The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.
Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis
Open accessAbstract
SUMMARY Inflammasome activation and subsequent pyroptosis are critical defense mechanisms against microbes. However, overactivation of inflammasome leads to death of the host. While recent studies have uncovered the mechanism of pyroptosis following inflammasome activation, how pyroptotic cell death drives pathogenesis eventually leading to death of the host is unknown. Here we identified inflammasome activation as a trigger for blood clotting through pyroptosis. We have shown that canonical inflammasome activation by the conserved type III secretion system (T3SS) rod proteins from Gram-negative bacteria or noncanonical inflammasome activation by lipopolysaccharide (LPS) induced systemic blood clotting and massive thrombosis in tissues. Following inflammasome activation, pyroptotic macrophages released tissue factor (TF), an essential initiator of coagulation cascades. Genetic or pharmacological inhibition of TF abolished inflammasome-mediated blood clotting and protects against death. Our data reveal that blood clotting is the major cause of host death following inflammasome activation and demonstrate that inflammasome bridges inflammation with thrombosis.
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Cites
Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death
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Self-citationInflammasome-activated gasdermin D causes pyroptosis by forming membrane pores
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Cited by
Interplay between inflammation and thrombosis in cardiovascular pathology
Stark, K., & Massberg, S. (2021) · Nature Reviews Cardiology · doi:10.1038/s41569-021-00552-1 · Cited by 1,033
Pyroptosis-Induced Inflammation and Tissue Damage
Vasudevan, S. O., Behl, B., & Rathinam, V. A. (2023) · Seminars in Immunology · doi:10.1016/j.smim.2023.101781 · Cited by 412
Inflammasome activation at the crux of severe COVID-19
Vora, S. M., Lieberman, J., & Wu, H. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00588-x · Cited by 325
Immunopathophysiology of human sepsis
Wiersinga, W. J., & van der Poll, T. (2022) · eBioMedicine · doi:10.1016/j.ebiom.2022.104363 · Cited by 322
The role of lipopolysaccharide-induced cell signalling in chronic inflammation
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Metadata
- Authors
- Wu, C., Lu, W., Zhang, Y., Zhang, G., Shi, X., Hisada, Y., Grover, S. P., Zhang, X., Li, L., Xiang, B., Shi, J., Li, X.-A., Daugherty, A., Smyth, S. S., Kirchhofer, D., Shiroishi, T., Shao, F., Mackman, N., Wei, Y., & Li, Z.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2019-06
- Volume
- 50
- Issue
- 6
- Pages
- 1401-1411.e4
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2944725083
- Cited by
- 417
- References
- 61
- FWCI
- 12.82
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wu, C., Lu, W., Zhang, Y., Zhang, G., Shi, X., Hisada, Y., Grover, S. P., Zhang, X., Li, L., Xiang, B., Shi, J., Li, X.-A., Daugherty, A., Smyth, S. S., Kirchhofer, D., Shiroishi, T., Shao, F., Mackman, N., Wei, Y., & Li, Z. (2019). Inflammasome Activation Triggers Blood Clotting and Host Death through Pyroptosis. Immunity. https://doi.org/10.1016/j.immuni.2019.04.003
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