The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Bioresorbability, porosity and mechanical strength of bone substitutes: What is optimal for bone regeneration?
Open accessAbstract
Bone repair is a multi-dimensional process that requires osteogenic cells, an osteoconductive matrix, osteoinductive signalling, mechanical stability and vascularization. In clinical practice, bone substitute materials are being used for reconstructive purposes, bone stock augmentation, and bone repair. Over the last decade, the use of calcium phosphate (CaP) based bone substitute materials has increased exponentially. These bone substitute materials vary in composition, mechanical strength and biological mechanism of function, each having their own advantages and disadvantages. It is known that intrinsic material properties of CaP bone substitutes have a profound effect on their mechanical and biological behaviour and associated biodegradation. These material properties of bone substitutes, such as porosity, composition and geometry change the trade-off between mechanical and biological performance. The choice of the optimal bone substitutes is therefore not always an easy one, and largely depends on the clinical application and its associated biological and mechanical needs. Not all bone graft substitutes will perform the same way, and their performance in one clinical site may not necessarily predict their performance in another site. CaP bone substitutes unfortunately have yet to achieve optimal mechanical and biological performance and to date each material has its own trade-off between mechanical and biological performance. This review describes the effect of intrinsic material properties on biological performance, mechanical strength and biodegradability of CaP bone substitutes.
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Cites
Porosity of 3D biomaterial scaffolds and osteogenesis
Karageorgiou, V., & Kaplan, D. (2005) · Biomaterials · doi:10.1016/j.biomaterials.2005.02.002 · Cited by 6,622
Bone: Formation by Autoinduction
Urist, M. R. (1965) · Science · doi:10.1126/science.150.3698.893 · Cited by 5,546
Giannoudis, P. V., Dinopoulos, H., & Tsiridis, E. (2005) · Injury · doi:10.1016/j.injury.2005.07.029 · Cited by 2,078
Properties of Osteoconductive Biomaterials: Calcium Phosphates
LeGeros, R. Z. (2002) · Clinical Orthopaedics and Related Research · doi:10.1097/00003086-200202000-00009 · Cited by 1,987
Calcium Phosphate-Based Osteoinductive Materials
LeGeros, R. Z. (2008) · Chemical Reviews · doi:10.1021/cr800427g · Cited by 1,321
Fracture healing: The diamond concept
Giannoudis, P. V., Einhorn, T. A., & Marsh, D. (2007) · Injury · doi:10.1016/s0020-1383(08)70003-2 · Cited by 1,092
Potential of ceramic materials as permanently implantable skeletal prostheses
Hulbert, S. F., Young, F. A., Mathews, R. S., Klawitter, J. J., Talbert, C. D., & Stelling, F. H. (1970) · Journal of Biomedical Materials Research · doi:10.1002/jbm.820040309 · Cited by 1,019
Mechanical Testing of Bone and the Bone-Implant Interface
(1999) · CRC Press eBooks · doi:10.1201/9781420073560 · Cited by 709
Pore Size of Porous Hydroxyapatite as the Cell-Substratum Controls BMP-Induced Osteogenesis
Tsuruga, E., Takita, H., Itoh, H., Wakisaka, Y., & Kuboki, Y. (1997) · Journal of Biochemistry · doi:10.1093/oxfordjournals.jbchem.a021589 · Cited by 706
Ruth, S.-D. (1995) · Journal of Clinical Gastroenterology · doi:10.1097/00004836-199507000-00004 · Cited by 637
Cited by
Macrophages, Foreign Body Giant Cells and Their Response to Implantable Biomaterials
Sheikh, Z., Brooks, P., Barzilay, O., Fine, N., & Glogauer, M. (2015) · Materials · doi:10.3390/ma8095269 · Cited by 701
Jakus, A. E., Rutz, A. L., Jordan, S. W., Kannan, A., Mitchell, S. M., Yun, C., Koube, K. D., Yoo, S. C., Whiteley, H. E., Richter, C.-P., et al. (2016) · Science Translational Medicine · doi:10.1126/scitranslmed.aaf7704 · Cited by 396
Cellulose-based composite scaffolds for bone tissue engineering and localized drug delivery
Janmohammadi, M., Nazemi, Z., Salehi, A. O. M., Seyfoori, A., John, J. V., Nourbakhsh, M. S., & Akbari, M. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.05.018 · Cited by 323
Semyari, H., Salehi, M., Taleghani, F., Ehterami, A., Bastami, F., Jalayer, T., Semyari, H., Hamed Nabavi, M., & Semyari, H. (2018) · Journal of Biomaterials Applications · doi:10.1177/0885328218805229 · Cited by 45
Zhu, Y., Liu, X., Zhang, K., EL-Newehy, M., Abdulhameed, M. M., Mo, X., Cao, L., & Wang, Y. (2025) · Colloids and Surfaces B: Biointerfaces · doi:10.1016/j.colsurfb.2024.114337 · Cited by 11
Metadata
- Authors
- Hannink, G., & Arts, J. J. C.
- Venue
- Injury
- Publisher
- Elsevier BV
- Published
- 2011-09
- Volume
- 42
- Pages
- S22-S25
- ISSN
- 0020-1383 (ISSN-L)
- OpenAlex
- W2046043107
- Cited by
- 444
- References
- 34
- FWCI
- 6.02
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Hannink, G., & Arts, J. J. C. (2011). Bioresorbability, porosity and mechanical strength of bone substitutes: What is optimal for bone regeneration? Injury. https://doi.org/10.1016/j.injury.2011.06.008
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
