The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Mechanism and Regulation of Class Switch Recombination
Open accessAbstract
Antibody class switching occurs in mature B cells in response to antigen stimulation and costimulatory signals. It occurs by a unique type of intrachromosomal deletional recombination within special G-rich tandem repeated DNA sequences [called switch, or S, regions located upstream of each of the heavy chain constant (C H) region genes, except Cδ]. The recombination is initiated by the B cell–specific activation-induced cytidine deaminase (AID), which deaminates cytosines in both the donor and acceptor S regions. AID activity converts several dC bases to dU bases in each S region, and the dU bases are then excised by the uracil DNA glycosylase UNG; the resulting abasic sites are nicked by apurinic/apyrimidinic endonuclease (APE). AID attacks both strands of transcriptionally active S regions, but how transcription promotes AID targeting is not entirely clear. Mismatch repair proteins are then involved in converting the resulting single-strand DNA breaks to double-strand breaks with DNA ends appropriate for end-joining recombination. Proteins required for the subsequent S-S recombination include DNA-PK, ATM, Mre11-Rad50-Nbs1, γH2AX, 53BP1, Mdc1, and XRCC4-ligase IV. These proteins are important for faithful joining of S regions, and in their absence aberrant recombination and chromosomal translocations involving S regions occur.
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Cites
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Radu, A.-F., & Bungau, S. G. (2021) · Cells · doi:10.3390/cells10112857 · Cited by 1,089
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Molecular programming of B cell memory
McHeyzer-Williams, M., Okitsu, S., Wang, N., & McHeyzer-Williams, L. (2012) · Nature Reviews Immunology · doi:10.1038/nri3128 · Cited by 449
Role of B cells as antigen presenting cells
Rastogi, I., Jeon, D., Moseman, J. E., Muralidhar, A., Potluri, H. K., & McNeel, D. G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.954936 · Cited by 352
Metadata
- Authors
- Stavnezer, J., Guikema, J. E. J., & Schrader, C. E.
- Venue
- Annual Review of Immunology
- Publisher
- Annual Reviews
- Published
- 2008-04-01
- Volume
- 26
- Issue
- 1
- Pages
- 261-292
- ISSN
- 0732-0582 (ISSN-L)
- 1545-3278
- OpenAlex
- W2154841949
- Cited by
- 1,132
- References
- 13
- FWCI
- 3.93
- Type
- journal article
- Language
- en
- Open access
- green
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- Stavnezer, J., Guikema, J. E. J., & Schrader, C. E. (2008). Mechanism and Regulation of Class Switch Recombination. Annual Review of Immunology. https://doi.org/10.1146/annurev.immunol.26.021607.090248
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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