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Cited by 248Mesenchymal stem cell researchHematopoietic Stem Cell TransplantationPluripotent Stem Cells Research

The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.

The immunomodulatory properties of mesenchymal stem cells and their use for immunotherapy

Hoogduijn, Martin J, Popp, Felix, Verbeek, Richard, Masoodi, Mojgan, Nicolaou, Anna, Baan, Carla, Dahlke, Marc-H·2010·International Immunopharmacology
DOI 10.1016/j.intimp.2010.06.019
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Abstract

There is growing interest in the use of mesenchymal stem cells (MSC) for immune therapy. Clinical trials that use MSC for treatment of therapy resistant graft versus host disease, Crohn's disease and organ transplantation have initiated. Nevertheless, the immunomodulatory effects of MSC are only partly understood. Clinical trials that are supported by basic research will lead to better understanding of the potential of MSC for immunomodulatory applications and to optimization of such therapies. In this manuscript we review some recent literature on the mechanisms of immunomodulation by MSC in vitro and animal models, present new data on the secretion of pro-inflammatory and anti-inflammatory cytokines, chemokines and prostaglandins by MSC under resting and inflammatory conditions and discuss the hopes and expectations of MSC-based immune therapy.

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Metadata

Authors
Hoogduijn, M. J., Popp, F., Verbeek, R., Masoodi, M., Nicolaou, A., Baan, C., & Dahlke, M.-H.
Affiliations
  • Erasmus MC (NL)
  • University of Regensburg (DE)
  • University of Bradford (GB)
Corresponding author
Hoogduijn, Martin J
ORCID
Venue
International Immunopharmacology
Publisher
Elsevier BV
Published
2010-12
Volume
10
Issue
12
Pages
1496-1500
ISSN
1567-5769 (ISSN-L)
DOI
10.1016/j.intimp.2010.06.019
OpenAlex
W2166106062
Cited by
248
References
48
Citations by year
2026: 3 · 2025: 8 · 2024: 5 · 2023: 5 · 2022: 10 · 2021: 15 · 2020: 5 · 2019: 18 · 2018: 26 · 2017: 23 · 2016: 27 · 2015: 23 · 2014: 23 · 2013: 24 · 2012: 17
FWCI
8.08
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • International Immunopharmacology (publishedVersion)
  • PubMed (publishedVersion)
  • Research Explorer (The University of Manchester) (publishedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (publishedVersion)
  • University of Regensburg Publication Server (University of Regensburg) (acceptedVersion)
  • EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
  • Bradford Scholars (University of Bradford) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Mesenchymal stem cell research
  • Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
Keywords
mesenchymal stem cells, immunomodulation, immunotherapy, graft-versus-host disease, Crohn's disease, organ transplantation, cytokine production, chemokines, prostaglandins, anti-inflammatory activity, pro-inflammatory effects
MeSH terms
Animals, Clinical Trials as Topic, Graft vs Host Disease, Humans, Immunotherapy, Prostaglandins, Cytokines, Mesenchymal Stem Cells

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