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Dual ontogeny of disease-associated microglia and disease inflammatory macrophages in aging and neurodegeneration
Open accessAbstract
Brain macrophage populations include parenchymal microglia, border-associated macrophages, and recruited monocyte-derived cells; together, they control brain development and homeostasis but are also implicated in aging pathogenesis and neurodegeneration. The phenotypes, localization, and functions of each population in different contexts have yet to be resolved. We generated a murine brain myeloid scRNA-seq integration to systematically delineate brain macrophage populations. We show that the previously identified disease-associated microglia (DAM) population detected in murine Alzheimer's disease models actually comprises two ontogenetically and functionally distinct cell lineages: embryonically derived triggering receptor expressed on myeloid cells 2 (TREM2)-dependent DAM expressing a neuroprotective signature and monocyte-derived TREM2-expressing disease inflammatory macrophages (DIMs) accumulating in the brain during aging. These two distinct populations appear to also be conserved in the human brain. Herein, we generate an ontogeny-resolved model of brain myeloid cell heterogeneity in development, homeostasis, and disease and identify cellular targets for the treatment of neurodegeneration.
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“Notably, the R47H missense mutation in triggering receptor expressed on myeloid cells 2 (TREM2) has been shown to significantly increase the risk of AD, with an odds ratio comparable to that of the APOE ε4 allele”
From PU.1 dictates β-amyloid-induced TREM2 expression upregulation in microglia in a transgenic model of Alzheimer’s disease (2025) · cites this paper as Silvin et al., 2022
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“However, the role of the peripheral immune system in AD-related neuroinflammation and neurodegeneration is still largely understudied (9, 10).”
From Understanding monocyte-driven neuroinflammation in Alzheimer’s disease using human cortical organoid microphysiological systems (2025) · cites this paper as [9]
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“Moreover, recent studies have reported that during aging or neurodegeneration, bone marrow-derived blood monocytes can infiltrate the brain through a disrupted blood-brain barrier (BBB) and differentiate into microglia-like cells, exhibiting transcriptional and functional similarity to brain-resident microglia13–15.”
From Somatic cancer variants enriched in Alzheimer’s disease microglia-like cells drive inflammatory and proliferative states (2026) · cites this paper as [15]
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“microglial-sEVs, play two distinct roles in various phases of CNS diseases [38–40].”
From M2 microglia-derived small extracellular vesicles modulate NSC fate after ischemic stroke via miR-25-3p/miR-93-5p-TGFBR/PTEN/FOXO3 axis (2025) · cites this paper as [39]
Citations
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106
STAR: ultrafast universal RNA-seq aligner
Dobin, A., Davis, C. A., Schlesinger, F., Drenkow, J., Zaleski, C., Jha, S., Batut, P., Chaisson, M., & Gingeras, T. R. (2013) · Bioinformatics · doi:10.1093/bioinformatics/bts635 · Cited by 51,709
Robinson, M. D., McCarthy, D. J., & Smyth, G. K. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btp616 · Cited by 41,364
clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters
Yu, G., Wang, L.-G., Han, Y., & He, Q.-Y. (2012) · OMICS: A Journal of Integrative Biology · doi:10.1089/omi.2011.0118 · Cited by 36,259
featureCounts: an efficient general purpose program for assigning sequence reads to genomic features
Liao, Y., Smyth, G. K., & Shi, W. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt656 · Cited by 27,219
Ultrafast and memory-efficient alignment of short DNA sequences to the human genome.
Langmead, B., Trapnell, C., Pop, M., & Salzberg, S. L. (2009) · Genome Biology · doi:10.1186/gb-2009-10-3-r25 · Cited by 21,849
Comprehensive Integration of Single-Cell Data
Stuart, T., Butler, A., Hoffman, P., Hafemeister, C., Papalexi, E., Mauck, W. M., Hao, Y., Stoeckius, M., Smibert, P., & Satija, R. (2019) · Cell · doi:10.1016/j.cell.2019.05.031 · Cited by 15,453
Robust enumeration of cell subsets from tissue expression profiles
Newman, A. M., Liu, C. L., Green, M. R., Gentles, A. J., Feng, W., Xu, Y., Hoang, C. D., Diehn, M., & Alizadeh, A. A. (2015) · Nature Methods · doi:10.1038/nmeth.3337 · Cited by 13,224
Causal analysis approaches in Ingenuity Pathway Analysis
Krämer, A., Green, J., Pollard, J., & Tugendreich, S. (2014) · Bioinformatics · doi:10.1093/bioinformatics/btt703 · Cited by 5,724
A Unique Microglia Type Associated with Restricting Development of Alzheimer’s Disease
Keren-Shaul, H., Spinrad, A., Weiner, A., Matcovitch-Natan, O., Dvir-Szternfeld, R., Ulland, T. K., David, E., Baruch, K., Lara-Astaiso, D., Toth, B., et al. (2017) · Cell · doi:10.1016/j.cell.2017.05.018 · Cited by 5,493
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Paolicelli, R. C., Sierra, A., Stevens, B., Tremblay, M.-E., Aguzzi, A., Ajami, B., Amit, I., Audinat, E., Bechmann, I., Bennett, M., et al. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.020 · Cited by 1,973
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Park, M. D., Silvin, A., Ginhoux, F., & Merad, M. (2022) · Cell · doi:10.1016/j.cell.2022.10.007 · Cited by 644
Self-citationTissue macrophages: origin, heterogenity, biological functions, diseases and therapeutic targets
Guan, F., Wang, R., Yi, Z., Luo, P., Liu, W., Xie, Y., Liu, Z., Xia, Z., Zhang, H., & Cheng, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02124-y · Cited by 371
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Chen, X., & Holtzman, D. M. (2022) · Immunity · doi:10.1016/j.immuni.2022.10.016 · Cited by 297
De Schepper, S., Ge, J. Z., Sierksma, A., Crowley, G., Ferreira, L. S. S., Garceau, D., Toomey, C. E., Sokolova, D., Rueda-Carrasco, J., Shin, S.-H., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01257-z · Cited by 295
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Charabati, M., Wheeler, M. A., Weiner, H. L., & Quintana, F. J. (2023) · Cell · doi:10.1016/j.cell.2023.03.008 · Cited by 242
García‐Bonilla, L., Shahanoor, Z., Sciortino, R. K., Nazarzoda, O., Racchumi, G., Iadecola, C., & Anrather, J. (2024) · Nature Immunology · doi:10.1038/s41590-023-01711-x · Cited by 225
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Ding, X.-S., Gao, L., Han, Z., Eleuteri, S., Shi, W., Shen, Y., Song, Z.-Y., Su, M., Yang, Q., Qu, Y., et al. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102077 · Cited by 211
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Liu, Y., Tan, Y., Zhang, Z., Yi, M., Zhu, L., & Peng, W. (2024) · Translational Neurodegeneration · doi:10.1186/s40035-024-00397-x · Cited by 156
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Hasel, P., Aisenberg, W. H., Bennett, F. C., & Liddelow, S. A. (2023) · Cell Metabolism · doi:10.1016/j.cmet.2023.03.006 · Cited by 135
Martins-Ferreira, R., Calafell-Segura, J., Leal, B., Rodríguez-Ubreva, J., Martínez-Saez, E., Mereu, E., Pinho E Costa, P., Laguna, A., & Ballestar, E. (2025) · Nature Communications · doi:10.1038/s41467-025-56124-1 · Cited by 123
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Lawrence, A. R., Canzi, A., Bridlance, C., Olivié, N., Lansonneur, C., Catale, C., Pizzamiglio, L., Kloeckner, B., Silvin, A., Munro, D. A. D., et al. (2024) · Cell · doi:10.1016/j.cell.2024.01.012 · Cited by 126
Self-citationAntignano, I., Liu, Y., Offermann, N., & Capasso, M. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04775-y · Cited by 117
Skull bone marrow channels as immune gateways to the central nervous system
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Self-citationMicrobiota–gut–brain axis: interplay between microbiota, barrier function and lymphatic system
Zhuang, M., Zhang, X., & Cai, J. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2387800 · Cited by 129
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De Ponti, F. F., Bujko, A., Liu, Z., Collins, P. J., Schuermans, S., Maueroder, C., Amstelveen, S., Thoné, T., Martens, L., McKendrick, J. G., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.01.002 · Cited by 94
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Peng, M., Li, N., Wang, H., Li, Y., Liu, H., Luo, Y., Lang, B., Zhang, W., Li, S., Tian, L., et al. (2025) · MedComm · doi:10.1002/mco2.70304 · Cited by 98
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Zhu, H., Guan, A., Liu, J., Li, P., Zhang, Z., & Wang, S. (2023) · Journal of Neuroinflammation · doi:10.1186/s12974-023-02901-y · Cited by 91
Brioschi, S., Belk, J. A., Peng, V., Molgora, M., Rodrigues, P. F., Nguyen, K. M., Wang, S., Du, S., Wang, W.-L., Grajales‐Reyes, G. E., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.01.028 · Cited by 86
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Self-citationSchmassmann, P., Roux, J., Buck, A., Tatari, N., Hogan, S. A., Wang, J., Mantuano, N. R., Wieboldt, R., Lee, S., Snijder, B., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adf5302 · Cited by 82
Peripheral and central neuroimmune mechanisms in Alzheimer’s disease pathogenesis
Zhang, S., Gao, Y., Zhao, Y., Huang, T. Y., Zheng, Q., & Wang, X. (2025) · Molecular Neurodegeneration · doi:10.1186/s13024-025-00812-5 · Cited by 78
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Yang, L., Gao, L., Yang, Y., Shi, D., Zhang, Z., Wang, X., Huang, Y., Wu, J., Meng, J., Li, H., et al. (2025) · Journal of Neuroinflammation · doi:10.1186/s12974-025-03396-5 · Cited by 72
Zhang, X., Li, H., Gu, Y., Ping, A., Chen, J., Qia, Z., Xu, Z., Wang, J., Tang, S., Wang, R., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-58254-y · Cited by 72
Self-citationBido, S., Nannoni, M., Muggeo, S., Gambarè, D., Ruffini, G., Bellini, E. N., Passeri, L., Iaia, S., Luoni, M., Provinciali, M., et al. (2024) · Science Translational Medicine · doi:10.1126/scitranslmed.adm8563 · Cited by 73
Bormann, D., Knoflach, M., Poreba, E., Riedl, C. J., Testa, G., Orset, C., Levilly, A., Cottereau, A., Jauk, P., Hametner, S., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50465-z · Cited by 65
Muñoz-Castro, C., Mejias-Ortega, M., Sanchez-Mejias, E., Navarro, V., Trujillo-Estrada, L., Jimenez, S., Garcia-Leon, J. A., Fernandez-Valenzuela, J. J., Sanchez-Mico, M. V., Romero-Molina, C., et al. (2023) · Acta Neuropathologica Communications · doi:10.1186/s40478-023-01530-z · Cited by 66
Bastos, J., O’Brien, C. A., Vara‐Pérez, M., Mampay, M., van Olst, L., Barry-Carroll, L., Kancheva, D., Leduc, S., Lievens, A. L., Ali, L., et al. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.006 · Cited by 74
Metabolic heterogeneity of tissue-resident macrophages in homeostasis and during helminth infection
Heieis, G. A., Patente, T. A., Almeida, L., Vrieling, F., Tak, T., Perona‐Wright, G., Maizels, R. M., Stienstra, R., & Everts, B. (2023) · Nature Communications · doi:10.1038/s41467-023-41353-z · Cited by 67
Barclay, K. M., Abduljawad, N., Cheng, Z., Kim, M. W., Zhou, L., Yang, J., Rustenhoven, J., Mazzitelli, J. A., Smyth, L. C. D., Kapadia, D., et al. (2024) · Immunity · doi:10.1016/j.immuni.2024.05.005 · Cited by 65
Self-citationHuang, K. Y., Mishra, K., Park, H., Yi, X., Ouyang, J. F., Petretto, E. G., & Behmoaras, J. V. (2023) · eLife · doi:10.7554/elife.85530 · Cited by 68
Mishra, P., Silva, A., Sharma, J., Nguyen, J., Pizzo, D. P., Hinz, D., Sahoo, D., & Cherqui, S. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112956 · Cited by 64
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Yao, Y., Li, J., Zhou, Y., Wang, S., Zhang, Z., Jiang, Q., & Li, K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1276225 · Cited by 60
Wilk, C. M., Cathomas, F., Török, O., Le Berichel, J., Park, M. D., Bigenwald, C., Heaton, G. R., Hamon, P., Troncoso, L., Scull, B. P., et al. (2023) · Immunity · doi:10.1016/j.immuni.2023.11.011 · Cited by 51
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Amann, L., Masuda, T., & Prinz, M. (2023) · Nature Immunology · doi:10.1038/s41590-022-01415-8 · Cited by 50
Colella, P., Sayana, R., Suárez-Nieto, M. V., Sarno, J., Nyame, K., Xiong, J., Vera, L. N. P., Basurto, J. A., Corbo, M., Limaye, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49908-4 · Cited by 56
Malvaso, A., Gatti, A., Negro, G., Calatozzolo, C., Medici, V., & Poloni, T. E. (2023) · Cells · doi:10.3390/cells12242824 · Cited by 54
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Walgrave, H., Penning, A., Tosoni, G., Snoeck, S., Davie, K., Davis, E., Wolfs, L., Sierksma, A., Mars, M., Bu, T., et al. (2023) · iScience · doi:10.1016/j.isci.2023.106829 · Cited by 41
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Xue, S., Lozinski, B. M., Ghorbani, S., Ta, K., D’Mello, C., Yong, V. W., & Dong, Y. (2023) · Journal of Neuroscience · doi:10.1523/jneurosci.2312-22.2023 · Cited by 44
Hong, H., Wang, Y., Menard, M. A., Buckley, J. A., Zhou, L., Volpicelli‐Daley, L. A., Standaert, D. G., Qin, H., & Benveniste, E. N. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03210-8 · Cited by 44
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Groh, J., Abdelwahab, T., Kattimani, Y., Hörner, M., Loserth, S., Gudi, V., Adalbert, R., Imdahl, F., Saliba, A.-E., Coleman, M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-42570-2 · Cited by 39
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Tian, Y., Jing, G., Ma, M., Yin, R., & Zhang, M. (2024) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2024.105848 · Cited by 39
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Sprenger, K. G., Lietzke, E. E., Melchior, J. T., & Bruce, K. D. (2025) · Journal of Lipid Research · doi:10.1016/j.jlr.2025.100872 · Cited by 42
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Zhao, X., Yang, X., Du, C., Huimin, H., Liu, S., Liu, G., Zhang, G., Fan, K., & Ma, J. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03284-4 · Cited by 38
Kim, J.-S., Trzebanski, S., Shin, S.-H., Schori, L., Frumer Friedman, G. R., Ilani, N. C., Kadam, A., Vicario, R., Aust, O., Bugaeva, P., et al. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.115609 · Cited by 33
Self-citationSu, W., Ye, Z., Liu, J., Deng, K., Liu, J., Zhu, H., Duan, L., Chen, S., Wang, L., Zhao, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60028-5 · Cited by 37
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Liu, L., Zhang, X., Chai, Y., Zhang, J., Deng, Q., & Chen, X. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07336-2 · Cited by 41
Self-citationXu, Y., Hillman, H., Chang, M., Barrow, F., Ivanov, S., Revelo, X. S., & Williams, J. W. (2025) · Communications Biology · doi:10.1038/s42003-025-08387-z · Cited by 35
Mu, J., Lin, Q., Wang, S., Chen, M., Wang, J., Chen, Y., Li, Y., & Liang, Y. (2025) · npj Biofilms and Microbiomes · doi:10.1038/s41522-025-00830-7 · Cited by 37
Pramotton, F. M., Spitz, S., & Kamm, R. D. (2024) · Advanced Science · doi:10.1002/advs.202403892 · Cited by 33
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Shi, Y., Huang, L., Dong, H., Yang, M., Ding, W., Zhou, X., Lu, T., Liu, Z., Zhou, X., Wang, M., et al. (2024) · Cell Research · doi:10.1038/s41422-023-00897-x · Cited by 33
Self-citationUhlig, M., Billig, S., Wienhold, J., & Schumacher, D. (2025) · Cells · doi:10.3390/cells14050345 · Cited by 29
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Chen, H., Guo, Z., Sun, Y., & Dai, X. (2023) · Neurochemistry International · doi:10.1016/j.neuint.2023.105614 · Cited by 30
Du, S., Ou, F., Drieu, A., Xu, E. Z., Cheng, Y., Storck, S. E., Mamuladze, T., Cao, J., Abduljawad, N., Bhattarai, B., et al. (2026) · Neuron · doi:10.1016/j.neuron.2026.01.032 · Cited by 32
Self-citationErtaş, A., Yiğitkan, S., & Orhan, İ. E. (2023) · Pharmaceuticals · doi:10.3390/ph16020171 · Cited by 34
Zhou, W., He, J., Shen, G., Liu, Y., Zhao, P., & Li, J. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07002-z · Cited by 28
NBAtlas: A harmonized single-cell transcriptomic reference atlas of human neuroblastoma tumors
Bonine, N., Zanzani, V., Hemelryk, A. V., Vanneste, B., Zwicker, C., Thoné, T., Roelandt, S., Bekaert, S.-L., Köster, J., Janoueix‐Lerosey, I., et al. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114804 · Cited by 29
Mast cell deficiency improves cognition and enhances disease-associated microglia in 5XFAD mice
Lin, C., Hérisson, F., Le, H., Jaafar, N., Chetal, K., Oram, M. K., Flynn, K. L., Gavrilles, E. P., Sadreyev, R. I., Schiffino, F. L., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113141 · Cited by 29
Myeloid cells in vascular dementia and Alzheimer's disease: Possible therapeutic targets?
García‐Culebras, A., Cuartero, M. I., Peña‐Martínez, C., Moraga, A., Vázquez‐Reyes, S., Castro-Millán, F. J., Cortés‐Canteli, M., Lizasoaín, I., & Moro, M. Á. (2023) · British Journal of Pharmacology · doi:10.1111/bph.16159 · Cited by 27
Zhang, Q., Yi, Y., Chen, T., Ai, Y., Chen, Z., Liu, G., Tang, Z., Chen, J., Xu, T., Chen, X., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03390-2 · Cited by 27
Self-citationWang, T., Kaneko, S., Kriukov, E., Álvarez, D., Lam, E., Wang, Y., Manna, S. L., Marasco, D., Fernandez‐Gonzalez, A., Mitsialis, S. A., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.03.025 · Cited by 26
Immune dysfunction in Alzheimer disease
Butovsky, O., Rosenzweig, N., Kleemann, K. L., Jorfi, M., Kuchroo, V. K., Tanzi, R. E., & Weiner, H. L. (2025) · Nature reviews. Neuroscience · doi:10.1038/s41583-025-00997-0 · Cited by 41
Li, D., He, T.-P., Zhang, Y., Liu, J.-R., Zhao, H.-Y., Wang, D.-L., Wang, Q., Yuan, Y., & Zhang, S.-X. (2023) · Experimental Neurology · doi:10.1016/j.expneurol.2023.114464 · Cited by 24
Ma, H., Gao, L., Chang, R., Zhai, L., & Zhao, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e38018 · Cited by 30
Hoffmann, M. H., Kirchner, H., Krönke, G., Riemekasten, G., & Bonelli, M. M. (2024) · Annals of the Rheumatic Diseases · doi:10.1136/ard-2023-224092 · Cited by 25
Zhang, G., Yao, Q., Long, C., Yi, P., Song, J., Wu, L., Wan, W., Rao, X., Lin, Y., Wei, G., et al. (2024) · Neural Regeneration Research · doi:10.4103/nrr.nrr-d-23-01508 · Cited by 25
Plasticity of human microglia and brain perivascular macrophages in aging and Alzheimer’s disease
Lee, D., Vicari, J. M., Porras, C., Spencer, C., Pjanic, M., Wang, X., Kinrot, S., Weiler, P., Kosoy, R., Bendl, J. M., et al. (2026) · Nature Genetics · doi:10.1038/s41588-026-02716-6 · Cited by 32
Liang, Y., Hu, Y., Zhang, J., Song, H., Zhang, X., Chen, Y., Peng, Y., Sun, L., Sun, Y., Xue, R., et al. (2024) · Theranostics · doi:10.7150/thno.94121 · Cited by 27
Self-citationThe molecular mechanism of ferroptosis and its relationship with Parkinson's disease
Su, Y. R., Jiao, Y., Cai, S., Xu, Y., Wang, Q., & Chen, X. (2024) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2024.110991 · Cited by 23
Microglial and TREM2 dialogues in the developing brain
Morini, R., Tagliatti, E., Bizzotto, M., & Matteoli, M. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.022 · Cited by 24
Zhu, J., Fan, J., Xia, Y., Wang, H., Li, Y., Feng, Z., & Fu, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1219487 · Cited by 26
Alzheimer’s disease and age-related macular degeneration: Shared and distinct immune mechanisms
Butovsky, O., & Rosenzweig, N. (2025) · Immunity · doi:10.1016/j.immuni.2025.04.013 · Cited by 22
A transcriptomic microglia taxonomy across mouse and human pathologies
Chhatbar, C., Sankowski, R., Schulz, M., Shimizu, T., Schwabenland, M., Staszewski, O., Scheiwe, C. F., Nessler, S., Borst, K., Dumas, A. A., et al. (2026) · Nature Immunology · doi:10.1038/s41590-026-02472-z · Cited by 26
Metadata
- Authors
- Silvin, A., Uderhardt, S., Piot, C., Da Mesquita, S., Yang, K., Geirsdottir, L., Mulder, K., Eyal, D., Liu, Z., Bridlance, C., Thion, M. S., Zhang, X. M., Kong, W. T., Deloger, M., Fontes, V., Weiner, A., Ee, R., Dress, R., Hang, J. W., Balachander, A., Chakarov, S., Malleret, B., Dunsmore, G., Cexus, O., Chen, J., Garel, S., Dutertre, C. A., Amit, I., Kipnis, J., & Ginhoux, F.
- Affiliations
- Agency for Science, Technology and Research (SG)
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Inserm (FR)
- Shanghai Jiao Tong University (CN)
- Centre National de la Recherche Scientifique (FR)
- Weizmann Institute of Science (IL)
- National University of Singapore (SG)
- Washington University in St. Louis (US)
- Corresponding author
- Ginhoux, Florent
- ORCID
- Silvin, Aymeric
- Uderhardt, Stefan
- Yang, Katharine
- Mulder, Kevin
- Liu, Zhaoyuan
- Thion, Morgane Sonia
- Zhang, Xiao Meng
- Kong, Wan Ting
- Deloger, Marc
- Fontes, Vasco
- Weiner, Assaf
- Dress, Regine
- Hang, Jing Wen
- Balachander, Akhila
- Chakarov, Svetoslav
- Dunsmore, Garett
- Cexus, Olivier
- Chen, Jinmiao
- Garel, Sonia
- Dutertre, Charles Antoine
- Amit, Ido
- Kipnis, Jonathan
- Ginhoux, Florent
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2022-08
- Volume
- 55
- Issue
- 8
- Pages
- 1448-1465.e6
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W4289794258
- Cited by
- 368
- References
- 69
- Citations by year
- 2026: 80 · 2025: 99 · 2024: 100 · 2023: 77 · 2022: 10
- FWCI
- 25.27
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 660 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Immunity (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Health Sciences › Medicine › Clinical Neurology › Multiple Sclerosis Research Studies
- Keywords
- disease-associated microglia, brain macrophages, TREM2, monocyte-derived macrophages, border-associated macrophages, aging, neurodegeneration, Alzheimer's disease, neuroprotection, single-cell transcriptomics
- MeSH terms
- Aging, Alzheimer Disease, Animals, Brain, Humans, Macrophages, Membrane Glycoproteins, Receptors, Immunologic, Microglia, Mice
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