The DOI matches its Crossref record; 358 of the 358 references it cites were found in a registry or an index.
Decoding Toll-like receptors: Recent insights and perspectives in innate immunity
Open accessAbstract
Toll-like receptors (TLRs) are an evolutionarily conserved family in the innate immune system and are the first line of host defense against microbial pathogens by recognizing pathogen-associated molecular patterns (PAMPs). TLRs, categorized into cell surface and endosomal subfamilies, recognize diverse PAMPs, and structural elucidation of TLRs and PAMP complexes has revealed their intricate mechanisms. TLRs activate common and specific signaling pathways to shape immune responses. Recent studies have shown the importance of post-transcriptional regulation in TLR-mediated inflammatory responses. Despite their protective functions, aberrant responses of TLRs contribute to inflammatory and autoimmune disorders. Understanding the delicate balance between TLR activation and regulatory mechanisms is crucial for deciphering their dual role in immune defense and disease pathogenesis. This review provides an overview of recent insights into the history of TLR discovery, elucidation of TLR ligands and signaling pathways, and their relevance to various diseases.
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Cites
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Cited by
Bacteriophages as Targeted Therapeutic Vehicles: Challenges and Opportunities
Venkataraman, S., Shahgolzari, M., Yavari, A., & Hefferon, K. (2025) · Bioengineering · doi:10.3390/bioengineering12050469 · Cited by 38
Metadata
- Authors
- Kawai, T., Ikegawa, M., Ori, D., & Akira, S.
- Venue
- Immunity
- Publisher
- Elsevier BV
- Published
- 2024-04
- Volume
- 57
- Issue
- 4
- Pages
- 649-673
- ISSN
- 1074-7613 (ISSN-L)
- OpenAlex
- W4394623029
- Cited by
- 528
- References
- 358
- FWCI
- 72.40
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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