The DOI matches its Crossref record; 38 of the 40 references it cites were found in a registry or an index.
Quercetin inhibits lipopolysaccharide-induced nitric oxide production in BV2 microglial cells by suppressing the NF-κB pathway and activating the Nrf2-dependent HO-1 pathway
Abstract
Abnormal nitrosative stress-induced neuroinflammation is implicated in the pathogenesis of neurodegenerative diseases. Therefore, it has been thought that nitric oxide (NO) production is a good therapeutic target. In this sense, quercetin is a good chemopreventive component, because it has free radical-scavenging and anti-inflammatory activities. However, explicit mechanisms are not clear in the lipopolysaccharide (LPS)-stimulated BV2 microglial cell line. Here, we found that quercetin significantly suppressed LPS-induced NO production and inducible NO synthase (iNOS) expression. Notably, quercetin inhibited nuclear factor-κB (NF-κB) activation by inhibiting degradation of the inhibitor of kappa Bα (IκBα) in LPS-stimulated BV2 microglial cells corresponding to the inhibitory effect of specific NF-κB inhibitors, namely proteasome inhibitor I (PSI) and MG132. Quercetin caused significant increases in the levels of heme oxgenase-1 (HO-1) mRNA and protein. Notably, treatment with an HO-1 inducer, cobalt protoporphyrin (CoPP), significantly diminished LPS-stimulated NO production. Additionally, quercetin induced the specific DNA-binding activity of nuclear factor-2-erythroid 2-related factor 2 (Nrf2), and siRNA-mediated knockdown of Nrf2 expression reduced the inhibitory effect of quercetin on LPS-stimulated NO production by inhibiting HO-1 expression, indicating that quercetin regulated NO production by inducing Nrf2-mediated HO-1 expression. Therefore, quercetin has the potential to decrease nitrosative stress by suppressing NF-κB activation and inducing Nrf2-mediated HO-1 expression.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Quercetin is also able to reduce iNOS-mediated NO production in lipopolysaccharide (LPS)-treated BV2 microglial cells by suppressing NF-κB activation (Kang et al., 2013)”
From Exploring the Therapeutic Potential of Phytochemicals in Alzheimer’s Disease: Focus on Polyphenols and Monoterpenes (2022) · cites this paper as Kang et al., 2013
Citations
Cites
NF-κB: a key role in inflammatory diseases
Tak, P. P., & Firestein, G. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11830 · Cited by 3,918
Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Otterbein, L. E., Bach, F. H., Alam, J., Soares, M., Tao Lu, H., Wysk, M., Davis, R. J., Flavell, R. A., & Choi, A. M. K. (2000) · Nature Medicine · doi:10.1038/74680 · Cited by 2,153
Nrf2–Keap1 defines a physiologically important stress response mechanism
Motohashi, H., & Yamamoto, M. (2004) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2004.09.003 · Cited by 1,725
iNOS-mediated nitric oxide production and its regulation
Aktan, F. (2004) · Life Sciences · doi:10.1016/j.lfs.2003.10.042 · Cited by 1,385
Radjendirane, V., & Jaiswal, A. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14960 · Cited by 1,034
Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice
Lee, T.-S., & Chau, L.-Y. (2002) · Nature Medicine · doi:10.1038/nm0302-240 · Cited by 1,019
Activation of Nrf2-antioxidant signaling attenuates NFκB-inflammatory response and elicits apoptosis
Li, W., Khor, T. O., Xu, C., Shen, G., Jeong, W.-S., Yu, S., & Kong, A.-N. (2008) · Biochemical Pharmacology · doi:10.1016/j.bcp.2008.07.017 · Cited by 738
Neuroinflammation, Oxidative Stress and the Pathogenesis of Alzheimers Disease
Agostinho, P., A. Cunha, R., & Oliveira, C. (2010) · Current Pharmaceutical Design · doi:10.2174/138161210793176572 · Cited by 685
Production of superoxide anions by a CNS macrophage, the microglia
Colton, C. A., & Gilbert, D. L. (1987) · FEBS Letters · doi:10.1016/0014-5793(87)80305-8 · Cited by 614
Inflammatory Neurodegeneration and Mechanisms of Microglial Killing of Neurons
Brown, G. C., & Neher, J. J. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8105-9 · Cited by 526
Cited by
Sorted by citations
Anti-inflammatory Effects of Flavonoids in Neurodegenerative Disorders
Spagnuolo, C., Moccia, S., & Russo, G. L. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.09.001 · Cited by 458
Biologically Active Compounds from Hops and Prospects for Their Use
Karabín, M., Hudcová, T., Jelínek, L., & Dostálek, P. (2016) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12201 · Cited by 268
Neuroprotective Natural Products for Alzheimer’s Disease
Chen, X., Drew, J., Berney, W., & Lei, W. (2021) · Cells · doi:10.3390/cells10061309 · Cited by 236
Hepatoprotective effect of quercetin: From chemistry to medicine
Miltonprabu, S., Tomczyk, M., Skalicka‐Woźniak, K., Rastrelli, L., Daglia, M., Nabavi, S. F., Alavian, S. M., & Nabavi, S. M. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.08.034 · Cited by 217
The Roles of Flavonols/Flavonoids in Neurodegeneration and Neuroinflammation
Çalış, Z., Moğulkoç, R., & Baltacı, A. K. (2019) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557519666190617150051 · Cited by 221
Sun, G. Y., Chen, Z., Jasmer, K. J., Chuang, D. Y., Gu, Z., Hannink, M., & Simonyi, Á. (2015) · PLoS ONE · doi:10.1371/journal.pone.0141509 · Cited by 177
Bahar, E., Kim, J., & Yoon, H. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18091989 · Cited by 163
Quercetin reduced inflammation and increased antioxidant defense in rat adjuvant arthritis
Gardi, C., Bauerová, K., Stringa, B., Kuncírová, V., Slovák, L., Poništ, S., Dráfi, F., Bezáková, L., Tedesco, I., Acquaviva, A., et al. (2015) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2015.08.008 · Cited by 150
Bocquet, L., Şahpaz, S., Hilbert, J., Rambaud, C., & Rivière, C. (2018) · Phytochemistry Reviews · doi:10.1007/s11101-018-9584-y · Cited by 141
Liu, C., Ma, J., Wan-ru, X., Liu, S., Zhao-jun, F., Zheng, G., & Wang, A. (2015) · Food and Chemical Toxicology · doi:10.1016/j.fct.2015.05.001 · Cited by 140
Molecular targets of quercetin with anti-inflammatory properties in atopic dermatitis
Karuppagounder, V., Arumugam, S., Thandavarayan, R. A., Sreedhar, R., Giridharan, V. V., & Watanabe, K. (2016) · Drug Discovery Today · doi:10.1016/j.drudis.2016.02.011 · Cited by 135
Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?
Cirmi, S., Ferlazzo, N., Lombardo, G. E., Ventura-Spagnolo, E., Gangemi, S., Calapai, G., & Navarra, M. (2016) · Molecules · doi:10.3390/molecules21101312 · Cited by 129
Zhang, L., Xu, L.-Y., Tang, F., Liu, D., Zhao, X.-L., Zhang, J.-N., Xia, J., Wu, J.-J., Yang, Y., Peng, C. Y., et al. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2023.12.020 · Cited by 130
Modulation of nitric oxide by flavonoids
Duarte, J., Francisco, V., & Pérez‐Vizcaíno, F. (2014) · Food & Function · doi:10.1039/c4fo00144c · Cited by 131
Quercetin in brain diseases: Potential and limits
Dajas, F., Abin‐Carriquiry, J. A., Arredondo, F., Blasina, F., Echeverry, C., Martinez, M. M., Rivera, F., & Vaamonde, L. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.07.002 · Cited by 126
Hypothalamic Microglial Activation in Obesity: A Mini-Review
Mendes, N. F., Kim, Y., Velloso, L. A., & ARAUJO, E. P. D. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00846 · Cited by 122
Zhang, Y., Yi, B., Ma, J., Zhang, L., Zhang, H., Yang, Y., & Dai, Y. Z. (2014) · Neurochemical Research · doi:10.1007/s11064-014-1457-1 · Cited by 105
Protective effects of rutin on liver injury induced by biliary obstruction in rats
Pan, P., Lin, S., Wang, Y., Chen, W., Chuang, Y., Wu, C.-C., & Chen, C. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.05.001 · Cited by 97
Sun, G. Y., Li, R., Cui, J., Hannink, M., Gu, Z., Fritsche, K. L., Lubahn, D. B., & Simonyi, A. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8411-0 · Cited by 95
Kostenko, V. О., Akimov, O. Y., Gutnik, O. M., Kostenko, H., Kostenko, V., Romantseva, T. O., Morhun, Y., Nazarenko, S. M., & Taran, O. V. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e15551 · Cited by 97
Nichols, M. T., Zhang, J., Polster, B. M., Elustondo, P. A., Thirumaran, A., Pavlov, E. V., & Robertson, G. S. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.012 · Cited by 94
Alzheimer’s disease: natural products as inhibitors of neuroinflammation
Olajide, O. A., & Sarker, S. D. (2020) · Inflammopharmacology · doi:10.1007/s10787-020-00751-1 · Cited by 92
Rifaai, R. A., Mokhemer, S. A., Saber, E. A., El‐Aleem, S. A. A., & El‐Tahawy, N. F. G. (2020) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2020.101795 · Cited by 94
Park, S. Y., Jin, M. L., Ko, M. J., Park, G., & Choi, Y.-W. (2016) · Neurochemical Research · doi:10.1007/s11064-016-2018-6 · Cited by 87
Le, K., Song, Z., Deng, J., Peng, X., Zhang, J., Wang, L., Zhou, L., Bi, H., Liao, Z., & Feng, Z. (2020) · Inflammation Research · doi:10.1007/s00011-020-01402-5 · Cited by 85
Cardiovascular Effects of Flavonoids
Sánchez, M., Romero, M., Gómez‐Guzmán, M., Tamargo, J. L., Pérez‐Vizcaíno, F., & Duarte, J. (2018) · Current Medicinal Chemistry · doi:10.2174/0929867326666181220094721 · Cited by 87
Li, Y.-Y., Huang, S., Lee, M., Deng, J., & Huang, G. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.02.002 · Cited by 84
Phenolic-protein interactions in foods and post ingestion: Switches empowering health outcomes
Guan, H., Zhang, W., Sun‐Waterhouse, D., Jiang, Y., Li, F., Waterhouse, G. I. N., & Li, D. (2021) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2021.08.033 · Cited by 83
Beneficial effect of quercetin on cholestatic liver injury
Lin, S., Wang, Y., Chen, W., Chuang, Y., Pan, P., & Chen, C. (2014) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2014.06.003 · Cited by 83
Sangaran, P. G., Ibrahim, Z. A., Chik, Z., Mohamed, Z., & Ahmadiani, A. (2021) · Molecular Neurobiology · doi:10.1007/s12035-020-02227-3 · Cited by 78
Bhat, S. A., Goel, R., Shukla, R., & Hanif, K. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9584-5 · Cited by 79
Nrf2 as molecular target for polyphenols: A novel therapeutic strategy in diabetic retinopathy
Nabavi, S. F., Barber, A. J., Spagnuolo, C., Russo, G. L., Daglia, M., Nabavi, S. M., & Sobarzo‐Sánchez, E. (2016) · Critical Reviews in Clinical Laboratory Sciences · doi:10.3109/10408363.2015.1129530 · Cited by 82
Pingili, R. B., Challa, S. R., Pawar, A. K., Toleti, V., Kodali, T., & Koppula, S. (2019) · Phytotherapy Research · doi:10.1002/ptr.6503 · Cited by 77
Therapeutic benefits of flavonoids against neuroinflammation: a systematic review
Hamsalakshmi, Alex, A. M., Marappa, M. A., Joghee, S., & Chidambaram, S. B. (2022) · Inflammopharmacology · doi:10.1007/s10787-021-00895-8 · Cited by 79
You, M., Chen, Y., Pan, Y., Liu, Y.-C., Tu, J., Wang, K., & Hu, F. (2018) · Mediators of Inflammation · doi:10.1155/2018/7834381 · Cited by 74
Piccialli, I., Tedeschi, V., Caputo, L., D’Errico, S., Ciccone, R., De Feo, V., Secondo, A., & Pannaccione, A. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.876614 · Cited by 73
Yang, J., Kim, C.-S., Tu, T. H., Kim, M., Goto, T., Kawada, T., Choi, M., Park, T., Sung, M., Yun, J. W., et al. (2017) · Nutrients · doi:10.3390/nu9070650 · Cited by 73
Khadrawy, O., Gebremedhn, S., Salilew‐Wondim, D., Taqi, M. O., Neuhoff, C., Tholen, E., Hoelker, M., Schellander, K., & Tesfaye, D. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20071635 · Cited by 69
Dwivedi, S., Rajasekar, N., Hanif, K., Nath, C., & Shukla, R. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9451-4 · Cited by 65
Vauzour, D., Martinsen, A., & Layé, S. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.08.004 · Cited by 60
Kühnl, J., Roggenkamp, D., Gehrke, S. A., Stäb, F., Wenck, H., Kolbe, L., & Neufang, G. (2015) · Experimental Dermatology · doi:10.1111/exd.12588 · Cited by 56
Jakaria, M., Azam, S., Jo, S.-H., Kim, I., Dash, R., & Choi, D. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8111789 · Cited by 57
Wu, M., Liu, F., & Guo, Q.-H. (2019) · International Immunopharmacology · doi:10.1016/j.intimp.2019.105704 · Cited by 54
Chen, J., Yin, W. H., Tu, Y., Wang, S., Yang, X., Chen, Q., Zhang, X., Han, Y., & Pi, R. (2017) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2017.03.025 · Cited by 53
Chan, C. K., Tan, L. T., Andy, S. N., Kamarudin, M. N. A., Goh, B. H., & Kadir, H. A. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00397 · Cited by 51
The emerging role of dipeptidyl peptidase 3 in pathophysiology
Malovan, G., Hierzberger, B., Suraci, S., Schaefer, M. M., Santos, K. F., Jha, S., & Macheroux, P. (2022) · FEBS Journal · doi:10.1111/febs.16429 · Cited by 55
Modulation of BV-2 microglia functions by novel quercetin pivaloyl ester
Mrvová, N., Škandík, M., Kuniaková, M., & Račková, L. (2015) · Neurochemistry International · doi:10.1016/j.neuint.2015.09.005 · Cited by 50
Ajit, D., Simonyi, Á., Li, R., Chen, Z., Hannink, M., Fritsche, K. L., Mossine, V. V., Smith, R. E., Dobbs, T. K., Luo, R., et al. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.05.004 · Cited by 50
Lim, H.-S., Kim, O. S., Kim, B., & Jeong, S. (2016) · Journal of Medicinal Food · doi:10.1089/jmf.2016.0074 · Cited by 50
Cho, Y., Kim, N., Khan, I., Yu, J.-M., Jung, H. G., Kim, H. H., Jang, J. Y., Kim, H. J., Kim, D., Kwak, J., et al. (2016) · Journal of Food Science · doi:10.1111/1750-3841.13497 · Cited by 49
Mohsenpour, H., Pesce, M., Patruno, A., Bahrami, A., Pour, P. M., & Farzaei, M. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020833 · Cited by 48
Quercetin Reverses Altered Energy Metabolism in the Heart of Rats Receiving Adriamycin Chemotherapy
Eleiwa, N. Z. H., Khalil, S. R., Awad, A., & Khairy, G. M. (2017) · Cardiovascular Toxicology · doi:10.1007/s12012-017-9420-4 · Cited by 47
Ganesan, K., Ramkumar, K. M., & Xu, B. (2020) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2020.173606 · Cited by 47
RetractedGenipin Inhibits LPS-Induced Inflammatory Response in BV2 Microglial Cells
Wang, J., Chen, L., Liang, Z., Li, Y., Yuan, F., Liu, J., Tian, Y., Hao, Z., Zhou, F., Liu, X., et al. (2017) · Neurochemical Research · doi:10.1007/s11064-017-2289-6 · Cited by 44
Cecerska‐Heryć, E., Wiśniewska, Z., Serwin, N. M., Polikowska, A., Goszka, M., Engwert, W., Michałów, J., Pękała, M., Budkowska, M., Michalczyk, A., et al. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084505 · Cited by 48
Supriady, H., Kamarudin, M. N. A., Chan, C. K., Goh, B. H., & Kadir, H. A. (2015) · Journal of Functional Foods · doi:10.1016/j.jff.2015.05.042 · Cited by 43
Park, S. Y., JIN, M. L., Wang, Z., Park, G., & Choi, Y. W. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.09.010 · Cited by 41
Beckmann, D. V., Carvalho, F. B., Mazzanti, C. M. D. A., dos Santos, R. P., de Andrades, A. O., Aiello, G., Rippilinger, A., Graça, D. L., Abdalla, F. H., de Oliveira, L. S., et al. (2014) · Life Sciences · doi:10.1016/j.lfs.2014.03.033 · Cited by 41
Kurtys, E., Eisel, U. L. M., Verkuyl, J. M., Broersen, L. M., Dierckx, R. A. J. O., & de Vries, E. F. J. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.07.008 · Cited by 40
Vargas-Restrepo, F., Sabogal-Guáqueta, A. M., & Cardona‐Gómez, G. P. (2017) · Biomédica · doi:10.7705/biomedica.v38i0.3761 · Cited by 36
Ameliorating effect of quercetin on epilepsy by inhibition of inflammation in glial cells
Wu, D., Zheng, Z., Fan, S., Wen, X., Han, X., Wang, S., Wang, Y., Zhang, Z., Shan, Q., Li, M., et al. (2020) · Experimental and Therapeutic Medicine · doi:10.3892/etm.2020.8742 · Cited by 38
Khallaf, W. A. I., Messiha, B. A. S., Abo‐Youssef, A. M., & Sayed, N. S. E. (2017) · Canadian Journal of Physiology and Pharmacology · doi:10.1139/cjpp-2017-0042 · Cited by 34
The Antiinflammatory Potential of Flavonoids
Catarino, M. D., Talhi, O., Rabahi, A., Silva, A. M. S., & Cardoso, S. M. (2016) · Studies in natural products chemistry · doi:10.1016/b978-0-444-63602-7.00003-5 · Cited by 34
Škandík, M., Mrvová, N., Bezek, Š., & Račková, L. (2020) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2020.02.030 · Cited by 35
Anti-Neuroinflammatory Potential of Natural Products in the Treatment of Alzheimer’s Disease
Deng, M., Yan, W., Gu, Z., Li, Y., Chen, L., & He, B. (2023) · Molecules · doi:10.3390/molecules28031486 · Cited by 38
Quercetin exhibits adjuvant activity by enhancing Th2 immune response in ovalbumin immunized mice
Singh, D. K., Tanwar, H., Jayashankar, B., Sharma, J., Murthy, S., Chanda, S., Singh, S. B., & Ganju, L. (2017) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2017.03.067 · Cited by 32
Yavtushenko, I. V., Nazarenko, S. M., Катрушов, О. В., & Kostenko, V. O. (2020) · Wiadomości Lekarskie · doi:10.36740/wlek202010104 · Cited by 32
Ju, I. G., Huh, E., Kim, N., Lee, S., Choi, J. G., Hong, J., & Oh, M. S. (2021) · Phytomedicine · doi:10.1016/j.phymed.2021.153501 · Cited by 32
Ashari, S., Karami, M. Y., Shokrzadeh, M., Bagheri, A., Ghandadi, M., Ranaee, M., Dashti, A., & Mohammadi, H. (2022) · Toxicology Research · doi:10.1093/toxres/tfac006 · Cited by 32
Martín‐Aragón, S., Jiménez‐Aliaga, K., Benedı́, J., & Bermejo‐Bescós, P. (2016) · Phytomedicine · doi:10.1016/j.phymed.2016.07.007 · Cited by 30
Petruk, G., Donadio, G., Lanzilli, M., Isticato, R., & Monti, D. M. (2018) · Scientific Reports · doi:10.1038/s41598-018-20153-2 · Cited by 29
Khalil, S. R., Mohammed, A. T., El‐fattah, A. H. A., & Zaglool, A. W. (2018) · Toxicology Letters · doi:10.1016/j.toxlet.2018.02.024 · Cited by 29
Querectin improves myelin repair of optic chiasm in lyolecithin-induced focal demyelination model
Naeimi, R., Baradaran, S., Ashrafpour, M., Moghadamnia, A. A., & Ghasemi‐Kasman, M. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.125 · Cited by 28
Park, S. Y., JIN, M. L., Chae, S. Y., Ko, M. J., Choi, Y. H., Park, G., & Choi, Y.-W. (2016) · Neurochemistry International · doi:10.1016/j.neuint.2016.08.006 · Cited by 29
Lunić, T. M., Pavlović, M. O., Mandić, M. R., Sabovljević, A. D., Sabovljević, M., Gašić, U. M., Duletić-Laušević, S. N., Božić, B. D., & Nedeljković, B. B. (2020) · Molecules · doi:10.3390/molecules25153343 · Cited by 28
Singh, D. P., Borse, S., & Nivsarkar, M. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.04.006 · Cited by 28
Microglial activation in Alzheimer's disease: The role of flavonoids and microRNAs
Medrano-Jiménez, E., Meza‐Sosa, K. F., Aragon, J. A. U., Secundino, I., Pedraza-Alva, G., & Pérez-Martínez, L. (2022) · Journal of Leukocyte Biology · doi:10.1002/jlb.3mr1021-531r · Cited by 28
Quercetin and tin protoporphyrin attenuate hepatic ischemia reperfusion injury: role of HO-1
Atef, Y., El-Fayoumi, H. M., Abdel-mottaleb, Y., & Mahmoud, M. F. (2017) · Naunyn-Schmiedeberg's Archives of Pharmacology · doi:10.1007/s00210-017-1389-9 · Cited by 27
Quercetin-biapigenin nanoparticles are effective to penetrate the blood–brain barrier
Oliveira, A. I., Pinho, C., Sarmento, B. F. C. C., & Dias, A. C. P. (2021) · Drug Delivery and Translational Research · doi:10.1007/s13346-021-00917-6 · Cited by 26
Chen, M., Vial, M., Gee, L., Davis, R. A., John, J. A. S., & Ekberg, J. A. K. (2020) · Scientific Reports · doi:10.1038/s41598-020-57793-2 · Cited by 25
Khadrawy, O., Gebremedhn, S., Salilew‐Wondim, D., Rings, F., Neuhoff, C., Hoelker, M., Schellander, K., & Tesfaye, D. (2020) · Reproduction in Domestic Animals · doi:10.1111/rda.13688 · Cited by 25
Kozaeva, R., Klymenko, M. O., Катрушов, О. В., & Kostenko, V. O. (2022) · Wiadomości Lekarskie · doi:10.36740/wlek202203121 · Cited by 25
Inflammation, Autoimmunity and Neurodegenerative Diseases, Therapeutics and Beyond
Garmendia, J. V., Sanctis, C. V. D., Das, V., Annadurai, N., Hajdúch, M., & Sanctis, J. B. D. (2023) · Current Neuropharmacology · doi:10.2174/1570159x22666231017141636 · Cited by 27
An unmet clinical need: roads to remyelination in MS
Göttle, P., Förster, M., Weyers, V., Küry, P., Rejdak, K., Hartung, H., & Kremer, D. (2019) · Neurological Research and Practice · doi:10.1186/s42466-019-0026-0 · Cited by 24
Quercetin effect on the efficiency of ovine oocyte vitrification at GV stage
Davoodian, N., Kadivar, A., Ahmadi, E., Nazari, H., & Mehrban, H. (2021) · Theriogenology · doi:10.1016/j.theriogenology.2021.07.027 · Cited by 23
Harun, A., Vidyadaran, S., Lim, S. M., Cole, A. L. J., & Ramasamy, K. (2015) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-015-0685-5 · Cited by 22
Yelins’ka, A. M., Ляшенко, Л. И., & Kostenko, V. O. (2019) · Wiadomości Lekarskie · doi:10.36740/wlek201908116 · Cited by 23
Huang, D., Zhou, J., Li, W., Zhang, L., Wang, X., & Liu, Q. (2021) · Pharmacology Research & Perspectives · doi:10.1002/prp2.752 · Cited by 22
Medicinal herbal remedies in neurodegenerative diseases: an update on antioxidant potential
Sarkar, B., Rana, N., Singh, C., & Singh, A. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03027-5 · Cited by 26
Hepatoprotective effect of 7-Hydroxycoumarin against Methyl glyoxal toxicity via activation of Nrf2
Li, D., Wang, N., Zhang, J., Ma, S., Zhao, Z., & Ellis, E. M. (2017) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2017.02.020 · Cited by 21
Miquelianin Inhibits Allergic Responses in Mice by Suppressing CD4+ T Cell Proliferation
Choi, D. W., Jung, S. Y., Kim, G.-D., Lee, S., & Shin, H. S. (2021) · Antioxidants · doi:10.3390/antiox10071120 · Cited by 21
Davoodian, N., Kadivar, A., Davoodian, N., Ahmadi, E., Nazari, H., & Mehrban, H. (2022) · Theriogenology · doi:10.1016/j.theriogenology.2022.06.026 · Cited by 20
Liu, L., Lin, S., Chan, D. S., Vong, C. T., Hoi, M. P. M., Wong, C., Ma, D., & Leung, C. (2014) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2014.06.020 · Cited by 20
Covalent adduction of endogenous and food-derived quinones to a protein: its biological significance
Kato, Y., & Suga, N. (2018) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.18-26 · Cited by 20
Lin, H., Tsai, C., Lin, C., Yeh, W., Tsai, C., Chang, P.-C., Wu, L.-H., & Lu, D. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9376-y · Cited by 19
Piano, I., Votta, A., Colucci, P., Corsi, F., Vitolo, S., Cerri, C., Puppi, D., Lai, M., Maya‐Vetencourt, J. F., Leigheb, M., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-47540-8 · Cited by 22
Chuang, D. Y., Simonyi, Á., Cui, J., Lubahn, D. B., Gu, Z., & Sun, G. Y. (2016) · NeuroMolecular Medicine · doi:10.1007/s12017-016-8419-5 · Cited by 19
Wang, W., Chen, J., Li, X. G., & Xu, J. (2016) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2016.09.044 · Cited by 19
Opryshko, V., Prokhach, A. V., Akimov, O. Y., Ryabushko, M. М., Kostenko, H., Kostenko, V., Mishchenko, A. V., Solovyova, N. V., & Kostenko, V. О. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e25058 · Cited by 15
Park, J., Lee, C.-H., & Kim, Y. T. (2023) · Pharmaceuticals · doi:10.3390/ph16070941 · Cited by 17
Metadata
- Authors
- Kang, C.-H., Choi, Y. H., Moon, S.-K., Kim, W.-J., & Kim, G.-Y.
- Affiliations
- Jeju National University (KR)
- Dong-Eui University (KR)
- Chung-Ang University (KR)
- Chungbuk National University (KR)
- Corresponding author
- Kim, Gi-Young
- Venue
- International Immunopharmacology
- Publisher
- Elsevier BV
- Published
- 2013-11
- Volume
- 17
- Issue
- 3
- Pages
- 808-813
- ISSN
- 1567-5769 (ISSN-L)
- OpenAlex
- W4247659709
- Cited by
- 138
- References
- 40
- Citations by year
- 2026: 6 · 2025: 12 · 2024: 10 · 2023: 6 · 2022: 8 · 2021: 11 · 2020: 11 · 2019: 8 · 2018: 11 · 2017: 14 · 2016: 18 · 2015: 15 · 2014: 7
- FWCI
- 7.47
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- International Immunopharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Science and Technology (2008-0062611)
- National Research Foundation of Korea
- Topics
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Health Sciences › Medicine › Pharmacology (medical) › Flavonoids in Medical Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics, phytochemicals, and oxidative stress
- Keywords
- quercetin, nitric oxide production, lipopolysaccharide, BV2 microglial cells, NF-κB signaling, Nrf2, heme oxygenase-1, inducible nitric oxide synthase, IκBα degradation, neuroinflammation, nitrosative stress, cobalt protoporphyrin, neurodegenerative diseases
- MeSH terms
- Animals, Cell Line, Lipopolysaccharides, Membrane Proteins, Nitric Oxide, Quercetin, NF-kappa B, Microglia, Neuroprotective Agents, NF-E2-Related Factor 2, Mice, Heme Oxygenase-1, Nitric Oxide Synthase Type II
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review