Cited by 202T-cell and B-cell ImmunologyPsoriasis: Treatment and PathogenesisMultiple Sclerosis Research Studies

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Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β

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Komuczki, Juliana, Tuzlak, Selma, Friebel, Ekaterina, Hartwig, Tom, Spath, Sabine, Rosenstiel, Philip, Waisman, Ari, Opitz, Lennart, Oukka, Mohammed, Schreiner, Bettina, Pelczar, Pawel, Becher, Burkhard·2019·Immunity

DOI 10.1016/j.immuni.2019.04.006

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Abstract

Pathogenic lymphocytes initiate the development of chronic inflammatory diseases. The cytokine granulocyte-macrophage colony-stimulating factor (GM-CSF) (encoded by Csf2) is a key communicator between pathogenic lymphocytes and tissue-invading inflammatory phagocytes. However, the molecular properties of GM-CSF-producing cells and the mode of Csf2 regulation in vivo remain unclear. To systematically study and manipulate GM-CSF+ cells and their progeny in vivo, we generated a fate-map and reporter of GM-CSF expression mouse strain (FROG). We mapped the phenotypic and functional profile of auto-aggressive T helper (Th) cells during neuroinflammation and identified the signature and pathogenic memory of a discrete encephalitogenic Th subset. These cells required interleukin-23 receptor (IL-23R) and IL-1R but not IL-6R signaling for their maintenance and pathogenicity. Specific ablation of this subset interrupted the inflammatory cascade, despite the unperturbed tissue accumulation of other Th subsets (e.g., Th1 and Th17), highlighting that GM-CSF expression not only marks pathogenic Th cells, but that this subset mediates immunopathology and tissue destruction.

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Authors: Komuczki, J., Tuzlak, S., Friebel, E., Hartwig, T., Spath, S., Rosenstiel, P., Waisman, A., Opitz, L., Oukka, M., Schreiner, B., Pelczar, P., & Becher, B.
Affiliations: University of Zurich (CH)
Christian-Albrechts-Universität zu Kiel (DE)
University Medical Center of the Johannes Gutenberg University Mainz (DE)
Seattle Children's Research Institute (US)
Corresponding author: Becher, Burkhard
ORCID: Tuzlak, Selma
Friebel, Ekaterina
Spath, Sabine
Rosenstiel, Philip
Waisman, Ari
Opitz, Lennart
Schreiner, Bettina
Becher, Burkhard
Venue: Immunity
Publisher: Elsevier BV
Published: 2019-05
Volume: 50
Issue: 5
Pages: 1289-1304.e6
ISSN: 1074-7613 (ISSN-L)
DOI: 10.1016/j.immuni.2019.04.006
OpenAlex: W2944572075
Cited by: 201
References: 99
Citations by year: 2026: 18 · 2025: 27 · 2024: 22 · 2023: 24 · 2022: 27 · 2021: 36 · 2020: 34 · 2019: 12
FWCI: 10.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 386 d)
Locations: Immunity (publishedVersion)
PubMed (publishedVersion)
Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
Zurich Open Repository and Archive (University of Zurich)
Funders: Swiss National Science Foundation (316030_150768, 310030_146130)
European Community FP7 (602239)
University Research Priority Program
Austrian Academy of Science
DFG Cluster of Excellence Inflammation at Interfaces
EU H2020 (SYSCID (#733100))
DFG (CRC/TR 128)
Hertie Stiftung
Topics: Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
Keywords: GM-CSF, T helper cells, neuroinflammation, multiple sclerosis, encephalitogenic T cells, IL-23, IL-1β, IL23R, IL-1 receptor, fate mapping, immunopathology, Th1 cells, Th17 cells
MeSH terms: Receptors, CXCR6, Animals, Female, Inflammation, Interferon-gamma, Male, Mice, Inbred C57BL, Tumor Necrosis Factor-alpha, Granulocyte-Macrophage Colony-Stimulating Factor, Receptors, Interleukin, Mice, Knockout, Th1 Cells, Mice, Receptors, Interleukin-1 Type I, Interleukin-1beta, Interleukin-23 Subunit p19, Th17 Cells

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Fate-Mapping of GM-CSF Expression Identifies a Discrete Subset of Inflammation-Driving T Helper Cells Regulated by Cytokines IL-23 and IL-1β

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