Expression of NADPH oxidases and enhanced H2O2-generating activity in human coronary artery endothelial cells upon induction with tumor necrosis factor-α
Abstract
Tumor necrosis factor (TNF)-alpha, which potentiates reactive oxygen species (ROS) generation, is crucial for the development of coronary arteritis and aneurysm in Kawasaki disease. We hypothesized that vascular NADPH oxidase (Nox) enzymes participate in the TNF-alpha-triggered endothelial damage through elevating ROS generation. Thus, we herein examine the expression of Nox enzymes in human coronary artery endothelial cells (HCAEC) and the effects of TNF-alpha on Nox-mediated ROS generation. We show that HCAEC in culture spontaneously generate H(2)O(2) at basal level (0.53 nmol/min/mg protein). In searching for Nox components responsible for the H(2)O(2) generation, two distinct isoforms of Nox4 are found expressed in HCAEC: the prototype Nox4A and the shorter Nox4B, respectively in the postnuclear supernatant and the nuclear fractions. Other expressed Nox family components are: as mRNAs, Nox4C, Nox4D, Nox1, p51(nox), and Racs; as mRNAs and proteins, Nox2, p22(phox), p47(phox), and p67(phox). The H(2)O(2)-generating activity increases up to three-fold upon inclusion of TNF-alpha in culture, concomitantly with augmented expressions of Nox4A, p22(phox), p47(phox) and p67(phox) proteins. Together, these results suggest that Nox2 and Nox4A enzymes are induced by TNF-alpha endowing HCAEC with enhanced ROS-generating activity, which may play a role in the initial endothelial dysfunction through oxidative stress.
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High l-arginine levels have been correlated with higher incidence of ischemic heart disease.
“In some cases high, l-arginine levels have even been correlated with higher incidence of ischemic heart disease (1045).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [1045]
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Al‐Jameil, N., Tabassum, H., Fatima, S., Ali, M. N., Rizwana, H., & Khan, F. A. (2017) · International Journal of Pharmacology · doi:10.3923/ijp.2017.990.999 · Cited by 8 · see citing works
Increased levels of circulating fibroblast growth factor 21 in children with Kawasaki disease
Peng, Y., Pei, Q., Feng, S., Su, Y., Liu, R., Yi, Q., & Guo, P. (2019) · Clinical and Experimental Medicine · doi:10.1007/s10238-019-00577-4 · Cited by 6 · see citing works
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A Stepwise Targeting Curcumin Derivative, Ser@TPP@CUR, for Acute Kidney Injury
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The search for monomer-interaction-based alternative TNF-α therapies
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How to Prevent Complication of KD
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Ultrafine Particles Alter Endothelial Phenotype Through Oxidant Signaling
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- Authors
- Yoshida, L. S., & Tsunawaki, S.
- Affiliations
- National Research Institute for Child Health and Development (JP)
- Corresponding author
- Tsunawaki, Shohko
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2008-10
- Volume
- 8
- Issue
- 10
- Pages
- 1377-1385
- ISSN
- 1567-5769 (ISSN-L)
- OpenAlex
- W2097467525
- Cited by
- 68
- References
- 43
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 1 · 2023: 1 · 2022: 9 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 2 · 2017: 4 · 2016: 1 · 2015: 4 · 2014: 4 · 2013: 4 · 2012: 4
- FWCI
- 4.51
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Mitsukoshi Health and Welfare Foundation
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Health Sciences › Medicine › Surgery › Kawasaki Disease and Coronary Complications
- Keywords
- NADPH oxidase, TNF-α, hydrogen peroxide, reactive oxygen species, coronary artery endothelial cells, NOX2, p22phox, p47phox, p67phox, endothelial dysfunction, oxidative stress, Kawasaki disease, coronary arteritis
- MeSH terms
- NADPH Oxidase 2, NADPH Oxidase 4, Cells, Cultured, Coronary Vessels, Endothelium, Vascular, Humans, Hydrogen Peroxide, Membrane Glycoproteins, RNA, Messenger, Tumor Necrosis Factor-alpha, Gene Expression, Reactive Oxygen Species, NADPH Oxidases
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