The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Class-Switch Recombination Occurs Infrequently in Germinal Centers
Open accessAbstract
Summary Class switch recombination (CSR) is a DNA recombination process that replaces the immunoglobulin (Ig) constant region for the isotype that can best protect against the pathogen. Dysregulation of CSR can cause self-reactive BCRs and B cell lymphomas; understanding the timing and location of CSR is therefore important. Although CSR commences upon T cell priming, it is generally considered a hallmark of germinal centers (GCs). Here we have used multiple approaches to show that CSR is triggered prior to differentiation into GC B cells or plasmablasts and is greatly diminished in GCs. Despite finding a small percentage of GC B cells expressing germline transcripts, phylogenetic trees of GC BCR from secondary lymphoid organs revealed that the vast majority of CSR events occurred prior to the onset of somatic hypermutation. As such, we have demonstrated the existence of IgM-dominated GCs, which are unlikely to occur under the assumption of ongoing switching.
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Self-citationMechanism and Regulation of Class Switch Recombination
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Metadata
- Authors
- Roco, J. A., Mesin, L., Binder, S. C., Nefzger, C., Gonzalez-Figueroa, P., Canete, P. F., Ellyard, J., Shen, Q., Robert, P. A., Cappello, J., Vohra, H., Zhang, Y., Nowosad, C. R., Schiepers, A., Corcoran, L. M., Toellner, K.-M., Polo, J. M., Meyer-Hermann, M., Victora, G. D., & Vinuesa, C. G.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2019-08
- Volume
- 51
- Issue
- 2
- Pages
- 337-350.e7
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W2965090569
- Cited by
- 521
- References
- 73
- FWCI
- 20.67
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Roco, J. A., Mesin, L., Binder, S. C., Nefzger, C., Gonzalez-Figueroa, P., Canete, P. F., Ellyard, J., Shen, Q., Robert, P. A., Cappello, J., Vohra, H., Zhang, Y., Nowosad, C. R., Schiepers, A., Corcoran, L. M., Toellner, K.-M., Polo, J. M., Meyer-Hermann, M., Victora, G. D., & Vinuesa, C. G. (2019). Class-Switch Recombination Occurs Infrequently in Germinal Centers. Immunity. https://doi.org/10.1016/j.immuni.2019.07.001
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
