Cited by 179Probiotics and Fermented Foodsinterferon and immune responsesInfluenza Virus Research Studies

Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice

Maeda, Naoyoshi, Nakamura, Risa, Hirose, Yoshitaka, Murosaki, Shinji, Yamamoto, Yoshihiro, Kase, Tetsuo, Yoshikai, Yasunobu·2009·International Immunopharmacology

Abstract

We have previously reported that heat-killed Lactobacillus plantarum L-137 (HK-LP) stimulates macrophage/dendritic cells to produce T helper (Th) 1-related cytokines in vitro and in vivo in mice. We here examined the effect of oral administration of HK-LP on protection against influenza virus infection in mice. C57BL/6 mice were orally given HK-LP from day -7 to 7 and intranasally infected with influenza virus A/FM/1/47 (H1N1, a mouse-adapted strain) at 100 pfu on day 0. The survival time was significantly prolonged in mice treated with HK-LP than that in mice treated with PBS as controls. The viral titers in the lung were significantly lower in mice treated with HK-LP than controls at the early stage after influenza virus infection. An appreciable level of interferon (IFN)-beta was detected in the serum of mice treated with HK-LP, while no IFN-beta was detected in controls after influenza infection. Our results suggest that HK-LP, a potent IFN-beta inducer, is useful for prevention against influenza infection.

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Crossref · 10.1016/j.intimp.2009.04.015

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  • Oral administration of Lactobacillus plantarum enhanced the type I IFN response and lowered viral titers in the lungs in a murine model of influenza infection.

    “oral administration of Lactobacillus plantarum enhanced the type I IFN response and lowered viral titers in the lungs in a murine model of influenza infection”

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Authors
Maeda, N., Nakamura, R., Hirose, Y., Murosaki, S., Yamamoto, Y., Kase, T., & Yoshikai, Y.
Affiliations
  • Kyushu University (JP)
  • House Wellness Foods Corporation (Japan) (JP)
  • Osaka Prefectural Institute of Public Health (JP)
Corresponding author
Yoshikai, Yasunobu
Venue
International Immunopharmacology
Publisher
Elsevier BV
Published
2009-08
Volume
9
Issue
9
Pages
1122-1125
ISSN
1567-5769 (ISSN-L)
OpenAlex
W1992144919
Cited by
179
References
35
Citations by year
2026: 6 · 2025: 6 · 2024: 15 · 2023: 18 · 2022: 14 · 2021: 20 · 2020: 18 · 2019: 6 · 2018: 12 · 2017: 11 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 10 · 2012: 14
FWCI
14.73
Type
journal article
Language
en
Open access
closed
Locations
  • International Immunopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Japan Society for the Promotion of Science
  • Ministry of Education, Culture, Sports, Science and Technology
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
  • Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
  • Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
Keywords
probiotics, oral administration, influenza, type I interferon, interferon-beta, antiviral defense, macrophages, dendritic cells, Th1 cytokines, survival, lung viral titers
MeSH terms
Administration, Oral, Animals, Female, Influenza Vaccines, Interferon Type I, Lung, Mice, Inbred C57BL, Orthomyxoviridae, Orthomyxoviridae Infections, Vaccines, Inactivated, Viral Load, Probiotics, Lactiplantibacillus plantarum, Mice

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