Oral administration of heat-killed Lactobacillus plantarum L-137 enhances protection against influenza virus infection by stimulation of type I interferon production in mice
Abstract
We have previously reported that heat-killed Lactobacillus plantarum L-137 (HK-LP) stimulates macrophage/dendritic cells to produce T helper (Th) 1-related cytokines in vitro and in vivo in mice. We here examined the effect of oral administration of HK-LP on protection against influenza virus infection in mice. C57BL/6 mice were orally given HK-LP from day -7 to 7 and intranasally infected with influenza virus A/FM/1/47 (H1N1, a mouse-adapted strain) at 100 pfu on day 0. The survival time was significantly prolonged in mice treated with HK-LP than that in mice treated with PBS as controls. The viral titers in the lung were significantly lower in mice treated with HK-LP than controls at the early stage after influenza virus infection. An appreciable level of interferon (IFN)-beta was detected in the serum of mice treated with HK-LP, while no IFN-beta was detected in controls after influenza infection. Our results suggest that HK-LP, a potent IFN-beta inducer, is useful for prevention against influenza infection.
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Oral administration of Lactobacillus plantarum enhanced the type I IFN response and lowered viral titers in the lungs in a murine model of influenza infection.
“oral administration of Lactobacillus plantarum enhanced the type I IFN response and lowered viral titers in the lungs in a murine model of influenza infection”
From Respiratory viral infection-induced microbiome alterations and secondary bacterial pneumonia. (2018) · cites this paper as [60]
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- Authors
- Maeda, N., Nakamura, R., Hirose, Y., Murosaki, S., Yamamoto, Y., Kase, T., & Yoshikai, Y.
- Affiliations
- Kyushu University (JP)
- House Wellness Foods Corporation (Japan) (JP)
- Osaka Prefectural Institute of Public Health (JP)
- Corresponding author
- Yoshikai, Yasunobu
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 9
- Issue
- 9
- Pages
- 1122-1125
- ISSN
- 1567-5769 (ISSN-L)
- OpenAlex
- W1992144919
- Cited by
- 179
- References
- 35
- Citations by year
- 2026: 6 · 2025: 6 · 2024: 15 · 2023: 18 · 2022: 14 · 2021: 20 · 2020: 18 · 2019: 6 · 2018: 12 · 2017: 11 · 2016: 4 · 2015: 4 · 2014: 7 · 2013: 10 · 2012: 14
- FWCI
- 14.73
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Japan Society for the Promotion of Science
- Ministry of Education, Culture, Sports, Science and Technology
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Immunology and Microbiology › Immunology › interferon and immune responses
- Health Sciences › Medicine › Epidemiology › Influenza Virus Research Studies
- Keywords
- probiotics, oral administration, influenza, type I interferon, interferon-beta, antiviral defense, macrophages, dendritic cells, Th1 cytokines, survival, lung viral titers
- MeSH terms
- Administration, Oral, Animals, Female, Influenza Vaccines, Interferon Type I, Lung, Mice, Inbred C57BL, Orthomyxoviridae, Orthomyxoviridae Infections, Vaccines, Inactivated, Viral Load, Probiotics, Lactiplantibacillus plantarum, Mice
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