Cited by 254SARS-CoV-2 and COVID-19 ResearchLegal, Health, Environmental and COVID-19 ChallengesVaccine Coverage and Hesitancy

The DOI matches its Crossref record; 131 of the 149 references it cites were found in a registry or an index, and 5 are not checked yet.

Accelerated COVID-19 vaccine development: milestones, lessons, and prospects

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Abstract

The development of effective vaccines to combat infectious diseases is a complex multi-year and multi-stakeholder process. To accelerate the development of vaccines for coronavirus disease 2019 (COVID-19), a novel pathogen emerging in late 2019 and spreading globally by early 2020, the United States government (USG) mounted an operation bridging public and private sector expertise and infrastructure. The success of the endeavor can be seen in the rapid advanced development of multiple vaccine candidates, with several demonstrating efficacy and now being administered around the globe. Here, we review the milestones enabling the USG-led effort, the methods utilized, and ensuing outcomes. We discuss the current status of COVID-19 vaccine development and provide a perspective for how partnership and preparedness can be better utilized in response to future public-health pandemic emergencies.

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Crossref · 10.1016/j.immuni.2021.07.017

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Research works printed but not linked: 5

  1. Andrejko, 2021, Early evidence of COVID-19 vaccine effectiveness within the general population of California, medRxiv
  2. Barouch, 2021, Durable Humoral and Cellular Immune Responses Following Ad26.COV2.S Vaccination for COVID-19, medRxiv
  3. Swift, 2021, Effectiveness of mRNA COVID-19 vaccines against SARS-CoV-2 infection in a cohort of healthcare personnel, Clin. Infect. Dis.
  4. Tande, 2021, Impact of the COVID-19 Vaccine on Asymptomatic Infection Among Patients Undergoing Pre-Procedural COVID-19 Molecular Screening, Clin. Infect. Dis.
  5. Walsh, 2020, Safety and Immunogenicity of Two RNA-Based Covid-19 Vaccine Candidates, N. Engl. J. Med., 383, 2439, 10.1056/NEJMoa2027906 · DOI · Paper page

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Metadata

Authors
Bok, K., Sitar, S., Graham, B. S., & Mascola, J. R.
Affiliations
National Institutes of Health (US)
Corresponding author
Mascola, John R.
Venue
Immunity
Publisher
Elsevier BV
Published
2021-08
Volume
54
Issue
8
Pages
1636-1651
ISSN
1074-7613 (ISSN-L)
OpenAlex
W3187496430
Cited by
254
References
149
Citations by year
2026: 9 · 2025: 36 · 2024: 46 · 2023: 74 · 2022: 77 · 2021: 12
FWCI
6.11
Type
journal article
Language
en
Open access
Locations
  • Immunity (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • U.S. Department of Health and Human Services (63/140,250, PCT/US2021/017709, WO/2018/081318)
  • Centers for Disease Control and Prevention
  • National Institute of Allergy and Infectious Diseases
  • Biomedical Advanced Research and Development Authority
  • National Institutes of Health
Topics
  • Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Legal, Health, Environmental and COVID-19 Challenges
  • Social Sciences › Health › Vaccine Coverage and Hesitancy
Keywords
COVID-19 vaccine development, SARS-CoV-2, public-private partnerships, vaccine candidate, pandemic preparedness, public health emergencies, vaccine efficacy
MeSH terms
Vaccination Coverage, Vaccinology, COVID-19, SARS-CoV-2, COVID-19 Vaccines, Biotechnology, Humans, Models, Molecular, Research, United States, Outcome Assessment, Health Care, Bioengineering, Public Health Surveillance

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