A review on phytochemical and pharmacological properties of holy basil (Ocimum sanctum L.)

Singh, Deepika; Chaudhuri, Prabir K.

doi:10.1016/j.indcrop.2018.03.048

Cited by 218Phytochemicals and Medicinal PlantsMedicinal Plant ResearchPharmacological Effects of Medicinal Plants

A review on phytochemical and pharmacological properties of holy basil (Ocimum sanctum L.)

Singh, Deepika, Chaudhuri, Prabir K.·2018·Industrial Crops and Products

DOI 10.1016/j.indcrop.2018.03.048

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Abstract

Ocimum sanctum Linn. commonly known as Holy Basil or Tulsi is an Ayurvedic herb of Southeast Asia with a long history of traditional use. The culinary, medicinal and industrial importance of this plant led to explore its chemical and pharmacological properties. Here, we provide a comprehensive review on scientific findings of O. sanctum chemical constituents and their related anticancer, antioxidant, anti-inflammatory, antistress, γ-irradiation protection, antidiabetic and antileishmanicidal activities. More than 60 chemical compounds have been reported from O. sanctum, including phenolics, flavonoids, phenyl propanoids, terpenoids, fatty acid derivatives, essential oil, fixed oil, and steroids. The pharmacological activities of O. sanctum compounds reflect their medicinal importance and in the standardization of medicinal products. This compilation will be helpful in the development of new active principle and nutraceuticals in the area of drug resistance and emerging chronic disease vectors.

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The active chemical components of essential oil from Ocimum spp. plants are estragole (methyl chavicol), eugenol, and methyl eugenol.
“The active chemical components of essential oil from Ocimum spp. plants are estragole (methyl chavicol), eugenol, and methyl eugenol [11,32,33].”
From Aromatic Profiles of Essential Oils from Five Commonly Used Thai Basils (2018) · cites this paper as [33]

Indian materia medica
Nadkarni, A., & Nadkarni, K. M. (1955) · Cited by 2,443 · see citing works
Medicinal plants used by traditional healers in Kancheepuram District of Tamil Nadu, India
Muthu, C., Ayyanar, M., Raja, N., & Savarimuthu Ignacimuthu, S. J. (2006) · Journal of Ethnobiology and Ethnomedicine · doi:10.1186/1746-4269-2-43 · Cited by 768 · see citing works
Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review.
Prakash, P., & Gupta, N. (2005) · PubMed · Cited by 549 · see citing works
Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview
Pattanayak, P., Behera, P., Das, D., & Panda, S. K. (2010) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · doi:10.4103/0973-7847.65323 · Cited by 549 · see citing works
Antioxidant and cyclooxygenase inhibitory phenolic compounds from Ocimum sanctum Linn.
Kelm, M. A., Nair, M. G., Strasburg, G. M., & DeWitt, D. L. (2000) · Phytomedicine · doi:10.1016/s0944-7113(00)80015-x · Cited by 428 · see citing works
Cancer—an ayurvedic perspective
Balachandran, P., & Govindarajan, R. (2004) · Pharmacological Research · doi:10.1016/j.phrs.2004.04.010 · Cited by 386 · see citing works
Chemical Characterization of Basil (Ocimum basilicum L.) Found in Local Accessions and Used in Traditional Medicines in Iran
Javanmardi, J., Khalighi, A., Kashi, A., Bais, H. P., & Vivanco, J. M. (2002) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf020487q · Cited by 303 · see citing works
Chemistry and bioactivities of essential oils of some Ocimum species: an overview
Pandey, A. K., Singh, P., & Tripathi, N. N. (2014) · Asian Pacific Journal of Tropical Biomedicine · doi:10.12980/apjtb.4.2014c77 · Cited by 296 · see citing works
Validation of traditional claim of Tulsi, Ocimum sanctum Linn. as a medicinal plant.
Gupta, S. K., Prakash, J., & Srivastava, S. (2002) · PubMed · Cited by 256 · see citing works
Ethanolic extract of Ocimum sanctum leaves partially attenuates streptozotocin-induced alterations in glycogen content and carbohydrate metabolism in rats
Vats, V., Yadav, S. P., & Grover, J. K. (2003) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2003.09.034 · Cited by 248 · see citing works
Radiation Protection by the Ocimum Flavonoids Orientin and Vicenin: Mechanisms of Action
Devi, P. U., Ganasoundari, A., Vrinda, B., Srinivasan, K. K., & Unnikrishnan, M. K. (2000) · Radiation Research · doi:10.1667/0033-7587(2000)154[0455:rpbtof]2.0.co;2 · Cited by 224 · see citing works
Acetylcholinesterase Inhibitory Activity and Chemical Composition of Commercial Essential Oils
Dohi, S., Terasaki, M., & Makino, M. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf804013j · Cited by 215 · see citing works
Chemical composition, antifungal and antiaflatoxigenic activities of Ocimum sanctum L. essential oil and its safety assessment as plant based antimicrobial
Kumar, A., Shukla, R., Singh, P., & Dubey, N. K. (2009) · Food and Chemical Toxicology · doi:10.1016/j.fct.2009.11.028 · Cited by 205 · see citing works
The science behind sacredness of Tulsi (Ocimum sanctum Linn.).
Mondal, S., Mirdha, B. R., & Mahapatra, S. C. (2010) · PubMed · Cited by 193 · see citing works
Functional properties and applications of basil seed gum: An overview
Naji‐Tabasi, S., & Razavi, S. M. A. (2017) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2017.07.007 · Cited by 193 · see citing works
Traditional use of medicinal plants by the Jaintia tribes in North Cachar Hills district of Assam, northeast India
Sajem, A. L., & Gosai, K. (2006) · Journal of Ethnobiology and Ethnomedicine · doi:10.1186/1746-4269-2-33 · Cited by 189 · see citing works
Content, Composition, and Bioactivity of the Essential Oils of Three Basil Genotypes as a Function of Harvesting
Zheljazkov, V. D., Cantrell, C. L., Tekwani, B. L., & Khan, S. I. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0725629 · Cited by 175 · see citing works
Evaluation of anti-inflammatory potential of fixed oil of Ocimum sanctum (Holybasil) and its possible mechanism of action
Singh, S., MAJUMDAR, D. K., & Rehan, H. M. S. (1996) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(96)83992-4 · Cited by 171 · see citing works
In Vivo Radioprotection by Ocimum Flavonoids: Survival of Mice
Devi, P. U., Ganasoundari, A., Rao, B. S. S., & Srinivasan, K. K. (1999) · Radiation Research · doi:10.2307/3579750 · Cited by 171 · see citing works
Ocimum SanctumL (Holy Basil or Tulsi) and Its Phytochemicals in the Prevention and Treatment of Cancer
Baliga, M. S., Jimmy, R., Thilakchand, K. R., et al. (2013) · Nutrition and Cancer · doi:10.1080/01635581.2013.785010 · Cited by 162 · see citing works
Ethnobotany of the Monpa ethnic group at Arunachal Pradesh, India
Namsa, N. D., Mandal, M., Tangjang, S., et al. (2011) · Journal of Ethnobiology and Ethnomedicine · doi:10.1186/1746-4269-7-31 · Cited by 157 · see citing works
Anthelmintic activity of essential oil of Ocimum sanctum and eugenol
Asha, M. K., Prashanth, D., Murali, B., Padmaja, R., & Amit, A. (2001) · Fitoterapia · doi:10.1016/s0367-326x(01)00270-2 · Cited by 151 · see citing works
Optimisation of microencapsulation of holy basil essential oil in gelatin by response surface methodology
Sutaphanit, P., & Chitprasert, P. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.10.159 · Cited by 141 · see citing works
Evaluation of the gastric antiulcer activity of fixed oil of Ocimum sanctum (Holy Basil)
Singh, S., & MAJUMDAR, D. K. (1999) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(98)00142-1 · Cited by 134 · see citing works
Biological activities of Ocimum sanctum L. fixed oil--an overview.
Singh, S., Taneja, M., & MAJUMDAR, D. K. (2007) · PubMed · Cited by 129 · see citing works
Anti-cancer effects of novel flavonoid vicenin-2 as a single agent and in synergistic combination with docetaxel in prostate cancer
Nagaprashantha, L. D., Vatsyayan, R., Singhal, J., Fast, S. A., Roby, R. K., Awasthi, S., & Singhal, S. S. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.07.078 · Cited by 127 · see citing works
Evaluation of antioxidant and neuroprotective effect of on transient cerebral ischemia and long-term cerebral hypoperfusion
Yanpallewar, S. U., RAI, S., Kumar, M., & ACHARYA, S. (2004) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2004.07.008 · Cited by 126 · see citing works
Chemopreventive activity of Ocimum sanctum seed oil
Prakash, J., & Gupta, S. (2000) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(00)00194-x · Cited by 123 · see citing works
Radioprotective, anticarcinogenic and antioxidant properties of the Indian holy basil, Ocimum sanctum (Tulasi).
Devi, P. U. (2001) · PubMed · Cited by 121 · see citing works
Radiation protection of human lymphocyte chromosomes in vitro by orientin and vicenin
Vrinda, B., & Devi, P. U. (2001) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(01)00263-7 · Cited by 112 · see citing works
Ocimum sanctum— A preliminary study evaluating its immunoregulatory profile in albino rats
Godhwani, S., Godhwani, J. L., & Was, D. S. (1988) · Journal of Ethnopharmacology · doi:10.1016/0378-8741(88)90151-1 · Cited by 110 · see citing works
Studies on the essential oil‐bearing plants of Bangladesh. Part VIII. Composition of some Ocimum oils O. basilicum L. var. purpurascens ; O. sanctum L. green; O. sanctum L. purple; O. americanum L., citral type; O. americanum L., camphor type
Mondello, L., Zappia, G., Cotroneo, A., Bonaccorsi, I., Chowdhury, J. U., Yusuf, M., & Dugo, G. (2002) · Flavour and Fragrance Journal · doi:10.1002/ffj.1108 · Cited by 108 · see citing works
Constituents of Ocimum sanctum with Antistress Activity
Gupta, P., Yadav, D. K., Siripurapu, K. B., Palit, G., & Maurya, R. (2007) · Journal of Natural Products · doi:10.1021/np0700164 · Cited by 104 · see citing works
A comparative study of radioprotection by Ocimum flavonoids and synthetic aminothiol protectors in the mouse.
Devi, P. U., Bisht, K. S., & Vinitha, M. S. (1998) · British Journal of Radiology · doi:10.1259/bjr.71.847.9771390 · Cited by 104 · see citing works
Radioprotective effect of leaf extract of Indian medicinal plant Ocimum sanctum.
Devi, P. U., & Ganasoundari, A. (1995) · PubMed · Cited by 103 · see citing works
Trace Element Studies on Tinospora cordifolia (Menispermaceae), Ocimum sanctum (Lamiaceae), Moringa oleifera (Moringaceae), and Phyllanthus niruri (Euphorbiaceae) Using PIXE
Ramadurai, G., Kumar, M., Menon, V., Divi, S. M., Saravanan, M., Magudapathy, P., Panigrahi, B. K., Nair, K., & Venkataramaniah, K. (2009) · Biological Trace Element Research · doi:10.1007/s12011-009-8439-1 · Cited by 103 · see citing works
Chemotaxonomical analysis of the essential oil aroma compounds of four different Ocimum species from southern India
Jirovetz, L., Buchbauer, G., Shafi, M. P., et al. (2003) · European Food Research and Technology · doi:10.1007/s00217-003-0708-1 · Cited by 103 · see citing works
Evaluation of antiinflammatory activity of fatty acids of Ocimum sanctum fixed oil.
Singh, S., & MAJUMDAR, D. K. (1997) · PubMed · Cited by 101 · see citing works
Immunotherapeutic potential of Ocimum sanctum (L) in bovine subclinical mastitis
Mukherjee, R., Dash, P. K., & Ram, G. C. (2004) · Research in Veterinary Science · doi:10.1016/j.rvsc.2004.11.001 · Cited by 101 · see citing works
Inhibition of lipid peroxidation by botanical extracts of Ocimum sanctum: In vivo and in vitro studies
Geetha, G., Kedlaya, R., & Vasudevan, D. M. (2004) · Life Sciences · doi:10.1016/j.lfs.2004.05.036 · Cited by 100 · see citing works
Anticandidal effect of Ocimum sanctum essential oil and its synergy with fluconazole and ketoconazole
Amber, K., Aijaz, A. W., Immaculata, X., Luqman, K. A., & Nikhat, M. (2010) · Phytomedicine · doi:10.1016/j.phymed.2010.02.012 · Cited by 98 · see citing works
Essential oil yield and quality of methyl eugenol rich Ocimum tenuiflorum L.f. (syn. O. sanctum L.) grown in south India as influenced by method of harvest
Kothari, S. K., Bhattacharya, A., & Ramesh, S. (2004) · Journal of Chromatography A · doi:10.1016/j.chroma.2004.03.019 · Cited by 97 · see citing works
Characterization of the Volatile Pattern and Antioxidant Capacity of Essential Oils from Different Species of the Genus Ocimum
Trevisan, M. T. S., Silva, M. G. V., Pfundstein, B., Spiegelhalder, B., & Owen, R. W. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf060181+ · Cited by 96 · see citing works
Antibacterial activity of Ocimum sanctum L. fixed oil.
Singh, S., Malhotra, M., & MAJUMDAR, D. K. (2005) · PubMed · Cited by 94 · see citing works
Mineral Content of Some Medicinal Plants Used in the Treatment of Diabetes Mellitus
Narendhirakannan, R. T., Subramanian, S. P., & Kandaswamy, M. (2005) · Biological Trace Element Research · doi:10.1385/bter:103:2:109 · Cited by 93 · see citing works
Comparative volatile oil composition of fourOcimumspecies from northern India
Padalia, R. C., & Verma, R. S. (2011) · Natural Product Research · doi:10.1080/14786419.2010.482936 · Cited by 91 · see citing works
Ethnobotanical study towards conservation of medicinal and aromatic plants in upper catchments of Dhauli Ganga in the central Himalaya
Kandari, L. S., Phondani, P. C., Payal, K., et al. (2012) · Journal of Mountain Science · doi:10.1007/s11629-012-2049-7 · Cited by 91 · see citing works
Comparative study of volatile compounds from genus Ocimum
Vani (2009) · American Journal of Applied Sciences · doi:10.3844/ajassp.2009.523.528 · Cited by 91 · see citing works
A Survey of Plant Crude Drugs of Anantapur District, Andhra Pradesh, India
Reddy, M. B., Reddy, K. R., & Reddy, M. N. (1989) · International Journal of Crude Drug Research · doi:10.3109/13880208909053955 · Cited by 89 · see citing works
An ethnobotanical survey of medicinal plants used by ethnic people in West and South district of Tripura, India
Sen, S., Chakraborty, R., De, B., et al. (2011) · Journal of Forestry Research · doi:10.1007/s11676-011-0184-6 · Cited by 89 · see citing works
Chemopreventive effect of Ocimum sanctum on DMBA-induced hamster buccal pouch carcinogenesis
Karthikeyan, K., Ravichandran, P., & Govindasamy, S. (1999) · Oral Oncology · doi:10.1016/s1368-8375(98)00035-9 · Cited by 88 · see citing works
Leaf flavonoid glycosides as chemosystematic characters in Ocimum
Grayer, R. J., Kite, G. C., Veitch, N. C., Eckert, M. R., Marin, P. D., Senanayake, P., & Paton, A. J. (2002) · Biochemical Systematics and Ecology · doi:10.1016/s0305-1978(01)00103-x · Cited by 87 · see citing works
Distribution of 8-oxygenated leaf-surface flavones in the genus Ocimum
Grayer, R. J., Veitch, N. C., Kite, G. C., Price, A. M., & Kokubun, T. (2001) · Phytochemistry · doi:10.1016/s0031-9422(00)00439-8 · Cited by 82 · see citing works
Antidiabetic, antihypercholesterolaemic and antioxidant effect of Ocimum sanctum (Linn) seed oil.
Gupta, S. K., Mediratta, P. K., Singh, S., et al. (2006) · PubMed · Cited by 82 · see citing works
Hypoglycaemic effects of some plant extracts are possibly mediated through inhibition in corticosteroid concentration.
Gholap, S., & Kar, A. (2004) · PubMed · Cited by 81 · see citing works
Traditional and indigenous uses of medicinal plants by local residents in Himachal Pradesh, North Western Himalaya, India
Vidyarthi, S., Samant, S. S., & Sharma, P. (2013) · International Journal of Biodiversity Science Ecosystems Services & Management · doi:10.1080/21513732.2013.823113 · Cited by 79 · see citing works
Chemistry and bioactivities of essential oils of some Ocimum species:an overview
Abhay, Kumar, Pandey, Pooja, P., Singh, S., Nijendra, Nath, & Tripathi (2014) · Cited by 76 · see citing works
Isolation and characterization of anti-diabetic component (bioactivity—guided fractionation) from Ocimum sanctum L. (Lamiaceae) aerial part
Patil, R. N., Patil, R. Y., Ahirwar, B., & Ahirwar, D. (2011) · Asian Pacific Journal of Tropical Medicine · doi:10.1016/s1995-7645(11)60086-2 · Cited by 75 · see citing works
Toxicological Study ofOcimum sanctumLinn Leaves: Hematological, Biochemical, and Histopathological Studies
Gautam, M. K., & Goel, R. K. (2014) · Journal of Toxicology · doi:10.1155/2014/135654 · Cited by 70 · see citing works
REVERSIBLE ANTI-FERTILITY EFFECT OF BENZENE EXTRACT OF OCIMUM SANCTUM LEAVES ON SPERM PARAMETERS AND FRUCTOSE CONTENT IN RATS
Ahmed, M., Ahamed, R. N., Aladakatti, R. H., et al. (2002) · Journal of Basic and Clinical Physiology and Pharmacology · doi:10.1515/jbcpp.2002.13.1.51 · Cited by 67 · see citing works
Investigation of the cultivars of the basils (Ocimum)
Darrah, H. H. (1974) · Economic Botany · doi:10.1007/bf02861381 · Cited by 63 · see citing works
Chemical Compositions and Antimicrobial Activities of Ocimum sanctum L. Essential Oils at Different Harvest Stages
Saharkhiz, M. J., Kamyab, A. A., Kazerani, N. K., Zomorodian, K., Pakshir, K., & Rahimi, M. J. (2014) · Jundishapur Journal of Microbiology · doi:10.5812/jjm.13720 · Cited by 62 · see citing works
Quantification of Eugenol, Luteolin, Ursolic Acid, and Oleanolic Acid in Black (Krishna Tulasi) and Green (Sri Tulasi) Varieties of Ocimum sanctum Linn. Using High-Performance Thin-Layer Chromatography
Anandjiwala, S., Kalola, J., & Rajani, M. (2006) · Journal of AOAC International · doi:10.1093/jaoac/89.6.1467 · Cited by 62 · see citing works
In vitro antimicrobial activity of flavanoids of Ocimum sanctum with synergistic effect of their combined form
Ali, H., & Dixit, S. (2012) · Asian Pacific Journal of Tropical Disease · doi:10.1016/s2222-1808(12)60189-3 · Cited by 61 · see citing works
Volatile Constituents in Oil from Different Plant Parts of Methyl Eugenol-RichOcimum tenuiflorumL.f. (syn.O. sanctumL.) Grown in South India
Kothari, S. K., Bhattacharya, A. K., Ramesh, S., Garg, S. N., & Khanuja, S. P. S. (2005) · Journal of Essential Oil Research · doi:10.1080/10412905.2005.9699025 · Cited by 60 · see citing works
Anti-diabetic and anti-oxidative activity of fixed oil extracted from Ocimum sanctum L. leaves in diabetic rats
Suanarunsawat, T., Anantasomboon, G., & Piewbang, C. (2016) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2016.2991 · Cited by 60 · see citing works
A Survey of Medicinal Plants of Chenchu Tribes of Andhra Pradesh, India
Reddy, M. B., Reddy, K. R., & Reddy, M. N. (1988) · International Journal of Crude Drug Research · doi:10.3109/13880208809053918 · Cited by 58 · see citing works
Effect of Ocimum sanctum fixed oil on blood pressure, blood clotting time and pentobarbitone-induced sleeping time
Singh, S., Rehan, H., & MAJUMDAR, D. K. (2001) · Journal of Ethnopharmacology · doi:10.1016/s0378-8741(01)00336-1 · Cited by 57 · see citing works
Protection of Mouse Bone Marrow against Radiation-Induced Chromosome Damage and Stem Cell Death by the Ocimum Flavonoids Orientin and Vicenin
Nayak, V., & Devi, P. U. (2005) · Radiation Research · doi:10.1667/rr3263 · Cited by 57 · see citing works
Folk Herbal Medicines of Makawanpur District, Nepal
Bhattarai, N. K. (1991) · Pharmaceutical Biology · doi:10.3109/13880209109082899 · Cited by 56 · see citing works
LC-MS QUANTIFICATION OF ROSMARINIC ACID AND URSOLIC ACID IN THE OCIMUM SANCTUM LINN. LEAF EXTRACT (HOLY BASIL, TULSI)
Sundaram, R. S., Ramanathan, M., Rajesh, R., et al. (2012) · Journal of Liquid Chromatography & Related Technologies · doi:10.1080/10826076.2011.606583 · Cited by 51 · see citing works
Pharmacological Evaluation of Ocimum sanctum
Bano, N., Ahmed, A. A. E., Tanveer, M., et al. (2017) · Journal of Bioequivalence & Bioavailability · doi:10.4172/jbb.1000330 · Cited by 50 · see citing works
Effect of Ocimum sanctum Linn. on normal and dexamethasone suppressed wound healing.
Udupa, S. L., Shetty, S., Udupa, A. L., et al. (2006) · PubMed · Cited by 49 · see citing works
Changes in aroma profiles of 11 Indian Ocimum taxa during plant ontogeny
Padalia, R. C., Verma, R. S., Chauhan, A., & Chanotiya, C. S. (2013) · Acta Physiologiae Plantarum · doi:10.1007/s11738-013-1293-y · Cited by 47 · see citing works
Screening of medicinal plants againstLeishmania amazonensis
García, M., Monzote, L., Montalvo, A. M., et al. (2010) · Pharmaceutical Biology · doi:10.3109/13880200903485729 · Cited by 45 · see citing works
Fatty acid variation in seed oil amongOcimum species
Angers, P., Morales, M. R., & Simon, J. E. (1996) · Journal of the American Oil Chemists Society · doi:10.1007/bf02523437 · Cited by 43 · see citing works
Anti-lipidemic actions of essential oil extracted from Ocimum sanctum L. leaves in rats fed with high cholesterol diet
Suanarunsawat, T., Ayutthaya, W. D. N., Songsak, T., & Rattanamahaphoom, J. (2009) · Journal of Applied Biomedicine · doi:10.32725/jab.2009.004 · Cited by 43 · see citing works
Novel Ocimumoside A and B as anti-stress agents: Modulation of brain monoamines and antioxidant systems in chronic unpredictable stress model in rats
Ahmad, A., Rasheed, N., Gupta, P., Singh, S., Siripurapu, K. B., Ashraf, G. M., Kumar, R., Chand, K., Maurya, R., Banu, N., et al. (2012) · Phytomedicine · doi:10.1016/j.phymed.2012.02.012 · Cited by 42 · see citing works
Anti‐stress Activity of Ocimum sanctum: Possible Effects on Hypothalamic–Pituitary–Adrenal Axis
Richard, E. J., Illuri, R., Bethapudi, B., Anandhakumar, S., Bhaskar, A., Velusami, C. C., Mundkinajeddu, D., & Agarwal, A. (2016) · Phytotherapy Research · doi:10.1002/ptr.5584 · Cited by 41 · see citing works
Leishmanicidal Active Constituents from Nepalese Medicinal Plant Tulsi (Ocimum sanctum L.)
Suzuki, A., Shirota, O., Mori‐Yasumoto, K., Sekita, S., Fuchino, H., Takano, A., & Kuroyanagi, M. (2009) · Chemical and Pharmaceutical Bulletin · doi:10.1248/cpb.57.245 · Cited by 38 · see citing works
Effect of Ocimum sanctum Linn on noise induced changes in plasma corticosterone level.
Sembulingam, K., Sembulingam, P., & Namasivayam, A. (1997) · PubMed · Cited by 37 · see citing works
Protective effect of Ocimum sanctum L after high-dose 131iodine exposure in mice: an in vivo study.
Bhartiya, U. S., Raut, Y. S., & Joseph, L. J. (2006) · PubMed · Cited by 37 · see citing works
New Constituents fromOcimum sanctum
Nörr, H., & Wagner, H. (1992) · Planta Medica · doi:10.1055/s-2006-961558 · Cited by 36 · see citing works
Inhibition by an extract of Ocimum sanctum of DNA-binding activity of 7,12-dimethylbenz[a]anthracene in rat hepatocytes in vitro
Prashar, R., Kumar, A., Hewer, A. J., et al. (1998) · Cancer Letters · doi:10.1016/s0304-3835(98)00068-8 · Cited by 36 · see citing works
Mosquitocidal Compounds and a Triglyceride, 1,3-Dilinoleneoyl-2-palmitin, from Ocimum sanctum
Kelm, M. A., & Nair, M. G. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980304t · Cited by 34 · see citing works
Effect of Ocimum sanctum fixed oil on vascular permeability and leucocytes migration.
Singh, S., & MAJUMDAR, D. K. (1999) · PubMed · Cited by 34 · see citing works
Antioxidant and radioprotective properties of anOcimum sanctumpolysaccharide
Subramanian, M., Chintalwar, G. J., & Chattopadhyay, S. (2005) · Redox Report · doi:10.1179/135100005x70206 · Cited by 33 · see citing works
Protection against prenatal irradiation‐induced genomic instability and its consequences in adult mice byOcimumflavonoids, orientin and vicenin
Devi, P. U., & Satyamitra, M. M. (2004) · International Journal of Radiation Biology · doi:10.1080/09553000400005494 · Cited by 31 · see citing works
The Essential Oil ofOcimum tenuiflorumL. (Lamiaceae) Growing in Northern Australia
Brophy, J. J., Goldsack, R. J., & Clarkson, J. R. (1993) · Journal of Essential Oil Research · doi:10.1080/10412905.1993.9698260 · Cited by 31 · see citing works
Essential oil composition of fourOcimumspp. from the Peninsular India
Verma, R. S., Kumar, A., Mishra, P. P., Baskaran, K., Padalia, R. C., & Sundaresan, V. (2015) · Journal of Essential Oil Research · doi:10.1080/10412905.2015.1076742 · Cited by 31 · see citing works
Composition of the Essential Oil ofOcimum tenuiflorumL. Grown in Cuba
Pino, J. A., Rosado, A., Rodriguez, M., et al. (1998) · Journal of Essential Oil Research · doi:10.1080/10412905.1998.9700937 · Cited by 29 · see citing works
Evaluation of Some Chemical Composition, Minerals Fatty Acid Profiles, antioxidant and Antimicrobial Activities of Tulsi (Ocimum sanctum) from India
Vidhani, S. I., G.Vyas, V., Parmar, H. J., et al. (2016) · American journal of food science and technology · doi:10.12691/ajfst-4-2-5 · Cited by 29 · see citing works
Volatile Constituents from Leaves and Inflorescence Oil ofOcimum tenuiflorumL. f. (syn. O. sanctumL.) Grown in Northeastern Brazil
Machado, M. I. L., Silva, M. G. D. V., Matos, F. J. A., Craveiro, A. A., & Alencar, J. W. (1999) · Journal of Essential Oil Research · doi:10.1080/10412905.1999.9701145 · Cited by 28 · see citing works
Toxicity ofOcimum sanctumL. Essential oil toAedes aegyptiLarvae and its Chemical Composition
Gbolade, A. A., & Lockwood, G. B. (2008) · Journal of Essential Oil Bearing Plants · doi:10.1080/0972060x.2008.10643611 · Cited by 28 · see citing works
Effect of Leaf Development Stage on Changes in Essential Oil of Ocimum sanctum L.
Dey, B. B., & Choudhuri, M. A. (1983) · Biochemie und Physiologie der Pflanzen · doi:10.1016/s0015-3796(83)80049-3 · Cited by 26 · see citing works
Composition of the Essential Oil ofOcimum sanctumL. Grown in Poland During Vegetation
Kicel, A., Kurowska, A., & Kalemba, D. (2005) · Journal of Essential Oil Research · doi:10.1080/10412905.2005.9698880 · Cited by 25 · see citing works
A report on the effects of Ocimum sanctum (Tulsi) leaves and seeds on blood and urinary uric acid, urea and urine volume in normal albino rabbits.
Sarkar, A., Dn, P., & Mc, P. (1990) · PubMed · Cited by 24 · see citing works
Traditional treatment of skin diseases in Uttar Pradesh, india
Siddiqui, M. B., Alam, M. M., & Husain, W. (1989) · Economic Botany · doi:10.1007/bf02935922 · Cited by 24 · see citing works
Chemical Compositions ofOcimum sanctumShyama and0cimum sanctumRama Oils from the Plains of Northern India
Awasthi, P. K., & Dixit, S. C. (2007) · Journal of Essential Oil Bearing Plants · doi:10.1080/0972060x.2007.10643557 · Cited by 24 · see citing works
Note Polyphenols of Ocimum sanctum from Suriname
Skaltsa, H. D., Tzakou, O. A., & Singh, M. N. (1999) · Pharmaceutical Biology · doi:10.1076/phbi.37.1.92.6318 · Cited by 23 · see citing works
Plant folk medicines among Nicobarese tribals of Car Nicobar Island, India
Dagar, H. S. (1989) · Economic Botany · doi:10.1007/bf02859863 · Cited by 23 · see citing works
Ethnomedicinal Importance of the Plants in Villages in Kushtia Sador and Mirpur Upozila, Bangladesh
Sharkar, P., Rahman, M., Masum, G. Z. H., Nayeem, M. A., Hossen, M. M., & Azad, A. K. (2013) · Journal of Herbs Spices & Medicinal Plants · doi:10.1080/10496475.2013.818606 · Cited by 22 · see citing works
Antioxidant activity, total phenolics, and rosmarinic acid content in different basils (Ocimum spp.)
Koroch, A. R., Juliani, H. R., Sims, C. A., et al. (2010) · Israel Journal of Plant Sciences · doi:10.1560/ijps.58.3-4.191 · Cited by 20 · see citing works
Anti-diabetic activity of Ocimum sanctum L. roots and isolation of new phytoconstituents using two-dimensional nuclear magnetic resonance spectroscopy
Ahmad, Z. (2012) · Journal of Pharmacognosy and Phytotherapy · doi:10.5897/jpp12.008 · Cited by 20 · see citing works
Chemical composition and minerals analysis of Hippophae rhamnoides, Azadirachta indica, Punica granatu and Ocimum sanctum leaves.
Ashif, M. K., & Ullah, S. (2013) · Cited by 18 · see citing works
A review on rasayana
Chulet, R., & Pradhan, P. (2009) · Pharmacognosy Reviews/Bioinformatics Trends/Pharmacognosy review · Cited by 16 · see citing works
Ethnopharmacological Survey of Medicinal Plants along the Southwest Coast of India
Nazar, S., Ravikumar, S., & Williams, G. P. (2008) · Journal of Herbs Spices & Medicinal Plants · doi:10.1080/10496470802598917 · Cited by 16 · see citing works
An efficient approach of Laser Induced Breakdown Spectroscopy (LIBS) and ICAP-AES to detect the elemental profile of Ocimum L. species
Tripathi, D. K., Pathak, A. K., Chauhan, D. K., Dubey, N. K., Rai, A. K., & Prasad, R. (2015) · Biocatalysis and Agricultural Biotechnology · doi:10.1016/j.bcab.2015.07.003 · Cited by 16 · see citing works
Biochemical Studies of Ocimum sanctum and Olax subscorpioidea Leaf Extracts
Wisdom, N., Bassey, E. E., Jelani, F. B., et al. (2016) · Journal of Pharmaceutical Research International · doi:10.9734/bjpr/2016/27804 · Cited by 16 · see citing works
Volatile Constituents of the Leaves ofOcimum sanctumL.
Raju, P. M., Ali, M. A., Velasco‐Negueruela, A., & Pérez‐Alonso, M. J. (1999) · Journal of Essential Oil Research · doi:10.1080/10412905.1999.9701098 · Cited by 15 · see citing works
Traditional Medico-Botanical Knowledge of Local Communities in Hosanagara Taluk of Shimoga District in Karnataka, India
Shivanna, M. B., & Rajakumar, N. (2011) · Journal of Herbs Spices & Medicinal Plants · doi:10.1080/10496475.2011.602617 · Cited by 15 · see citing works
Evaluation of some anti-oxidative constituents of three species of Ocimum
Bhattacharya, A., Aggarwal, A., Sharma, N., & Cheema, J. (2015) · International Journal of Life Sciences · doi:10.3126/ijls.v8i5.11858 · Cited by 15 · see citing works
Towards exploration of plant-based ethno-medicinal knowledge of rural community: basis for biodiversity conservation in Bangladesh
Chowdhury, M. S. H., & Koike, M. (2010) · New Forests · doi:10.1007/s11056-010-9197-9 · Cited by 14 · see citing works
Analysis of Phytoconstiuents and Cytotoxic Activities of Different Parts of Ocimum sanctum
Joshi, S., & Karna, A. K. (2013) · International Journal of Applied Sciences and Biotechnology · doi:10.3126/ijasbt.v1i3.8609 · Cited by 12 · see citing works
Medicinal plant usage by traditional medical practitioners of rural villages in Chuadanga district, Bangladesh
Rahman, M., Masum, G. Z. H., Sharkar, P., et al. (2013) · International Journal of Biodiversity Science Ecosystems Services & Management · doi:10.1080/21513732.2013.841757 · Cited by 11 · see citing works
NEW FATTY ACID DERIVATIVES FROM OCIMUM SANCTUM L. LEAVES
Ali, A. M. A., & Ali, M. A. (2012) · INDIAN DRUGS · doi:10.53879/id.49.11.p0013 · Cited by 11 · see citing works
New Antiproliferative Tricyclic Sesquiterpenoid from the Leaves of Ocimum sanctum
Singh, D., Chaudhuri, P. K., & Darokar, M. P. (2014) · Helvetica Chimica Acta · doi:10.1002/hlca.201300269 · Cited by 10 · see citing works
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Diversity, phytochemical and medicinal potential of the genus Ocimum L. (Lamiaceae)
Zahran, E. M., Abdelmohsen, U. R., Khalil, H. E., Desoukey, S. Y., Fouad, M. A., & Kamel, M. S. (2020) · Phytochemistry Reviews · doi:10.1007/s11101-020-09690-9 · Cited by 90 · see citing works
Aromatic Profiles of Essential Oils from Five Commonly Used Thai Basils
Tangpao, T., Chung, H.-H., & Sommano, S. R. (2018) · Foods · doi:10.3390/foods7110175 · Cited by 87 · see citing works
“plants are estragole (methyl chavicol), eugenol, and methyl eugenol [11,32,33].”
Background
A glance at the chemodiversity of Ocimum species: trends, implications, and strategies for the quality and yield improvement of essential oil
Gurav, T. P., Dholakia, B. B., & Giri, A. P. (2022) · Phytochemistry Reviews · doi:10.1007/s11101-021-09767-z · Cited by 87 · see citing works
Rapid metabolic fingerprinting with the aid of chemometric models to identify authenticity of natural medicines: Turmeric, Ocimum, and Withania somnifera study
Khan, S., Rai, A. K., Singh, A., Singh, S., Dubey, B. K., Lal, R. K., Negi, A. S., Birse, N., Trivedi, P. K., Elliott, C. T., et al. (2023) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.04.018 · Cited by 34 · see citing works
“Ocimum is one of the most widely used medicinal herbs, especially in Asia and Africa, to treat diarrhea, kidney diseases, coughs, and many other ailments [20,21].”
Background
Comprehensive Metabolomic Fingerprinting Combined with Chemometrics Identifies Species- and Variety-Specific Variation of Medicinal Herbs: An Ocimum Study
Rai, A. K., Khan, S., Kumar, A., Dubey, B. K., Lal, R. K., Tiwari, A., Trivedi, P. K., Elliott, C. T., & Ch, R. (2023) · Metabolites · doi:10.3390/metabo13010122 · Cited by 33 · see citing works
“Ocimum, a genus of aromatic annual and perennial herbs in the family Lamiaceae, has been used for thousands of years due to its diverse medicinal properties [7].”
Background
Comparative Morpho-micrometric Investigations in Six Indigenous Ocimum Species of India with DOE Based HPTLC Method for Multi-class Component Analysis
Mirgal, A., Ghoshal, S., Ghule, C., Bhatt, K., Patel, K., Girme, A., & Hingorani, L. (2023) · Planta Medica · doi:10.1055/a-1876-3009 · Cited by 3 · see citing works

Authors: Singh, D., & Chaudhuri, P. K.
Affiliations: Central Institute of Medicinal and Aromatic Plants (IN)
Corresponding author: Singh, Deepika
ORCID: Singh, Deepika
Venue: Industrial Crops and Products
Publisher: Elsevier BV
Published: 2018-08
Volume: 118
Pages: 367-382
ISSN: 0926-6690 (ISSN-L)
DOI: 10.1016/j.indcrop.2018.03.048
OpenAlex: W2796145859
Cited by: 218
References: 117
Citations by year: 2026: 23 · 2025: 30 · 2024: 39 · 2023: 33 · 2022: 39 · 2021: 25 · 2020: 20 · 2019: 7 · 2018: 2
FWCI: 18.53
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Industrial Crops and Products (publishedVersion)
Topics: Health Sciences › Medicine › Complementary and alternative medicine › Phytochemicals and Medicinal Plants
Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Health Sciences › Medicine › Pharmacology › Pharmacological Effects of Medicinal Plants
Keywords: Ocimum sanctum, phytochemical constituents, pharmacological activity, anticancer activity, antioxidant activity, anti-inflammatory activity, anti-stress activity, radiation protection, antidiabetic activity, antileishmanial activity, phenolic compounds, flavonoids, terpenoids, essential oils, Ayurveda, nutraceuticals

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A review on phytochemical and pharmacological properties of holy basil (Ocimum sanctum L.)

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