The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Dendritic cell migration in inflammation and immunity
Open accessAbstract
Dendritic cells (DCs) are the key link between innate immunity and adaptive immunity and play crucial roles in both the promotion of immune defense and the maintenance of immune tolerance. The trafficking of distinct DC subsets across lymphoid and nonlymphoid tissues is essential for DC-dependent activation and regulation of inflammation and immunity. DC chemotaxis and migration are triggered by interactions between chemokines and their receptors and regulated by multiple intracellular mechanisms, such as protein modification, epigenetic reprogramming, metabolic remodeling, and cytoskeletal rearrangement, in a tissue-specific manner. Dysregulation of DC migration may lead to abnormal positioning or activation of DCs, resulting in an imbalance of immune responses and even immune pathologies, including autoimmune responses, infectious diseases, allergic diseases and tumors. New strategies targeting the migration of distinct DC subsets are being explored for the treatment of inflammatory and infectious diseases and the development of novel DC-based vaccines. In this review, we will discuss the migratory routes and immunological consequences of distinct DC subsets, the molecular basis and regulatory mechanisms of migratory signaling in DCs, and the association of DC migration with the pathogenesis of autoimmune and infectious diseases.
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Cites
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Cited by
NF-κB in inflammation and cancer
Mao, H., Zhao, X., & Sun, S.-C. (2025) · Cellular & Molecular Immunology · doi:10.1038/s41423-025-01310-w · Cited by 489
The monocytic cell line THP-1 as a validated and robust surrogate model for human dendritic cells
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Zhao, F., He, Y., Zhao, Z., He, J., Huang, H., Ai, K., Liu, L., & Cai, X. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1272133 · Cited by 42
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Metadata
- Authors
- Liu, J., Zhang, X., Cheng, Y., & Cao, X.
- Venue
- Cellular & Molecular Immunology
- Published
- 2021-07-23
- Volume
- 18
- Issue
- 11
- Pages
- 2461-2471
- ISSN
- 1672-7681 (ISSN-L)
- 2042-0226
- OpenAlex
- W3186513334
- Cited by
- 537
- References
- 149
- FWCI
- 21.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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