Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration

Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2

Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106

STAR: ultrafast universal RNA-seq aligner

Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709

<tt>edgeR</tt> : a Bioconductor package for differential expression analysis of digital gene expression data

Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259

featureCounts: an efficient general purpose program for assigning sequence reads to genomic features

Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.

Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849

Comprehensive Integration of Single-Cell Data

Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453

Robust enumeration of cell subsets from tissue expression profiles

Newman, A. M., Liu, C. L., Green, M. R., Gentles, A. J., Feng, W., Xu, Y., Hoang, C. D., Diehn, M., & Alizadeh, A. A. (2015) · Nature Methods · doi:10.1038/nmeth.3337 · Cited by 13,224

Causal analysis approaches in Ingenuity Pathway Analysis

Krämer, A., Green, J., Pollard, J., & Tugendreich, S. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt703 · Cited by 5,724

A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease

Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493

Microglia in brain aging: An overview of recent basic science and clinical research developments

Fan, H., Zhang, M., Wen, J., Wang, S., Yuan, M., Sun, H., Shu, L., Xu, Y., Pu, Y., & Cai, Z. (2023) · Journal of Biomedical Research · doi:10.7555/jbr.37.20220220 · Cited by 23

Microglial replacement in a Sandhoff disease mouse model reveals myeloid-derived β-hexosaminidase is necessary for neuronal health

Tsourmas, K. I., Butler, C. A., Kwang, N. E., Sloane, Z. R., Dykman, K. J. G., Maloof, G. O., Choudhury, B., Paulchakrabarti, M., Prekopa, C. A., Tabaie, E. Z., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63237-0 · Cited by 25

Key roles of glial cells in the encephalopathy of prematurity

Steenwinckel, J. V., Bokobza, C., Laforge, M., Shearer, I. K., Miron, V. E., Rua, R., Matta, S. M., Hill‐Yardin, E. L., Fleiss, B., & Gressèns, P. (2023) · Glia · doi:10.1002/glia.24474 · Cited by 26

Phenotypic and spatial heterogeneity of brain myeloid cells after stroke is associated with cell ontogeny, tissue damage, and brain connectivity

Patir, A., Barrington, J., Szymkowiak, S., Brezzo, G., Straus, D., Alfieri, A., Lefèvre, L., Liu, Z., Ginhoux, F., Henderson, N. C., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114250 · Cited by 19

GLP-1R activation restores Gas6-driven efferocytosis in senescent foamy macrophages to promote neural repair

Xia, M., Li, C., Zhang, Y., Wang, T., Zhang, C., Zhou, J., Zhu, X., Hong, H., Li, H., Qian, Z., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103857 · Cited by 19

CD300f immune receptor contributes to healthy aging by regulating inflammaging, metabolism, and cognitive decline

Evans, F., Alí‐Ruiz, D., Rego, N., Negro‐Demontel, M. L., Lago, N., Cawen, F. A., Pannunzio, B., Sanchez-Molina, P., Reyes, L., Paolino, A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113269 · Cited by 18

Microglia pack a toolbox for life

Zengeler, K. E., & Lukens, J. R. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.03.010 · Cited by 19

Fate mapping of peripherally-derived macrophages after traumatic brain injury in mice reveals a long-lasting population with a distinct transcriptomic signature

Paladini, M. S., Yang, B. A., Torkenczy, K. A., Frias, E. S., Feng, X., Krukowski, K., Sit, R. V., Morri, M., Lam, W., Pedoia, V., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63952-8 · Cited by 22

Single-cell RNA-seq reveals alterations in peripheral CX3CR1 and nonclassical monocytes in familial tauopathy

Sirkis, D. W., Solsberg, C. W., Johnson, T. P., Bonham, L. W., Sturm, V. E., Lee, S. E., Rankin, K. P., Rosen, H. J., Boxer, A. L., Seeley, W. W., et al. (2023) · Genome Medicine · doi:10.1186/s13073-023-01205-3 · Cited by 19

Inflammation and Brain Structure in Alzheimer’s Disease and Other Neurodegenerative Disorders: a Mendelian Randomization Study

Liu, W., Zhang, Y.-R., Ge, Y., Wang, H.-F., Cheng, W., & Yu, J. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03648-6 · Cited by 18

Retinal microglia express more MHC class I and promote greater T-cell-driven inflammation than brain microglia

Bloomfield, C. L., Gong, J., Droho, S., Makinde, H. M., Gurra, M. G., Stumpf, C. H., Kharel, A., Gadhvi, G. T., Winter, D. R., Cui, W., et al. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1399989 · Cited by 18

Role of Microglia in Central Nervous System Development and PlasticityPreprint

Schafer, D. P., Stevens, B., Bennett, M. L., & Bennett, F. C. (2024) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a041810 · Cited by 19

TREM1 induces microglial ferroptosis through the PERK pathway in diabetic-associated cognitive impairment

Zhao, Y., Guo, H., Li, Q., Wang, N., Yan, C., Zhang, S., Dong, Y., Liu, C., Gao, W., Zhu, Y., et al. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115031 · Cited by 17

Non-linear microglial, inflammatory and oligodendrocyte dynamics across stages of Alzheimer's disease

Badina, A. M., Ceyzériat, K., Amossé, Q., Tresh, A., Abjean, L., Guénat, L., Vauthey, E., Tsartsalis, S., Millet, P., & Tournier, B. B. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.106950 · Cited by 17

Meningeal immunity and neurological diseases: new approaches, new insights

Su, Y., Zheng, H., Shi, C., Li, X., Zhang, S., Guo, G., Yu, W.-K., Zhang, S., Hu, Z., Yang, J., et al. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02803-z · Cited by 21

Single‐Cell and Spatial Multiomics: Applications for Diseases

Li, W., Chen, C., Zhu, X., & Zhang, C. (2025) · MedComm · doi:10.1002/mco2.70553 · Cited by 16

The role of microglial TREM2 in development: A path toward neurodegeneration?

Matteoli, M. (2024) · Glia · doi:10.1002/glia.24574 · Cited by 16

BRAFV600E induces key features of LCH in iPSCs with cell type–specific phenotypes and drug responses

Abagnale, G., Schwentner, R., Soussia-Weiss, P. B., van Midden, W., Sturtzel, C., Pötschger, U., Radoš, M., Taschner‐Mandl, S., Simonitsch‐Klupp, I., Hafemeister, C., et al. (2024) · Blood · doi:10.1182/blood.2024026066 · Cited by 17

Single‐microglia transcriptomic transition network‐based prediction and real‐world patient data validation identifies ketorolac as a repurposable drug for Alzheimer's disease

Xu, J., Song, W., Xu, Z., Danziger, M. M., Karavani, E., Zang, C., Chen, X., Li, Y., Paz, I. R., Gohel, D., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14373 · Cited by 17

Somatic cancer driver mutations are enriched and associated with inflammatory states in Alzheimer’s disease microglia

Huang, A. Y., Zhou, Z., Talukdar, M., Miller, M. B., Chhouk, B., Enyenihi, L., Rosen, I., Stronge, E., Zhao, B., Kim, D., et al. (2024) · doi:10.1101/2024.01.03.574078 · Cited by 16

Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states

Huang, A. Y., Zhou, Z., Talukdar, M., Enyenihi, L., Miller, M. B., Chhouk, B., Rosen, I., Zheng, M., Zhou, M., Yang, A., et al. (2026) · Cell · doi:10.1016/j.cell.2026.03.040 · Cited by 15

Immunity in Alzheimer’s disease: From mechanisms to therapies

Chen, X., Holtzman, D. M., & Colonna, M. (2026) · Immunity · doi:10.1016/j.immuni.2026.02.004 · Cited by 18

Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications

Menéndez‐González, M., Tamba, B.-I., Leclere, M., Mabrouk, M., Schreiner, T. G., Ciobanu, R. C., & Tomás‐Zapico, C. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15030768 · Cited by 15

Myeloid-specific blockade of notch signaling alleviates dopaminergic neurodegeneration in Parkinson’s disease by dominantly regulating resident microglia activation through NF-κB signaling

Liang, S.-Q., Li, P.-H., Hu, Y., Zhao, J., Shao, F.-Z., Kuang, F., Ren, K., Wei, T., Fan, F., Feng, L., et al. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1193081 · Cited by 16

Single‐cell transcriptomics analysis of cellular heterogeneity and immune mechanisms in neurodegenerative diseases

He, Z., Chen, Q., Wang, K., Lin, J., Peng, Y., Zhang, J., Yan, X., & Yan, J. (2024) · European Journal of Neuroscience · doi:10.1111/ejn.16242 · Cited by 18

Aging and Parkinson’s disease: a complex interplay of vulnerable neurons, the immune system and the blood-brain barrier

Bendig, J., Frank, A. K., & Reichmann, H. (2024) · Ageing and Neurodegenerative Diseases · doi:10.20517/and.2023.36 · Cited by 15

Single-nucleus transcriptome unveils the role of ferroptosis in ischemic stroke

Shi, C.-L., Han, X.-L., Chen, J.-C., Pan, Q.-F., Gao, Y.-C., Guo, P.-Y., Min, X., & Gao, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e32727 · Cited by 17

Microglia signaling in health and disease – Implications in sex-specific brain development and plasticity

Pramanik, S., Harini Devi, M., Chakrabarty, S., Paylar, B., Pradhan, A., Thaker, M., Ayyadhury, S., Manavalan, A., Olsson, P., Pramanik, G., et al. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105834 · Cited by 18

Neonatal inflammation impairs developmentally-associated microglia and promotes a highly reactive microglial subset

Dufour, A., Olya, A. H., Foulon, S., Réda, C., Mokhtari, A., Faivre, V., Hua, J., Bokobza, C., Griffiths, A. D., Nghe, P., et al. (2024) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2024.09.019 · Cited by 18

Monocyte Invasion into the Retina Restricts the Regeneration of Neurons from Müller Glia

Blasdel, N., Bhattacharya, S., Donaldson, P. C., Reh, T. A., & Todd, L. J. (2024) · Journal of Neuroscience · doi:10.1523/jneurosci.0938-24.2024 · Cited by 15

Single-cell multiomic analysis reveals the involvement of Type I interferon-responsive CD8+ T cells in amyloid beta-associated memory lossPreprint

Fernando, N., Gopalakrishnan, J., Behensky, A. A., Reich, L. N., Liu, C., Bass, V., Bono, M., Montgomery, W., Pace, R. D., Mattapallil, M. J., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.18.533293 · Cited by 15

Human longevity and Alzheimer’s disease variants act via microglia and oligodendrocyte gene networks

Graham, A. C., Bellou, E., Harwood, J. C., Yaman, Ü., Celikag, M., Magusali, N., Rambarack, N., Botía, J. A., Frigerio, C. S., Hardy, J., et al. (2024) · Brain · doi:10.1093/brain/awae339 · Cited by 23

Human microglia phenotypes in the brain associated with HIV infection

Schlachetzki, J. C. M., Zhou, Y., & Glass, C. K. (2022) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2022.102637 · Cited by 15

Unraveling dynamic immunological landscapes in intracerebral hemorrhage: insights from single‐cell and spatial transcriptomic profiling

Gu, L., Chen, H., Sun, M., Chen, Y., Shi, Q., Chang, J., Wei, J., Ma, W., Bao, X., & Wang, R. (2024) · MedComm · doi:10.1002/mco2.635 · Cited by 15

Microglia aging in the hippocampus advances through intermediate states that drive activation and cognitive decline

Shea, J. M., & Villeda, S. (2025) · eLife · doi:10.7554/elife.97671.3 · Cited by 13

Modeling brain macrophage biology and neurodegenerative diseases using human iPSC-derived neuroimmune organoids

Cerneckis, J., & Shi, Y. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1198715 · Cited by 14

State-specific enhancer landscapes govern microglial plasticity

Hamagami, N., Kapadia, D., Barclay, K. M., Yanlong, H., Abduljawad, N., Cheng, Z., McLaughlin, L., Singhania, D., Ding, X., Yang, J., et al. (2026) · Immunity · doi:10.1016/j.immuni.2025.11.023 · Cited by 20

Microglia in systemic neuroimmune communication: functions beyond phagocytosis

Di Pietro, A. A., Powley, S., Perciballi, E., Stewart, M., Therrien, M., & Scott-Hewitt, N. (2026) · Trends in Immunology · doi:10.1016/j.it.2025.12.002 · Cited by 13

Myeloid masquerade: Microglial transcriptional signatures in retinal development and disease

Pitts, K. M., & Margeta, M. A. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1106547 · Cited by 14

Immunity in malignant brain tumors: Tumor entities, role of immunotherapy, and specific contribution of myeloid cells to the brain tumor microenvironment

Kienzler, J. C., & Becher, B. (2023) · European Journal of Immunology · doi:10.1002/eji.202250257 · Cited by 13

Boosting peripheral immunity to fight neurodegeneration in the brain

Schwartz, M., & Colaiuta, S. P. (2024) · Trends in Immunology · doi:10.1016/j.it.2024.08.002 · Cited by 15

Peripheral innate immunophenotype in neurodegenerative disease: blood-based profiles and links to survival

Strauss, A., Swann, P., Kigar, S. L., Christou, R., Yarkoni, N. S., Turner, L., Murley, A. G., Chouliaras, L., Shapiro, N. L., Ashton, N. J., et al. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02809-w · Cited by 16

CNS macrophage contributions to myelin health

Hoffmann, A., & Miron, V. E. (2024) · Immunological Reviews · doi:10.1111/imr.13416 · Cited by 13

Multifaceted microglia during brain development: Models and tools

Bridlance, C., & Thion, M. S. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1125729 · Cited by 14

Deciphering microglia phenotypes in health and disease

Balak, C. D., Han, C. Z., & Glass, C. K. (2024) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2023.102146 · Cited by 14

Microglia aging in the hippocampus advances through intermediate states that drive activation and cognitive declinePreprint

Shea, J. M., & Villeda, S. (2024) · eLife · doi:10.7554/elife.97671 · Cited by 18

Microglia in early brain development: A window of opportunity

Catale, C., & Garel, S. (2025) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2025.103062 · Cited by 13

Targeting Inflammation in Alzheimer’s Disease: Insights Into Pathophysiology and Therapeutic Avenues-A Comprehensive Review

Topalis, V., Voros, C., & Ziaka, M. (2025) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/08919887251361578 · Cited by 14

Therapeutic targeting of neuroimmune mechanisms in neurodegeneration

Monroe, K. M., Hong, S. Y., Lewcock, J. W., & Yang, A. C. (2026) · Nature Reviews Drug Discovery · doi:10.1038/s41573-025-01370-7 · Cited by 16

Microglia–Neuron Crosstalk: An Intimate Molecular Conversation in Neurodegeneration

Wang, S., Wang, S., Hongzhuan, C. H. E. N., & Xu, J. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27042011 · Cited by 13

The multivalency game ruling the biology of immunity

Aiassa, L. V., Battaglia, G., & Rizzello, L. (2023) · Biophysics Reviews · doi:10.1063/5.0166165 · Cited by 11

Unveiling disulfidptosis-related biomarkers and predicting drugs in Alzheimer’s disease

Huang, L., Li, Z., Lv, Y., Zhang, X., Li, Y., Li, Y., & Yu, C. (2024) · Scientific Reports · doi:10.1038/s41598-024-70893-7 · Cited by 12

Brain and blood single-cell transcriptomics in acute and subacute phases after experimental strokePreprint

García‐Bonilla, L., Shahanoor, Z., Sciortino, R. K., Nazarzoda, O., Racchumi, G., Iadecola, C., & Anrather, J. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.31.535150 · Cited by 12

Single‐Cell Transcriptomes of Immune Cells from Multiple Compartments Redefine the Ontology of Myeloid Subtypes Post‐Stroke

Yang, M., Li, Y., Shi, K., Wang, X., Liu, X., Huang, X., Shi, F., Ma, S., Li, M., & Wang, Y. (2025) · Advanced Science · doi:10.1002/advs.202408722 · Cited by 12

The mitochondrial unfolded protein response in human microglia disrupts neuronal–glial communication and promotes senescence

Maria Jose Perez, J., Lam, A., Weissleder, C., Bertoli, F., Raji, H., Bosch, M., Nemazanyy, I., Kalb, S., Kehili, M., Hirschberg, I., et al. (2026) · Nature Neuroscience · doi:10.1038/s41593-026-02320-1 · Cited by 15

From static to dynamic: live observation of the support system after ischemic stroke by two photon-excited fluorescence laser-scanning microscopy

Wu, X., Li, J., Fu, Y., Chen, D., Nie, H., & Tang, Z. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.369099 · Cited by 11

Analysis of human brain RNA-seq data reveals combined effects of 4 types of RNA modifications and 18 types of programmed cell death on Alzheimer’s disease

Ye, K., Han, X., Tian, M., Liu, L., Gao, X., Xia, Q. H., & Wang, D. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06324-6 · Cited by 11

Circulatory proteins shape microglia state and boost phagocytosisPreprint

Lu, N., Losada, P. M., Hahn, O., Saksena, A., Tapp, E., Chadarevian, J. P., Dong, W., Shi, S. M., Shuken, S. R., Guldner, I. H., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.30.615861 · Cited by 12

Border-associated macrophages: an emerging perspective from physiological basis and multi-disease roles to the mechanism of vascular cognitive impairment and dementia

Li, T., Zhang, J., Song, H., Zhang, R., Fan, F., Huang, Z., Zeng, M., Peng, B., & Zhang, J. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03631-z · Cited by 11

Macrophage heterogeneity and plasticity: mechanism and therapeutics

Li, S., Yang, Y., Qiu, H., & Pang, L. (2026) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2026.02.002 · Cited by 10

Cellular Components of the Blood-Brain Barrier and Their Involvement in Aging-Associated Cognitive Impairment

Shen, K., Shi, Y., Wang, X., & Leung, S. W. S. (2024) · Aging and Disease · doi:10.14336/ad.202.0424 · Cited by 12

NACC2, a molecular effector of miR-132 regulation at the interface between adult neurogenesis and Alzheimer’s disease

Penning, A., Snoeck, S., Garritsen, O., Tosoni, G., Hof, A., de Boer, F., van Hasenbroek, J., Zhang, L., Thrupp, N., Craessaerts, K., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-72096-6 · Cited by 11

Microglial Responses to Alzheimer's Disease Pathology: Insights From “Omics” Studies

Reid, A. N., Jayadev, S., & Prater, K. E. (2025) · Glia · doi:10.1002/glia.24666 · Cited by 10

Early precursor-derived pituitary gland tissue-resident macrophages play a pivotal role in modulating hormonal balance

Lehtonen, H., Jokela, H., Hofmann, J. I., Tola, L., Mehmood, A., Ginhoux, F., Becher, B., Greter, M., Yegutkin, G. G., Salmi, M., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2024.115227 · Cited by 9

Maternal immune activation followed by peripubertal stress combinedly produce reactive microglia and confine cerebellar cognition

Hikosaka, M., Parvez, M. S. A., Yamawaki, Y., Oe, S., Yuan, L., Wada, Y., Hirahara, Y., Koike, T., Imai, H., Oishi, N., et al. (2025) · Communications Biology · doi:10.1038/s42003-025-07566-2 · Cited by 13

Acute and Chronic Macrophage Differentiation Modulates TREM2 in a Personalized Alzheimer’s Patient-Derived Assay

Cosma, N. C., Eren, N., Üsekes, B., Gerike, S., Heuser, I., Peters, O., & Hellmann‐Regen, J. (2023) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-023-01351-7 · Cited by 10

Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems

Tian, C., Ao, Z., Cerneckis, J., Cai, H., Chen, L., Niu, H., Takayama, K., Kim, J., Shi, Y., Gu, M., et al. (2025) · Science Advances · doi:10.1126/sciadv.adu2708 · Cited by 9

Spatiotemporal dynamics of the CD11c+ microglial population in the mouse brain and spinal cord from developmental to adult stages

Nomaki, K., Fujikawa, R., Masuda, T., & Tsuda, M. (2024) · Molecular Brain · doi:10.1186/s13041-024-01098-2 · Cited by 9

Emerging Models to Study Human Microglia In vitro

Jäntti, H., Kistemaker, L., Buonfiglioli, A., de Witte, L. D., Malm, T., & Hol, E. M. (2024) · Advances in neurobiology · doi:10.1007/978-3-031-55529-9_30 · Cited by 8

Single-Cell RNA Sequencing of the Primary Visual Cortex in Mice With Optic Nerve Injury

Li, D., Zou, B., Hu, Q., Zhang, X., Zeng, W., Liu, L., & Yu, M. (2025) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.66.5.31 · Cited by 9

Knowledge domains and emerging trends of microglia research from 2002 to 2021: A bibliometric analysis and visualization study

Liu, G., Li, T., Yang, A., Zhang, X., Qi, S., & Feng, W. (2023) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.1057214 · Cited by 9

Alterations in immune cell heterogeneities in the brain of aged zebrafish using single-cell resolution

He, J., Zhao, F., Chen, B., Cui, N., Li, Z., Qin, J., Luo, L., Zhao, C., & Li, L. (2023) · Science China Life Sciences · doi:10.1007/s11427-021-2223-4 · Cited by 9

Microglia at the scene of the crime: what their transcriptomics reveal about brain health

Arutyunov, A., & Klein, R. S. (2023) · Current Opinion in Neurology · doi:10.1097/wco.0000000000001151 · Cited by 9

Manganese activates autophagy and microglia M2 polarization against endoplasmic reticulum stress-induced neuroinflammation: Involvement of GSK-3β signaling

Yang, Y., Gao, L., Meng, J., Li, H., Wang, X., Huang, Y., Wu, J., Ma, H., & Yan, D. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116053 · Cited by 9

Repopulation of microglia and its implications for CNS disorders: Insights from the single-cell era

Chen, C., Qiao, G., Tang, D., Xu, F., Dong, J., Zhang, J., & Jin, B. (2025) · Neurobiology of Disease · doi:10.1016/j.nbd.2025.107066 · Cited by 8

Oxidized phosphatidylcholines deposition drives chronic neurodegeneration in a mouse model of progressive multiple sclerosis via IL-1β signaling

Yu, R., Lozinski, B. M., Seifert, A., Ta, K., Zandee, S., Kaushik, D. K., Park, J., Klément, W., Larouche, S., Tsimikas, S., et al. (2025) · Nature Neuroscience · doi:10.1038/s41593-025-02113-y · Cited by 10

The industrial genomic revolution: A new era in neuroimmunology

Shalita, R., & Amit, I. (2022) · Neuron · doi:10.1016/j.neuron.2022.09.030 · Cited by 9

Hepialiamides A–C: Aminated Fusaric Acid Derivatives and Related Metabolites with Anti-Inflammatory Activity from the Deep-Sea-Derived Fungus Samsoniella hepiali W7

Zou, Z., Wu, T., Yang, L., He, X., Liu, W.-Y., Zhang, K., Xie, C.-L., Xie, M., Zhang, Y., Yang, X., et al. (2023) · Marine Drugs · doi:10.3390/md21110596 · Cited by 8

Border-associated macrophages: From physiology to therapeutic targets in Alzheimer's disease

Zheng, F., Dong, T., Chen, Y., Wang, L., & Peng, G. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.115021 · Cited by 8

PU.1 dictates β-amyloid-induced TREM2 expression upregulation in microglia in a transgenic model of Alzheimer’s disease

Wei, Z., Pan, X., Cui, X., Zhang, J., Dai, X., Zeng, Y., & Chen, X. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1537388 · Cited by 7

Endothelial senescence alleviates cognitive impairment in a mouse model of Alzheimer 's disease

Horibe, S., Emoto, T., Mizoguchi, T., Tanaka, T., Kawauchi, S., Sasaki, N., Yamashita, T., Ikeda, K., Emoto, N., Hirata, K., et al. (2023) · Glia · doi:10.1002/glia.24461 · Cited by 7

A novel carbamate-based hybrid derivative with anti-neuroinflammatory properties as a selective butyrylcholinesterase inhibitor for Alzheimer's disease therapy

Liu, X., Xu, J., Yu, C., Dai, C., Chen, J., Zhong, J., Yang, Y., Lin, H., Chen, X., Zhang, Q., et al. (2025) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2025.108551 · Cited by 7

Microglial states revisited: from homeostasis to disease

Eggen, B. J. L., & Kooistra, S. M. (2026) · Nature Reviews Neuroscience · doi:10.1038/s41583-026-01066-w · Cited by 6

Landscape of multiple tissues' gene expression pattern associated with severe sepsis: Genetic insights from Mendelian randomization and trans-omics analysis

Wang, L., Zhang, A., Hu, Y., Yang, W., Zhong, L., Shi, J., Wang, Z., Tao, Q., Liang, Q., & Yao, X. (2024) · Life Sciences · doi:10.1016/j.lfs.2024.123181 · Cited by 6

Deciphering the NLRP3 inflammasome in diabetic encephalopathy: Molecular insights and emerging therapeutic targets

Zeng, X., Yuan, Y., Li, Y., Hu, Z., & Hu, S. (2025) · Experimental Neurology · doi:10.1016/j.expneurol.2025.115304 · Cited by 8

CXCL10highTNFαhighKi67 + Microglia Recruit and Activate CD8 + T Cells in the Brainstem During Experimental Cerebral Malaria

Wang, Y., Liang, J., Yang, C., Wang, J., Zhu, Q., Tong, G., Li, T., Li, G., Huang, Y., Yang, Y., et al. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70425 · Cited by 6

Repopulating Microglia Suppress Peripheral Immune Cell Infiltration to Promote Poststroke Recovery

Shi, L., Lu, L., Hu, J., Chen, J., Zhang, Q., Jin, Z., Wang, Z., Zheng, Z., & Zhang, J. (2025) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.70565 · Cited by 6

Microglial colonization of the developing mouse brain is controlled by both microglial and neural CSF-1

Bridlance, C., Viguier, S., Olivié, N., Dupont, E., Thobois, D., Mathieu, B., Jiang, J. X., López‐Bendito, G., Greter, M., Becher, B., et al. (2025) · The EMBO Journal · doi:10.1038/s44318-025-00625-8 · Cited by 6

Evolving insights into the identity and function of dark microglia

Flury, A. G., St‐Pierre, M., Ayata, P., & Tremblay, M. (2025) · Trends in Neurosciences · doi:10.1016/j.tins.2025.11.002 · Cited by 7

Neuroimmune dysregulation in Alzheimer's disease: Mechanisms and therapeutic strategies

He, H., Zhu, S., Zhang, C., Wang, H., Li, Y., & Qian, H. (2026) · Ageing Research Reviews · doi:10.1016/j.arr.2026.103055 · Cited by 8

Brain perivascular macrophages regulate endothelial cell function via a cMAF-dependent transcriptional program in mouse and human

Brioschi, S., Belk, J. A., Storck, S. E., Wu, Y., Wang, Z., Feng, Z., van Olst, L., Emery, J. L., Sudan, R., Wu, J., et al. (2026) · Cell · doi:10.1016/j.cell.2026.07.043 · Cited by 6

Effects of autologous serum on TREM2 and APOE in a personalized monocyte-derived macrophage assay of late-onset Alzheimer’s patients

Eren, N., Gerike, S., Üsekes, B., Peters, O., Cosma, N. C., & Hellmann‐Regen, J. (2023) · Immunity & Ageing · doi:10.1186/s12979-023-00376-2 · Cited by 6

Early amyloid‐induced changes in microglia gene expression in male APP / PS1 mice

Oshima, T., Kater, M. S. J., Huffels, C. F. M., Wesseling, E. M., Middeldorp, J., Hol, E. M., Verheijen, M. H. G., Smit, A. B., Boddeke, E., & Eggen, B. J. L. (2024) · Journal of Neuroscience Research · doi:10.1002/jnr.25295 · Cited by 8

Advancements in Immunity and Dementia Research: Highlights from the 2023 AAIC Advancements: Immunity Conference

Kloske, C. M., Mahinrad, S., Barnum, C. J., Batista, A. F., Bradshaw, E. M., Butts, B., Carrillo, M. C., Chakrabarty, P., Chen, X., Craft, S., et al. (2024) · Alzheimer s & Dementia · doi:10.1002/alz.14291 · Cited by 6

Glucose Metabolism, Lactate, Lactylation and Alzheimer’s Disease

Hai, S., Hou, Y., Zhang, M., Gao, X., Yang, T., Shang, X., & Sun, X. (2025) · Aging and Disease · doi:10.14336/ad.2025.0338 · Cited by 9

Peripheral Klotho protects the kidney and brain by regulating M2a/M2c macrophage polarization in d-gal-treated aged mice

Wang, Y., Xiong, X., Wang, K., Bao, Y., Zhang, T., Ainiwaer, D., Wang, G., Li, H., & Sun, Z. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102049 · Cited by 6

Single-cell transcriptomics reveals ependymal subtypes related to cytoskeleton dynamics as the core driver of syringomyelia pathological development

Lu, C., Wu, X., Wang, X., Xiao, Z., Ma, L., Dai, J., & Jian, F. (2023) · iScience · doi:10.1016/j.isci.2023.106850 · Cited by 6

Rationale and emerging evidence for microglial replacement in Alzheimer’s disease

Bang, J. Y., & Yoo, Y. (2025) · Molecules and Cells · doi:10.1016/j.mocell.2025.100265 · Cited by 6

Triose phosphate isomerase 1 remodels mitochondrial cristae ultrastructure to rewire microglial immunometabolism against ischemic stroke

Zhang, X.-W., Ye, X.-M., Wang, R., Guo, Y.-D., Li, L., Chen, Y., Liu, T.-T., Xiao-qing, Z., Wang, Y., Li, Z.-Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72779-w · Cited by 5

Hematopoietic Growth Factors Regulate the Entry of Monocytes into the Adult Brain via Chemokine Receptor CCR5

Ren, X. S., He, J., Li, S., Hu, H., Kyle, M. M., Kohsaka, S., & Zhao, L. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25168898 · Cited by 5

Aging and neurodegeneration: when systemic dysregulations affect brain macrophage heterogeneity

Joly, P., Labsy, R., & Silvin, A. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkae034 · Cited by 5

Brain macrophage development, diversity and dysregulation in health and disease

Silvin, A., Qian, J., & Ginhoux, F. (2023) · Cellular & Molecular Immunology · doi:10.1038/s41423-023-01053-6 · Cited by 137

Microglia and CD206+ border-associated mouse macrophages maintain their embryonic origin during Alzheimer’s disease

Wu, X., Saito, T., Saido, T. C., Barron, A. M., & Ruedl, C. (2021) · eLife · doi:10.7554/elife.71879 · Cited by 52

Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease

Lee, D., Vicari, J. M., Porras, C., Spencer, C., Pjanic, M., Wang, X., Kinrot, S., Weiler, P., Kosoy, R., Bendl, J. M., et al. (2026) · Nature Genetics · doi:10.1038/s41588-026-02716-6 · Cited by 32

Reprogramming brain-resident macrophages: from disease drivers to therapeutic allies in neurological disorders

Zhao, P., Li, S., Liu, Q., Peng, X.-C., Liu, L., Yang, F.-Y., Wang, C., Qian, F., & Tang, F.-R. (2026) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2026.1726194 · Cited by 6