The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
CCR7 Chemokine Receptor-Inducible lnc-Dpf3 Restrains Dendritic Cell Migration by Inhibiting HIF-1α-Mediated Glycolysis
Open accessAbstract
&NA; CCR7 chemokine receptor stimulation induces rapid but transient dendritic cell (DC) migration toward draining lymph nodes, which is critical for the initiation of protective immunity and maintenance of immune homeostasis. The mechanisms for terminating CCR7‐mediated DC migration remain incompletely understood. Here we have identified a long non‐coding RNA lnc‐Dpf3 whose feedback restrained CCR7‐mediated DC migration. CCR7 stimulation upregulated lnc‐Dpf3 via removing N6‐methyladenosine (m6A) modification to prevent RNA degradation. DC‐specific lnc‐Dpf3 deficiency increased CCR7‐mediated DC migration, leading to exaggerated adaptive immune responses and inflammatory injuries. Mechanistically, CCR7 stimulation activated the HIF‐1&agr; transcription factor pathway in DCs, leading to metabolic reprogramming toward glycolysis for DC migration. lnc‐Dpf3 directly bound to HIF‐1&agr; and suppressed HIF‐1&agr;‐dependent transcription of the glycolytic gene Ldha, thus inhibiting DC glycolytic metabolism and migratory capacity. We demonstrate a critical role for CCR7‐inducible lnc‐Dpf3 in coupling epigenetic and metabolic pathways to feedback‐control DC migration and inflammatory responses. Graphical Abstract Figure. No caption available. Highlightslnc‐Dpf3 feedback restrains CCR7‐induced DC migration and inflammatory responseCCR7 stimulation upregulates lnc‐Dpf3 via m6A demethylation to prevent its degradationlnc‐Dpf3 suppresses DC migration via inhibiting HIF1&agr;‐dependent glycolysislnc‐Dpf3 directly binds to HIF1&agr; and inhibits HIF1&agr; activity via an HRE motif
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Cites
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Self-citationDynamic RNA Modifications in Gene Expression Regulation
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HIF-1α is essential for myeloid cell-mediated inflammation
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Cited by
The role of HIF in immunity and inflammation
McGettrick, A. F., & O’Neill, L. A. J. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.08.002 · Cited by 768
Dendritic cell migration in inflammation and immunity
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Self-citationMettl3-mediated mRNA m6A methylation promotes dendritic cell activation
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Self-citationLong non-coding RNAs: From disease code to drug role
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Metadata
- Authors
- Liu, J., Zhang, X., Chen, K., Cheng, Y., Liu, S., Xia, M., Chen, Y., Zhu, H., Li, Z., & Cao, X.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 50
- Issue
- 3
- Pages
- 600-615.e15
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2915534090
- Cited by
- 351
- References
- 53
- FWCI
- 12.97
- Type
- journal article
- Language
- en
- Open access
- bronze
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