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Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β
Open accessAbstract
Pathogenic lymphocytes initiate the development of chronic inflammatory diseases. The cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) (encoded by Csf2) is a key communicator between pathogenic lymphocytes and tissue-invading inflammatory phagocytes. However, the molecular properties of GM-CSF-producing cells and the mode of Csf2 regulation in vivo remain unclear. To systematically study and manipulate GM-CSF+ cells and their progeny in vivo, we generated a fate-map and reporter of GM-CSF expression mouse strain (FROG). We mapped the phenotypic and functional profile of auto-aggressive T helper (Th) cells during neuroinflammation and identified the signature and pathogenic memory of a discrete encephalitogenic Th subset. These cells required interleukin-23 receptor (IL-23R) and IL-1R but not IL-6R signaling for their maintenance and pathogenicity. Specific ablation of this subset interrupted the inflammatory cascade, despite the unperturbed tissue accumulation of other Th subsets (e.g., Th1 and Th17), highlighting that GM-CSF expression not only marks pathogenic Th cells, but that this subset mediates immunopathology and tissue destruction.
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Trimmomatic: a flexible trimmer for Illumina sequence data
Bolger, A. M., Lohse, M., & Usadel, B. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btu170 · Cited by 65,548
Fast gapped-read alignment with Bowtie 2
Langmead, B., & Salzberg, S. L. (2012) · Nature Methods · doi:10.1038/nmeth.1923 · Cited by 56,400
(2008) · Journal of Machine Learning Research · Cited by 33,051
ggplot2: Elegant Graphics for Data Analysis
Ginestet, C. E. (2011) · Journal of the Royal Statistical Society Series A (Statistics in Society) · doi:10.1111/j.1467-985x.2010.00676_9.x · Cited by 14,511
ggplot2: Elegant Graphics for Data Analysis
Wickham, H. (2009) · doi:10.1007/978-0-387-98141-3 · Cited by 14,447
A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
Buenrostro, J. D., Giresi, P. G., Zaba, L. C., Chang, H. Y., & Greenleaf, W. J. (2013) · Nature Methods · doi:10.1038/nmeth.2688 · Cited by 6,422
IL-23 drives a pathogenic T cell population that induces autoimmune inflammation
Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., Sedgwick, J. D., McClanahan, T., Kastelein, R. A., & Cua, D. J. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041257 · Cited by 4,099
Veldhoen, M., Hocking, R. J., Atkins, C. J., Locksley, R. M., & Stockinger, B. (2006) · Immunity · doi:10.1016/j.immuni.2006.01.001 · Cited by 3,605
Liao, Y., Smyth, G. K., & Shi, W. (2019) · Nucleic Acids Research · doi:10.1093/nar/gkz114 · Cited by 2,927
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Items 101–200 of 202
Neuroinflammation at single cell level: What is new?
Brandão, W. N., de Oliveira, M. G., Andreoni, R., Nakaya, H. I., Farias, A. S., & Peron, J. P. S. (2020) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr0620-035r · Cited by 14
Hassan, A., Wlodarczyk, M. F., Benamar, M., Bassot, E., Salvioni, A., Kassem, S., Berry, A., Saoudi, A., & Blanchard, N. (2020) · mBio · doi:10.1128/mbio.03394-19 · Cited by 14
Dendritic Cells as a Nexus for the Development of Multiple Sclerosis and Models of Disease
Alakhras, N. S., & Kaplan, M. H. (2023) · Advanced Biology · doi:10.1002/adbi.202300073 · Cited by 16
Mononuclear phagocytes in autoimmune neuroinflammation
Gogoleva, V. S., Mundt, S., Feo, D. D., & Becher, B. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.08.005 · Cited by 13
Self-citationHasegawa, H., Mizoguchi, I., Orii, N., Inoué, S., Katahira, Y., Yoneto, T., Xu, M., Miyazaki, T., & Yoshimoto, T. (2021) · Scientific Reports · doi:10.1038/s41598-021-84624-9 · Cited by 12
Natural killer cells in multiple sclerosis: foe or friends?
Aghaee, F., Abedinpour, M., Anvari, S., Saberi, A., Fallah, A., & Bakhshi, A. (2025) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2025.1500770 · Cited by 11
Safavi, F., Thomé, R., Li, Z.-C., Zhang, G.-X., & Rostami, A. (2020) · Neurology: Neuroimmunology & Neuroinflammation · doi:10.1212/nxi.0000000000000729 · Cited by 11
Pinteaux, E., Abdulaal, W. H., Mufazalov, I. A., Humphreys, N. E., Jackson, M. S., Francis, S., Müller, W., & Waisman, A. (2020) · Journal of Molecular Medicine · doi:10.1007/s00109-020-01928-5 · Cited by 11
Self-citationAram, J., Frakich, N., Morandi, E., Alrouji, M., Samaraweera, A. P. R., Onion, D., Spendlove, I., Colombo, S., Tanasescu, R., Gran, B., et al. (2020) · Biomedicines · doi:10.3390/biomedicines8070226 · Cited by 9
Casale, G. P., Thompson, J. R., Carpenter, L. C., Kim, J. S., Lackner, T. J., Mietus, C. J., Ha, D. M., Myers, S. A., Brunette, K. E., Li, S., et al. (2020) · Translational research · doi:10.1016/j.trsl.2020.08.008 · Cited by 11
Transcription Factor RUNX3 Mediates Plasticity of ThGM Cells Toward Th1 Phenotype
Rasouli, J., Casella, G., Zhang, W., Xiao, D., Kumar, G., Fortina, P. M., Zhang, G., Ćirić, B., & Rostami, A. M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.912583 · Cited by 12
Rewiring immune suppression in NSCLC: Roles and plasticity of Tregs and Th17 cells
Zhu, S., Zhou, N., Li, Q., & Liu, X. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1658848 · Cited by 10
Thymosin β4 Alleviates Autoimmune Dacryoadenitis via Suppressing Th17 Cell Response
Zhao, X., Li, N., Yang, N., Mi, B., Dang, W., Sun, D., Ma, S., Nian, H., & Wei, R. (2023) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.64.11.3 · Cited by 10
Kerdiles, T., Lejeune, S., Portais, A., Bourgeois, G., Lefèvre, B., Charmillon, A., Sixt, T., Moretto, F., Cornille, C., Vidal, M., et al. (2024) · Open Forum Infectious Diseases · doi:10.1093/ofid/ofae269 · Cited by 10
A T H 17-intrinsic IL-1β–STAT5 axis drives steroid resistance in autoimmune neuroinflammation
Miller-Little, W. A., Chen, X., Salazar, V., Liu, C., Bulek, K., Zhou, J. Y., Xiao, L., Stüve, O., Stappenbeck, T. S., Dubyak, G., et al. (2024) · Science Immunology · doi:10.1126/sciimmunol.abq1558 · Cited by 10
Sawabe, A., Okazaki, S., Nakamura, A., Goitsuka, R., & Kaifu, T. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae009 · Cited by 9
Meitei, H. T., Kulkarni, N., Shirolkar, A. R., Rapole, S., Sharma, P., Mujeeb, V. R., Srivastava, S., & Lal, G. (2025) · iScience · doi:10.1016/j.isci.2025.114385 · Cited by 8
Wójcik, M., Zieba, D. A., Tomczyk, M., Bochenek, J., Antushevich, H., Krawczyńska, A., & Herman, A. P. (2023) · Journal of Animal and Feed Sciences · doi:10.22358/jafs/175380/2023 · Cited by 9
Li, J., Mao, N., Wang, Y., Deng, S., & Chen, K. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.11.011 · Cited by 9
Trumet, L., Grötsch, B., Agaimy, A., Galler, K. M., Geppert, C. E., Winter, L., Ries, J., Kesting, M. R., & Weber, M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1569490 · Cited by 8
Cook, M. E., Shchukina, I., Lin, C., Bradstreet, T. R., Schwarzkopf, E. A., Jarjour, N. N., Webber, A. M., Zaitsev, K., Artyomov, M. N., & Edelson, B. T. (2023) · ImmunoHorizons · doi:10.4049/immunohorizons.2300042 · Cited by 7
An immunopathogenic perspective of interleukin-1 signaling
Lin, X., Twelkmeyer, T., Wang, S., Xu, R., Wang, F., Zhang, C., & Tang, H. (2020) · Cellular and Molecular Immunology · doi:10.1038/s41423-020-0475-y · Cited by 8
A T cell-intrinsic function for NF-κB RelB in experimental autoimmune encephalomyelitis
Lalle, G., Lautraite, R., Voisin, A., Twardowski, J., Stéphan, P., Perrin-Niquet, M., Igalouzene, R., Soudja, S. M., Marie, J. C., Vocanson, M., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-99134-x · Cited by 8
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Moss, J. A., & Xiao, Y. (2002) · PubMed Central · Cited by 8
SiglecF Expressing Neutrophils Exacerbate Th17-Mediated Autoimmune Neuroinflammation
Hu, W., Kwon, L., Jeong, Y. S., Bae, G. H., Kim, Y. S., Zabel, B. A., & Bae, Y. (2025) · Immune Network · doi:10.4110/in.2025.25.e19 · Cited by 8
Cognate interaction-dependent pathogenicity of meningeal B cells drives neuroinflammation relapse
Wang, Y., Xu, D., Liu, S., Li, H., Wang, Y., Li, H., Xu, H., & He, D. (2025) · Immunity · doi:10.1016/j.immuni.2025.06.016 · Cited by 9
Westermann, F., Tuzlak, S., Kreiner, V., Ignácio, A., Bejarano, D. A., Bijnen, M., Cecconi, V., Hove, H. V., Wang, H., Andreadou, M., et al. (2025) · Nature Immunology · doi:10.1038/s41590-025-02356-8 · Cited by 7
Self-citationSwan, G. A., Geng, J., Park, E., Ding, Q., Zhou, J., Walcott, C., Zhang, J. J., Huang, H.-I., Hammer, G. E., & Wang, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.641188 · Cited by 7
Li, P., Guo, Z., & Wan, Y. Y. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.707899 · Cited by 7
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Waller, E. K. (2020) · Blood · doi:10.1182/blood.2019004681 · Cited by 7
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Clements, D. R., & Idoyaga, J. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20211583 · Cited by 7
Li, Y., Chen, P., Huang, X., Huang, H., Ma, Q., Lin, Z., Li, Q., Ou, C., & Liu, W. (2024) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2024.578464 · Cited by 6
Tao, Y., Jiang, Z., Wang, H., Li, J., Li, X., Ni, J., Liu, J., Xiang, H., Guan, C., Cao, W., et al. (2024) · Science Advances · doi:10.1126/sciadv.adp2919 · Cited by 8
GATA3 induces the pathogenicity of Th17 cells via regulating GM-CSF expression
Butcher, M. J., Gurram, R. K., Zhu, X., Chen, X., Hu, G., Lazarevic, V., Zhao, K., & Zhu, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1186580 · Cited by 7
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Azizi, G., Rasouli, J., Naziri, H., Gonzalez, M. V., Garifallou, J. P., Zhang, G., Ćirić, B., & Rostami, A. M. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1617074 · Cited by 5
Mannion, J. M., Segal, B. M., McLoughlin, R. M., & Lalor, S. J. (2023) · Mucosal Immunology · doi:10.1016/j.mucimm.2023.04.003 · Cited by 7
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Li, H., Cao, X., Gu, X., Dong, M., Huang, L., Mao, C., Xia, S., Yang, H., Bao, X., Yang, Y., et al. (2023) · Neuroscience Bulletin · doi:10.1007/s12264-023-01158-y · Cited by 5
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Sun, J., Ma, J., Chen, L., Xiao, S., Xiao, X., & Fang, L. (2024) · Veterinary Microbiology · doi:10.1016/j.vetmic.2024.110088 · Cited by 5
Zhang, Z., Li, Y., Chen, N., Li, H., Chen, S., Cui, X., Shao, H., Wei, L., Ma, J., Zhang, S., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02707-y · Cited by 5
Cytokines and Transgenic Matrix in Autoimmune Diseases: Similarities and Differences
Szewczak, L., & Donskow-Łysoniewska, K. (2020) · Biomedicines · doi:10.3390/biomedicines8120559 · Cited by 7
Mills, K. A. M., Westermann, F., Espinosa, V., Rosiek, E., Desai, J. V., Aufiero, M. A., Guo, Y., Mitchell, K. A., Tuzlak, S., Feo, D. D., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.03.574062 · Cited by 5
Self-citationAdvances in how the peripheral immune system interacts with the brain in health and disease
Ruiz-Rodríguez, V. M., Cuellar-Santoyo, A. O., & Estrada‐Sánchez, A. M. (2025) · Neuroscience · doi:10.1016/j.neuroscience.2025.12.059 · Cited by 4
Lin, X., Singh, A., Shan, X., Tawch, S., Sakarin, I., Bahadur, T., Abbott, D., McLinskey, N., Melville, P., Fries, B. C., et al. (2026) · Mucosal Immunology · doi:10.1016/j.mucimm.2026.100377 · Cited by 8
Bernardi, C., Charvet, C., Zeiser, R., & Simonetta, F. (2024) · Transplantation and Cellular Therapy · doi:10.1016/j.jtct.2024.01.060 · Cited by 4
Gene Regulatory Network of Human GM-CSF-Secreting T Helper Cells
Éliás, S., Schmidt, A., Gómez-Cabrero, D., & Tegner, J. N. (2021) · Journal of Immunology Research · doi:10.1155/2021/8880585 · Cited by 4
Lin, X., Singh, A. A., Shan, X., Tawch, S., Sakarin, I., Bahadur, T., Abbott, D. A., McLinskey, N., Melville, P., Fries, B. C., et al. (2022) · SSRN Electronic Journal · doi:10.2139/ssrn.4065073 · Cited by 4
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Raparia, C., & Davidson, A. (2024) · Nature Reviews Nephrology · doi:10.1038/s41581-024-00911-4 · Cited by 3
Costa-Pereira, S., Lanzinger, M., Andreadou, M., Nuñez, N., Villar-Vesga, J., Prisco, F., Häne, P., Roussel, E., Krishnarajah, S., Lindemann, R. C., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115642 · Cited by 3
Self-citationThomé, R., Boehm, A., Ishikawa, L. L. W., Casella, G., Munhoz, J., Ćirić, B., Zhang, G., & Rostami, A. M. (2020) · Brain Sciences · doi:10.3390/brainsci10060348 · Cited by 3
Parween, F., Singh, S. P., Zhang, H. H., Kathuria, N., Otaizo-Carrasquero, F. A., Shamsaddini, A., Gardina, P. J., Ganesan, S., Kabát, J., Lorenzi, H., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.01.25.525561 · Cited by 3
The multiple roles of GM-CSF in autoimmune and autoinflammatory uveitis
Tao, T., Jiang, G., Su, Y., He, D., Zhu, L., Jiang, Q., & Su, W. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.117090 · Cited by 3
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Nematullah, M., Fatma, M., Zhou, G., Prajapati, B., Rashid, F., Ayasolla, K., Ahmed, M. E., She, R., Sajad, M., Zahoor, I., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2427052122 · Cited by 2
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Sengupta, S., & Williamson, P. R. (2025) · mBio · doi:10.1128/mbio.01380-25 · Cited by 2
Ho, A. W., Huang, L., Sandhu, S., Xiao, S., Sgodzai, M., Ullerich, E., Krishnan, R. K., Schnell, A., & Kuchroo, V. K. (2026) · Science Immunology · doi:10.1126/sciimmunol.aee1481 · Cited by 3
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Kubanov, A. A., Karamova, A. Е., Chikin, V. V., Анатольевич, В. Д., Znamenskaya, L. F., & Artamonova, O. G. (2021) · Vestnik dermatologii i venerologii · doi:10.25208/vdv1260 · Cited by 2
Zhou, Y., Li, J., Wang, D., Peng, L., & Chen, K. (2025) · Neuropharmacology · doi:10.1016/j.neuropharm.2025.110760 · Cited by 2
Yerushalmi, R., Sagi, M., Goldvaser, H., Daliot, J., Mutai, R., & Krause, I. (2021) · Molecular and Clinical Oncology · doi:10.3892/mco.2021.2279 · Cited by 2
Hwang, D., Seyedsadr, M., Ishikawa, L. L. W., Boehm, A., Sahin, Z., Casella, G., Jang, S., Gonzalez, M. V., Garifallou, J. P., Hakonarson, H. H., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.10.23.352534 · Cited by 2
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Andreadou, M., Ingelfinger, F., Feo, D. D., Friebel, E., Tuzlak, S., Cramer, T. L. M., Schreiner, B., Eede, P., Schneeberger, S., Geesdorf, M., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.09.14.506749 · Cited by 2
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Pigatto, G. R., Lucena-Silva, G. V., Gonçalves, W. A., Quadros, A. U., Damasceno, S., Silva, C. E. A., Hovhannisyan, V., Acharya, T. K., Nascimento, D. C., Jager, S. E., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.23.690022 · Cited by 4
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Mordovina, A. I., Rudenko, Е. Е., & Демура, Т. А. (2023) · Saratov Journal of Medical Scientific Research · doi:10.15275/ssmj1901089 · Cited by 1
Farris, T., Ochoa, S. G., Mohammed, M. A., Rajakaruna, H., Tonello, J. M., Kanagasabai, T., Korolkova, O. Y., Shimamoto, A., Ivanova, A. V., & Shanker, A. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25137406 · Cited by 1
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Teo, J. M. N., Chen, W., & Ling, G. S. (2024) · Journal of Leukocyte Biology · doi:10.1093/jleuko/qiae222 · Cited by 1
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Passos, I. B. S., Peschke, B., Gandhi, S., Derdelinckx, J., Müller‐Miny, L., Neumann, H., Lünemann, J. D., & Keller, C. W. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1656087 · Cited by 1
Pirronello, M., Picozza, M., Guerrera, G., Corbisiero, S., Misiti, A., Placido, R., Verdiani, A., Marco, L. D., Sambucci, M., Olivieri, E., et al. (2026) · Annals of Neurology · doi:10.1002/ana.78277 · Cited by 1
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Huang, F., Lin, Y., & Tan, G. (2026) · EMBO Molecular Medicine · doi:10.1038/s44321-026-00465-x · Cited by 1
Li, X., Liu, S. J., Qian, D., Huang, M., Na, M., Mo, Q., Ju, M., Ge, J., Gao, J., Zhang, X., et al. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1802735 · Cited by 1
Li, J., Li, Y., Sun, S., Yang, L., Ma, L., Shi, B., Ma, R., & Yao, X. (2021) · International Immunopharmacology · doi:10.1016/j.intimp.2021.108292 · Cited by 1
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Ito, Y., Watanabe, D., Okamoto, N., Miyazaki, H., Tokunaga, E., Ku, Y., Ooi, M., Hoshi, N., Kohashi, M., Kanzawa, M., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-87076-7 · Cited by 1
Mannion, J. M., Segal, B., McLoughlin, R., & Lalor, S. (2023) · bioRxiv · doi:10.1101/2023.03.30.534905 · Cited by 5
Hwang, D., Seyedsadr, M., Ishikawa, L. L. W., Boehm, A., Sahin, Z., Casella, G., Jang, S., Gonzalez, M. V., Garifallo, J. P., Hakonarson, H. H., et al. (2022) · The Journal of Immunology · doi:10.4049/jimmunol.208.supp.60.14
Teng, X., Li, L., Tang, M., Li, H., Ren, X.-Y., Jiao, L., Wu, S., Mou, D., & Miao, Z.-Y. (2022) · Journal of Visualized Experiments · doi:10.3791/63755
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(2023) · Advances in magnetic resonance technology and applications · doi:10.1016/b978-0-323-91771-1.00002-2
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Costa-Pereira, S., Lanzinger, M., Andreadou, M., Núñez, N. G., Villar-Vesga, J., Prisco, F., Häne, P., Roussel, E., Krishnarajah, S., Lindemann, R. C., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.01.24.577048
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Borst, K., & Prinz, M. (2024) · Elsevier eBooks · doi:10.1016/b978-0-12-823848-6.00006-3
Iijima, N., Yamaguchi, M., Hayashi, T., Rui, Y., Ohira, Y., Miyamoto, Y., Niino, M., Okuno, T., Suzuki, O., Oka, M., et al. (2024) · Journal of Autoimmunity · doi:10.1016/j.jaut.2024.103319 · Cited by 1
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Westermann, F., Tuzlak, S., Kreiner, V., Bejarano, D. A., Bijnen, M., Cecconi, V., Hove, H. V., Wang, H., Litscher, G., Ignácio, A., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.10.30.620897
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Gogoleva, V. S., Nguyen, Q. C., & Drutskaya, M. S. (2024) · Biochemistry (Moscow) · doi:10.31857/s0320972524050106
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Han, C. W., Heng, A. H. S., Belz, G. T., Brüstle, A., McColl, S. R., & Comerford, I. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.26.661866
Liu, T., Bi, X., Ma, F., & Chen, Y. (2025) · Brain and Behavior · doi:10.1002/brb3.70811
Ntalli, A., Beckstette, M., Kumar, S., Maggi, L., Annunziato, F., Graça, L., Floess, S., & Huehn, J. (2025) · Immunology and Cell Biology · doi:10.1111/imcb.70063
Kuo, P., Weng, W., Scofield, B. A., Paraiso, H. C., Brown, D. A., Wang, P.-Y., Yu, I.-C. I., & Yen, J.-H. J. (2020) · Figshare · doi:10.6084/m9.figshare.12218909
The fate and plasticity of Th17 cells
Lee, H. J., Kim, S., Lee, W. G., & Seok, J. (2025) · Daehan geonseon hakoeji (Online) · doi:10.23203/jksp.2025.22.2.63
Morrissette, J. A., Dang, V., Huang, L., Varghese, J., Lanzar, Z. R., Frank‐Kamenetskii, A., & Canna, S. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.01.26.701759
Generation of TCRγδ + T cells from human embryonic stem cells
Zhang, X., Chen, C., Fu, Y., Wu, H., Wang, N., Shi, X., Zhou, Y., & Duan, Y. (2026) · Scientific Reports · doi:10.1038/s41598-026-37941-w
Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation
Hammond, B. P., Hahn, E., Lee, K. V., Kerr, B. J., & Plemel, J. R. (2026) · Glia · doi:10.1002/glia.70150
Regulation of the T cell response in Multiple Sclerosis
Benallegue, N. (2021) · theses.fr (ABES) · doi:10.70675/1139fcb3z40a7z4b84zbd80z1d8a0860fb29
Blood endothelial cells control the homeostasis of non-classical monocytes
Thierry, G. R. (2021) · theses.fr (ABES) · doi:10.70675/67143778z4fd3z4a9bza25bz923d37c8e077
Alanazi, M. S., Motl, R. W., Jones, B. A., Qu, H., Li, P., & Reed, W. R. (2026) · Frontiers in Rehabilitation Sciences · doi:10.3389/fresc.2026.1699274
Wang, H., Yang, Y., Tang, J.-J., Wang, X.-L., Liu, X.-Y., Wang, H., Wang, H., Wang, R., Ma, H.-H., Gu, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-76756-1
Liu, W., Peng, L., Wang, R., Fan, J., Chen, L., & Shen, Z. (2026) · Molecular Immunology · doi:10.1016/j.molimm.2026.08.009
Liu, X., Zhang, J., Yan, X., Meng, Y., Wang, H., Lv, F., Peng, B., Zheng, Z., Li, Y., Feng, Y., et al. (2026) · mBio · doi:10.1128/mbio.01091-26
Neuroimmune interactions: from molecular mechanisms to therapeutic targets
Hao, Y.-H., Shi, R.-J., Tang, Y., & Liang, X. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00565-7
Davidorf, B., Ho, D., Bouch, R., Yu, J., Dong, P., Liu, L., Song, Q., & He, Z. (2026) · Cell Insight · doi:10.1016/j.cellin.2026.100366
Dynamic contributions of astrocytes in Alzheimer’s disease
Guo, F., Li, T., & He, X. (2026) · Experimental Neurology · doi:10.1016/j.expneurol.2026.116032
D’Orso, S., Picozza, M., Guerrera, G., Verdiani, A., Pirronello, M., Misiti, A., Olivieri, E., Corbisiero, S., Angelini, D. F., Ingrascì, A., et al. (2026) · Journal of Neurology · doi:10.1007/s00415-026-14202-4
Metadata
- Authors
- Komuczki, J., Tuzlak, S., Friebel, E., Hartwig, T., Spath, S., Rosenstiel, P., Waisman, A., Opitz, L., Oukka, M., Schreiner, B., Pelczar, P., & Becher, B.
- Affiliations
- University of Zurich (CH)
- Christian-Albrechts-Universität zu Kiel (DE)
- University Medical Center of the Johannes Gutenberg University Mainz (DE)
- Seattle Children's Research Institute (US)
- Corresponding author
- Becher, Burkhard
- ORCID
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2019-05
- Volume
- 50
- Issue
- 5
- Pages
- 1289-1304.e6
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2944572075
- Cited by
- 201
- References
- 99
- Citations by year
- 2026: 18 · 2025: 27 · 2024: 22 · 2023: 24 · 2022: 27 · 2021: 36 · 2020: 34 · 2019: 12
- FWCI
- 10.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Swiss National Science Foundation (316030_150768, 310030_146130)
- European Community FP7 (602239)
- University Research Priority Program
- Austrian Academy of Science
- DFG Cluster of Excellence Inflammation at Interfaces
- EU H2020 (SYSCID (#733100))
- DFG (CRC/TR 128)
- Hertie Stiftung
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- GM-CSF, T helper cells, neuroinflammation, multiple sclerosis, encephalitogenic T cells, IL-23, IL-1β, IL23R, IL-1 receptor, fate mapping, immunopathology, Th1 cells, Th17 cells
- MeSH terms
- Receptors, CXCR6, Animals, Female, Inflammation, Interferon-gamma, Male, Mice, Inbred C57BL, Tumor Necrosis Factor-alpha, Granulocyte-Macrophage Colony-Stimulating Factor, Receptors, Interleukin, Mice, Knockout, Th1 Cells, Mice, Receptors, Interleukin-1 Type I, Interleukin-1beta, Interleukin-23 Subunit p19, Th17 Cells
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