxidative Stress, Senescence in Atherosclerosis: Thioredoxine-1 as an Emerging Therapeutic Target
Hadri, K. E., Smith, R., Duplus, E., & Amri, C. E. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms23010077 · Cited by 71
Moyamoya Disease Susceptibility Gene RNF213 Regulates Endothelial Barrier Function
Roy, V., Ross, J. P., Pépin, R., Ghio, S. C., Brodeur, A., Deschênes, L. T., Le‐Bel, G., Phillips, D. E., Milot, G., Dion, P. A., et al. (2022) · Stroke · doi:10.1161/strokeaha.120.032691 · Cited by 68
Reducing residual cardiovascular risk in Europe: Therapeutic implications of European medicines agency approval of icosapent ethyl/eicosapentaenoic acid
Chapman, M. J., Zamorano, J. L., & Parhofer, K. G. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108172 · Cited by 69
Recent advances in targeted stimuli-responsive nano-based drug delivery systems combating atherosclerosis
Song, Y., Jing, H., Vong, L. B., Wang, J., & Li, N. (2021) · Chinese Chemical Letters · doi:10.1016/j.cclet.2021.10.055 · Cited by 66
Macrophages regulate vascular smooth muscle cell function during atherosclerosis progression through IL-1β/STAT3 signaling
Xue, Y., Luo, M., Hu, X., Li, X., Shen, J., Zhu, W., Huang, L., Hu, Y., Guo, Y., Liu, L., et al. (2022) · Communications Biology · doi:10.1038/s42003-022-04255-2 · Cited by 69
Porphyromonas gingivalis regulates atherosclerosis through an immune pathway
Ruan, Q., Guan, P., Qi, W., Li, J., Xi, M., Xiao, L., Zhong, S., Ma, D., & Ni, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1103592 · Cited by 72
Immune checkpoint inhibition alters the inflammatory cell composition of human coronary artery atherosclerosis
Newman, J. L., & Stone, J. R. (2019) · Cardiovascular Pathology · doi:10.1016/j.carpath.2019.107148 · Cited by 66
Effects of fatty acids on T cell function: role in atherosclerosis
Reilly, N. A., Lutgens, E., Kuiper, J., Heijmans, B. T., & Jukema, J. W. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00582-9 · Cited by 65
Anti-dsDNA Antibodies Increase the Cardiovascular Risk in Systemic Lupus Erythematosus Promoting a Distinctive Immune and Vascular Activation
Patiño-Trives, A. M., Pérez-Sánchez, C., Pérez‐Sánchez, L., Luque-Tévar, M., Ábalos‐Aguilera, M. C., Alcaide‐Ruggiero, L., de la Rosa, I. A., Román-Rodríguez, C., Segui, P., Espinosa, M., et al. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.121.315928 · Cited by 64

Authors: Tabas, I., & Lichtman, A. H.
Affiliations: Columbia University Irving Medical Center (US)
Brigham and Women's Hospital (US)
Corresponding author: Tabas, Ira
Lichtman, Andrew H.
ORCID: Tabas, Ira
Lichtman, Andrew H.
Venue: Immunity
Publisher: Elsevier BV
Published: 2017-10
Volume: 47
Issue: 4
Pages: 621-634
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2017.09.008
PMC: PMC5747297
OpenAlex: W2766451938
Cited by: 646
References: 155
Citations by year: 2026: 53 · 2025: 57 · 2024: 72 · 2023: 65 · 2022: 86 · 2021: 102 · 2020: 80 · 2019: 78 · 2018: 49 · 2017: 4
FWCI: 6.01
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 381 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: NIH (R01 HL132412, HL127464, HL075662, P01 HL087123, R01 HL087282, HL131862)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Cholesterol and Lipid Metabolism
Life Sciences › Immunology and Microbiology › Immunology › Immune cells in cancer
Keywords: atherosclerosis, monocytes/macrophages, T cells, innate immune response, adaptive immune response, damage-associated molecular patterns, apolipoprotein B-containing lipoproteins, macrophage activation, regulatory T cells, effector T cells, chronic inflammation, thrombosis, hematopoiesis, cholesterol, phenotypic plasticity, aging, atherosclerosis treatment
MeSH terms: Animals, Humans, Immunity, Innate, Lipoproteins, Macrophages, Monocytes, T-Lymphocytes, Models, Immunological, Atherosclerosis, Adaptive Immunity

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Monocyte-Macrophages and T Cells in Atherosclerosis

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks