The DOI matches its Crossref record; 52 of the 52 references it cites were found in a registry or an index.
Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation
Open accessAbstract
Summary Innate lymphocytes maintain tissue homeostasis at mucosal barriers, with group 2 innate lymphoid cells (ILC2s) producing type 2 cytokines and controlling helminth infection. While the molecular understanding of ILC2 responses has advanced, the complexity of microenvironmental factors impacting ILC2s is becoming increasingly apparent. Herein, we used single cell analysis to explore the diversity of gene expression among lung lymphocytes during helminth infection. Following infection, we identified a subset of ILC2s that preferentially expressed Il5 encoding interleukin (IL)-5, together with Calca encoding calcitonin gene related peptide (CGRP) and its cognate receptor components. CGRP in concert with IL-33 and neuromedin-U (NMU) supported IL-5 but constrained IL-13 expression and ILC2 proliferation. Without CGRP signaling, ILC2 responses and worm expulsion were enhanced. Collectively, these data point to CGRP as a context dependent negative regulatory factor that shapes innate lymphocyte responses to alarmins and neuropeptides during type 2 innate immune responses.
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Metadata
- Authors
- Nagashima, H., Mahlakõiv, T., Shih, H.-Y., Davis, F. P., Meylan, F., Huang, Y., Harrison, O. J., Yao, C., Mikami, Y., Urban, J. F., Caron, K. M., Belkaid, Y., Kanno, Y., Artis, D., & O’Shea, J. J.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2019-10
- Volume
- 51
- Issue
- 4
- Pages
- 682-695.e6
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2963632051
- Cited by
- 322
- References
- 52
- FWCI
- 10.81
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Nagashima, H., Mahlakõiv, T., Shih, H.-Y., Davis, F. P., Meylan, F., Huang, Y., Harrison, O. J., Yao, C., Mikami, Y., Urban, J. F., Caron, K. M., Belkaid, Y., Kanno, Y., Artis, D., & O’Shea, J. J. (2019). Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation. Immunity. https://doi.org/10.1016/j.immuni.2019.06.009
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